California is currently home to 5617 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study to Evaluate Maximum Tolerated Dose of Oral CB-03-10 With Dose Expansion Phase, in Advanced Solid Tumors
Recruiting
Subjects will undergo baseline evaluation and an assessment of extent of disease. Subjects in Part 1 (Dose Escalation) will receive escalating doses of CB-03-10 based on a modified Fibonacci schema using a standard oncology 3+3 study design to define an MTD and a RP2D. Plasma PK samples will be collected at predetermined timepoints for all subjects. Subjects in Part 2 (Dose Expansion) of the study will receive CB-03-10 at the RP2D determined in the Part 1 of the study. The indications included... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/06/2024
Locations: University of California Irvine Health Chao Family Comprehensive Cancer Center, California City, California
Conditions: Advanced Refractory Solid Tumors, Subjects Considered Likely to Respond to CB-03-10
Hyperbaric Oxygen Brain Injury Treatment Trial
Recruiting
The purpose of this innovative adaptive phase II trial design is to determine the optimal combination of hyperbaric oxygen treatment parameters that is most likely to demonstrate improvement in the outcome of severe TBI patients in a subsequent phase III trial.
Gender:
ALL
Ages:
Between 16 years and 65 years
Trial Updated:
02/06/2024
Locations: UCSD Medical Center - Hillcrest Hospital, San Diego, California
Conditions: Traumatic Brain Injury
Use of Allograft Adipose Matrix for Small Joint Arthritis of the Hand
Recruiting
The purpose the research is to evaluate the safety and efficacy of injection of adipose allograft matrix (AAM) to the small joints of the hand for treatment of early stage osteoarthritis. The hypothesis is that use of AAM injected directly into the joint will show improvements in pain and disability while providing a safe, off-the-shelf alternative which can obviate the need for, and risks associated with, current treatment options with autologous fat transfer. As standard of care, routine stre... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2024
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Osteoarthritis Hand
CNS10-NPC-GDNF Delivered to the Motor Cortex for ALS
Recruiting
The investigator is examining the safety of transplanting cells, that have been engineered to produce a growth factor, into the motor cortex (brain) of patients with Amyotrophic Lateral Sclerosis (ALS). The cells are called neural progenitor cells, which are a type of stem cell that can become several different types of cells in the nervous system. These cells have been derived to specifically become astrocytes, which is a type of neural cell. The growth factor is called glial cell line-derived... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2024
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Amyotrophic Lateral Sclerosis
MS-ResearchBiomarkerS
Recruiting
This study is being conducted to investigate risk factors for disability progression in Multiple Sclerosis and related disorders (MSRD). The primary goal is to assess whether combining information from visual assessment, blood markers, as well as historical and ongoing longitudinal MRIs of the brain, orbit (the part of the skull where eyes are located), and/or spinal cord can predict changes in quantitative disability measures related to MSRD and neurological disease.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2024
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Secondary Progressive, Clinically Isolated Syndrome, Radiologically Isolated Syndrome, Neuromyelitis Optica Spectrum Disorders, Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease, Neurologic Autoimmune Disease, Neurologic Disorder, Healthy Aging
RB Liquid Biopsy Biorepository
Recruiting
Retinoblastoma (RB) is a primary eye cancer that forms in the back of the eye of infants and toddlers. Traditionally, RB is diagnosed without a biopsy; tumor can only be studied once an eye has been surgically removed. Given this limitation, we use aqueous humor (AH), the clear fluid in the front of the eye to detect specific markers, or information, that comes from the tumor itself.
Gender:
ALL
Ages:
Between 0 years and 18 years
Trial Updated:
02/05/2024
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Retinoblastoma, Retinoblastoma Bilateral, Retinoblastoma Unilateral
Treatment of Refractory Infantile Spasms With Fenfluramine
Recruiting
This is a phase II clinical trial in which children with refractory infantile spasms (also called epileptic spasms or West syndrome) will be treated with fenfluramine, to evaluate efficacy, safety, and tolerability. Patients with infantile spasms that have not responded to treatment with vigabatrin and ACTH we will be invited to participate. Study participants will undergo baseline video-EEG, receive treatment with fenfluramine for 21 days, and then undergo repeat video-EEG to determine effectiv... Read More
Gender:
ALL
Ages:
Between 12 months and 36 months
Trial Updated:
02/05/2024
Locations: UCLA Health, Los Angeles, California
Conditions: Infantile Spasm
CNS10-NPC for the Treatment of RP
Recruiting
The investigator is examining the safety of transplanting cells into the subretinal space of patients with Retinitis Pigmentosa (RP). The cells are called neural progenitor cells, which are a type of stem cell that can become several different types of cells in the nervous system. These cells have been derived to specifically become astrocytes, which is a type of neuronal cell. The cells are called "CNS10-NPC." The investigational treatment has been tested in animals, but it has not yet been tes... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2024
Locations: Retina-Vitreous Associates Medical Group, Beverly Hills, California
Conditions: Retinitis Pigmentosa
Microdosing ICG for Serial Colonic Perfusion Study During Surgery
Recruiting
using microdosing of ICG vs regular dosing of ICG for perfusion assessment during surgery
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/03/2024
Locations: UC San Diego, La Jolla, California
Conditions: Perfusion; Complications
Epidemiology of Young Lung Cancer - Survey
Recruiting
This is a 100% virtual (remote), case-case study to explore potential environmental, lifestyle and genetic factors that may be associated with driver mutations of young lung cancer in the U.S.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/01/2024
Locations: USC Keck School of Medicine, Los Angeles, California
Conditions: NSCLC
Safety, Tolerability and Pharmacokinetics of a Monoclonal Antibody Specific to B-and T-Lymphocyte Attenuator (BTLA) as Monotherapy and in Combination With an Anti-PD1 Monoclonal Antibody for Injection in Subjects With Advanced Malignancies
Recruiting
The primary objective is to assess the safety and tolerability of TAB004 as monotherapy and in combination with toripalimab in subjects with selected advanced solid malignancies, including lymphoma, and to evaluate the recommended Phase 2 dose. The secondary objectives are to: 1) describe the pharmacokinetic (PK) profile of TAB004 monotherapy and in combination with toripalimab and to describe the PK profile of toripalimab when administered with TAB004, 2) evaluate antitumor activity of TAB004... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/01/2024
Locations: UCLA Health Westwood Cancer Care, Los Angeles, California
Conditions: Advanced Unresectable Solid Tumor, Metastatic Solid Tumor
STAT: Standard Therapy Plus Active Therapy
Recruiting
The objective of the study is to assess the efficacy of STAT, an activity-based therapy protocol compared to standard therapy (ST) to improve functional outcome and reduce disability in patients recovering from burn injury. This randomized multi-center trial is designed with two parallel treatment groups: STAT and ST. Efficacy of the STAT protocol will be determined through comparison to the ST only group. It will be conducted at seven burn centers.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/31/2024
Locations: University of California Davis Medical Center-Regional Burn Center, Sacramento, California
Conditions: Burn Injury, Physical Injury, Thermal Burn