California is currently home to 5966 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Pilot Comparing ctDNA IDV vs. SPV Sample in Pts Undergoing Biopsies for Hepatobiliary and Pancreatic Cancers
Recruiting
This is a prospective pilot protocol investigating whether ctDNA detection be improved by sampling the cancer draining vein versus the standard practice of sampling from a peripheral vein in patients who are undergoing biopsies for hepatobiliary and pancreatic cancers.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/02/2023
Locations: Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, California
Conditions: Hepatobiliary Cancer, Pancreatic Cancer, Hepatocellular Carcinoma, Cholangiocarcinoma, Ampullary Cancer, Pancreatic Carcinoma
Impact of Meal Timing on Glycemic Profiles in Adolescents With Type 2 Diabetes
Recruiting
Because of its simplicity, TLE may represent a more feasible approach for adolescents than other caloric restriction regimens based on macronutrient composition and kilocalories. Our preliminary data support TLE feasibility, acceptability, and safety in adolescents with obesity, with and without T2D. However, no trial to date has studied the effects of TLE on glycemic control and body composition in adolescents with T2D. Our long-term goal is to determine whether TLE is a beneficial as part of t... Read More
Gender:
All
Ages:
Between 12 years and 21 years
Trial Updated:
05/02/2023
Locations: Children's Hospital of Los Angeles, Los Angeles, California
Conditions: Pediatric Obesity, Type 2 Diabetes, Time Restricted Eating
Analgesia-First Sedation in Trauma Patients
Recruiting
The study's aim is to ascertain the best approach for providing sedation and pain management for patients who have sustained trauma and are requiring respiratory support from a mechanical ventilator. The common approach to patients who need mechanical ventilation is to provide continuous drips of sedatives and pain medicine and awaken the patient once a day to check the brain functions. Another approach is to provide pain medicine and reserve sedatives for only a short duration when needed. The... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/01/2023
Locations: Long Beach Memorial Medical Center, Long Beach, California
Conditions: Mechanical Ventilation, Respiratory Failure
Prevalence of Pathogens in Synovial Fluid Obtained From Emergency Department Patients
Recruiting
This is a prospective, observational study of patients presenting to the emergency departments at 9 EMERGEncy ID NET sites. The objectives of the proposed study are to: Describe the range and proportion of infectious agents in synovial fluid as detected by standard C&S and investigational PCR testing, i.e., Biofire® Film Array® Bone and Joint Infection (BJI) Panel, Describe the epidemiology of patients receiving diagnostic arthrocentesis and those diagnosed with septic arthritis in the emergenc... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/01/2023
Locations: Olive View-UCLA Medical Center, Sylmar, California
Conditions: Septic Arthritis, Joint Infection
Peri-operative Oral Pain Control Following Buccal Graft Urethroplasty
Recruiting
Patients undergoing buccal urethroplasty will often have significant post-operative oral pain from the graft site. Various graft harvest techniques and methods for post-harvest hemostasis including graft site closure have been explored. Despite the frequency of this clinical scenario there is no established best practice for peri-operative pain management in this patient population. In addition to traditional post operative pain control, groups have sought various peri-operative anesthetic regim... Read More
Gender:
Male
Ages:
18 years and above
Trial Updated:
05/01/2023
Locations: University of California San Francisco, San Francisco, California
Conditions: Urethral Stricture, Male
Integrating Abbott Point-of-Care Technologies and the Community Scientist Model to Support HbA1c Testing Per ADA
Recruiting
In the United States, the growing Hispanic/Latino population is at high risk for type 2 diabetes and associated complications, yet underserved in healthcare and underrepresented in research. The purpose of this Sansum Diabetes Research Institute (SDRI) study is to create an HbA1c testing and support closed-loop system for U.S. Hispanic/Latino families. This loop will integrate Abbott's point-of-care (POC) technology with SDRI's Community Scientist Model to contact, test, intervene, and monitor L... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/01/2023
Locations: Sansum Diabetes Research Institute, Santa Barbara, California
Conditions: Diabetes Mellitus, Type 2, Cardiovascular Diseases
Chemoradiation vs Immunotherapy and Radiation for Head and Neck Cancer
Recruiting
The purpose of this study is to compare any good or bad effects of using pembrolizumab (an experimental drug) and radiation therapy (RT), compared to using cisplatin chemotherapy and radiation therapy (RT) in the treatment of patients with head and neck squamous cell carcinoma (HNSCC).
Gender:
All
Ages:
18 years and above
Trial Updated:
05/01/2023
Locations: UC San Diego Moores Cancer Center, La Jolla, California
Conditions: Head and Neck Squamous Cell Carcinoma, Cancer, Cancer of Head and Neck, Cancer, Advanced, Cancer, Metastatic, Tumor, Tumor Recurrence, Tumor Neck, Tumor Metastasis, Oral Cancer, Oropharyngeal Cancer, Oropharynx Cancer, Oropharynx Cancer, Stage III, Oropharynx Cancer, Recurrent, Oropharynx Cancer, Metastatic
Fertility Preservation Using Tamoxifen and Letrozole in Estrogen Sensitive Tumors Trial
Recruiting
Latrogenic infertility as a result of cancer treatment has a profound effect on long-term quality of life in survivors of reproductive-age cancers. Oocyte cryopreservation prior to cancer treatment has been associated with improved quality of life, with a potential ability to reduce long-term decision-related regret in cancer survivors. Though letrozole plus gonadotropin and and tamoxifen plus gonadotropin are currently routinely used worldwide in ovarian stimulation cycles for fertility preserv... Read More
Gender:
Female
Ages:
Between 18 years and 50 years
Trial Updated:
05/01/2023
Locations: University of California at San Francisco, San Francisco, California
Conditions: Infertility
PARTNER 3 Trial - Aortic Valve-in-Valve
Recruiting
This study will assess the safety and effectiveness of the SAPIEN 3/SAPIEN 3 Ultra transcatheter heart valve (THV) in patients with a failing aortic bioprosthetic valve.
Gender:
All
Ages:
All
Trial Updated:
05/01/2023
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Aortic Stenosis, Aortic Stenosis, Severe
Blood Glucose Differences Using CGMs Between the Left and Right Arm in Patients With Diabetes
Recruiting
There are multiple CGMs that are FDA approved. However, there are few studies looking at the variability of measurements between the left and right arm, and none looking at this effect in diabetic patients. This study may identify if glucose differences exist in the left and right arm in patients with Type 1 or Type 2 Diabetes. Furthermore, it may point to future directions for research to standardize methods of glucose measurement such as consistently measuring on only one side of the body.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
04/28/2023
Locations: University of the Pacific, Stockton, California
Conditions: Type 1 Diabetes, Type 2 Diabetes
Natural History Study of Patients With HPDL Mutations
Recruiting
This study uses medical records that allow retrospective data extraction of clinical manifestation to assess the natural history of HPDL mutations
Gender:
All
Ages:
All
Trial Updated:
04/28/2023
Locations: Eun Hae Lee, San Diego, California
Conditions: Mitochondrial Encephalomyopathies, Hereditary Spastic Paraplegia, Spastic Paraplegia, White Matter Disease, Neonatal Encephalopathy, Mutation, Genetic Disease
Cannabidiol to Reduce Anxiety Reactivity
Recruiting
This study seeks to understand how cannabidiol (CBD) - a non-intoxicating chemical compound obtained from the Cannabis sativa plant - affects biological and stress-related responses that are believed to underlie anxiety disorders. This study will evaluate the effects of different doses of CBD on blood plasma levels of anandamide (a molecule in the brain that has been shown to help regulate stress responses; primary biological signature) and anxiety reactivity to a standardized stress task (secon... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
04/28/2023
Locations: University of California, San Deigo, San Diego, California
Conditions: Social Anxiety, Social Anxiety Disorder