California is currently home to 5617 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
TPIV100 and Sargramostim for the Treatment of HER2 Positive, Stage II-III Breast Cancer in Patients With Residual Disease After Chemotherapy and Surgery
Recruiting
This phase II trial studies how well TPIV100 and sargramostim work in treating patients with HER2 positive, stage II-III breast cancer that has residual disease after chemotherapy prior to surgery. It also studies why some HER2 positive breast cancer patients respond better to chemotherapy in combination with trastuzumab and pertuzumab. TPIV100 is a type of vaccine made from HER2 peptide that may help the body build an effective immune response to kill tumor cells that express HER2. Sargramostim... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/15/2023
Locations: City of Hope Comprehensive Cancer Center, Duarte, California
Conditions: Breast Adenocarcinoma, Stage II Breast Cancer AJCC v6 and v7, Stage IIA Breast Cancer AJCC v6 and v7, Stage IIB Breast Cancer AJCC v6 and v7, Stage III Breast Cancer AJCC v7, Stage IIIA Breast Cancer AJCC v7, Stage IIIB Breast Cancer AJCC v7, Stage IIIC Breast Cancer AJCC v7
Contrast Enhanced Endoscopic Ultrasound in Pancreas Lesions
Recruiting
The purpose of this study is to determine whether quantitative contrast-enhanced endoscopic ultrasound (CE-EUS) improves the evaluation of pancreas tumors and precursor lesions, including cysts, compared to conventional endoscopic ultrasound.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/13/2023
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Pancreatitis, Pancreas Cancer, Pancreas Cyst
The Effects of Noninvasive Neuromodulation on Mental Wellness, Behavior, and Electrophysiology
Recruiting
The purpose of the study is to test the effects of brief, low-intensity transcranial focused ultrasound (TUS) on electrophysiological, behavioral, and cognitive markers related to anxiety disorders.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/12/2023
Locations: Sanmai Technologies PBC, Sunnyvale, California
Conditions: Anxiety Disorders
Investigate the Efficacy and Safety of Farudodstat Compared With Its Placebo in Adult Alopecia Areata Participants
Recruiting
The main purpose of this study is to measure the efficacy of farudodstat compared to placebo at Week 12 from the treatment start, in adult participants with Alopecia Areata (AA) with 30% or greater scalp hair loss.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/12/2023
Locations: 1 Site, Fountain Valley, California
Conditions: Alopecia Areata
Hyperpolarized Pyruvate (13C) Magnetic Resonance Imaging In Patients With Fatty Liver Disease
Recruiting
The recent development of dissolution dynamic nuclear polarization (DNP) technology for hyperpolarized (HP) 13C imaging offers a promising new avenue for non-invasively accessing fundamental metabolic changes associated with the progression of fatty liver disease in vivo. The purpose of this pilot study is to optimize sequence parameters for hyperpolarized 13C acquisition in the human liver and determine which metabolic changes can be seen in humans with simple, non-alcoholic fatty liver disease... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/10/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Non-Alcoholic Fatty Liver Disease, Non Alcoholic Fatty Liver, Non Alcoholic Steatohepatitis, NAFLD, NASH
AM for Refractory Achilles Tendinopathy
Recruiting
To evaluate outcomes after use of micronized amniotic membrane to replace or supplement damaged or inadequate integumental tissue in patients with "chronic" insertional or non-insertional Achilles tendinopathy that remains refractory to standard care. Outcomes between a control and treatment group in this pilot study will be used to devise a multi-center study with larger sample size.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
12/07/2023
Locations: North Park Podiatry, San Diego, California
Conditions: Achilles Tendinopathy
iMmune SignAtures and Clinical outComes in AP
Recruiting
The MoSAIC study is a prospective, observational study designed to develop an early prediction tool for severe acute pancreatitis (SAP) and define a distinct immunologic profile compared to moderate acute pancreatitis (MAP). The aims are to validate a new multi-cytokine panel for early prediction of SAP and to identify the specific immune cells that correspond with cytokine signatures in early acute pancreatitis to characterize the immune pathways driving the development of SAP. Participants wil... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
12/07/2023
Locations: University of Southern California, Los Angeles, California
Conditions: Acute Pancreatitis
Evaluation of the Effectiveness of Nail Genesis DLSO Product for Onychomycosis
Recruiting
This is a Pre-IDE, prospective, multicenter, randomized, parallel-group, double-blind, vehicle- controlled study to evaluate safety and effectiveness of Nail Genesis DLSO Product for the treatment of DLSO compared with vehicle in infected great toenails in a total of 338 males and non-pregnant, non-lactating, females between 18 and 65 years of age (inclusive). Subjects will be randomized in a 2:1 ratio to receive either Nail Genesis DLSO Product or vehicle. Subject eligibility will be determine... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/06/2023
Locations: Catalina Research Institute, LLC, Montclair, California
Conditions: Distal Lateral Subungual Onychomycosis, Onychomycosis
Autologous Fat Grafting to the Face With Use of the Viality™ System
Recruiting
The purpose of this research is to collect data on the short and long-term effects of facial fat grafting by injectable tissue replacement and regeneration in the midfacial zone, with the use of the VialityTM system. The Viality system is a US Food and Drug Administration (FDA) cleared device.
Gender:
FEMALE
Ages:
Between 18 years and 65 years
Trial Updated:
12/05/2023
Locations: Faces Plus, San Diego, California
Conditions: Adipose Tissue
Prostate Resection After Microwave Ablation (PRAMA)
Recruiting
This phase I trial tests the safety of magnetic resonance imaging (MRI)/ ultrasound (US) fusion guided transperineal targeted microwave ablation (TMA) before a radical prostatectomy (RP) and how well it works in treating patients with prostate cancer. Prostate cancer is the second most common cancer in men and most will never become aggressive. Despite this, most men choose to undergo treatment which may include surgery. Removing the prostate gland and sometimes the lymph nodes (radical prostate... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
12/05/2023
Locations: USC / Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Prostate Carcinoma
International CDKL5 Clinical Research Network
Recruiting
Pathogenic variants in the Cyclin-dependent kinase like 5 (CDKL5) gene cause CDKL5 deficiency disorder (CDD, MIM 300672, 105830), a severe developmental and epileptic encephalopathy associated with cognitive and motor impairments and cortical visual impairment. While capability for disease modifying therapies is accelerating, there is a critical barrier for clinical trial readiness that may result in failure of these therapies, not due to lack of efficacy but due to lack of validated outcome mea... Read More
Gender:
ALL
Ages:
Between 1 month and 100 years
Trial Updated:
12/05/2023
Locations: University of California Los Angeles/UCLA Mattel Children's Hospital, Los Angeles, California
Conditions: CDKL5, CDKL5 Deficiency Disorder, CDD
Probing the Dorsolateral Prefrontal Cortex and Central Executive Network for Improving Neuromodulation in Depression
Recruiting
Depression is a highly prevalent condition characterized by persistent low mood, energy, and activity that can affect one's thoughts, mood, behavior, and sense of well-being. Repetitive transcranial magnetic stimulation (rTMS), a non-invasive neuromodulatory technique, is an effective treatment for depression when targeting the dorsolateral prefrontal cortex (dlPFC) of the central executive network (CEN). However, remission rates are suboptimal and individual methods to target the dlPFC are lack... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/05/2023
Locations: Stanford University, Stanford, California
Conditions: Major Depressive Disorder