California is currently home to 5915 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Psilocybin Therapy for Depression in Bipolar II Disorder
Recruiting
The purpose of this study is to determine the safety, tolerability, and feasibility of psilocybin therapy in people with Bipolar II Disorder.
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
04/19/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Bipolar II Disorder
Danazol for Treatment of Cytopenias in Patients With Cirrhosis
Recruiting
This is a phase II pilot study designed to assess the safety and efficacy of danazol for treatment of cytopenias in patients with CPC A/B cirrhosis. Subjects with or without telomere mutations and/or shortened telomeres will be treated with danazol 600 mg per day by mouth for a duration of 24 months. The goal will be to treat a total of 10 patients.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/19/2023
Locations: Keck Hosital of USC, Los Angeles, California
Conditions: Cirrhosis, Liver, Cytopenia
A Study of DF6002 Alone and in Combination With Nivolumab
Recruiting
The purpose of this study is to evaluate the safety, tolerability, drug-levels, drug-effects and preliminary anti-tumor activity of DF6002 alone and in combination with Nivolumab in participants with advanced solid tumors.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/19/2023
Locations: Local Institution, Orange, California
Conditions: Solid Tumors
Shifting Sleep Timing in Teens
Recruiting
The goal of this clinical trial is to determine whether a combination of a novel lighting intervention and a behavioral intervention are able to increase total sleep time in adolescents. The main questions this trial aims to answer are whether this combination therapy is able to meaningfully increase total sleep time in adolescents, and do so over a sustained period of time, and whether such a changes is associated with concomitant changes in mood and cognitive performance.
Gender:
All
Ages:
Between 14 years and 18 years
Trial Updated:
04/18/2023
Locations: Stanford University, Stanford, California
Conditions: Sleep Insufficiency, Sleep, Adolescent Behavior
A Clinical Investigation to Follow the Progress of Exuding Chronic Wounds Using Mepilex® Up as the Primary Dressing.
Recruiting
The goal of this clinical trial is to follow the progress of wounds in those with venous leg ulcers and diabetic foot ulcers while using an absorbent dressing called Mepilex Up. The main objective is to follow the progress of these wounds over time from initial visit to each follow-up visit. Participants will be asked to wear Mepilex Up dressing for up to 6 weeks of treatment or until healed, changed at every one-week interval.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/18/2023
Locations: Center for Clinical Research, Inc., Castro Valley, California
Conditions: Wounds, Wound of Skin, Wound Leg, Wound; Foot, Diabetic Foot Ulcer, Venous Leg Ulcer
Mobile Mindfulness for Alcohol Use and PTSD Among Veterans
Recruiting
The purpose of the present study is to develop and test a mobile mindfulness intervention for Alcohol Use Disorder and PTSD among OEF/OIF veterans
Gender:
All
Ages:
18 years and above
Trial Updated:
04/18/2023
Locations: University of Southern California, Los Angeles, California
Conditions: Alcohol Use Disorder, Posttraumatic Stress Disorder
Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)
Recruiting
Spinal muscular atrophy (SMA) is a neurogenetic disorder caused by a loss or mutation in the survival motor neuron 1 gene (SMN1) on chromosome 5q13, which leads to reduced SMN protein levels and a selective dysfunction of motor neurons. SMA is an autosomal recessive, early childhood disease with an incidence of 1:10,000 live births. SMA is the leading cause of infant mortality due to genetic diseases. Until recently, the mainstay of treatment for these patients was supportive medical care. Howe... Read More
Gender:
All
Ages:
All
Trial Updated:
04/18/2023
Locations: Loma Linda University Health, Loma Linda, California
Conditions: Spinal Muscular Atrophy (SMA)
Parkinson Progression Marker Initiative Online (PPMI Online)
Recruiting
Parkinson Progression Marker Initiative Online (PPMI Online) is an observational study collecting participant reported information from people with and without Parkinson's disease (PD), for the goal of better understanding risk and predictive factors for PD. PPMI Online is part of the broader Parkinson Progression Marker Initiative aimed at identifying markers of disease progression for use in clinical trials of therapies to reduce progression of PD disability.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/17/2023
Locations: UCSF Movement Disorders and Neuromodulation Center (MDNC), San Francisco, California
Conditions: Parkinson Disease
Bedside Ultrasound of Gastric Contents in Pediatric Populations
Recruiting
Perioperative aspiration of gastric contents is a rare but serious adverse event. The risk of aspiration can be estimated by perioperative evaluation of stomach contents with ultrasound using a validated technique and scoring system. A lack of knowledge or familiarity is frequently cited by anesthesia providers as a rationale for not performing perioperative ultrasound assessments. The purpose of this study is to determine whether novice ultrasonography users (medical students, undergraduates, o... Read More
Gender:
All
Ages:
Between 2 years and 60 years
Trial Updated:
04/17/2023
Locations: LPCH/SHC, Stanford, California
Conditions: Gastric Contents
Brain Stimulation, Clinical Symptoms and Cognition
Recruiting
The purpose of this study is to test the impact of non-invasive brain stimulation, transcranial direct current stimulation (tDCS), on auditory hallucinations, negative symptoms and cognition in schizophrenia. Clinical measures will be used to assess clinical symptoms and cognitive performance to test the hypothesis that a course of tDCS can reduce auditory hallucinations and negative symptoms in schizophrenia.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
04/16/2023
Locations: Imaging Research Center, Sacramento, California
Conditions: Schizophrenia
Neuroimaging Biomarkers for Predicting rTMS Response in OCD
Recruiting
This study evaluates an accelerated schedule of theta-burst stimulation using a Transcranial Magnetic Stimulation (TMS) device for treatment-resistant Obsessive Compulsive Disorder (OCD). In a randomized fashion, half the participants will receive accelerated theta-burst stimulation at the dorsomedial prefrontal cortex (DMPFC), while half will receive accelerated theta-burst stimulation at the right orbitofrontal (rOFC) site.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
04/16/2023
Locations: Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine, Stanford, California
Conditions: Obsessive-Compulsive Disorder
Virtual Reality Attention Management
Recruiting
Problems with distraction are widespread in the 21st century, but for people with developmental delays or behavioral challenges they can have more damaging effects. For example, susceptibility to distraction is associated with worse school and social performance, lower high school graduation rates, and increased incidence of serious accidents. The investigators' goal is to improve understanding of distractibility and develop a targeted treatment. The proposed intervention is based on models of h... Read More
Gender:
All
Ages:
Between 8 years and 12 years
Trial Updated:
04/16/2023
Locations: UC Davis MIND Institute, Sacramento, California
Conditions: ADHD