California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Contrast Enhanced Endoscopic Ultrasound in Pancreas Lesions
Recruiting
The purpose of this study is to determine whether quantitative contrast-enhanced endoscopic ultrasound (CE-EUS) improves the evaluation of pancreas tumors and precursor lesions, including cysts, compared to conventional endoscopic ultrasound.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/13/2023
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Pancreatitis, Pancreas Cancer, Pancreas Cyst
The Effects of Noninvasive Neuromodulation on Mental Wellness, Behavior, and Electrophysiology
Recruiting
The purpose of the study is to test the effects of brief, low-intensity transcranial focused ultrasound (TUS) on electrophysiological, behavioral, and cognitive markers related to anxiety disorders.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/12/2023
Locations: Sanmai Technologies PBC, Sunnyvale, California
Conditions: Anxiety Disorders
Investigate the Efficacy and Safety of Farudodstat Compared With Its Placebo in Adult Alopecia Areata Participants
Recruiting
The main purpose of this study is to measure the efficacy of farudodstat compared to placebo at Week 12 from the treatment start, in adult participants with Alopecia Areata (AA) with 30% or greater scalp hair loss.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/12/2023
Locations: 1 Site, Fountain Valley, California
Conditions: Alopecia Areata
Hyperpolarized Pyruvate (13C) Magnetic Resonance Imaging In Patients With Fatty Liver Disease
Recruiting
The recent development of dissolution dynamic nuclear polarization (DNP) technology for hyperpolarized (HP) 13C imaging offers a promising new avenue for non-invasively accessing fundamental metabolic changes associated with the progression of fatty liver disease in vivo. The purpose of this pilot study is to optimize sequence parameters for hyperpolarized 13C acquisition in the human liver and determine which metabolic changes can be seen in humans with simple, non-alcoholic fatty liver disease... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/10/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Non-Alcoholic Fatty Liver Disease, Non Alcoholic Fatty Liver, Non Alcoholic Steatohepatitis, NAFLD, NASH
AM for Refractory Achilles Tendinopathy
Recruiting
To evaluate outcomes after use of micronized amniotic membrane to replace or supplement damaged or inadequate integumental tissue in patients with "chronic" insertional or non-insertional Achilles tendinopathy that remains refractory to standard care. Outcomes between a control and treatment group in this pilot study will be used to devise a multi-center study with larger sample size.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
12/07/2023
Locations: North Park Podiatry, San Diego, California
Conditions: Achilles Tendinopathy
Evaluation of the Effectiveness of Nail Genesis DLSO Product for Onychomycosis
Recruiting
This is a Pre-IDE, prospective, multicenter, randomized, parallel-group, double-blind, vehicle- controlled study to evaluate safety and effectiveness of Nail Genesis DLSO Product for the treatment of DLSO compared with vehicle in infected great toenails in a total of 338 males and non-pregnant, non-lactating, females between 18 and 65 years of age (inclusive). Subjects will be randomized in a 2:1 ratio to receive either Nail Genesis DLSO Product or vehicle. Subject eligibility will be determine... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/06/2023
Locations: Catalina Research Institute, LLC, Montclair, California
Conditions: Distal Lateral Subungual Onychomycosis, Onychomycosis
Autologous Fat Grafting to the Face With Use of the Viality™ System
Recruiting
The purpose of this research is to collect data on the short and long-term effects of facial fat grafting by injectable tissue replacement and regeneration in the midfacial zone, with the use of the VialityTM system. The Viality system is a US Food and Drug Administration (FDA) cleared device.
Gender:
FEMALE
Ages:
Between 18 years and 65 years
Trial Updated:
12/05/2023
Locations: Faces Plus, San Diego, California
Conditions: Adipose Tissue
International CDKL5 Clinical Research Network
Recruiting
Pathogenic variants in the Cyclin-dependent kinase like 5 (CDKL5) gene cause CDKL5 deficiency disorder (CDD, MIM 300672, 105830), a severe developmental and epileptic encephalopathy associated with cognitive and motor impairments and cortical visual impairment. While capability for disease modifying therapies is accelerating, there is a critical barrier for clinical trial readiness that may result in failure of these therapies, not due to lack of efficacy but due to lack of validated outcome mea... Read More
Gender:
ALL
Ages:
Between 1 month and 100 years
Trial Updated:
12/05/2023
Locations: University of California Los Angeles/UCLA Mattel Children's Hospital, Los Angeles, California
Conditions: CDKL5, CDKL5 Deficiency Disorder, CDD
Probing the Dorsolateral Prefrontal Cortex and Central Executive Network for Improving Neuromodulation in Depression
Recruiting
Depression is a highly prevalent condition characterized by persistent low mood, energy, and activity that can affect one's thoughts, mood, behavior, and sense of well-being. Repetitive transcranial magnetic stimulation (rTMS), a non-invasive neuromodulatory technique, is an effective treatment for depression when targeting the dorsolateral prefrontal cortex (dlPFC) of the central executive network (CEN). However, remission rates are suboptimal and individual methods to target the dlPFC are lack... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/05/2023
Locations: Stanford University, Stanford, California
Conditions: Major Depressive Disorder
Exercise for Brain Regeneration in Epilepsy
Recruiting
Nearly 100 million Americans are affected by neurological disorders with an overall cost above $765 billion for the more prevalent conditions. Given this significant burden, effective treatments to prevent dementia and new disease modifying therapies are urgently needed. Regeneration of lost neurons with new ones (i.e., neurogenesis) is compromised at early stages of dementia and in part correlates with cognitive impairment in Alzheimer's disease. Boosting the neurogenesis delays the cognitive... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/05/2023
Locations: University of Southern California Department of Neurosurgery, Los Angeles, California
Conditions: Temporal Lobe Epilepsy
Brain Imaging Biomarkers for Response to Spinal Cord Stimulation in Patients With Chronic Low Back Pain
Recruiting
In this protocol, "Brain imaging biomarkers for response to Spinal Cord Stimulation in patients with chronic low back pain," the investigators plan to perform brain mapping studies in 42 patients who are undergoing spinal cord stimulation (SCS) for chronic low back pain (CLBP) as part of the participants normal clinical care during a 2-year period. This imagining study is completed for research purposes. There is no standard of care imaging for the participants. This study requires two visits in... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
12/05/2023
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Chronic Low-back Pain
Closed-loop Optimized rTMS for Depression
Recruiting
Targeted and individualized treatments for mental health disorders are critically needed. Repetitive transcranial magnetic stimulation (rTMS) represents the front-line of new and innovative approaches to normalizing dysfunctional brain networks in those with mental illness. rTMS is FDA-approved for depression and obsessive-compulsive disorder with clinical trials underway for PTSD and addiction, among others. However, remission rates are suboptimal and ideal stimulation parameters are unknown. W... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/05/2023
Locations: Stanford University, Stanford, California
Conditions: Major Depressive Disorder