California is currently home to 5617 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Exercise for Brain Regeneration in Epilepsy
NCT05179083
Recruiting
Nearly 100 million Americans are affected by neurological disorders with an overall cost above $765 billion for the more prevalent conditions. Given this significant burden, effective treatments to prevent dementia and new disease modifying therapies are urgently needed. Regeneration of lost neurons with new ones (i.e., neurogenesis) is compromised at early stages of dementia and in part correlates with cognitive impairment in Alzheimer's disease. Boosting the neurogenesis delays the cognitive... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/05/2023
Locations: University of Southern California Department of Neurosurgery, Los Angeles, California
Conditions: Temporal Lobe Epilepsy
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Brain Imaging Biomarkers for Response to Spinal Cord Stimulation in Patients With Chronic Low Back Pain
NCT04658628
Recruiting
In this protocol, "Brain imaging biomarkers for response to Spinal Cord Stimulation in patients with chronic low back pain," the investigators plan to perform brain mapping studies in 42 patients who are undergoing spinal cord stimulation (SCS) for chronic low back pain (CLBP) as part of the participants normal clinical care during a 2-year period. This imagining study is completed for research purposes. There is no standard of care imaging for the participants. This study requires two visits in... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
12/05/2023
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Chronic Low-back Pain
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Closed-loop Optimized rTMS for Depression
NCT04142320
Recruiting
Targeted and individualized treatments for mental health disorders are critically needed. Repetitive transcranial magnetic stimulation (rTMS) represents the front-line of new and innovative approaches to normalizing dysfunctional brain networks in those with mental illness. rTMS is FDA-approved for depression and obsessive-compulsive disorder with clinical trials underway for PTSD and addiction, among others. However, remission rates are suboptimal and ideal stimulation parameters are unknown. W... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/05/2023
Locations: Stanford University, Stanford, California
Conditions: Major Depressive Disorder
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Peer Support for Patients With Diabetic Foot Ulcers
NCT06004219
Recruiting
The objective of the study is to develop a peer support program that helps improve ulcer care in patients with a diabetic foot ulcer (DFU).Diabetes, peripheral arterial disease (PAD), foot ulceration, and subsequent amputation are unevenly patterned in terms of racial/ethnicity, socioeconomic status, health insurance, and geographic area. The project will identify opportunities to reduce health disparities among economically marginalized patients regarding DFU outcomes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/04/2023
Locations: Rancho Los Amigos National Rehabilitation Center, Downey, California
Conditions: Diabetic Foot Ulcer, Diabetic Wound, Diabetes Mellitus, Type 2, Diabetic Foot, Diabetes Complications, Peripheral Neuropathy
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Simplified IMmunosuppressive Protocol Utilizing Low Dose EnvarsusXR
NCT04773392
Recruiting
The purpose of this study is to determine if the combination of once-daily tacrolimus extended-release (EnvarsusXR) and Azathioprine is non inferior with respect to the composite outcome of acute rejection, graft and patient survival as compared to a combination of twice-daily immediate release tacrolimus and mycophenolate mofetil/mycophenolic acid.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
12/04/2023
Locations: University of Southern California, Los Angeles, California
Conditions: Kidney Transplantation, Kidney Transplant Rejection
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The K-Map Study, Global Prevalence of KC
NCT03115710
Recruiting
Keratoconus is a ocular disease classified under ectatic diseases which often results in bilateral and asymmetrical corneal distortion. It usually affects patients at young age and can cause severe visual loss. The overall goal of this study is to assess the prevalence of keratoconus (KC) in children and adolescents in various regions of the world based on modern tomographic imaging methods, and to verify whether the occurrence rates reported from literature should be corrected. Our hypothesis... Read More
Gender:
ALL
Ages:
Between 6 years and 23 years
Trial Updated:
12/04/2023
Locations: USC Roski Eye Institute, Los Angeles, California
Conditions: Keratoconus
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Normative Radiographic Parameters and Growth Curve of Hips Less Than Six Weeks of Gestational Age Using Ultrasound
NCT03109444
Recruiting
This study aims to collect normative population data on the ultrasound radiographic parameters used to evaluate hip dysplasia in infants between 32 and 46 weeks of gestational age. This data would be utilized to develop a growth chart with standard deviations for this cohort that would be beneficial in the appropriate treatment of suspected hip dysplasia.
Gender:
ALL
Ages:
6 weeks and below
Trial Updated:
12/04/2023
Locations: Community Regional Medical Center, Fresno, California
Conditions: Newborn, Hip Dysplasia
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Biomarker Verification in Pediatric Chronic GvHD: ABLE 2.0 / PTCTC GVH 1901 Study
NCT04372524
Recruiting
This study will validate a previously developed pediatric prognostic biomarker algorithm aimed at improving prediction of risk for the later development of chronic graft-versus-host disease (cGvHD) in children and young adults undergoing allogeneic hematopoietic stem cell transplant. By developing an early risk stratification of patients into low-, intermediate-, and high-risk for future cGvHD development (based upon their biomarker profile, before the onset of cGvHD), pre-emptive therapies aim... Read More
Gender:
ALL
Ages:
Between 0 years and 24 years
Trial Updated:
12/02/2023
Locations: University of California San Francisco, San Francisco, California
Conditions: Chronic Graft-versus-Host-Disease, Leukemia, Allogeneic Hematopoietic Stem Cell Transplantation, Blood Cancer, Non-Malignant Hematologic and Lymphocytic Disorder
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Travoprost Ophthalmic Topical Cream for Open-angle Glaucoma or Ocular Hypertension
NCT06152861
Recruiting
The goal of this clinical trial is to learn about the safety of Travoprost Ophthalmic Topical Cream and how well it works in lowering high intraocular pressure (IOP) in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT). A low dose, medium dose and high dose of Travoprost Ophthalmic Topical Cream will be compared to timolol maleate ophthalmic solution, 0.5% and to travoprost ophthalmic solution, 0.004%.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/30/2023
Locations: Glaukos Clinical Study Site, Newport Beach, California
Conditions: Open Angle Glaucoma, Ocular Hypertension
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Adolescent Acts of Kindness Intervention With Reflection
NCT05267132
Recruiting
Adolescents will complete a 4-week intervention, during which they will either complete a kind act for others, complete a kind act for others with a reflection component, or report their daily activities three days per week. Psychological measures will be indexed before and after the intervention.
Gender:
ALL
Ages:
Between 14 years and 17 years
Trial Updated:
11/29/2023
Locations: Adolescent Development Lab, Los Angeles, California
Conditions: Mental Health Wellness 1
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Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C Melanoma Patients
NCT03567889
Recruiting
The trial aims to evaluate the efficacy of Daromun neoadjuvant treatment followed by surgery and adjuvant therapy to improve in a statistically significant manner the recurrence-free survival (RFS) of Stage IIIB/C melanoma patients with respect to the standard of care (surgery and adjuvant therapy).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/29/2023
Locations: UC San Diego Moores Cancer Center, La Jolla, California
Conditions: Melanoma Stage IIIB/C
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A Phase 3 Study to Evaluate Safety and Biomarkers of Resmetirom (MGL-3196) in Patients With Non-alcoholic Fatty Liver Disease (NAFLD), MAESTRO-NAFLD-Open-Label-Extension (MAESTRO-NAFLD-OLE)
NCT04951219
Recruiting
A 52-Week, Multi-center, Open-label, Active Treatment Extension Study to Evaluate Safety and Tolerability of Once Daily, Oral Administration of Resmetirom (MGL-3196)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/28/2023
Locations: Fresno Clinical Research Center, Fresno, California
Conditions: Non-Alcoholic Fatty Liver Disease
Register for Updates