California is currently home to 5930 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Glycemic Targets for Pregnant Women With GDM and T2DM
Recruiting
The purpose of this randomized clinical trial is to determine whether glycemic targets that are lower than those currently recommended by the American Diabetes Association (ADA) and the American College of Obstetricians and Gynecologists (ACOG) would improve overall outcomes in pregnant patients with diabetes. Eligible pregnant women with a diagnosis of gestational diabetes or Type 2 diabetes will be randomized into either routine care with glycemic targets as currently recommended by ADA and AC... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
05/09/2023
Locations: Los Angeles County + University of Southern California Medical Center (LAC+USC), Los Angeles, California
Conditions: Diabetes Mellitus in Pregnancy, Diabetes, Gestational, Diabetes Mellitus, Type 2
Aging and Reward System Response to Inflammation and Anxiety Study
Recruiting
The purpose of this study is to use an experimental inflammatory challenge to examine whether older adults with symptoms of anxiety experience loss of pleasure or loss of motivation when they are exposed to inflammation. Loss of pleasure or loss of motivation will be evaluated using self-report questionnaires, computer tasks, and during a brain scan.
Gender:
All
Ages:
Between 60 years and 80 years
Trial Updated:
05/08/2023
Locations: Norman Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, Los Angeles, California
Conditions: Anhedonia, Inflammation, Anxiety, Aging, Depression
Food Prescriptions to Promote Affordable Diets
Recruiting
This is an Randomized controlled trial (RCT) to assess the impact of meal planning and affordable grocery delivery on weight loss, dietary quality and health on members of multigenerational Latino households.
Gender:
All
Ages:
2 years and above
Trial Updated:
05/08/2023
Locations: Kaiser Permanente, Pasadena, California
Conditions: Diet, Healthy, Overweight and Obesity
Affect Treatment for Depression and Anxiety
Recruiting
The purpose of this study is to evaluate the efficacy and mediators of change in Positive Affect Treatment, a psychotherapy specifically aimed at enhancing reward sensitivity in individuals with low positive affect (a core feature of anhedonia) in the context of depression or anxiety. Target enrollment is 100 male and female participants with low positive affect and depression or anxiety and impaired functioning, between the ages of 18 and 65 years, who will be randomized to either Positive Aff... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
05/08/2023
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Depression, Anxiety
Evaluation of Smoked THC and CBD in Men and Women
Recruiting
The purpose of this study is to determine the pharmacokinetics and pharmacodynamics of inhaled cannabis with varying amounts of delta-9-tetrahydrocannabinol (THC), and cannabidiol (CBD) and to evaluate detection of recently smoked THC in oral fluid.
Gender:
All
Ages:
Between 21 years and 55 years
Trial Updated:
05/08/2023
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Drug Abuse, Intoxication by Drug, Impairment
Frailty and Physician Modified Fenestrated Endograft for Thoracoabdominal Aortic Pathologies
Recruiting
The primary objective of this single arm, prospective feasibility study, Impact of Frailty on Clinical Outcomes of Patients Treated for Thoracoabdominal and Complex Abdominal Aortic Aneurysms with Physician-Modified Fenestrated and Branched Stent Grafts, is to assess the use of the physician-modified fenestrated/branched endografts to repair thoracoabdominal and complex aortic aneurysms in subjects having appropriate anatomy, at high risks for open repairs. The primary intent of the study is to... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/08/2023
Locations: Keck Hospital of University of Southern California, Los Angeles, California
Conditions: Thoracoabdominal Aortic Aneurysm, Thoracoabdominal; Aortic, Aneurysm, Dissecting, Pararenal Aneurysm, Frailty Syndrome
Addressing Obesity in Early Care and Education Settings
Recruiting
Childhood obesity is a national epidemic that disproportionately burdens low income and ethnic minority populations. By preschool, nearly one-third of low income children are already overweight or obese, setting the stage for adverse health outcomes over their life course. Evidence is mounting that individual-focused, single-component interventions fail to produce long-term population-level changes in obesity-related outcomes. Evidence increasingly supports creating entire environments (e.g., sc... Read More
Gender:
All
Ages:
30 months and above
Trial Updated:
05/08/2023
Locations: UCLA Fielding School of Public Health, Los Angeles, California
Conditions: Obesity
Assessment of Clemastine Fumarate as a Remyelinating Agent in Acute Optic Neuritis (ReCOVER)
Recruiting
The main purpose of this study is to assess clemastine as a remyelinating agent in patients with acute optic neuritis.The study will also evaluate the tolerability of clemastine, originally approved as first-generation antihistamine, in patients with optic neuritis. Study procedures will include assessments for evidence of remyelination in the anterior visual pathway and in the brain using electrophysiologic techniques and magnetic resonance imaging. If they are on one, patients in this study ca... Read More
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
05/08/2023
Locations: University of California San Francisco, San Francisco, California
Conditions: Optic Neuritis
A Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR and Anti-c-MET Bispecific Antibody, in Patients With Advanced NSCLC and Other Solid Tumors
Recruiting
A phase 1/2 open-label multicenter study will be performed with an initial dose escalation part to determine the MTD and/or the RP2D of MCLA-129 as monotherapy in patients with NSCLC, HNSCC, GC/GEJ, ESCC, or other solid tumors and who have progressed after receiving prior therapy for advanced/metastatic disease.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/07/2023
Locations: University of California, Irvine, Orange, California
Conditions: Non-Small Cell Lung Cancer Metastatic, Gastric Cancer, Esophageal Squamous Cell Carcinoma, Head and Neck Squamous Cell Carcinoma
Role of Ashwagandha Extract (Capsule KSM-66 300 mg) in Improving Sexual Health in Healthy Men
Recruiting
The clinical study aims to evaluate Efficacy and Safety of KSM66 Ashwagandha Standardized Root Extract for Improving Sexual Health in Healthy Men by measuring sex hormone levels in participant's blood, analyzing results of questionnaires, and monitoring adverse events in the post-marketing phase. Changes in the sex hormone levels in blood may affect sexual health or sexual health satisfaction. Efficacy is defined as increase in sex hormone levels in blood, and improvement in results or scores of... Read More
Gender:
Male
Ages:
Between 30 years and 50 years
Trial Updated:
05/06/2023
Locations: San Francisco Research Institute, San Francisco, California
Conditions: Sexual Health
Smart Boot Use to Measure Offloading Adherence
Recruiting
The purpose of this study is to help people with diabetes who develop neuropathic diabetic foot ulcers (DFUs). These ulcers, or sores, if left untreated can increase the chance of amputation. Part of the treatment is to have the person wear a diabetic shoe or boot to help their foot heal. Sometimes people don't wear the boot like they are told. The investigators want to compare three different kinds of diabetic boots to see if they can help make it easier for people to wear their boots as instru... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/05/2023
Locations: Rancho Los Amigos National Rehabilitation Center, Downey, California
Conditions: Diabetic Foot Ulcer
Molecular Signatures of Cutaneous Dupilumab Response
Recruiting
This study examines the effect of IL4RA blockade with dupilumab on the immune cells of atopic dermatitis skin lesions.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/04/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Atopic Dermatitis