California is currently home to 5582 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Treatment Recommendations for Gastrointestinal Cancers Via Large Language Models
Recruiting
This study will evaluate the utility of ChatGPT in recommending treatment plans for patients with gastrointestinal cancers, using both retrospective and prospective data.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/06/2023
Locations: City of Hope, Duarte, California
Conditions: Gastrointestinal Neoplasm Malignant
The Cedars-Sinai Smidt Heart Institute Takotsubo Registry & Proteomic Study
Recruiting
The Cedars-Sinai SHI Takotsubo Registry and Proteomic Study is an observational registry that will collect retrospective and prospective demographic, clinical, hemodynamic, laboratory and other diagnostic parameters, therapy and outcome data from individuals who meet the inclusion/exclusion criteria of Takotsubo Registry protocol. Subjects will also be invited to provide a blood sample utilizing a Mitra kit sent to their homes. Researchers from the Barbra Streisand Women's Heart Center will anal... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/06/2023
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Takotsubo Cardiomyopathy
Diode Laser as a Biomarker for Neuropathic Pain of Peripheral Origin.
Recruiting
The R61 will perform a four-part double-blind randomized crossover study transitioning from a pretreatment baseline phase, to randomized treatment with either lidocaine or an identical placebo patch, washout, and alternate arm. DLss measures will be obtained before and after each phase. Twice daily report of pain using a visual analogue scale will track severity of ongoing spontaneous pain in participants. The hybrid biomarker will distinguish between placebo and active treatment arms, will sign... Read More
Gender:
ALL
Ages:
Between 18 years and 69 years
Trial Updated:
09/05/2023
Locations: Stanford University, Palo Alto, California
Conditions: Peripheral Neuropathy
Bacteriophage Therapy in Patients With Diabetic Foot Osteomyelitis
Recruiting
This is a phase IIa randomized trial designed to evaluate bacteriophage therapy in patients with diabetic foot osteomyelitis.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
09/05/2023
Locations: NorthBay Healthcare, Fairfield, California
Conditions: Osteomyelitis, Diabetic Foot Osteomyelitis
Do Oral Contraceptives Protect Against ACL Injuries in Female Athletes
Recruiting
The purpose of this research study is to examine the impact of one type of commonly used birth control pill on blood levels of relaxin and measure changes in knee movement to determine whether there are changes in joint instability (indicating the knee is less stable) that may predispose female athletes to injury. Women not on hormonal birth control will also be enrolled to analyze differences between athletes on and not on birth control and to evaluate typical relaxin levels and knee laxity whe... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
09/05/2023
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Ligament Injury
Fluad vs. Fluzone High-Dose Vaccine Effectiveness Among Adults ≥65 Years
Recruiting
This study will evaluate the relative vaccine effectiveness of quadrivalent adjuvanted inactivated influenza vaccine (aIIV4) versus quadrivalent high-dose inactivated influenza vaccine (HD-IIV4) in preventing polymerase chain reaction (PCR)-confirmed influenza and influenza-related outcomes in adults ≥65 years of age during the 2023/24 and 2024/25 influenza seasons. The study is an observational study conducted at Kaiser Permanente Northern California (KPNC), an integrated health care system in... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
09/01/2023
Locations: Kaiser Permanente Northern California (entire region), Oakland, California
Conditions: Influenza, Community-acquired Pneumonia, Cardiovascular Events
Adherence to Different Exercise Interventions
Recruiting
Only 50% of sedentary adults that start an exercise training program adhere to the program after 6 months. Exercise variety may improve adherence. The goal of this study is to examine different exercise interventions that include a variety of exercise on adherence.
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
09/01/2023
Locations: California Polytechnic State University, San Luis Obispo, California
Conditions: Exercise Adherence
Semaglutide Treatment in the Real-world for Fibrosis Due to NAFLD in Obesity and T2DM
Recruiting
Conduct a community intervention study that will 1) validate a screening approach to identify patients at risk for advanced NAFLD in the obese or T2DM population, and 2) test whether semaglutide treatment is effective for the management of significant fibrosis due to NAFLD in high-risk patients.
Gender:
ALL
Ages:
Between 40 years and 79 years
Trial Updated:
09/01/2023
Locations: University of California, San Diego, La Jolla, California
Conditions: Fibrosis, Liver, Type 2 Diabetes Mellitus in Obese, Non-Alcoholic Fatty Liver Disease
A Phase 3 Study to Investigate the Efficacy and Safety of SHR0302 With Moderately to Severely Active Ulcerative Colitis
Recruiting
This is a randomized, double-blind, placebo-controlled, multicenter Phase 3 study that will enroll approximately 368 subjects aged 18 to 75 years old with Moderately to Severely Active Ulcerative Colitis.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
09/01/2023
Locations: Om Research LLC, Lancaster, California
Conditions: Ulcerative Colitis
Effects of Emicizumab vs. Factor VIII Prophylaxis on Joint and Bone Health in Severe Hemophilia A
Recruiting
The investigators propose to study longitudinal joint and bone density changes in patients with severe Hemophilia A. Per current standard of care, most patients are on prophylactic FVIII replacement therapy intravenously several times weekly with a goal of keeping the trough \>1% FVIII. Recent phase 3 data suggest superior bleed protection with emicizumab prophylaxis every 1-2 weeks. It is the purpose of this study to longitudinally assess joint health and bone density over 3 years and to compar... Read More
Gender:
MALE
Ages:
16 years and above
Trial Updated:
08/31/2023
Locations: Orthopedic Hemophilia Treatment Center, Los Angeles, California
Conditions: Hemophilia A
AltaValve Early Feasibility Study Protocol
Recruiting
Prospective, single-arm, multicenter study to evaluate the safety and performance of the AltaValve for the treatment of moderate to severe or severe mitral valve regurgitation in subjects who are considered high risk for mortality and morbidity from conventional open-heart surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/31/2023
Locations: Los Robles Regional Medical Center, Thousand Oaks, California
Conditions: Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation, Mitral Incompetence
Development of a Novel Stress Testing Protocol to Define the Relationship Between Coronary Microvascular Dysfunction and Diastology in Women With Angina But No Evidence of Obstructive Coronary Artery Disease
Recruiting
Microvascular coronary dysfunction (MCD) (abnormities in small blood vessels/arteries in heart) with symptoms of persistent chest pain, primarily impacts women. There are an estimated 2-3 million women in the US with MCD and about 100,000 new cases annually. Recent data from our research group suggests that coronary microvascular disease impairs the way the heart relaxes. This pilot study will attempt to exacerbate this phenotype in an effort to better understand the pathophysiology of the disea... Read More
Gender:
FEMALE
Ages:
Between 18 years and 60 years
Trial Updated:
08/31/2023
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Microvascular Coronary Dysfunction