California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
The RESBIOP-study: Resection Versus Biopsy in High-grade Glioma Patients (ENCRAM 2202)
NCT06146725
Recruiting
There are no guidelines or prospective studies defining the optimal surgical treatment for gliomas of older patients (≥70 years) or those with limited functioning performance at presentation (KPS ≤70). Therefore, the decision between resection and biopsy is varied, amongst neurosurgeons internationally and at times even within an instiutition. This study aims to compare the effects of maximal tumor resection versus tissue biopsy on survival, functional, neurological, and quality of life outcomes... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
11/18/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Glioblastoma, Glioblastoma, IDH-wildtype, Glioblastoma Multiforme, Glioblastoma Multiforme, Adult, Glioblastoma Multiforme of Brain
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Use of Virtual and Augmented Reality Devices in Vestibular Physical Therapy for mTBI
NCT05326100
Recruiting
Rapidly evolving virtual reality (VR) and augmented reality (AR) technologies are being incorporated by many large-scale industries, and the medical field is no exception. One area that has gained significant attention in recent years is virtual rehabilitation which allows physical therapists to leverage state-of-the-art immersive virtual environments to uniquely address functional deficits in patients who are unresponsive to conventional treatment techniques. Advanced VR and AR technologies are... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/17/2023
Locations: Naval Health Research Center, San Diego, California
Conditions: MTBI - Mild Traumatic Brain Injury, Dysfunction of Vestibular System
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Efficacy of the Nanodropper Device on Intraocular Pressure in Patients With Glaucoma
NCT05273385
Recruiting
Glaucoma is the leading cause of irreversible blindness worldwide. Previous studies demonstrate that smaller eye drops used in the treatment of glaucoma are just as efficacious as their larger counterparts. The proposed study hopes to demonstrate the non-inferiority of using Nanodropper to lower intraoccular pressure (IOP) in glaucoma patients compared to standard of care eye drops.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/16/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Glaucoma, Ocular Hypertension, Open Angle Glaucoma
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Still Climbin': An Intervention to Improve Coping Among Black Sexual Minority Men
NCT04587869
Recruiting
This study consists of a randomized controlled trial of a multi-session cognitive behavior therapy (CBT) group intervention that addresses coping with discrimination and medical mistrust among Black sexual minority men (SMM). Primary intervention objectives include increasing health care engagement and receipt of evidence-based preventive care, as well as better coping and reduced anticipated and internalized stigma, and medical mistrust among intervention participants.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
11/16/2023
Locations: APLA Health, Los Angeles, California
Conditions: Discrimination, Social, Health Care Utilization
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Biomarkers of Depression and Treatment Response
NCT04581902
Recruiting
This study is a stratified, parallel-group, single-center study utilizing multimodal imaging techniques to identify biomarkers for Major Depressive Disorder (MDD). The study goal is to identify biomarkers for MDD and treatment response that can be implemented in clinical diagnosis and care as valid and reliable measures, through monitoring neurophysiological and electrophysiological changes across the course of transcranial magnetic stimulation (TMS) treatment.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
11/16/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Depressive Disorder, Major
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The Reducing Risk Study
NCT03665337
Recruiting
The present study will test an innovative mobile health adaptation of a behavioral intervention that improves sleep and mental health concerns among adolescents.
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
11/16/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Insomnia, Delayed Sleep Phase
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Glucose Evaluation Through Continuous Glucose Monitors in Polycystic Ovary Syndrome
NCT06050265
Recruiting
PCOS is the most common endocrine disorder of reproductive aged women. In addition to menstrual and endocrine abnormalities, PCOS is characterized by insulin resistance and glycemic dysregulation. The pattern of glycemic abnormalities among patients with PCOS may be different than the general population, as evidenced by invasive, time consuming, and costly procedures such as the euglycemic clamp or oral glucose tolerance test. Continuous glucose monitoring (CGM) offers an opportunity to evaluate... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
11/15/2023
Locations: UCSF Center for Reproductive Health, San Francisco, California
Conditions: PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Dysglycemia, Insulin Resistance
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Fatigue in Short-Haul Operations
NCT05524441
Recruiting
The purpose of the present study is to assess fatigue levels of short-haul pilots during normal operations. The investigators will collect objective and subjective sleep, sleepiness, workload, and performance data from on-duty pilots during short-haul flight operations. Data will be collected during days off prior to the trip start, during flights, and during days off following the flight operations.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
11/14/2023
Locations: NASA Ames Research Center, Mountain View, California
Conditions: Fatigue
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The KinematX Midcarpal Total Wrist Arthroplasty Registry
NCT05719935
Recruiting
The goal of this observational study is to learn about functional and patient reported outcomes in patient undergoing total wrist replacement with the KinematX total wrist replacement study. The main questions it aims to answer are: * What is the range of motion (flexion, extension, radial, ulnar, grip and pinch strength) at 3-, 6-, and 12-months after surgery and yearly up to 10 years among patients having total wrist replacement with the KinematX implant. * What are the patient reported outc... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
11/13/2023
Locations: Loma Linda University, Loma Linda, California
Conditions: Scapholunate Advanced Collapse (SLAC), Scapholunate Crystalline Advanced Collapse (SCAC), Scaphoid, Trapezium, and Trapezoid Advanced Collapse (STTAC), Carpal Tunnel Syndrome (CTS), Kienbock's Disease of Adults, Radial Malunion, Ulnar Translocation, Post Traumatic Arthritis, Inflammatory Arthritis, Osteoarthritis, Scaphoid Non-union Advanced Collapse (SNAC)
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Use of a Subcutaneous Catheter for Controlled Ovarian Stimulation
NCT05505474
Recruiting
Subcutaneous medications are an integral part of controlled ovarian stimulation protocols for in-vitro fertilization (IVF), but daily or twice daily injections are both physically and emotionally burdensome for patients and their partners. This is a feasibility study to evaluate the use of the Neria Guard™ (Unomedical, Convatec) subcutaneous catheter for ovarian stimulation in IVF.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
11/13/2023
Locations: HRC Fertility, Los Angeles, California
Conditions: Infertility, Female
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Model-based Electrical Brain Stimulation
NCT05327387
Recruiting
Neuropsychiatric disorders are a leading cause of disability worldwide with depressive disorders being one of the most disabling among them. Also, millions of patients do not respond to current medications or psychotherapy, which makes it critical to find an alternative therapy. Applying electrical stimulation at various brain targets has shown promise but there is a critical need to improve efficacy. Given inter- and intra-subject variabilities in neuropsychiatric disorders, this study aims to... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/09/2023
Locations: University of Southern California, Los Angeles, California
Conditions: Medication Refractory Epilepsy Patients With Electrodes Already Implanted Based on Clinical Criteria for Standard Monitoring
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Study of Food Aversion in Patients With Anorexia Nervosa
NCT03100656
Recruiting
This study uses a meal-challenge protocol to assess if patients with anorexia nervosa show a differential metabolism in response to food in comparison to healthy controls. This study determines how heritable and biochemical factors influence food metabolism in anorexia nervosa in order to develop more effective treatment strategies.
Gender:
FEMALE
Ages:
Between 18 years and 55 years
Trial Updated:
11/09/2023
Locations: UC San Diego Altman Clinical and Translational Research Institute, La Jolla, California
Conditions: Anorexia Nervosa
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