California is currently home to 5930 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Enhance Study: Evaluation of Accuracy and Safety of the Eversense CGM System With Enhanced Features
Recruiting
A Prospective, Multicenter Evaluation of Accuracy and Safety of the Eversense CGM System with Enhanced Features. The purpose of this clinical investigation is to evaluate the accuracy of the Eversense 524 Continuous Glucose Monitoring System (Eversense 524 CGM System) and ROME CGM System with next generation feature enhancements compared to reference glucose measurements in adults 18 years of age and older with diabetes. The investigation will also evaluate safety of the Eversense 524 CGM System... Read More
Gender:
All
Ages:
14 years and above
Trial Updated:
04/24/2023
Locations: AMCR Institute Inc., Escondido, California
Conditions: Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Investigating Medication vs. Prostatic Urethral Lift: Assessment and Comparison of Therapies for BPH
Recruiting
This prospective, multicenter, two-arm, 1:1 randomized controlled trial (RCT) will enroll approximately 250 males at approximately 25 sites located within the United States. All enrolled subjects will be 45 years of age or older diagnosed with symptomatic benign prostatic hyperplasia (BPH). They will be randomized to one of two readily available, marketed BPH therapies; Prostatic Urethral Lift procedure with the UroLift System (PUL Arm) or 0.4mg tamsulosin HCl (MED Arm).
Gender:
Male
Ages:
45 years and above
Trial Updated:
04/24/2023
Locations: Neotract, Pleasanton, California
Conditions: BPH
Implementation Supports to Reduce Burnout in Therapists Delivering Child Trauma EBPs
Recruiting
The majority of children exposed to early adversity and trauma do not have access to sustainably delivered evidence-based mental health programs (EBPs), despite the growing prevalence of large-scale multiple-EBP implementation efforts aimed at increasing access to these services. The objective of this proposal is to develop and test a package of implementation strategies designed to promote the sustained delivery of child trauma EBPs by reducing provider turnover through targeting the associated... Read More
Gender:
All
Ages:
Between 3 years and 99 years
Trial Updated:
04/24/2023
Locations: San Diego State University, San Diego, California
Conditions: Mental Health Issue
Transcranial Electrostimulation and Obstructive Sleep Apnea Surgery
Recruiting
Postoperative pain after major surgery for obstructive sleep apnea (OSA), such as palatopharyngoplasty (PPP) and maxillomandibular advancement (MMA) is moderate-to-severe, and may persist for weeks. Control of this pain may be difficult, because OSA patients are very sensitive to traditional opioid pain medications, and their side effects. Poorly controlled pain slows down patients' recovery after surgery, including a return to normal daily activities and work, and may also delay wound healing.... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
04/23/2023
Locations: Stanford Univeristy Medical Center, Stanford, California
Conditions: Transcranial Electrical Stimulation
Comparative Effectiveness of Online 8-session CBT vs. 1-Session Empowered Relief for Chronic Pain - The PROGRESS Study
Recruiting
The purpose of this study is to conduct a pragmatic clinical trial comparing the effectiveness of: (1) 8-week cognitive behavioral therapy for chronic pain (pain-CBT; sixteen hours total treatment time); and (2) a 1-session pain relief skills intervention for chronic pain (Empowered Relief; two hours total treatment time).
Gender:
All
Ages:
18 years and above
Trial Updated:
04/21/2023
Locations: SCAN Health Plan, Long Beach, California
Conditions: Pain, Chronic
MIT-001 for Prevention of CCRT-Induced OM in HNSCC Patients
Recruiting
The proposed study in patients with previously untreated locally advanced head and neck squamous cell carcinoma (HNSCC) is designed to evaluate the efficacy and safety of three different doses of MIT-001 compared to the placebo in prevention of oral mucositis (OM) in patients with HNSCC who are undergoing concurrent chemoradiotherapy (CCRT).
Gender:
All
Ages:
18 years and above
Trial Updated:
04/21/2023
Locations: Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Oral Mucositis, Head and Neck Squamous Cell Carcinoma
Filipino Family Health Initiative
Recruiting
The overall objective of this research is to test the effectiveness of a parenting program on Filipino parents living in California. The sample will include 180 Filipino immigrant families, half of which will receive the Online Incredible Years® School Age Basic & Advanced Parent Training Program (intervention) and the other half will receive the American Academy of Pediatrics' Bright Futures handouts (control) and be placed on a 3-month waitlist for the IY parenting program.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/21/2023
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Parenting, Family Relations, Education
Breathing With a Facemask Exercise Performance
Recruiting
This study will determine the dyspnea response in chronic lung disease volunteers during treadmill walking with and without added inspiratory resistance. This study will also determine the level of dyspnea and exercise sense of effort in individuals walking on a treadmill when elevations occur. Comparisons will be made of a participant's exercise response with and without increased inspiratory resistance. In this study, exercise performance will be analyzed based on physiological and perceptual... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/19/2023
Locations: John Muir Health, Pleasant Hill, California
Conditions: Pulmonary Disease, Chronic Obstructive
Post-Exablate Pregnancy Outcomes Registry Study: Exablate Treatment of Symptomatic Uterine Fibroids
Recruiting
The goal of this Registry Study is to capture clinical pregnancy outcomes and fibroid treatment background data for any subject post-Exablate treatment for their symptomatic fibroids.
Gender:
Female
Ages:
Between 18 years and 50 years
Trial Updated:
04/19/2023
Locations: UCLA, Los Angeles, California
Conditions: Uterine Fibroid
Psilocybin Therapy for Depression in Bipolar II Disorder
Recruiting
The purpose of this study is to determine the safety, tolerability, and feasibility of psilocybin therapy in people with Bipolar II Disorder.
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
04/19/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Bipolar II Disorder
Danazol for Treatment of Cytopenias in Patients With Cirrhosis
Recruiting
This is a phase II pilot study designed to assess the safety and efficacy of danazol for treatment of cytopenias in patients with CPC A/B cirrhosis. Subjects with or without telomere mutations and/or shortened telomeres will be treated with danazol 600 mg per day by mouth for a duration of 24 months. The goal will be to treat a total of 10 patients.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/19/2023
Locations: Keck Hosital of USC, Los Angeles, California
Conditions: Cirrhosis, Liver, Cytopenia
A Study of DF6002 Alone and in Combination With Nivolumab
Recruiting
The purpose of this study is to evaluate the safety, tolerability, drug-levels, drug-effects and preliminary anti-tumor activity of DF6002 alone and in combination with Nivolumab in participants with advanced solid tumors.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/19/2023
Locations: Local Institution, Orange, California
Conditions: Solid Tumors