California is currently home to 5617 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Acceptance and Commitment Therapy (ACT) for Combating the Effects of Race-Related Stress Among Black Adolescents
Recruiting
The current study seeks to build on previous research that demonstrates the efficacy of Acceptance and Commitment Therapy in combating stigma by investigating the feasibility and acceptability of a protocol to support Black adolescents and young adults in coping with race related stress. The study will consist of a small, purposeful, non-randomized sample (N = 30) of clients enrolled into a 10-session Acceptance and Commitment Therapy group. The group will be offered as part of regular clinical... Read More
Gender:
ALL
Ages:
Between 13 years and 21 years
Trial Updated:
11/03/2023
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Race-related Stress, Depression, Anxiety, Quality of Life, Stress Reaction
MAGESTIC Trial: MiRNA in Detecting Active Germ Cell Tumors in Early Suspected and MetastaTIC Disease Trial
Recruiting
This study evaluates the accuracy of blood-based biomarker testing to predict the presence of active testicular cancer.
Gender:
MALE
Ages:
16 years and above
Trial Updated:
11/02/2023
Locations: Los Angeles County-USC Medical Center, Los Angeles, California
Conditions: Malignant Testicular Germ Cell Tumor
Electrical Stimulation for Continence After Spinal Cord Injury
Recruiting
This study aims to improve continence and voiding of patients with spinal cord injury using electrical stimulation. The Finetech Vocare Bladder System is an implantable sacral nerve stimulator for improving bladder and bowel function in patients with spinal cord injury (SCI). It has been commercially available in Britain and other countries since 1982, and has been used in thousands of patients with SCI to improve bladder, bowel and sexual function. It received FDA approval in 1998 under Humani... Read More
Gender:
ALL
Ages:
22 years and above
Trial Updated:
11/01/2023
Locations: Palo Alto Veterans Institute for Research, Palo Alto, California
Conditions: Spinal Cord Injury, Neurogenic Bladder, Incontinence
Selinexor Treatment for Multiple Myeloma Patients Who Are Refractory to Lenalidomide-containing Therapy.
Recruiting
This is a pilot study evaluating the safety and efficacy of selinexor among multiple myeloma (MM) patients that are refractory to lenalidomide-containing regimens with or without steroids.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/30/2023
Locations: James R Berenson, MD, Inc., West Hollywood, California
Conditions: Refractory Multiple Myeloma
A Phase 1 Study of Ruxolitinib, Steroids and Lenalidomide for Relapsed/Refractory Multiple Myeloma (RRMM) Patients
Recruiting
This is a phase 1, multicenter, open-label study evaluating the safety and efficacy of ruxolitinib, steroids and lenalidomide among MM patients who currently show progressive disease.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/30/2023
Locations: Global Oncology, Inc., Alhambra, California
Conditions: Multiple Myeloma
LOcally ABLatIve ThErapy for OligopRogressive Lung And Thoracic MalignanciEs (OBLITERATE)
Recruiting
This is a phase 2 pragmatic study that evaluates the clinical benefit of continuing systemic therapy with the addition of locally ablative therapies for oligo-progressive solid tumors as the primary objective. The primary outcome measure is the time to treatment failure (defined as time to change in systemic failure or permanent discontinuation of therapy) following locally ablative therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/27/2023
Locations: University of California, Davis, Sacramento, California
Conditions: Non-small Cell Lung Cancer, Oligoprogressive, Small-cell Lung Cancer
Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL
Recruiting
This study is for older children, adolescents, and young adults with B-cell Acute Lymphoblastic Leukemia (B-ALL). Higher amounts of body fat is associated with resistance to chemotherapy in patients with B-ALL. Chemotherapy during the first month causes large gains in body fat in most people, even those who start chemotherapy at a healthy weight. This study is being done to find out if caloric restriction achieved by a personalized nutritional menu and exercise plan during routine chemotherapy... Read More
Gender:
ALL
Ages:
Between 10 years and 25 years
Trial Updated:
10/25/2023
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: B-cell Acute Lymphoblastic Leukemia, Obesity
VR to Reduce Pain/Anxiety During Painful Procedures
Recruiting
This study aims to test the effectiveness of virtual reality (VR) as a non-pharmaceutical intervention to reduce pain and anxiety in children undergoing painful procedures in Phlebotomy, Radiology, Infusion, Orthopedics, Gastroenterology, and Immunology, amongst others, at CHLA, as measured by self- and proxy-report. Examples of the painful procedures include IV sticks, cast removals, allergy testing, and anorectal manometries.
Gender:
ALL
Ages:
Between 7 years and 21 years
Trial Updated:
10/25/2023
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Phlebotomy, Orthopedics, Radiology, Pain, Anxiety, Virtual Reality, Allergy, Gastroenterology
Detection of Unsuspected Small Airways Obstruction in Cystic Fibrosis
Recruiting
Goal is to physiologically detect unsuspected small airways obstruction in children and adults with treated heterozygous and homozygous cystic fibrosis. Unsuspected refers to normal routine pre bronchodilator spirometry including normal FEV1(L), FVC (L). and FEV1/FVC%. This is a retrospective study.
Gender:
ALL
Ages:
Between 5 years and 40 years
Trial Updated:
10/25/2023
Locations: Arthur F Gelb MD, Lakewood, California
Conditions: Cystic Fibrosis in Children
Site and Mechanism(s) of Expiratory Airflow Limitation in COPD, Emphysema and Asthma-COPD Overlap
Recruiting
The purpose of this cross-sectional, observational study is to evaluate the site and mechanism(s) for expiratory airflow limitation in chronic, treated, current or former smokers (\>15 pack years) with COPD, Emphysema, and Asthma-COPD Overlap with mild to severe expiratory airflow limitation. Treatment may include short and long acting inhaled beta2agonists, short and long acting inhaled muscarinic receptor antagonists, inhaled and or oral corticosteroid, oral antibiotic, supplemental oxygen, an... Read More
Gender:
ALL
Ages:
30 years and above
Trial Updated:
10/25/2023
Locations: Arthur F Gelb MD, Lakewood, California
Conditions: COPD, Emphysema, Asthma COPD Overlap, Emphysema
Mechanism(s) of Airflow Limitation During Exacerbation of Asthma
Recruiting
The purpose of this study is to evaluate the site and mechanisms responsible for expiratory airflow limitation in chronic, treated, non-smoking, stable asthmatics with moderate to severe persistent expiratory airflow obstruction. Treatment will include inhaled corticosteroids and long acting beta2agonists. The investigators are interested in determining whether the large and/or small airways are the predominant site of airflow limitation. The investigators are also interested in determining whet... Read More
Gender:
ALL
Ages:
Between 10 years and 80 years
Trial Updated:
10/25/2023
Locations: Arthur F Gelb Medical Corporation, Lakewood, California
Conditions: Asthma
Mechanism(s)of Airflow Limitation in Moderate-severe Persistent Asthma
Recruiting
The purpose of this study is to evaluate the site and mechanisms responsible for expiratory airflow limitation in chronic, treated, non-smoking, stable asthmatics with moderate to severe persistent expiratory airflow obstruction. Treatment will include inhaled corticosteroids and long acting beta2agonists and long acting muscarinic antagonists. We are interested in determining whether the large and/or small airways are the predominant site of airflow limitation. We are also interested in determi... Read More
Gender:
ALL
Ages:
Between 10 years and 95 years
Trial Updated:
10/25/2023
Locations: Arthur F Gelb Medical Corporation, Lakewood, California
Conditions: Asthma