California is currently home to 5591 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
DETERMINE: Detemir vs NPH
Recruiting
The purpose of the study is to compare rates of neonatal hypoglycemia with maternal NPH vs determir use.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/25/2023
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Gestational Diabetes, Diabetes Mellitus, Type 2
Using Indoor Air Filtration to Slow Atherothrombosis Progression in Adults With Ischemic Heart Disease History
Recruiting
This double-blind, randomized, crossover trial aims to test the hypothesis that longer-term indoor air filtration intervention can slow atherothrombosis progression by reducing indoor fine particulate matter (PM2.5) exposure in adults with ischemic heart disease history.
Gender:
ALL
Ages:
Between 65 years and 84 years
Trial Updated:
09/22/2023
Locations: Keck School of Medicine, University of Southern California, Los Angeles, California
Conditions: Air Pollution, Atherosclerosis
PV Loop and Pulmonary Hypertension
Recruiting
The right ventricular (RV) systolic function is a key determinant of outcome in patients with pulmonary hypertension and elevated pulmonary vascular resistance. As the pulmonary artery pressure and vascular resistance increase (i.e. RV afterload) in these patients, so does the right ventricular contractility in an attempt to maintain cardiac output. This is response of a ventricle to its afterload is termed ventriculo-arterial (VA) coupling. However, there is a limit to this increase in contract... Read More
Gender:
ALL
Ages:
Between 1 year and 21 years
Trial Updated:
09/22/2023
Locations: Pediatric Pulmonary Hypertension Program, San Francisco, California
Conditions: Pulmonary Vascular Resistance Abnormality
OPN-375 Efficacy and Safety in Adolescents With Bilateral Nasal Polyps
Recruiting
This is a 16-Week Randomized, Double-Blind, Placebo Controlled, Parallel-Group, Multicenter Study Evaluating the Efficacy and Safety of OPN-375 186 μg Twice a Day (BID) in Adolescents with Bilateral Nasal Polyps followed by a 12-Week Open-Label Treatment Phase. The total planned number of subjects is approximately 120 adolescents (12-17 years of age) who will be randomly assigned to receive 1 of 2 study treatments using a 2:1 ratio (OPN-375 186 μg: Placebo). For the PK sub-study, up to 14 subjec... Read More
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
09/22/2023
Locations: Kern Research, Bakersfield, California
Conditions: Bilateral Nasal Polyposis
Biological and Behavioral Outcomes of Community Nature Walks
Recruiting
The investigators will test the efficacy of our proposed intervention to reduce embodied stress in four racial/ethnic groups (Black, Latinx, Pilipinx, and Pacific Islander) as a preventative intervention for health disparities found in these communities. The intervention is comprised of two phases. The first consists of community nature walks in a pristine redwood forest for six months. This is followed by chosen nature activities with family and/or friends for three months. The investigators wi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/20/2023
Locations: San Francisco State University, San Francisco, California
Conditions: Stress, Psychological, Telomere Shortening, Stress Reaction
Bioaerosol Sampling Device (BSD) Clinical Study
Recruiting
The goal of this clinical trial is to learn about the bioaerosol sampling device (BSD) and how it can sample patient bioaerosols (breath) and patient's nares for the detection of COVID-19 viral particles in patients seeking to be tested for COVID-19.
Gender:
ALL
Ages:
5 years and above
Trial Updated:
09/14/2023
Locations: JPRA Enterprise, LLC, S. Gate, California
Conditions: COVID-19
PK Study of Single-Dose ZTI-01 in Children (<12 Years of Age)
Recruiting
Phase 1 study, a single dose of ZTI-01 given to pediatric subjects (under 12 years of age) who require antibiotic therapy to see what the body does to the drug (pharmacokinetics) and to compare if these effects are similar to those observed in adults at a 6g ZTI-01 dose. Study will help establish pediatric dosing in younger children by age cohort. This is a multiple-center, open-label, PK study of ZTI-01 (fosfomycin for injection) single dose scaled by allometric weight-modeling from an adult ZT... Read More
Gender:
ALL
Ages:
11 years and below
Trial Updated:
09/14/2023
Locations: Children's Hospital of Orange County, Orange, California
Conditions: Pediatric ALL
A Comparison of Dynamic Vision & Balance Between College Athletes & Controls
Recruiting
The purpose of this study is to determine the value of including dynamic vision testing into California State University, Northridge (CSUN) Athletics' established concussion protocol. The study's hypotheses are 1) dynamic vision testing will reveal vision impairments right after a person sustains a concussion, 2) these impairments may still be present upon clearance to return to play.
Gender:
ALL
Ages:
All
Trial Updated:
09/12/2023
Locations: California State University, Northridge, Jacaranda Hall 1578, 1576, 1574, Northridge, California
Conditions: Head Injury, Sport Injury, Concussion, Brain
Online Insomnia Treatment Program
Recruiting
The purpose of this study is to investigate improvements in sleep by comparing two 6-week digital programs, either online or app-based, that deliver Cognitive Behavioral Therapy for Insomnia (CBT-I), the "gold standard" treatment for insomnia, with or without a bedside device to help track sleep.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/12/2023
Locations: Stanford Sleep Medicine Center, Redwood City, California
Conditions: Insomnia, Sleep, Sleep Disturbance, Sleep Disorder, Sleep Hygiene, Sleep Initiation and Maintenance Disorders
A Dose Escalation Study of HBI-2438 in Patients With Solid Tumors Harboring KRAS G12C Mutation
Recruiting
A Phase 1 dose escalation study in patients with advanced solid tumors harboring KRAS G12C mutation to determine the maximum tolerated dose and recommended Phase II dose of HBI-2438 and characterize its pharmacokinetic profile.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/12/2023
Locations: California Cancer Associates for Research and Excellence, Inc. (cCare), Encinitas, California
Conditions: Lung Cancer, Non Small Cell Lung Cancer, Colorectal Cancer, Cancer of Pancreas, Colon Cancer, Solid Tumor, Cancer
A Dose Escalation Study of SHP2 Inhibitor in Patients With Solid Tumors Harboring KRAS of EGFR Mutations
Recruiting
A Phase 1 dose escalation study in patients with advanced solid tumors harboring KRAS or EGFR mutations to determine the maximum tolerated dose and recommended Phase II dose of HBI-2376 and characterize its pharmacokinetic profile.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/12/2023
Locations: City of Hope, Duarte, California
Conditions: Non Small Cell Lung Cancer, Colorectal Cancer, Pancreatic Cancer, Solid Tumor, Cancer, Cancer of Pancreas, Cancer of Colon
Dynamic Vision Testing and Concussion Management
Recruiting
The purpose of this study is to determine the value of including dynamic vision testing into California State University, Northridge (CSUN) Athletics' established concussion protocol. The study's hypotheses are 1) dynamic vision testing will reveal vision impairments right after a person sustains a concussion, 2) these impairments may still be present upon clearance to return to play.
Gender:
ALL
Ages:
All
Trial Updated:
09/12/2023
Locations: California State University, Northridge, Jacaranda Hall 1578, 1576, 1574, Northridge, California
Conditions: Head Injury, Sport Injury, Concussion, Brain