California is currently home to 5582 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Tigulixostat, Phase 3 Study, Placebo Controlled in Gout Patients
Recruiting
The aim of this 6-month randomized multi-regional double-blind parallel group placebo-controlled phase 3 study is to assess the efficacy and safety of three different doses of Tigulixostat in gout patients with hyperuricemia.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
08/24/2023
Locations: Medvin Clinical Research, Covina, California
Conditions: Gout, Hyperuricemia, Gout Flare, Tophi
Neostigmine Route for Acute Colonic Pseudo Obstruction
Recruiting
Neostigmine is commonly used for medical treatment of acute colonic pseudo obstruction, however, the ideal route of administration has not been determined. Though IV push works rapidly, it is likely associated with the most side effects. This study will compare the efficacy and side effect profile of 2 potential routes of administration: IV push and subcutaneous.
Gender:
ALL
Ages:
16 years and above
Trial Updated:
08/24/2023
Locations: Los Angeles University of Southern California Medical Center, Los Angeles, California
Conditions: Ogilvie Syndrome
Phase 2 Clinical Trial of CartiLife® in the United States
Recruiting
To evaluate the safety and efficacy of implanting pellet-type extracellular matrix-associated autologous chondrocytes (CartiLife®) obtained by cultivating costal chondrocytes of the subject with articular cartilage defects of the knee as a result of trauma or degeneration.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/24/2023
Locations: Tilda Research, Irvine, California
Conditions: Articular Cartilage Defect, Articular Cartilage Degeneration
Clinical Study of ALLO-ASC-SHEET in Subjects With Diabetic Wagner Grade II Foot Ulcers
Recruiting
This is a phase 2 double-blind clinical study to evaluate the efficacy and Safety of ALLO-ASC-SHEET in subjects with Diabetic Wagner Grade II Foot Ulcers, compared to placebo therapy.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/23/2023
Locations: University of Southern California, Los Angeles, California
Conditions: Diabetic Foot Ulcer
Pilot Study for PET/MR Imaging of Covid-19
Recruiting
The primary goal of this project is to study the feasibility of a prototype brain-dedicated PET insert for an MR scanner for simultaneous acquisition of PET/MR images of metabolism and perfusion in Covid-19 negative and positive/once positive subjects. This study serves as a pilot study for establishing an imaging protocol for combined PET and MR derived functional information as well as MRI acquired anatomical information.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
08/19/2023
Locations: Stanford University, Palo Alto, California
Conditions: Brain Diseases, Covid19
Branched Aortic Arch Study
Recruiting
This is a study to assess the safety and effectiveness of endovascular treatment of aortic aneurysms involving the proximal aortic arch. The investigational operation involves placing a stent-graft over the aortic aneurysm.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/17/2023
Locations: UCSF Division of Vascular and Endovascular Surgery, San Francisco, California
Conditions: Aortic Aneurysm of the Proximal Arch
Prospective Multicenter Trial to Determine the Efficacy and Outcome of the UCRI Biomarker Panel and Algorithm to Detect Mucosal Healing in Moderate to Severe Ulcerative Colitis Patients.
Recruiting
The purpose of this research study is to determine the efficacy and outcome of the UCRI (an in-vitro diagnostics device in the form of a blood test and an algorithm) as a tool to detect mucosal healing (level of inflammation in the colon) in people with moderate-to-severe ulcerative colitis treated with anti-TNFα. Another reason is to explore additional biomarkers in blood, stool or voice to detect disease activity and/or mucosal healing. A tool to detect the level of inflammation in the colon b... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/15/2023
Locations: UC Davis Inflammatory Bowel Disease Center, Sacramento, California
Conditions: Ulcerative Colitis
Chronic Thromboembolic Disease Registry
Recruiting
The goal of this patient registry is to learn about the natural history in patients with chronic thromboembolic disease (CTD) and/or chronic thromboembolic pulmonary hypertension (CTEPH). The main question\[s\] it aims to answer are: * Long-term outcome after various types of treatment, including medication, balloon pulmonary angioplasty, and pulmonary endarterectomy * Effect of treatment on patient's quality of life and exercise tolerance Participants will be followed longitudinally to assess... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2023
Locations: University of California San Francisco, San Francisco, California
Conditions: Chronic Thromboembolic Pulmonary Hypertension, Chronic Thromboembolic Disease
A Study to Evaluate the PK and PD of IM or SQ Injections of Levonorgestrel Butanoate (LB) for Female Contraception
Recruiting
This is a Phase I multicenter, open-label, dose-ranging, three-dose PK and PD study of injectable LB administered as an IM or SQ injection at 40 mg, and subsequently at 50mg SQ and then 60 mg SQ depending on the preliminary pharmacokinetic and pharmacodynamic results obtained with 40 mg dosing.
Gender:
FEMALE
Ages:
Between 18 years and 40 years
Trial Updated:
08/11/2023
Locations: University of California, Davis, Davis, California
Conditions: Healthy Women, Female Contraception
Follow-up After Endovascular Repair of Abdominal Aortic Aneurysm
Recruiting
To collect and analyze clinical follow-up data which can be used to assess the safety, efficacy, and durability of endovascular AAA repair with Zenith and Chuter-Gianturco stent-grafts.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/11/2023
Locations: Division of Vascular Surgery, SFVAMC, San Francisco, California
Conditions: Abdominal Aortic Aneurysm
The Effect of Sodium-glucose Cotransporter (SGLT) 2 Inhibitors on Cystine Stone Formation: A Preliminary Study
Recruiting
Cystinuria is an inherited autosomal recessive disorder of the kidney that is the result of an inability to reabsorb cystine from the urine. Supersaturation of cystine in the urine produces crystals that precipitate and form stones in the kidney, which can be a cause of obstruction, infection, and chronic kidney disease. Cystine stones constitute a major health challenge for affected individuals with cystinuria because of the frequent recurrence of painful symptoms and the current absence of eff... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/10/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Cystinuria
Pilot Trial of Fetoscopic Endoluminal Tracheal Occlusion (FETO) in Severe Left Congenital Diaphragmatic Hernia (CDH)
Recruiting
Despite advances in prenatal diagnosis and postnatal therapies, including ECMO (Extracorporeal Membrane Oxygenation), inhaled nitric oxide therapy, and ventilator strategies that minimize ventilator-induced lung injury, morbidity and mortality rates for babies with severe CDH remain high. The rationale for fetal therapy in severe CDH is to promote adequate lung growth for neonatal survival. Prenatal tracheal occlusion obstructs the normal egress of lung fluid during pulmonary development leading... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/10/2023
Locations: University of California San Francisco Fetal Treatment Center, San Francisco, California
Conditions: Congenital Diaphragmatic Hernia