California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Online Insomnia Treatment Program
NCT05778812
Recruiting
The purpose of this study is to investigate improvements in sleep by comparing two 6-week digital programs, either online or app-based, that deliver Cognitive Behavioral Therapy for Insomnia (CBT-I), the "gold standard" treatment for insomnia, with or without a bedside device to help track sleep.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/12/2023
Locations: Stanford Sleep Medicine Center, Redwood City, California
Conditions: Insomnia, Sleep, Sleep Disturbance, Sleep Disorder, Sleep Hygiene, Sleep Initiation and Maintenance Disorders
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A Dose Escalation Study of HBI-2438 in Patients With Solid Tumors Harboring KRAS G12C Mutation
NCT05485974
Recruiting
A Phase 1 dose escalation study in patients with advanced solid tumors harboring KRAS G12C mutation to determine the maximum tolerated dose and recommended Phase II dose of HBI-2438 and characterize its pharmacokinetic profile.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/12/2023
Locations: California Cancer Associates for Research and Excellence, Inc. (cCare), Encinitas, California
Conditions: Lung Cancer, Non Small Cell Lung Cancer, Colorectal Cancer, Cancer of Pancreas, Colon Cancer, Solid Tumor, Cancer
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A Dose Escalation Study of SHP2 Inhibitor in Patients With Solid Tumors Harboring KRAS of EGFR Mutations
NCT05163028
Recruiting
A Phase 1 dose escalation study in patients with advanced solid tumors harboring KRAS or EGFR mutations to determine the maximum tolerated dose and recommended Phase II dose of HBI-2376 and characterize its pharmacokinetic profile.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/12/2023
Locations: City of Hope, Duarte, California
Conditions: Non Small Cell Lung Cancer, Colorectal Cancer, Pancreatic Cancer, Solid Tumor, Cancer, Cancer of Pancreas, Cancer of Colon
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Dynamic Vision Testing and Concussion Management
NCT04837066
Recruiting
The purpose of this study is to determine the value of including dynamic vision testing into California State University, Northridge (CSUN) Athletics' established concussion protocol. The study's hypotheses are 1) dynamic vision testing will reveal vision impairments right after a person sustains a concussion, 2) these impairments may still be present upon clearance to return to play.
Gender:
ALL
Ages:
All
Trial Updated:
09/12/2023
Locations: California State University, Northridge, Jacaranda Hall 1578, 1576, 1574, Northridge, California
Conditions: Head Injury, Sport Injury, Concussion, Brain
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Effects of Voluntary Adjustments During Walking in Participants Post-stroke
NCT06034119
Recruiting
People post-stroke retain the capacity to modify walking patterns explicitly using biofeedback and implicitly when encountering changes in the walking environment. This proposal will assess changes in muscle activation patterns associated with walking modifications driven explicitly vs. implicitly, to determine whether individuals generate different amounts of co-contraction during explicit vs. implicit walking modifications. Understanding how walking modifications driven explicitly vs. implicit... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
09/11/2023
Locations: Chapman University, Irvine, California
Conditions: Stroke
Register for Updates
The Efficacy and Safety of Bonjesta® for Nausea and Vomiting of Pregnancy in Pregnant Adolescents
NCT05289557
Recruiting
The primary objective of this study is to compare the efficacy of Bonjesta for the treatment of nausea and vomiting of pregnancy (NVP) in pregnant adolescents aged 12 to 17 years with placebo. The secondary objective of this study is to compare the safety of Bonjesta in pregnant adolescents aged 12 to 17 years with placebo.
Gender:
FEMALE
Ages:
Between 12 years and 17 years
Trial Updated:
09/08/2023
Locations: Velvet Clinical Research, Burbank, California
Conditions: Morning Sickness
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Primary Cytoreductive Surgery With or Without Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
NCT03772028
Recruiting
stage III epithelial ovarian cancer randomizing between primary cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
09/07/2023
Locations: City of Hope, Duarte, California
Conditions: Ovarian Cancer
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Study of 3D Scanning for Adolescent Scoliosis
NCT06035952
Recruiting
The investigators aim to validate three-dimensional topographical scanning technology as a tool for evaluation of scoliosis. Through the incorporation of 3D topographical technology in the measurement of deformity, the investigators hope to validate a novel approach to quantify deformity progression and provide an accessible alternative to traditional radiographic workup.
Gender:
ALL
Ages:
Between 10 years and 18 years
Trial Updated:
09/06/2023
Locations: Stanford University School of Medicine, Palo Alto, California
Conditions: Scoliosis
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Treatment Recommendations for Gastrointestinal Cancers Via Large Language Models
NCT06002425
Recruiting
This study will evaluate the utility of ChatGPT in recommending treatment plans for patients with gastrointestinal cancers, using both retrospective and prospective data.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/06/2023
Locations: City of Hope, Duarte, California
Conditions: Gastrointestinal Neoplasm Malignant
Register for Updates
Diode Laser as a Biomarker for Neuropathic Pain of Peripheral Origin.
NCT06030297
Recruiting
The R61 will perform a four-part double-blind randomized crossover study transitioning from a pretreatment baseline phase, to randomized treatment with either lidocaine or an identical placebo patch, washout, and alternate arm. DLss measures will be obtained before and after each phase. Twice daily report of pain using a visual analogue scale will track severity of ongoing spontaneous pain in participants. The hybrid biomarker will distinguish between placebo and active treatment arms, will sign... Read More
Gender:
ALL
Ages:
Between 18 years and 69 years
Trial Updated:
09/05/2023
Locations: Stanford University, Palo Alto, California
Conditions: Peripheral Neuropathy
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Fluad vs. Fluzone High-Dose Vaccine Effectiveness Among Adults ≥65 Years
NCT06029933
Recruiting
This study will evaluate the relative vaccine effectiveness of quadrivalent adjuvanted inactivated influenza vaccine (aIIV4) versus quadrivalent high-dose inactivated influenza vaccine (HD-IIV4) in preventing polymerase chain reaction (PCR)-confirmed influenza and influenza-related outcomes in adults ≥65 years of age during the 2023/24 and 2024/25 influenza seasons. The study is an observational study conducted at Kaiser Permanente Northern California (KPNC), an integrated health care system in... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
09/01/2023
Locations: Kaiser Permanente Northern California (entire region), Oakland, California
Conditions: Influenza, Community-acquired Pneumonia, Cardiovascular Events
Register for Updates
Adherence to Different Exercise Interventions
NCT06024577
Recruiting
Only 50% of sedentary adults that start an exercise training program adhere to the program after 6 months. Exercise variety may improve adherence. The goal of this study is to examine different exercise interventions that include a variety of exercise on adherence.
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
09/01/2023
Locations: California Polytechnic State University, San Luis Obispo, California
Conditions: Exercise Adherence
Register for Updates