California is currently home to 5582 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
PET/MRI in the Diagnosis of Chronic Pain
Recruiting
Several studies have implicated involvement of sigma-1 receptors (SR1s) in the generation of chronic pain, while others are investigating anti SR1 drugs for treatment of chronic pain. Using \[18F\]-FTC-146 and positron emission tomography/magnetic resonance imaging (PET/MRI), the investigators hope to identify the source of pain generation in patients with chronic pain. The purpose of this study is to compare the uptake of \[18F\]FTC-146 in healthy volunteers to that of individuals suffering fro... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/18/2023
Locations: Stanford University, Stanford, California
Conditions: Neuropathic Pain, Nociceptive Pain, MIxed Pain (Nociceptive and Neuropathic), Spinal Pain, Radiculopathy, Myelopathy, Neurogenic Claudication
Collaborative Approach to Examining Adversity and Building Resilience Study
Recruiting
To examine the behavioral, psychosocial, and biologic impact of resilience-promoting interventions associated with primary care.
Gender:
ALL
Ages:
2 years and above
Trial Updated:
07/17/2023
Locations: UCSF Benioff Children's Hospital Oakland, Oakland, California
Conditions: Early Life Adversity, Caregiver Stress
The Effect of Beetroot Juice Supplementation Dose on Neuromuscular Performance During Resistance Exercise
Recruiting
Dietary nitrate supplementation, administered in the form of nitrate-rich beetroot juice, has been shown to improve exercise performance and may have more pronounced effects on exercise that requires high-power and high-velocity muscle contraction such as weightlifting and body-mass resisted exercise (i.e, resistance exercise). However, limited data are available that have examined the potential performance enhancing effect of beetroot juice in resistance exercise. Moreover, there is no informat... Read More
Gender:
MALE
Ages:
Between 18 years and 45 years
Trial Updated:
07/16/2023
Locations: Pepperdine University, Malibu, California
Conditions: High Nitrate Dose, Moderate Nitrate Dose, Low Nitrate Dose, Nitrate-depleted Dose
Early Trial of Allogeneic Hematopoietic Stem Cell Transplantation for Patients Who Will Receive a Kidney Transplant From the Same Donor
Recruiting
This is a single center, non-randomized, non-controlled open-label phase 1b/2a trial of performing sequential αβdepleted-HSCT and KT in patients requiring KT to prevent kidney rejection post-KT, in the absence of any post-KT immunosuppression, to abrogate the need for lifelong immunosuppression, the risk of chronic rejection and, ultimately, the need for repeated transplantation.
Gender:
ALL
Ages:
Between 1 year and 30 years
Trial Updated:
07/13/2023
Locations: Lucile Packard Children's Hospital, Palo Alto, California
Conditions: SIOD, Cystinosis, FSGS, SLE Nephritis, CKD Stage 4
Hydrus Microstent as a Quality of Life Consideration
Recruiting
The study aims to identify if Hydrus microstent implantation in patients with open angle glaucoma (OAG) at the time of cataract surgery improves quality of life for patients and explore what quality of life factors motivate patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/12/2023
Locations: Terri Smith, Fresno, California
Conditions: Open Angle Glaucoma
The Efficacy of Systemic Valacyclovir (Valtrex) on Periodontitis
Recruiting
The experiment outlined in this proposal is designed to test the hypothesis that herpesvirus suppression by the systemic anti-herpesvirus valacyclovir (Valtrex) can significantly help to arrest the progressive course of severe marginal periodontitis in adult patients. A prospective, randomized, placebo-controlled, double-blind, clinical trial is employed to test this hypothesis.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/11/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Severe Periodontitis
A Clinical Trial of KVA12123 Treatment Alone and in Combination With Pembrolizumab In Advanced Solid Tumors (VISTA-101)
Recruiting
The goal of this clinical trial is to test the safety and efficacy of KVA12123 alone or combined with pembrolizumab in patients with advanced solid tumors. The main questions this study aims to answer are: 1. What is the safety of KVA12123 when administered alone and in combination with pembrolizumab to advanced cancer patients? 2. What is an appropriate dose of KVA12123 to administer alone and in combination with pembrolizumab to advanced cancer patients in future clinical trials? Participant... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/11/2023
Locations: UCLA Health (Santa Monica Cancer Care), Santa Monica, California
Conditions: Cancer, Solid Tumor, Melanoma, Carcinoma, Sarcoma, Lung Cancer, Prostate Cancer, Breast Cancer, Colo-rectal Cancer, Uterine Cancer, Pancreatic Cancer, Gastric Cancer, Esophageal Cancer, Thyroid Cancer, Ovarian Cancer, Kidney Cancer, Head and Neck Cancer
Valacyclovir in Pain Management of Acute Apical Abscesses
Recruiting
The Virus in Endodontics (VE) phase I pilot study for preoperative pain will be analyzed and adjusted for the Phase II clinical trial. The Phase II clinical trial on preoperative pain, postoperative pain, and clinical healing will involve 250 patients. Patients will be recruited from the same pool of participants as the Phase II clinical trial. Preoperative cone beam computed tomography (CBCT) scans will be taken as well as three and six month postoperative CBCT scans. The secondary outcomes for... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/11/2023
Locations: UCSF Dental, San Francisco, California
Conditions: Acute Apical Abscess, Pain, Acute
Simple Bone Cysts in Kids
Recruiting
Simple bone cysts (SBCs) are cysts filled with fluid that occur most frequently in the long bones (arms or legs) of children. There are many ways to treat SBCs but it is unclear if one is better than another. The purpose of this research trial is to compare the effectiveness of two common treatments that are used by surgeons today.
Gender:
ALL
Ages:
Between 2 years and 21 years
Trial Updated:
07/10/2023
Locations: Loma Linda University, Loma Linda, California
Conditions: Bone Cyst
Novel α2-Antiplasmin Inactivation for Lysis of Intravascular Thrombi (NAIL-IT) Trial
Recruiting
Phase II trial of TS23
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/08/2023
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Pulmonary Embolism
Cognition and Motor Learning Post-stroke
Recruiting
This project seeks to determine how post-stroke cognitive impairment moderates motor learning during walking in older adults with chronic stroke and identify brain structural markers that mediate this relationship. The chosen experimental design integrates biomechanical analyses, neuropsychological assessments, and brain imaging techniques to determine the impact of post-stroke cognitive impairment severity on two forms of motor learning (explicit and implicit) and examine the role of the dorsol... Read More
Gender:
ALL
Ages:
Between 45 years and 85 years
Trial Updated:
07/08/2023
Locations: Center for Health Professions, Los Angeles, California
Conditions: CVA (Cerebrovascular Accident), Stroke
A Multicenter National Prospective Study of Pregnancy and Neonatal Outcomes in Women With Inflammatory Bowel Disease
Recruiting
A Multicenter National Prospective Study of Pregnancy and Neonatal Outcomes in Women with Inflammatory Bowel Disease study is being conducted at the University of California San Francisco and 30 other sites around the United States who are part of the CCFA Clinical Alliance. The aim of this study is to determine the effect of medication use and disease activity on the outcome of pregnancy among women with IBD up to 18 years from birth.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
07/06/2023
Locations: Please Contact Jessica Lim For Further Information Regarding Other Sites' Locations, San Francisco, California
Conditions: Inflammatory Bowel Disease