California is currently home to 5615 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Phase 2a Multiple Ascending Dose Study in Hospitalized Patients With Pneumonia.
NCT05123755
Recruiting
A Phase 2a, randomized, double-blind, placebo-controlled, multiple ascending dose study in patients who are hospitalized with presumed pneumonia requiring supplemental oxygen therapy. The purpose of this study is to examine the safety, tolerability and efficacy of AV-001 Injection administration daily to the earlier of day 28 or EOT (day prior to hospital discharge). A total of 120 eligible patients (20 patients in each of cohort 1, 2 and 3 and 60 patients in cohort 4) will be recruited from up... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/27/2023
Locations: Hoag Memorial Hospital Presbyterian, Newport Beach, California
Conditions: Acute Respiratory Distress Syndrome, COVID-19 Acute Respiratory Distress Syndrome, Viral or Bacterial Infections, Pneumonia, Pneumonia, Viral, Respiratory Infection
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Imaging of T-cell Activation With [18F]F-AraG in Advanced Non Small Cell Lung Cancer
NCT04726215
Recruiting
This is a pilot study using \[18F\]F AraG PET imaging to evaluate the immunological response to checkpoint inhibitor therapy (CkIT) in patients with advanced NSCLC tumors at multiple study sites. The main objectives of the study are to quantify the change in \[18F\]F AraG PET signal before and after CkIT therapy, and to correlate this change in \[18F\]F AraG PET signal with a radiographic response.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/27/2023
Locations: Palo Alto Veterans Institute of Research, Palo Alto, California
Conditions: Non Small Cell Lung Cancer
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Cannabis Consumption and Driving Impairment Assessment on a Closed Course
NCT06059677
Recruiting
In a true experiment, roughly 300 volunteer participants will smoke active cannabis, a corresponding placebo, or no substance at all (control). Next, participants will complete a drive test and then be observed by actual California Highway Patrol (CHP) officers who will attempt to classify participants as impaired or unimpaired. CHP Officers will evaluate participants in the context of driving (i.e., while following participants in an actual patrol car), as part of a roadside behavioral assessme... Read More
Gender:
ALL
Ages:
Between 21 years and 55 years
Trial Updated:
09/26/2023
Locations: California Department of Motor Vehicles Headquarters, Sacramento, California
Conditions: Cannabis Smoking, Driving Impaired
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A Phase I First in Human Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of WGI-0301 in Patients With Advanced Solid Tumors
NCT05267899
Recruiting
The purpose of this study is to learn about the effects of a study medicine, WGI-0301 to find the best dose for treating solid tumors, and to see how safe and tolerable the study drug is for patients with solid tumors. The study is also done to learn how the study drug is taken up by your body; this is called Pharmacokinetic (PK) studies and how the study drug affects the body; this is called Pharmacodynamics (PD)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/25/2023
Locations: Valkyrie Clinical Trials, Los Angeles, California
Conditions: Advanced Solid Tumors
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DETERMINE: Detemir vs NPH
NCT05124457
Recruiting
The purpose of the study is to compare rates of neonatal hypoglycemia with maternal NPH vs determir use.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/25/2023
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Gestational Diabetes, Diabetes Mellitus, Type 2
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PV Loop and Pulmonary Hypertension
NCT05484596
Recruiting
The right ventricular (RV) systolic function is a key determinant of outcome in patients with pulmonary hypertension and elevated pulmonary vascular resistance. As the pulmonary artery pressure and vascular resistance increase (i.e. RV afterload) in these patients, so does the right ventricular contractility in an attempt to maintain cardiac output. This is response of a ventricle to its afterload is termed ventriculo-arterial (VA) coupling. However, there is a limit to this increase in contract... Read More
Gender:
ALL
Ages:
Between 1 year and 21 years
Trial Updated:
09/22/2023
Locations: Pediatric Pulmonary Hypertension Program, San Francisco, California
Conditions: Pulmonary Vascular Resistance Abnormality
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Biological and Behavioral Outcomes of Community Nature Walks
NCT06056375
Recruiting
The investigators will test the efficacy of our proposed intervention to reduce embodied stress in four racial/ethnic groups (Black, Latinx, Pilipinx, and Pacific Islander) as a preventative intervention for health disparities found in these communities. The intervention is comprised of two phases. The first consists of community nature walks in a pristine redwood forest for six months. This is followed by chosen nature activities with family and/or friends for three months. The investigators wi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/20/2023
Locations: San Francisco State University, San Francisco, California
Conditions: Stress, Psychological, Telomere Shortening, Stress Reaction
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Bioaerosol Sampling Device (BSD) Clinical Study
NCT06047067
Recruiting
The goal of this clinical trial is to learn about the bioaerosol sampling device (BSD) and how it can sample patient bioaerosols (breath) and patient's nares for the detection of COVID-19 viral particles in patients seeking to be tested for COVID-19.
Gender:
ALL
Ages:
5 years and above
Trial Updated:
09/14/2023
Locations: JPRA Enterprise, LLC, S. Gate, California
Conditions: COVID-19
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PK Study of Single-Dose ZTI-01 in Children (<12 Years of Age)
NCT03709914
Recruiting
Phase 1 study, a single dose of ZTI-01 given to pediatric subjects (under 12 years of age) who require antibiotic therapy to see what the body does to the drug (pharmacokinetics) and to compare if these effects are similar to those observed in adults at a 6g ZTI-01 dose. Study will help establish pediatric dosing in younger children by age cohort. This is a multiple-center, open-label, PK study of ZTI-01 (fosfomycin for injection) single dose scaled by allometric weight-modeling from an adult ZT... Read More
Gender:
ALL
Ages:
11 years and below
Trial Updated:
09/14/2023
Locations: Children's Hospital of Orange County, Orange, California
Conditions: Pediatric ALL
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A Comparison of Dynamic Vision & Balance Between College Athletes & Controls
NCT05819489
Recruiting
The purpose of this study is to determine the value of including dynamic vision testing into California State University, Northridge (CSUN) Athletics' established concussion protocol. The study's hypotheses are 1) dynamic vision testing will reveal vision impairments right after a person sustains a concussion, 2) these impairments may still be present upon clearance to return to play.
Gender:
ALL
Ages:
All
Trial Updated:
09/12/2023
Locations: California State University, Northridge, Jacaranda Hall 1578, 1576, 1574, Northridge, California
Conditions: Head Injury, Sport Injury, Concussion, Brain
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Online Insomnia Treatment Program
NCT05778812
Recruiting
The purpose of this study is to investigate improvements in sleep by comparing two 6-week digital programs, either online or app-based, that deliver Cognitive Behavioral Therapy for Insomnia (CBT-I), the "gold standard" treatment for insomnia, with or without a bedside device to help track sleep.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/12/2023
Locations: Stanford Sleep Medicine Center, Redwood City, California
Conditions: Insomnia, Sleep, Sleep Disturbance, Sleep Disorder, Sleep Hygiene, Sleep Initiation and Maintenance Disorders
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A Dose Escalation Study of HBI-2438 in Patients With Solid Tumors Harboring KRAS G12C Mutation
NCT05485974
Recruiting
A Phase 1 dose escalation study in patients with advanced solid tumors harboring KRAS G12C mutation to determine the maximum tolerated dose and recommended Phase II dose of HBI-2438 and characterize its pharmacokinetic profile.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/12/2023
Locations: California Cancer Associates for Research and Excellence, Inc. (cCare), Encinitas, California
Conditions: Lung Cancer, Non Small Cell Lung Cancer, Colorectal Cancer, Cancer of Pancreas, Colon Cancer, Solid Tumor, Cancer
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