California is currently home to 5930 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Whole Brain Radiation Therapy With Standard Temozolomide Chemo-Radiotherapy and Plerixafor in Treating Patients With Glioblastoma
Recruiting
This phase II trial studies how well whole brain radiation therapy works with standard temozolomide chemo-radiotherapy and plerixafor in treating patients with glioblastoma (brain tumor). Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Plerixafor is a drug that... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
04/13/2023
Locations: Stanford Cancer Institute Palo Alto, Palo Alto, California
Conditions: Glioblastoma, Glioblastoma With Primitive Neuronal Component, Gliosarcoma, Malignant Glioma, Oligodendroglial Component Present
Assessment of the Effect of Coconut and Sunflower Seed Oil Derived Isosorbide Diseters and Colloidial Oatmeal
Recruiting
The goal of this study is to compare coconut oil and sunflower seed oil derived isosorbide disesters and colloidal oatmeal, and observe their effect on pediatric atopic dermatitis among males and females aged 2-17.
Gender:
All
Ages:
Between 2 years and 17 years
Trial Updated:
04/12/2023
Locations: Integrative Skin Science and Research, Sacramento, California
Conditions: Atopic Dermatitis
Comparison of Methods of Pulmonary Blood Flow Augmentation in Neonates: Shunt Versus Stent (The COMPASS Trial)
Recruiting
COMPASS is a prospective multicenter randomized interventional trial. Participants with ductal-dependent pulmonary blood flow will be randomized to receive either a systemic-to-pulmonary artery shunt or ductal artery stent. Block randomization will be performed by center and by single vs. two ventricle status. Participants will be followed through the first year of life.
Gender:
All
Ages:
Between 1 day and 30 days
Trial Updated:
04/12/2023
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Congenital Heart Disease in Children
Project 1: Diet and Exercise Modulate the Sperm Epigenome in Men
Recruiting
This is a rigorous, controlled clinical trial designed to show that diet, exercise training, and their combination in overweight, inactive men will alter epigenetic programming to create a "healthy" sperm epigenome. Our central hypotheses are: i) overweight and inactive lifestyle results in epimutations in the sperm epigenome relative to the normal epigenetic programming in lean and active men and ii) diet and exercise modulation leads to reversal of these epimutations resulting in both a health... Read More
Gender:
Male
Ages:
Between 18 years and 40 years
Trial Updated:
04/12/2023
Locations: The Lundquist Institute, Torrance, California
Conditions: Healthy Lifestyle, Obese, Men
Saliva Insulin as Biomarker of Risk Factors for Metabolic Dysregulation and Caries
Recruiting
Saliva insulin shows promise as a non-invasive biomarker of high carbohydrate intake and/or insulin resistance, key risk factors for metabolic dysregulation and caries. Saliva insulin monitoring could potentially inform the planning and evaluation of interventions to prevent child obesity, diabetes and caries, without relying on self-reported measures from children, parents, child care providers or teachers. School-based public health screening programs, which have staff and data collection in... Read More
Gender:
All
Ages:
Between 5 years and 10 years
Trial Updated:
04/11/2023
Locations: UCSF Pediatric Dentistry, San Francisco, California
Conditions: Caries, Metabolomic Profile
International Consortium for Multimodality Phenotyping in Adults With Non-compaction
Recruiting
Non-compaction cardiomyopathy (NCCM) is a heterogeneous, poorly understood disorder characterized by a prominent inner layer of loose myocardial tissue, and associated with heart failure, stroke, severe rhythm irregularities and death. For a growing population diagnosed with NCCM there is a need for better risk stratification to appropriately allocate (or safely withhold) these impactful preventive measures. The goal of this international consortium is to improve care of patients with non-compac... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/11/2023
Locations: Stanford University, Palo Alto, California
Conditions: Non-Compaction Cardiomyopathy
Revolutionizing Normative Re-education
Recruiting
Personalized Normative Feedback (PNF), the most widely-used college alcohol intervention approach, suffers from several limitations innovatively remedied in the current proposal through CampusGANDR, a smartphone-based app for college students that delivers alcohol-related PNF within a weekly game centered around testing first-year students' perceptions about the attitudes and behaviors of their peers in a variety of campus-relevant domains. Five pilot studies suggest that CampusGANDR will be sig... Read More
Gender:
All
Ages:
Between 18 years and 20 years
Trial Updated:
04/11/2023
Locations: Loyola Marymount University, Los Angeles, California
Conditions: College Drinking, Underage Drinking, Alcohol Use Disorder
The GAstric Precancerous Conditions Study
Recruiting
Gastric cancer afflicts 27,000 Americans annually and carries a dismal prognosis. One reason for poor outcomes is late diagnosis, as the majority of gastric cancers in the United States are diagnosed at a relatively advanced stage where curative resection is unlikely. Gastric intestinal metaplasia (GIM) is a precancerous change of the stomach which increases risk for subsequent gastric cancer multiple-fold. The Gastric Precancerous Conditions Study (GAPS) is an observational study with two over... Read More
Gender:
All
Ages:
Between 35 years and 84 years
Trial Updated:
04/11/2023
Locations: Stanford University, Stanford, California
Conditions: Gastric Cancer, Intestinal Metaplasia of Gastric Mucosa, Helicobacter Pylori Infection, Atrophic Gastritis
A Long-term Follow-up Study of Participants Who Received an Allogeneic CAR T-Cell Product
Recruiting
The goal of this study is to collect information on the long-term safety of study participants who received Allogeneic Chimeric Antigen Receptor (CAR) T-Cell Product in a Precision BioSciences, Inc. (PBI) Clinical Study. The main questions it aims to answer are: -What were the frequency, severity, duration, and outcome of clinically significant Clinical Events of Interest (CEI)? Participants will visit a study center 3 times during the first year, and once per year after that for a physical ex... Read More
Gender:
All
Ages:
Between 18 years and 95 years
Trial Updated:
04/10/2023
Locations: Science 37, Inc., Culver City, California
Conditions: Participants Who Received an Allogeneic Chimeric Antigen Receptor T-Cell Product (PBCAR) in a Precision BioSciences, Inc., Clinical Study
Oncoplastic Partial Mastectomy With Intraoperative Radiation Therapy (IORT) in Early Stage Breast Cancer Patients With Prior History of Chest Wall Radiation.
Recruiting
Prospective, Non-randomized, Single-arm.The objectives of this study are to evaluate cosmesis and perioperative complications associated with the use of intraoperative radiotherapy (IORT) at the time of partial mastectomy in patients with breast cancer and a prior history of radiation therapy. Secondary objectives include evaluating effectiveness of partial mastectomy with IORT, measured by local, regional and distant recurrence, mastectomy rate, and disease-specific and overall survival.
Gender:
Female
Ages:
50 years and above
Trial Updated:
04/10/2023
Locations: Providence Saint John's Hospital, Santa Monica, California
Conditions: IORT-Intra-Operative Radiation Therapy
Screening for High Frequency Malignant Disease
Recruiting
The SHIELD (Screening for High Frequency Malignant Disease) study is a prospective, observational, multi-site basket design trial without randomization. The primary objective of the study is to evaluate the sensitivity and specificity of a blood-based GuardantLUNAR-2 test to detect high frequency cancer in screen-relevant populations.
Gender:
All
Ages:
Between 50 years and 80 years
Trial Updated:
04/10/2023
Locations: Pacific Cancer Medical Center, Anaheim, California
Conditions: Lung Cancer
Diagnostic and Prognostic Biomarkers for High-impact Chronic Pain: Development and Validation
Recruiting
To identify diagnostic and prognostic biomarker signatures of recovery versus having persisting high-impact chronic pain and functional disability in adults with Chronic Musculoskeletal Pain.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
04/10/2023
Locations: Stanford University, Palo Alto, California
Conditions: Chronic Musculoskeletal Pain, Pain, Pain, Chronic, Joint Pain