California is currently home to 5582 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Use of CXCL9 as a Biomarker of Acthar Efficacy
Recruiting
The objective is this study is to test whether use of Acthar gel in the context of sarcoidosis will lead to improved symptoms and lung function and correlate with decreased levels of predictive blood biomarkers, like chemokine ligand 9 (CXCL9).
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/10/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Sarcoidosis
COVID-19 Outcome Prediction Algorithm
Recruiting
Severe acute respiratory syndrome coronavirus 2-mediated coronavirus disease (COVID-19) is an evolutionarily unprecedented natural experiment that causes major changes to the host immune system. We propose to develop a test that accurately predicts short- and long-term (within one-year) outcomes in hospitalized COVID-19 patients broadly reflecting US demographics who are at increased risk of adverse outcomes from COVID-19 using both clinical and molecular data. We will enroll patients from a hos... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2023
Locations: VA Greater Los Angeles Healthcare System, Los Angeles, California
Conditions: COVID-19, Post Acute Sequelae of COVID-19, Long COVID, Organ Dysfunction Syndrome, Multiple, Frailty Syndrome
Parent Intervention for Psychiatrically-Hospitalized Youth
Recruiting
The purpose of the present study is to conduct a pilot randomized clinical trial (RCT) of a parent coaching intervention for parents of youth hospitalized for suicidal ideation, suicide attempt(s), or non-suicidal self-injury. Parents will receive either the parent coaching intervention (which includes safety planning and behavioral parenting skills training with a clinician and assistance with linkage to follow-up care by a case manager) or treatment as usual (TAU) for the inpatient unit. The l... Read More
Gender:
ALL
Ages:
Between 12 years and 85 years
Trial Updated:
05/09/2023
Locations: Michele Berk, Stanford, California
Conditions: Adolescent - Emotional Problem, Suicide and Self-harm, Parenting
Glycemic Targets for Pregnant Women With GDM and T2DM
Recruiting
The purpose of this randomized clinical trial is to determine whether glycemic targets that are lower than those currently recommended by the American Diabetes Association (ADA) and the American College of Obstetricians and Gynecologists (ACOG) would improve overall outcomes in pregnant patients with diabetes. Eligible pregnant women with a diagnosis of gestational diabetes or Type 2 diabetes will be randomized into either routine care with glycemic targets as currently recommended by ADA and AC... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/09/2023
Locations: Los Angeles County + University of Southern California Medical Center (LAC+USC), Los Angeles, California
Conditions: Diabetes Mellitus in Pregnancy, Diabetes, Gestational, Diabetes Mellitus, Type 2
Food Prescriptions to Promote Affordable Diets
Recruiting
This is an Randomized controlled trial (RCT) to assess the impact of meal planning and affordable grocery delivery on weight loss, dietary quality and health on members of multigenerational Latino households.
Gender:
ALL
Ages:
2 years and above
Trial Updated:
05/08/2023
Locations: Kaiser Permanente, Pasadena, California
Conditions: Diet, Healthy, Overweight and Obesity
Affect Treatment for Depression and Anxiety
Recruiting
The purpose of this study is to evaluate the efficacy and mediators of change in Positive Affect Treatment, a psychotherapy specifically aimed at enhancing reward sensitivity in individuals with low positive affect (a core feature of anhedonia) in the context of depression or anxiety. Target enrollment is 100 male and female participants with low positive affect and depression or anxiety and impaired functioning, between the ages of 18 and 65 years, who will be randomized to either Positive Aff... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/08/2023
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Depression, Anxiety
Addressing Obesity in Early Care and Education Settings
Recruiting
Childhood obesity is a national epidemic that disproportionately burdens low income and ethnic minority populations. By preschool, nearly one-third of low income children are already overweight or obese, setting the stage for adverse health outcomes over their life course. Evidence is mounting that individual-focused, single-component interventions fail to produce long-term population-level changes in obesity-related outcomes. Evidence increasingly supports creating entire environments (e.g., sc... Read More
Gender:
ALL
Ages:
30 months and above
Trial Updated:
05/08/2023
Locations: UCLA Fielding School of Public Health, Los Angeles, California
Conditions: Obesity
Aneurysm Genetic Risk in Patients With QIB Changes
Recruiting
Intracranial aneurysm rupture is a leading cause of hemorrhagic strokes which carry high mortality and disability rates as well as high healthcare costs. Unruptured intracranial aneurysms (UIA) are common in the general population, occurring in 1-2% of individuals. Previous studies have shown that UIA growth and rupture are strongly associated with each other, with growing aneurysms 9-12 times more likely to rupture, and nearly all aneurysms growing prior to rupture. Thanks to advanced medical i... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/04/2023
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Brain Aneurysm
Study of Dietary Composition in Crohn's Disease
Recruiting
Patients with inflammatory bowel disease (IBD) often have narrowed microbial diversity and altered composition and function of the gut microbiome. We anticipate the anti-inflammatory diet, when compared with the usual diet, to produce favorable changes in these multi-omics profiles. These findings will provide insight into the interactions between diet and host biology, while providing clues on the mechanisms of diet therapy's effect and CD pathogenesis.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/04/2023
Locations: UCLA Center for Human Nutrition, 1000 Veteran Ave., Los Angeles, California
Conditions: Inflammatory Bowel Diseases, Crohn Disease
Metformin Treatment in Progressive Multiple Sclerosis
Recruiting
The purpose of this study is to assess the safety of metformin for treatment of progressive multiple sclerosis
Gender:
ALL
Ages:
Between 30 years and 65 years
Trial Updated:
05/03/2023
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Secondary Progressive Multiple Sclerosis, Primary Progressive Multiple Sclerosis
Analgesia-First Sedation in Trauma Patients
Recruiting
The study's aim is to ascertain the best approach for providing sedation and pain management for patients who have sustained trauma and are requiring respiratory support from a mechanical ventilator. The common approach to patients who need mechanical ventilation is to provide continuous drips of sedatives and pain medicine and awaken the patient once a day to check the brain functions. Another approach is to provide pain medicine and reserve sedatives for only a short duration when needed. The... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/01/2023
Locations: Long Beach Memorial Medical Center, Long Beach, California
Conditions: Mechanical Ventilation, Respiratory Failure
Closed-Loop Deep Brain Stimulation for Major Depression
Recruiting
Neurons are specialized types of cells that are responsible for carrying out the functions of the brain. Neurons communicate with electrical signals. In diseases such as major depression this electrical communication can go awry. One way to change brain function is using electrical stimulation to help alter the communication between groups of neurons in the brain. The purpose of this study is to test a personalized approach to brain stimulation as an intervention for depression. The study resea... Read More
Gender:
ALL
Ages:
Between 22 years and 70 years
Trial Updated:
04/27/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Major Depressive Disorder