California is currently home to 5930 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Integrative Therapy for Holistic, Natural Cognition and Lifestyle Rehabilitation
Recruiting
An observational study to determine outcomes of older adults who are under naturopathic medical care for cognitive complaints at a specific clinic in Southern California.
Gender:
All
Ages:
60 years and above
Trial Updated:
03/22/2023
Locations: North County Natural Medicine, Encinitas, California
Conditions: Cognitive Dysfunction
Light Flashes to Treat Delayed Sleep Phase Disorder (DSPD)
Recruiting
Delayed Sleep Phase Disorder (DSPD) is a sleep disruption that commonly occurs in teens and manifests as a difficulty in waking up in the morning, going to sleep early enough at night, and daytime disturbances such as depression, fatigue, and restlessness. The purpose of this study is to determine if brief flashes of light, that are scheduled to occur during sleep, are effective in treating DSPD.
Gender:
All
Ages:
Between 15 years and 19 years
Trial Updated:
03/22/2023
Locations: Stanford University, Palo Alto, California
Conditions: Delayed Sleep Phase Disorder
Acetazolamide in Persons With Type 1 Diabetes
Recruiting
This is a dose finding trial where participants will receive escalating doses of acetazolamide, each for a 2-week dosing period followed by a 2-week washout period. The three doses examined will be open-label 62.5mg twice daily, 125mg twice daily, and 250mg twice daily of acetazolamide. A baseline Iohexol GFR (glomerular filtration rate) measurement will be performed prior to the first administration of each acetazolamide dose and then again following each dosing period. Including a screening vi... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/21/2023
Locations: UC San Diego Altman Clinical & Translational Research Institute, La Jolla, California
Conditions: Type 1 Diabetes
LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell Histiocytosis
Recruiting
The LCH-IV is an international, multicenter, prospective clinical study for pediatric Langerhans Cell Histiocytosis LCH (age < 18 years).
Gender:
All
Ages:
18 years and below
Trial Updated:
03/21/2023
Locations: Children's Hospital of Los Angeles, Los Angeles, California
Conditions: Langerhans Cell Histiocytosis
Intraoperative Use of ClearEdge Device in Breast Conserving Surgery
Recruiting
Multi center, pivotal prospective, randomized clinical trial The proposed randomized controlled study will evaluate the benefits of adding the ClearEdge imaging device to the Standard of Care (SoC) of margins assessment in breast conserving surgeries. The study will assess whether there is an improvement in the detection of DCIS or invasive cancer involved margins by measuring whether removal at the time of primary surgical treatment can reduce the need for repeat surgeries as compared to the S... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
03/20/2023
Locations: UCSF Medical Center at Mission Bay, San Francisco, California
Conditions: Breast Cancer
DNA-Guided Second Line Adjuvant Therapy For High Residual Risk, Stage II-III, Hormone Receptor Positive, HER2 Negative Breast Cancer
Recruiting
A randomized, Phase II trial of circulating tumor DNA-guided second line Adjuvant therapy for high Residual risk, stage II-III, Estrogen Receptor positive, HER-2 negative breast cancer (DARE)
Gender:
All
Ages:
All
Trial Updated:
03/20/2023
Locations: USC/Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Breast Cancer
Proof of Concept Study of Latanoprost/Minoxidil (ANR-001.1) Topical Formulation
Recruiting
Study to Evaluate the safety and efficacy of a Latanoprost/Minoxidil formulation vs. placebo for the treatment of hypotrichosis of the eyebrows.
Gender:
All
Ages:
Between 22 years and 65 years
Trial Updated:
03/17/2023
Locations: WellMax, Indian Wells, California
Conditions: Hypotrichosis
Validity of AI in Treatment of the Musculoskeletal Conditions by Vifive
Recruiting
The purpose of this study is to evaluate the efficacy of the 12-week ViFive program, a vision-based artificial intelligent digital care plan for chronic knee pain. ViFive digital care plan is delivered by a physical therapy team consisting of physical therapists and a personal coach. We aim to understand the safety and efficacy of this vision artificial intelligent based home exercise program.
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
03/17/2023
Locations: Stanford University Hospitals and Clinics, Redwood City, California
Conditions: Shoulder Adhesive Capsulitis, Knee Osteoarthritis
Comparative Effectiveness of Particulate Versus Nonparticulate Steroid Injections for Musculoskeletal Conditions
Recruiting
This aims of this study are: To determine if particulate or non-particulate corticosteroid injections are more effective at treating pain from musculoskeletal pathologies of the hip, glenohumeral joint, biceps tendon, or subacromial/subdeltoid bursa at 2 weeks, 3 months, or 6 months. To determine if there is a significantly different side effect profile between particulate and non-particulate corticosteroids when used for hip, glenohumeral joint, biceps tendon, or subacromial/subdeltoid bursa i... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/17/2023
Locations: Stanford University, Redwood City, California
Conditions: Osteoarthritis, Tendinopathy, Impingement Shoulder
Physica System Total Knee Replacement Registry Study
Recruiting
The primary objective of this study is to obtain long-term implant survivorship (out to 10 years) and to assess clinical, patient-reported outcome measures, and radiographic data for the commercially available Physica system. For ancillary arm, from baseline to 5-year follow-up.
Gender:
All
Ages:
22 years and above
Trial Updated:
03/17/2023
Locations: Eisenhower Desert Orthopedics Center - Harry and Diane Rinker Bldg, Rancho Mirage, California
Conditions: Osteoarthritis, Knee, Traumatic Arthritis, Avascular Necrosis, Degenerative Joint Disease of Knee, Rheumatoid Arthritis, Deformity of Knee
Youth Ending the HIV Epidemic
Recruiting
Young adults have a disproportionately high rate of HIV infection, high rates of attrition at all stages of the HIV care continuum, an increased risk of antiretroviral therapy (ART) nonadherence and virologic failure, and a high probability of disease progression and transmission. Tracking and monitoring objective measures of ART adherence in real time is critical to strategies to support adherence and improve clinical outcomes. However, adherence monitoring often relies on self-reported and ret... Read More
Gender:
All
Ages:
Between 18 years and 29 years
Trial Updated:
03/16/2023
Locations: UCSF Center for AIDS Prevention Studies, San Francisco, California
Conditions: HIV/AIDS, Mobile Health, Young Adults
Women SHINE: Addressing Syndemics and HIV Among Women Through Tech-Based Peer Engagement
Recruiting
A two-arm RCT will be conducted to test the efficacy of Women SHINE, a web-based trauma-informed peer navigation-social support intervention (Figure 2). A total of 360 women living with HIV/AIDS (WLHA) with a history of adulthood interpersonal violence who have been prescribed ART but are non-adherent (< 90% ART adherent in the last 4 weeks) will be enrolled in the study. WLHA will be randomized (1:1) into one of the following conditions: 1) Women SHINE intervention arm (n=180) or 2) Control arm... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
03/15/2023
Locations: The Regents of the Univ. of Calif., U.C. San Diego, La Jolla, California
Conditions: HIV/AIDS