California is currently home to 5581 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Percutaneous Electrical Nerve Field Stimulation for Adults With Irritable Bowel Syndrome
Recruiting
This is a prospective, double-blind, randomized, sham-controlled pilot study evaluating the efficacy of percutaneous electrical nerve field stimulation for the treatment of adult patients with irritable bowel syndrome (IBS).
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
01/09/2023
Locations: UCLA, Los Angeles, California
Conditions: Irritable Bowel Syndrome, Abdominal Pain, Autonomic Nervous System Imbalance
Rady Children's Institute Genomic Biorepository
Recruiting
Rady Children's Institute for Genomic Medicine (RCI) will collect biological samples (such as blood), derived genomic sequences (from DNA and RNA), and clinical features in a Biorepository as a standardized resource for future research studies. The purpose of the Genomic Institute Biorepository is to provide consented samples and data for basic and clinical research related to the genomic cause and treatment of childhood disease, and, in the future, as reference (Quality Control) data to improve... Read More
Gender:
ALL
Ages:
All
Trial Updated:
12/08/2022
Locations: Rady Pediatric Genomics & Systems Medicine Institute, San Diego, California
Conditions: Genetic Diseases
A Study of Concurrent Stereotactic Body Radiotherapy With Opdualag in Metastatic Uveal Melanoma
Recruiting
This is a phase 2 trial of concurrent stereotactic radiation therapy (SBRT) with immunotherapy with relatlimab and nivolumab for up to two years. SBRT will be given in three doses of 15Gy each to 1-5 separate metastases. Opdualag (nivolumab 480mg and relatlimab 160mg) will be given every 4 weeks for two years
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/02/2022
Locations: California Pacific Medical Center Research Institute, San Francisco, California
Conditions: Uveal Melanoma
Adoptive Cell Transfer of Autologous Tumor Infiltrating Lymphocytes and High-Dose Interleukin 2 in Select Solid Tumors
Recruiting
To determine whether special tumor fighting cells that is taken from participants' tumors and grown in the laboratory and then given back to the participant will fight the participant's cancer when their immune system is suppressed from attacking these special tumor fighting cells. This is called transfer of autologous (they came from you) tumor infiltrating lymphocytes (the cells that have been grown in the laboratory. Participants getting these cell infusions will also be treated with interleu... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/01/2022
Locations: UC San Diego Moores Cancer Center, La Jolla, California
Conditions: Metastatic Melanoma, Locally Advanced Refractory/Recurrent Melanoma, Metastatic Head and Neck Cancer, Locally Advanced Refractory/Recurrent Head and Neck Cancer
Remote Dielectric Sensing (ReDS) Assisted Diuresis in Acute Decompensated Heart Failure
Recruiting
This study evaluates the use of a wearable vest capable of non-invasively measuring lung fluid content in hospitalized patients with heart failure
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/28/2022
Locations: University of California, San Francisco, San Francisco, California
Conditions: Heart Failure; With Decompensation
StimRouter Registry Clinical Protocol
Recruiting
This Registry study will prospectively evaluate the long-term effectiveness, safety, and tolerability of the StimRouter Neuromodulation System, along with evaluating the technical performance of StimRouter, surgical outcomes, health-related quality of life, concomitant medical use, and subject's impression of improvement.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/07/2022
Locations: University of California San Diego, La Jolla, California
Conditions: Chronic Pain, Peripheral Neuropathy, Nervous System Diseases, Peripheral Nervous System Diseases, Peripheral Nervous System Problem, Peripheral Nerve Injuries, Peripheral Nervous
MOON Shoulder Instability-Cohort of Patients Undergoing Operative Treatment.
Recruiting
This project will be a multi-center, prospective longitudinal cohort for all patients undergoing primary shoulder instability surgery, excluding isolated SLAP repairs. We will be looking for risk factors for recurrent instability, revision surgery, and poor outcomes. Patients will be asked to complete the RAND-36, ASES, Shoulder Activity, EQ-5D and WOSI outcome measures, as well as demographic and socioeconomic information. Surgeons will complete a form after surgery with information on radiogra... Read More
Gender:
ALL
Ages:
Between 12 years and 99 years
Trial Updated:
11/07/2022
Locations: UCSF Orthopedic Institute, San Francisco, California
Conditions: Other Instability, Shoulder, Dislocations, Subluxations, Recurrent Dislocation of Shoulder Region
Pediatric Cervical Spine Clearance: A Multicenter Prospective Observational Study
Recruiting
A prospective multicenter observational study, led by Dr. Katie Russell of Intermountain Primary Children's Hospital, that will examine the sensitivity, specificity, negative, and positive predictive values of CT scan and plain films in diagnosing cervical spine injury that requires treatment. This study is funded by the Primary Children's Hospital foundation.
Gender:
ALL
Ages:
Between 0 years and 17 years
Trial Updated:
11/01/2022
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Cervical Spine Fracture
2-level Cervical Disc Replacement Comparing Prodisc C SK & Vivo to Mobi-C
Recruiting
A multi-center, prospective, randomized, controlled comparison of the prodisc C SK and prodisc C Vivo to the control, a similar, legally marketed total disc replacement device in subjects with symptomatic cervical disc disease (SCDD).
Gender:
ALL
Ages:
Between 18 years and 69 years
Trial Updated:
10/27/2022
Locations: Todd Lanman, MD, Inc., Beverly Hills, California
Conditions: Symptomatic Cervical Disc Disease
Reducing Surgical Site Infection Rates Using an Alternative Sternal Dressing
Recruiting
This study will evaluate two alternative dressings compared to a standard Island dressing presently in use at Stanford Hospital to determine reductions in surgical site infection (SSI) rates among cardiac surgery patients. Cardiovascular surgery patients who will have a sternotomy incision as a routine part of their surgery will be approached to voluntarily participate. Participants will be randomized to one of three dressing to determine which dressing has the lowest rate of sternal wound infec... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2022
Locations: Stanford Healthcare, Stanford, California
Conditions: Wound of Skin
Safety and Effectiveness of the CustomFlex Artificial Iris Prosthesis for the Treatment of Iris Defects
Recruiting
The purpose of this study is to study the long term safety and effectiveness of an artificial iris prosthesis for the treatment of iris defects.
Gender:
ALL
Ages:
3 years and above
Trial Updated:
10/21/2022
Locations: Advanced Vision Care, Los Angeles, California
Conditions: Full Aniridia, Partial Aniridia
CERENOVUS Neurothrombectomy Devices Registry
Recruiting
A post-market registry evaluating the EmboTrap® Revascularization Device and CERENOVUS Large Bore Catheter/ EMBOVAC Aspiration Catheter in acute ischemic stroke patients with confirmed intracranial large vessel occlusion.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/19/2022
Locations: Vascular Neurology of Southern California: Dr. M. Asif Taqi, Thousand Oaks, California
Conditions: Cerebral Stroke