California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Aneurysm Genetic Risk in Patients With QIB Changes
NCT05317169
Recruiting
Intracranial aneurysm rupture is a leading cause of hemorrhagic strokes which carry high mortality and disability rates as well as high healthcare costs. Unruptured intracranial aneurysms (UIA) are common in the general population, occurring in 1-2% of individuals. Previous studies have shown that UIA growth and rupture are strongly associated with each other, with growing aneurysms 9-12 times more likely to rupture, and nearly all aneurysms growing prior to rupture. Thanks to advanced medical i... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/04/2023
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Brain Aneurysm
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Study of Dietary Composition in Crohn's Disease
NCT04431700
Recruiting
Patients with inflammatory bowel disease (IBD) often have narrowed microbial diversity and altered composition and function of the gut microbiome. We anticipate the anti-inflammatory diet, when compared with the usual diet, to produce favorable changes in these multi-omics profiles. These findings will provide insight into the interactions between diet and host biology, while providing clues on the mechanisms of diet therapy's effect and CD pathogenesis.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/04/2023
Locations: UCLA Center for Human Nutrition, 1000 Veteran Ave., Los Angeles, California
Conditions: Inflammatory Bowel Diseases, Crohn Disease
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Closed-Loop Deep Brain Stimulation for Major Depression
NCT04004169
Recruiting
Neurons are specialized types of cells that are responsible for carrying out the functions of the brain. Neurons communicate with electrical signals. In diseases such as major depression this electrical communication can go awry. One way to change brain function is using electrical stimulation to help alter the communication between groups of neurons in the brain. The purpose of this study is to test a personalized approach to brain stimulation as an intervention for depression. The study resea... Read More
Gender:
ALL
Ages:
Between 22 years and 70 years
Trial Updated:
04/27/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Major Depressive Disorder
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KRT-232 Versus Best Available Therapy for the Treatment of Subjects With Myelofibrosis Who Are Relapsed or Refractory to JAK Inhibitor Treatment
NCT03662126
Recruiting
This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, for the treatment of patients with myelofibrosis (MF) who no longer benefit from treatment with a JAK inhibitor. Inhibition of MDM2 is a novel mechanism of action in MF. This study will be conducted in 2 phases. Phase 2 will determine the KRT-232 recommended dose and dosing schedule; Phase 3 will test KRT-232 vs Best Available Therapy (BAT). Patients in the Phase 3 part of the study will be randomized 2:1 to receive ei... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/26/2023
Locations: University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Primary Myelofibrosis (PMF), Post-Polycythemia Vera MF (Post-PV-MF), Post-Essential Thrombocythemia MF (Post-ET-MF)
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Benzodiazepine Taper With Telehealth-Delivered Cognitive Behavioral Therapy for Patients Using Prescription Opioids
NCT05845606
Recruiting
The study aims to examine the efficacy of a telehealth-delivered cognitive behavioral therapy (CBT) + benzodiazepine taper (BZ-TP) program in facilitating reductions in benzodiazepine use among patients who are prescribed opioids for pain.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
04/25/2023
Locations: UCLA Health MPTF Toluca Lake Primary Care Clinic, Burbank, California
Conditions: Substance Use Disorders, Anxiety Disorders, Chronic Pain
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Enhance Study: Evaluation of Accuracy and Safety of the Eversense CGM System With Enhanced Features
NCT05131139
Recruiting
A Prospective, Multicenter Evaluation of Accuracy and Safety of the Eversense CGM System with Enhanced Features. The purpose of this clinical investigation is to evaluate the accuracy of the Eversense 524 Continuous Glucose Monitoring System (Eversense 524 CGM System) and ROME CGM System with next generation feature enhancements compared to reference glucose measurements in adults 18 years of age and older with diabetes. The investigation will also evaluate safety of the Eversense 524 CGM System... Read More
Gender:
ALL
Ages:
14 years and above
Trial Updated:
04/24/2023
Locations: AMCR Institute Inc., Escondido, California
Conditions: Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
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Investigating Medication vs. Prostatic Urethral Lift: Assessment and Comparison of Therapies for BPH
NCT04987892
Recruiting
This prospective, multicenter, two-arm, 1:1 randomized controlled trial (RCT) will enroll approximately 250 males at approximately 25 sites located within the United States. All enrolled subjects will be 45 years of age or older diagnosed with symptomatic benign prostatic hyperplasia (BPH). They will be randomized to one of two readily available, marketed BPH therapies; Prostatic Urethral Lift procedure with the UroLift System (PUL Arm) or 0.4mg tamsulosin HCl (MED Arm).
Gender:
MALE
Ages:
45 years and above
Trial Updated:
04/24/2023
Locations: Neotract, Pleasanton, California
Conditions: BPH
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A Clinical Investigation to Follow the Progress of Exuding Chronic Wounds Using Mepilex® Up as the Primary Dressing.
NCT05588583
Recruiting
The goal of this clinical trial is to follow the progress of wounds in those with venous leg ulcers and diabetic foot ulcers while using an absorbent dressing called Mepilex Up. The main objective is to follow the progress of these wounds over time from initial visit to each follow-up visit. Participants will be asked to wear Mepilex Up dressing for up to 6 weeks of treatment or until healed, changed at every one-week interval.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/18/2023
Locations: Center for Clinical Research, Inc., Castro Valley, California
Conditions: Wounds, Wound of Skin, Wound Leg, Wound; Foot, Diabetic Foot Ulcer, Venous Leg Ulcer
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Neuroimaging Biomarkers for Predicting rTMS Response in OCD
NCT04286126
Recruiting
This study evaluates an accelerated schedule of theta-burst stimulation using a Transcranial Magnetic Stimulation (TMS) device for treatment-resistant Obsessive Compulsive Disorder (OCD). In a randomized fashion, half the participants will receive accelerated theta-burst stimulation at the dorsomedial prefrontal cortex (DMPFC), while half will receive accelerated theta-burst stimulation at the right orbitofrontal (rOFC) site.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
04/16/2023
Locations: Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine, Stanford, California
Conditions: Obsessive-Compulsive Disorder
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Oncoplastic Partial Mastectomy With Intraoperative Radiation Therapy (IORT) in Early Stage Breast Cancer Patients With Prior History of Chest Wall Radiation.
NCT05289466
Recruiting
Prospective, Non-randomized, Single-arm.The objectives of this study are to evaluate cosmesis and perioperative complications associated with the use of intraoperative radiotherapy (IORT) at the time of partial mastectomy in patients with breast cancer and a prior history of radiation therapy. Secondary objectives include evaluating effectiveness of partial mastectomy with IORT, measured by local, regional and distant recurrence, mastectomy rate, and disease-specific and overall survival.
Gender:
FEMALE
Ages:
50 years and above
Trial Updated:
04/10/2023
Locations: Providence Saint John's Hospital, Santa Monica, California
Conditions: IORT-Intra-Operative Radiation Therapy
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Safety of AV-MEL-1 With Anti-PD-1 Therapy in Metastatic Melanoma
NCT03743298
Recruiting
This is an open label, single-arm, phase IB treatment study to determine the safety of administering anti-PD1 monoclonal antibodies with AV-MEL-1 and to get some suggestion of efficacy, in patients with measurable metastatic melanoma. The study is open to patients who have either never received treatment for metastatic melanoma or were previously treated with anti-PD-1 with or without anti-CTLA-4 or with enzymatic inhibitors of the BRAF/MEK pathway because of BRAF600E/K mutations, and are about... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/07/2023
Locations: Jericho Rabago, Irvine, California
Conditions: Metastatic Melanoma
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Exercise Intolerance in Non-obstructive Hypertrophic Cardiomyopathy
NCT05818605
Recruiting
The EXCITE-HCM study is a randomized, controlled, blinded clinical trial designed to evaluate the effect of moderate intensity exercise training versus usual physicial activity on the improvement of HCM-related symptoms and cardiac function. About 70 participants will be recruited and randomized on a 1:1 ratio to either moderate intensity training or usual physicial activity interventions. Patients will be followed during a period of 24 weeks and assesesments as physical examination, questionnai... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
04/05/2023
Locations: University of California - San Francisco, San Francisco, California
Conditions: Hypertrophic Cardiomyopathy
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