California is currently home to 5952 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Optimizing ctDNA-based MRD Assessment in DLBCL, MCL, and FL Patients Undergoing CAR Therapy
Recruiting
In this study, invesigators propose to analyze 150 DLBCL patients, 50 MCL patients, and 100 FL patients to determine the clinical utility of ctDNA- as well as circulating tumor cell (CTC)-based MRD assessment in CAR therapy patients. The project detailed in this protocol will utilize the clonoSEQ platform as specific quantification of residual DLBCL/FL/MCL and correlate its results with radiologic assessment of disease and clinical outcomes. Invesitgators predict there will be a strong correlati... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/30/2023
Locations: Stanford Cancer Center, Palo Alto, California
Conditions: Follicular Lymphoma, Diffuse Large B Cell Lymphoma, Mantle Cell Lymphoma
Medial-prefrontal Enhancement During Schizophrenia Systems Imaging
Recruiting
This randomized controlled trial in healthy controls (HC) and patients with schizophrenia (SZ) aims to examine 1) the underlying cognitive and neural cause of self-agency deficits in SZ; 2) the responsiveness to a novel navigated repetitive transcranial magnetic stimulation (nrTMS) target in the medial/superior prefrontal cortex (mPFC); and 3) how modulation of mPFC activity impacts the larger self-agency network to mediate changes in self-agency judgments. Our overall hypothesis is that increas... Read More
Gender:
All
Ages:
Between 18 years and 64 years
Trial Updated:
01/30/2023
Locations: UCSF, San Francisco, California
Conditions: Schizophrenia
A Study of ZN-c3 in Participants With Solid Tumors
Recruiting
This is a Phase 1 open-label, multicenter study of ZN-c3 monotherapy which consists of Dose Escalation, a Food Effect Cohort, and Dose Expansion.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/30/2023
Locations: Site 0167, Newport Beach, California
Conditions: Solid Tumor
Campath/Fludarabine/Melphalan Transplant Conditioning for Non-Malignant Diseases
Recruiting
The hypothesis for this study is that a preparative regimen that maximizes host immunosuppression without myeloablation will be well tolerated and sufficient for engraftment of donor hematopoietic cells. It is also to determine major toxicities from these conditioning regimens, within the first 100 days after transplantation.
Gender:
All
Ages:
20 years and below
Trial Updated:
01/30/2023
Locations: Children's Hospital of Orange County, Orange, California
Conditions: Metabolic Disorders, Hematologic, Immune, or Bone Marrow Disorders, Hemoglobinopathies, Non-malignant Disorders
Transcranial Magnetic Stimulation and Tobacco Use Disorder
Recruiting
The purpose of this study is to determine if brain stimulation using repetitive transcranial magnetic stimulation (rTMS) directed at different parts of the brain can decrease feelings of cigarette craving and symptoms of cigarette withdrawal, and also if men and women have different responses to rTMS. Participants will visit the University of California, Los Angeles (UCLA) five times: First, for in-person screening, then for four rTMS sessions, four three different brain regions. Everyone in th... Read More
Gender:
All
Ages:
Between 18 years and 45 years
Trial Updated:
01/27/2023
Locations: Semel Institute of Neuroscience, Los Angeles, California
Conditions: Tobacco Use Disorder
Collection of Samples USOPTIVAL Study
Recruiting
A prospective multi-center observational study. The study will enroll eligible subjects from the United States to optimize the biomarker panel and evaluate the performance of a cfDNA marker panel selected by the Sponsor for CRC and advanced adenoma detection.
Gender:
All
Ages:
Between 45 years and 84 years
Trial Updated:
01/26/2023
Locations: Precision Recearch Institute, Chula Vista, California
Conditions: Colorectal Cancer (CRC), Advanced Adenomas (AA)
Open Label Study for the Use of Transcranial Ultrasound Treatment of Tremor
Recruiting
The purpose of this Phase I open label study is to evaluate longer term tolerability and potential effectiveness of transcranial ultrasound in people with tremor as a results of Parkinson's Disease or Essential Tremor.
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
01/25/2023
Locations: Neurological Associates of West Los Angeles, Los Angeles, California
Conditions: Tremor, Parkinson Disease, Essential Tremor
The Effects of Specialty Coffee on Cognitive Function in People With Type 2 Diabetes
Recruiting
Coffee has been found to have beneficial effects on cognitive function and blood sugar control. Benefits include reduced risk of cognitive decline and improved performance on cognitive tests, as well as reduced risk of diabetes and improved blood sugar control in people with diabetes, a population that is at a higher risk of cognitive decline. These effects have been observed for both caffeinated and decaffeinated coffee, and have been associated with the polyphenol chlorogenic acid (CGA). This... Read More
Gender:
All
Ages:
Between 55 years and 70 years
Trial Updated:
01/24/2023
Locations: Kaiser Permanente, Berkeley, California
Conditions: Type 2 Diabetes
Outcomes After Weight Loss Surgery in Low-Risk Patients
Recruiting
The purpose of this research is to determine patient-reported outcomes after weight loss surgery, including changes in health, mood, quality of life, health satisfaction, and emotional health, in low-risk patients. Weight loss surgery has been well studied for patients with body mass index (BMI) 35 kg/m^2 or more and those with weight-related medical problems who have a BMI 30 kg/m^2 or more. However, outcomes after weight loss surgery in patients with BMI under 35 kg/m^2 and without co-morbidit... Read More
Gender:
All
Ages:
All
Trial Updated:
01/24/2023
Locations: Dr. Feiz and Associates, Beverly Hills, California
Conditions: Weight Loss, Bariatric Surgery
Autologous Mobilized Peripheral Blood CD34+ Hematopoietic Stem and Progenitor Cells (HSPC) Transduced With the Elongation Factor Alpha Short Promoter (EFS) - Adenosine Deaminase (ADA) Gene (EFS-ADA) Lentiviral Vector for Adenosine Deaminase Severe Combined Immune Deficiency (ADA SCID)
Recruiting
The aim of this study is to assess the safety and efficacy of autologous transplantation of hematopoietic stem cells (CD34+ cells) from mobilized peripheral blood (mPB) of ADA-deficient SCID infants and children following human ADA gene transfer by the EFS-ADA lentiviral vector. The level of gene transfer in blood cells and immune function will be measured as endpoints.
Gender:
All
Ages:
1 month and above
Trial Updated:
01/24/2023
Locations: University of California, Los Angeles (UCLA), Los Angeles, California
Conditions: Adenosine Deaminase Severe Combined Immune Deficiency
High Dose Steroid Therapy to Treat Flares in Patients With Inflammatory Bowel Disease (IBD)
Recruiting
This study will examine whether delivery of high dose steroids, directly into the inflamed bowel via its arterial blood supply, will be better for treating uncontrolled flares of inflammatory bowel disease in patients compared to conventional intra-venous or oral administration of this drug. Patients aged 4-25 years of age will be recruited. In this study, we hope to also learn how this directed steroid delivery during an active flare will improve patient symptoms as well as the appearance of i... Read More
Gender:
All
Ages:
Between 4 years and 25 years
Trial Updated:
01/23/2023
Locations: Stanford University, Palo Alto, California
Conditions: Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, Indeterminate Colitis
A Study of Evorpacept (ALX148) in Patients With Advanced HER2+ Gastric Cancer (ASPEN-06)
Recruiting
A Phase 2/3 Study of Evorpacept (ALX148) in Combination With Trastuzumab, Ramucirumab, and Paclitaxel in Patients With Advanced HER2-overexpressing gastric/GEJ adenocarcinoma.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/23/2023
Locations: The Oncology Institute of Hope & Innovation, Anaheim, California
Conditions: Gastric Cancer, Gastroesophageal Junction Adenocarcinoma, Gastric Adenocarcinoma