California Paid Clinical Trials

A prospective multicenter observational study, led by Dr. Katie Russell of Intermountain Primary Children's Hospital, that will examine the sensitivity, specificity, negative, and positive predictive values of CT scan and plain films in diagnosing cervical spine injury that requires treatment. This study is funded by the Primary Children's Hospital foundation. Read Less

A multi-center, prospective, randomized, controlled comparison of the prodisc C SK and prodisc C Vivo to the control, a similar, legally marketed total disc replacement device in subjects with symptomatic cervical disc disease (SCDD). Read Less

This study will evaluate two alternative dressings compared to a standard Island dressing presently in use at Stanford Hospital to determine reductions in surgical site infection (SSI) rates among cardiac surgery patients. Cardiovascular surgery patients who will have a sternotomy incision as a routine part of their surgery will be approached to voluntarily participate. Participants will be randomized to one of three dressing to determine which dressing has the lowest rate of sternal wound infection. The investigators will also assess the impact of alternative dressing use on hospital 30-day readmission rates related to SSI. Read Less

The purpose of this study is to study the long term safety and effectiveness of an artificial iris prosthesis for the treatment of iris defects. Read Less

A post-market registry evaluating the EmboTrap® Revascularization Device and CERENOVUS Large Bore Catheter/ EMBOVAC Aspiration Catheter in acute ischemic stroke patients with confirmed intracranial large vessel occlusion. Read Less

The Cal-FIRE project is designed to offer the R3 Academy for Dads, a robust 24-hour program, to predominantly low-income adult fathers, ages 18 and over in the state of California. The R3 Academy is an evidence-based parenting curriculum that helps fathers strengthen their relationships with their child, with their spouse/co-parent, and at work. The program also includes two evidence-based components that address economic stability and an innovative approach to Case Management that fosters client self-direction. The R3 Academy curricula will be delivered in both English and Spanish through two modalities: 1) live classes and 2) livestream classes via a video conferencing platform. The Local Evaluation will examine how modality, or in other words attending a live class versus a livestream class, influences the effectiveness of responsible fatherhood education when it comes to father involvement and coparenting. The question of modality is a timely one. In the COVID-19 era, many programs have become exclusively online-but the potential impact on effectiveness is not well known. Data from this study will help illuminate what can be gained or jeopardized in a world increasingly moving toward modes of virtual engagement. Specifically, the current evaluation will explore potential similarities and differences related to the implementation of the two modalities and their influence of father outcomes. Specific research questions include: RQ1: How do live (control) and livestream (treatment) responsible fatherhood workshops compare on father involvement outcomes? RQ2: How do live (control) and livestream (treatment) workshops compare on father involvement outcomes? RQ3: Do program effects last beyond program completion? Read Less

The REFRAME project is designed to offer the R3 Academy for Couples, a robust 24-hour program, to married adults ages 18 and over in the state of California. The R3 Academy is an evidence-based couple relationship education curriculum that helps couples strengthen their relationships with their child, with their spouse, and at work. The program also includes two evidence-based components that address economic stability and an innovative approach to Case Management that fosters client self-direction. The R3 Academy curricula will be delivered in both English and Spanish through two modalities: 1) live classes and 2) livestream classes via a video conferencing platform. The Local Evaluation will examine how modality, or in other words attending a live class versus a livestream class, influences the effectiveness of R3 Academy for Couples program when it comes to changes in couples' marital/relationship satisfaction, conflict management, support and affection, and commitment. The question of modality is a timely one. In the COVID-19 era, many programs have become exclusively online-but the potential impact on effectiveness is not well known. We address this issue by considering the impact on four relationship outcomes: marital/relationship satisfaction, conflict management, support and affection, and commitment. Moreover, one issue that many programs report is that couples have great difficulty finding time to be engaged in regularly scheduled, live, in-person classes. Our study will provide evidence about how the availability of materials in alternative formats, that may allow more couples to be involved and reduce issues around the ability to participate, may influence the efficacy of those programs. RQ1: How do live in-person (control) and online livestream (treatment) Marriage and Relationship Education (MRE) workshops compare on marital/relationship satisfaction outcomes immediately after program completion? RQ2: How do live in-person and online livestream MRE workshops compare on conflict management outcomes immediately after program completion? RQ3: How do live in-person and online livestream MRE workshops compare on support and affection outcomes immediately after program completion? RQ4: How do live in-person and online livestream MRE workshops compare on commitment outcomes immediately after program completion? RQ5: Do program effects last beyond program completion? Read Less

Discover, optimize, standardize, and validate clinical-trial measures and biomarkers used to diagnose and differentiate cardiovascular, oncologic, neurologic, and other diseases and disorders. Specifically, our research study endeavors to improve disease and disorder diagnosis to the earliest clinical states, in preclinical states, and to develop ensemble multivariate biomarker risk scores leading to cardiovascular, oncologic, neurologic, and other diseases and disorders. Additionally, the study aims to: * Evaluate data analysis techniques to improve diagnostic accuracy and reduce time to diagnosis. * Evaluate data analysis techniques to improve risk stratification for participants through machine learning algorithms. * Direct participants to relevant and applicable clinical trials. Read Less

Posttraumatic stress disorder (PTSD) affects approximately 30 % of American veterans returning from Iraq and Afghanistan. Although the current therapy is effective, a percentage of patients will fail to improve and will develop chronic treatment-resistant PTSD. Patients suffering from PTSD experience intense suffering, lack of productivity and a higher risk of suicide. Unfortunately, combat PTSD has a tendency to be resistant to current treatments. The central goal of this project is to develop a new therapeutic strategy involving the placement of intracranial electrodes to treat the symptoms of PTSD. The project is based on recent evidence showing abnormal activity in a specific brain region of PTSD patients, thought to be responsible for the core symptoms of PTSD. Read Less

This is a multi-center, randomized, double-masked clinical trial. All study devices are market approved/cleared in the localities where the study is conducted. Subjects will be randomly assigned to wear NaturalVue Sphere single vision contact lenses (SVCL) or NaturalVue Multifocal (NVMF) soft contact lenses for a total of three years. Read Less

The Accuryn Registry Study is an open-ended, global, multi-center, retrospective and prospective, single-arm data collection study with an FDA cleared device. The target population are cardiovascular surgery patients. Physiologic data measurements will be collected from enrolled subjects using electronic medical records and data streams via the Accuryn Monitoring System. Read Less

The objective of this study is to evaluate the safety, efficacy, pharmacokinetics, and immunogenicity of MRG004A in patients with Tissue Factor positive advanced or metastatic solid tumors. Read Less