California is currently home to 5954 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Microlearning Application for Diabetes Prevention
Recruiting
The purpose of this study is to test the effectiveness of a mobile application diabetes prevention program delivered with microlearning and microcoaching.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
01/17/2023
Locations: Stanford Health Care, Palo Alto, California
Conditions: PreDiabetes, Elevated Blood Sugar
Silicon Valley Guaranteed Income Project
Recruiting
The goal of this clinical trial is to learn about how unconditional cash payments equivalent to $1,000 for 24 months (also called 'guaranteed income') might help families experiencing homelessness and/or unstable housing in Santa Clara County, California. The main questions it aims to answer are: What is the impact of guaranteed income on homelessness and housing stability among families experiencing homelessness or housing instability? What is the impact of guaranteed income on the health and... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/13/2023
Locations: ¡Sí Se Puede! Collective, San Jose, California
Conditions: Families Experiencing Homelessness and/or Housing Instability
Preoperative Immunotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck
Recruiting
To determine the effect of neoadjuvant atezolizumab alone or in combination with other immune modulating agents on T-cell infiltration in advanced SCCHN. To determine the impact of neo-adjuvant immunotherapy on surgical outcomes.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/13/2023
Locations: University of San Francisco, California, San Francisco, California
Conditions: Cancer, Carcinoma, Squamous Cell Carcinoma, Head and Neck Cancer
Study to Assess Allogeneic Anti-CD38 A2 Dimeric Antigen Receptor T Cells in Relapsed or Refractory Multiple Myeloma
Recruiting
This is a phase 1b, open-label, dose-escalation study of STI-1492 administered by a single intravenous infusion in subjects with relapsed or refractory multiple myeloma.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/12/2023
Locations: UC Irvine, Orange, California
Conditions: Multiple Myeloma
Study of the Safety and Efficacy of STI-6643 in Subjects With Advanced Solid Tumors
Recruiting
This is a first-in-human, phase 1, open-label, dose-escalation study of STI-6643 administered by intravenous infusion in subjects with a relapsed/refractory advanced solid tumor.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/12/2023
Locations: University of California, San Diego, San Diego, California
Conditions: Solid Tumor, Relapsed Solid Neoplasm, Refractory Tumor
Study of the Safety and Efficacy of STI-6129 in Patients With Relapsed or Refractory Systemic AL Amyloidosis
Recruiting
The STI-6129-001 study is a three-stage, multicenter, open-label, dose-finding, phase 1b/2a trial. It is designed primarily to identify the recommended phase 2 dose (RP2D) of STI-6129 by assessing the safety, preliminary efficacy and pharmacokinetics of this anti-CD38-Duostatin 5.2 antibody-drug conjugate (ADC) for the treatment of relapsed or refractory systemic AL amyloidosis. The patients that will be treated with STI-6129 in this trial are relapsed or refractory systemic AL amyloidosis pati... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/12/2023
Locations: City of Hope National Medical Center, Duarte, California
Conditions: Light Chain (AL) Amyloidosis
Adapting the HOPE Online Support Intervention to Increase Uptake of Medications for Opioid Use Disorder
Recruiting
In a randomized controlled trial, with 3, 6-month and 1-year follow-up, this application aims to explore whether and how the HOPE intervention can be adapted to increase MOUD uptake among OUD patients, assess the effectiveness of using HOPE to increase MOUD requests, and analyze online community data to improve future intervention implementation and sustainability.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/11/2023
Locations: University of California, Irvine, Irvine, California
Conditions: Opioid-use Disorder
Rett Syndrome Registry
Recruiting
The Rett Syndrome Registry is a longitudinal observational study of individuals with MECP2 mutations and a diagnosis of Rett syndrome. Designed together with the IRSF Rett Syndrome Center of Excellence Network medical directors, this study collects data on the signs and symptoms of Rett syndrome as reported by the Rett syndrome experts and by the caregivers of individuals with Rett syndrome. This study will be used to develop consensus based guidelines for the care of your loved ones with Rett s... Read More
Gender:
All
Ages:
Between 0 years and 99 years
Trial Updated:
01/09/2023
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Rett Syndrome, Rett Syndrome, Atypical, Genetic Disease, Genetic Diseases, X-Linked, Intellectual Disability, Neurobehavioral Manifestations, Neurologic Manifestations, Neurologic Disorder, Neurodevelopmental Disorders, Nervous System Diseases
Discrimination and the Brain-Gut-Microbiome (BGM) Axis
Recruiting
Obesity is a major public health problem related to a variety of illnesses such as heart disease and diabetes. Prior research indicates that social stressors contribute to risk for obesity, possibly through alterations in diet and physical activity. However, it is not fully clear how these alterations contribute to obesity. The purpose of this study is to examine how the stressors of social isolation and discrimination relate to eating behaviors and dietary patterns, and further, how these behav... Read More
Gender:
Female
Ages:
Between 18 years and 50 years
Trial Updated:
01/09/2023
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Discrimination, Racial, Social Isolation, Stress
Effect of Myofunctional Therapy on OSA
Recruiting
The primary medical therapies for patients with Obstructive Sleep Apnea syndrome (OSA) require the use of medical devices on a nightly basis to help control breathing during sleep, which can be difficult for patients with mild-to-moderate disease. Because many patients use these therapies on a limited basis, or stop using them altogether, they continue to be at increased risk of the consequences of untreated OSA. Untreated and undertreated OSA compounds the risk of OSA consequences over time, pa... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
01/09/2023
Locations: VA San Diego Healthcare System, San Diego, CA, San Diego, California
Conditions: Obstructive Sleep Apnea
Percutaneous Electrical Nerve Field Stimulation for Adults With Irritable Bowel Syndrome
Recruiting
This is a prospective, double-blind, randomized, sham-controlled pilot study evaluating the efficacy of percutaneous electrical nerve field stimulation for the treatment of adult patients with irritable bowel syndrome (IBS).
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
01/09/2023
Locations: UCLA, Los Angeles, California
Conditions: Irritable Bowel Syndrome, Abdominal Pain, Autonomic Nervous System Imbalance
Safety & Effectiveness of TENS Weight Management Compared to a Sham
Recruiting
This is a multicenter, randomized, blinded, parallel group, controlled study intended to evaluate the safety and effectiveness of treating overweight and Class 1 obese patients with the Elira System (TENS active treatment) combined with a moderate intensity lifestyle follow-up compared to participants using the sham (control) device combined with a moderate intensity lifestyle follow-up
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
01/06/2023
Locations: EmVenio, Santa Monica, California
Conditions: Obesity, Mild