California is currently home to 5930 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Mi Propio Camino Intervention RCT for Blood Pressure Medication Adherence
Recruiting
The purpose of this study is to compare the effect of two educational interventions on adherence to blood pressure medications among adults with uncontrolled hypertension.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/03/2023
Locations: Health Policy Research Institute, Irvine, California
Conditions: Hypertension, Medication Adherence
Allograft Adipose Injectable for Vocal Fold Paralysis
Recruiting
Renuva is allograft adipose matrix commonly used as a filler in cosmetic procedures. The investigators are studying this material as an injectable in the vocal fold to treat glottic insufficiency. Currently, many products can be used as an injectable in the vocal fold to correct glottic insufficiency such as carbomethycellulose, hyaluronic acid, collagen derivatives and calcium hydroxyapatite amongst others. An ideal injectable would not impair the fibroelastic property of the vocal fold tissu... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/02/2023
Locations: University of Southern California, Los Angeles, California
Conditions: Vocal Fold Palsy
CORRECT Study of Minimal Residual Disease Detection in Colorectal Cancer
Recruiting
The CORRECT - MRD II study will prospectively enroll patients who have undergone complete surgical resection for stage II or III colorectal cancer. Patients will be followed for a minimum of 3 years and up to 5 years for recurrence.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/01/2023
Locations: Providence Facey Medical Foundation, Mission Hills, California
Conditions: Colorectal Cancer
Galcanezumab for Vestibular Migraine
Recruiting
Vestibular migraine (VM) has been recognized a distinct subtype of migraine that causes dizziness as the predominant symptom. Criteria for diagnosis have been adopted by the Barany Society. Previous epidemiological research from the investigators has shown that VM affects 2.7% of the adult population of the United States. Yet, despite its high prevalence, there is very little data upon which to guide treatment decisions. A Cochrane review in 2015 concluded that there were no placebo controlled t... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
02/01/2023
Locations: UCSF Medical Center at Mount Zion, San Francisco, California
Conditions: Vestibular Migraine
An Anesthesia-Centered Bundle to Reduce Postoperative Pulmonary Complications: The PRIME-AIR Study
Recruiting
Postoperative pulmonary complications (PPCs) are a major cause of morbidity and mortality in surgical patients. National estimates suggest 1,062,000 PPCs per year, with 46,200 deaths, and 4.8 million additional days of hospitalization. The objective of the study is to develop and implement perioperative strategies to eliminate PPCs in abdominal surgery, the field with the largest absolute number of PPCs. We will conduct a randomized controlled pragmatic trial in 750 studied participants. The eff... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/01/2023
Locations: University of California - San Francisco, San Francisco, California
Conditions: Postoperative Pulmonary Complications
ROCKIF Trial: Re-sensitization of Carboplatin-resistant Ovarian Cancer With Kinase Inhibition of FAK
Recruiting
The purpose of the study is to investigate the combination VS-6063, carboplatin, and paclitaxel. in the treatment of patients with ovarian cancer. The study will evaluate whether this regimen is safe. The study will also evaluate whether the regimen can reduce the amount of cancerous cells in your body. If you agree, you will be treated with VS-6063 by mouth, as well as carboplatin and paclitaxel infusions. Carboplatin and paclitaxel are approved by the FDA for the treatment of ovarian cancer. V... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/01/2023
Locations: University of California San Diego, San Diego, California
Conditions: Ovarian Cancer
AMDX-2011P Retinal Tracer in Subjects With Neurodegenerative Diseases Associated With Amyloidogenic Proteinopathy
Recruiting
The purpose of this research study is to assess safety and tolerability of a single intravenous (given through a vein) dose of the investigational retinal tracer AMDX-2011P in patients with neurodegenerative diseases (Parkinson's disease and ALS).
Gender:
All
Ages:
18 years and above
Trial Updated:
01/31/2023
Locations: Eye Research Foundation, Newport Beach, California
Conditions: Parkinson Disease, Amyotrophic Lateral Sclerosis
Pain Relief After Trapeziectomy: Ibuprofen & Acetaminophen Versus Oxycodone
Recruiting
In the US, pain management after surgery for surgical treatment of osteoarthritis at the base of the thumb typically consists of prescription opioids during the early recovery phase. Given the highly addictive nature of prescription opioids, guidelines are being evaluated by hand surgeons to reduce opioid use while still maintaining pain control after surgery. A promising approach is to use non-narcotic medication as the first line of treatment. The purpose of this study is to demonstrate the ef... Read More
Gender:
All
Ages:
45 years and above
Trial Updated:
01/31/2023
Locations: Stanford Health Care, Redwood City, California
Conditions: Pain, Postoperative, Osteoarthritis Thumb
Blood Flow Restriction After Meniscus Repair
Recruiting
The purpose of this study is to evaluate post-operative outcomes after meniscus surgery in participants undergoing blood flow restriction training as a rehabilitative adjunct compared to those with standard rehabilitation.
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
01/31/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Meniscus Disorder, Meniscus, Torn Tibial, Meniscus Lesion, Meniscus Tear, Tibial, Atrophy, Muscular
A Patient-Centric Platform Trial for Precision Oncology
Recruiting
XCELSIOR is a non-interventional data registry. Information about treatments, treatment decisions and rationale, and patient outcomes including safety and effectiveness of anti-cancer therapy and associated supportive care will be collected for analysis.
Gender:
All
Ages:
0 years and above
Trial Updated:
01/31/2023
Locations: Cancer Commons, Los Altos, California
Conditions: Oncology
A Study of Navicixizumab Monotherapy or in Combination in Patients With Select Advanced Solid Tumors
Recruiting
This is a study of navicixizumab monotherapy or in combination with paclitaxel or irinotecan in patients with advanced cancer. Patients will be enrolled into one of the following cancer cohorts: Cohort A: CRC Cohort B: Gastric and GEJ cancer Cohort C: TNBC Cohort D: Platinum-resistant/refractory epithelial ovarian, primary peritoneal, or fallopian tube cancer (ovarian cancer)
Gender:
All
Ages:
18 years and above
Trial Updated:
01/30/2023
Locations: Keck Medicine of USC, Los Angeles, California
Conditions: Colorectal Cancer, Triple Negative Breast Cancer, Gastric Cancer, Ovarian Cancer
Optimizing ctDNA-based MRD Assessment in DLBCL, MCL, and FL Patients Undergoing CAR Therapy
Recruiting
In this study, invesigators propose to analyze 150 DLBCL patients, 50 MCL patients, and 100 FL patients to determine the clinical utility of ctDNA- as well as circulating tumor cell (CTC)-based MRD assessment in CAR therapy patients. The project detailed in this protocol will utilize the clonoSEQ platform as specific quantification of residual DLBCL/FL/MCL and correlate its results with radiologic assessment of disease and clinical outcomes. Invesitgators predict there will be a strong correlati... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/30/2023
Locations: Stanford Cancer Center, Palo Alto, California
Conditions: Follicular Lymphoma, Diffuse Large B Cell Lymphoma, Mantle Cell Lymphoma