California is currently home to 5944 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Meditation and Education That is Nurse Delivered for Symptom Management in Paroxysmal Atrial Fibrillation (PAF)
Recruiting
The aim of this project is to determine whether the entire intervention (Mindfulness meditation, AF education, and weekly phone visits) that is nurse delivered to individuals with paroxysmal atrial fibrillation is more effective than a combination, single or no intervention in the reduction of overall AF symptoms, anxiety, and negative illness perception; or the improvement of quality of life (QOL) and functional status.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/06/2022
Locations: Stanford Health Care, Stanford, California
Conditions: Paroxysmal Atrial Fibrillation
Intraoperative Monitoring for the Lateral Lumbar Interbody Fusion Procedure
Recruiting
This study is designed to evaluate the clinical utility of a known intraoperative neuromonitoring modality (SSEP) using saphenous nerve as the site of stimulation to identify changes to the lumbar nerves which may be at risk during the lateral lumbar interbody fusion (LLIF) procedure.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/05/2022
Locations: Alphatec Spine Inc., Carlsbad, California
Conditions: Intervertebral Disc Degeneration, Stenosis, Spinal, Spondylolisthesis, Spinal Deformity, Spinal Instability
Clinical Trial Evaluating Outcomes of Self-Fit and Professionally Fit Hearing Aids
Recruiting
Approximately 48 million people in the United States have hearing loss or hearing difficulties in noisy environments. Whisper.ai Inc has previously brought to market a commercial hearing aid system that reduces background noise and amplifies voices and sounds of interest using its proprietary platform based on machine learning and artificial intelligence technologies. Whisper.ai Inc now seeks to bring to market a new hearing system that will incorporate a "self-fitting" capability. Self-fitting... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
12/02/2022
Locations: Whisper.ai, San Francisco, California
Conditions: Hearing Loss
A Study of Concurrent Stereotactic Body Radiotherapy With Opdualag in Metastatic Uveal Melanoma
Recruiting
This is a phase 2 trial of concurrent stereotactic radiation therapy (SBRT) with immunotherapy with relatlimab and nivolumab for up to two years. SBRT will be given in three doses of 15Gy each to 1-5 separate metastases. Opdualag (nivolumab 480mg and relatlimab 160mg) will be given every 4 weeks for two years
Gender:
All
Ages:
18 years and above
Trial Updated:
12/02/2022
Locations: California Pacific Medical Center Research Institute, San Francisco, California
Conditions: Uveal Melanoma
Phase II Study of Olaparib and Pembrolizumab in Advanced Melanoma With Homologous Recombination (HR) Mutation
Recruiting
This open-label phase II trial studies how well olaparib in combination with pembrolizumab works in treating patients with advanced, metastatic melanoma with the homologous recombination (HR) pathway gene mutation / alteration. Olaparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth, and potentially augment an anti-tumor immune response to pembrolizumab. The trial is designed to assess the efficacy and safety of olaparib in combination with pembrolizuma... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/02/2022
Locations: California Pacific Medical Center Research Institute, San Francisco, California
Conditions: Metastatic Melanoma
Oxaloacetate for the Improvement of Cognitive Complaints in Stage 0-IIIA Breast Cancer Survivors
Recruiting
This phase II trial studies how well oxaloacetate works in reducing cognitive complaints in stage 0-IIIA breast cancer survivors. Oxaloacetate is a natural substance found in the body and is available as a nutritional supplement. Giving oxaloacetate may reduce inflammation in the brain that could be contributing to cognitive complaints seen after cancer treatments.
Gender:
Female
Ages:
Between 18 years and 74 years
Trial Updated:
12/01/2022
Locations: UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California
Conditions: Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIA Breast Cancer AJCC v8, Anatomic Stage IIB Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Early-Stage Breast Carcinoma, Prognostic Stage 0 Breast Cancer AJCC v8, Prognostic Stage I Breast Cancer AJCC v8, Prognostic Stage IA Breast Cancer AJCC v8, Prognostic Stage IB Breast Cancer AJCC v8, Prognostic Stage II Breast Cancer AJCC v8, Prognostic Stage IIA Breast Cancer AJCC v8, Prognostic Stage IIB Breast Cancer AJCC v8, Prognostic Stage IIIA Breast Cancer AJCC v8
The BIomarker Guided Study for Depression
Recruiting
The diagnosis of major depression relies on patient reports, and two patients with the same diagnosis might share only one symptom. Thus, a single mechanism is unlikely to underlie a broad descriptive diagnosis such as major depression. Our approach is anchored by a neural circuit taxonomy that proposes distinct biotypes of depression derived from functional magnetic resonance imaging (fMRI) (Williams et al., 2016). In this study, we aim to target a putative type of major depression that arises... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
12/01/2022
Locations: Stanford Psychiatry, Palo Alto, California
Conditions: Major Depressive Disorder
Adoptive Cell Transfer of Autologous Tumor Infiltrating Lymphocytes and High-Dose Interleukin 2 in Select Solid Tumors
Recruiting
To determine whether special tumor fighting cells that is taken from participants' tumors and grown in the laboratory and then given back to the participant will fight the participant's cancer when their immune system is suppressed from attacking these special tumor fighting cells. This is called transfer of autologous (they came from you) tumor infiltrating lymphocytes (the cells that have been grown in the laboratory. Participants getting these cell infusions will also be treated with interleu... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/01/2022
Locations: UC San Diego Moores Cancer Center, La Jolla, California
Conditions: Metastatic Melanoma, Locally Advanced Refractory/Recurrent Melanoma, Metastatic Head and Neck Cancer, Locally Advanced Refractory/Recurrent Head and Neck Cancer
High Dose IL-2 in Combination With Anti-PD-1 to Overcome Anti-PD-1 Resistance in Metastatic Melanoma and Renal Cell Carcinoma
Recruiting
The primary objective of this single arm phase 2 trial is to assess the response rate [complete response (CR) + partial response (PR)] of combined nivolumab and HD IL-2 in subjects with metastatic melanoma and renal cell carcinoma. Response will be performed after each course of nivolumab and IL-2 using RECIST 1.1. Patients will be treated for one course past best response for a maximum of 3 courses.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/01/2022
Locations: UC San Diego Moores Cancer Center, La Jolla, California
Conditions: Melanoma Stage Iv, Renal Cell Carcinoma, Metastatic
[18F]FAraG PET Imaging for Analysis of Biodistribution in Cancer Patients Expected to Undergo Immunotherapy and/or Radiation Therapy
Recruiting
This is a Phase 1 study is to visualize biodistribution of a PET tracer called [18F]F-AraG (VisAcT) in cancer patients expected to undergo immunotherapy and/or radiation therapy.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
12/01/2022
Locations: UCSF Imaging Center at China Basin, San Francisco, California
Conditions: Cancer
Dietary Sodium Intake and Blood Pressure in Living Kidney Donors
Recruiting
This is a pilot study to determine the feasibility of the study design and examine the main outcome whether low dietary sodium intake is superior to high dietary sodium intake in controlling blood pressure to be within the normotensive range in living kidney donors.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/30/2022
Locations: University of California Irvine Medical Center, Orange, California
Conditions: Hypertension, Living Kidney Donor, Dietary Sodium Intake
Evaluate F901318 Treatment of Invasive Fungal Infections in Patients Lacking Treatment Options
Recruiting
A study to evaluate F901318 (study drug) for the treatment of invasive fungal infections in patients lacking suitable alternative treatment options.
Gender:
All
Ages:
16 years and above
Trial Updated:
11/30/2022
Locations: Valley Fever Institute at Kern Medical Center, Bakersfield, California
Conditions: Invasive Fungal Infections