California is currently home to 5618 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Duration of Urinary Catheterization
NCT04359069
Recruiting
This study is being conducted to determine the length of time a urinary catheter is needed to drain urine from the bladder after colorectal surgery. Urinary retention is a well known complication after pelvic colorectal surgery, and current practice is to continue urinary catheterization for 3- days following pelvic colorectal surgery in an effort to avoid this complication. However, prolonged urinary catheterization is associated with increased risk of urinary tract infections as well as longer... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/10/2023
Locations: Keck Hospital of USC, Los Angeles, California
Conditions: Colorectal Surgery
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Use of CXCL9 as a Biomarker of Acthar Efficacy
NCT02523092
Recruiting
The objective is this study is to test whether use of Acthar gel in the context of sarcoidosis will lead to improved symptoms and lung function and correlate with decreased levels of predictive blood biomarkers, like chemokine ligand 9 (CXCL9).
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/10/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Sarcoidosis
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COVID-19 Outcome Prediction Algorithm
NCT05471011
Recruiting
Severe acute respiratory syndrome coronavirus 2-mediated coronavirus disease (COVID-19) is an evolutionarily unprecedented natural experiment that causes major changes to the host immune system. We propose to develop a test that accurately predicts short- and long-term (within one-year) outcomes in hospitalized COVID-19 patients broadly reflecting US demographics who are at increased risk of adverse outcomes from COVID-19 using both clinical and molecular data. We will enroll patients from a hos... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2023
Locations: VA Greater Los Angeles Healthcare System, Los Angeles, California
Conditions: COVID-19, Post Acute Sequelae of COVID-19, Long COVID, Organ Dysfunction Syndrome, Multiple, Frailty Syndrome
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Glycemic Targets for Pregnant Women With GDM and T2DM
NCT04672031
Recruiting
The purpose of this randomized clinical trial is to determine whether glycemic targets that are lower than those currently recommended by the American Diabetes Association (ADA) and the American College of Obstetricians and Gynecologists (ACOG) would improve overall outcomes in pregnant patients with diabetes. Eligible pregnant women with a diagnosis of gestational diabetes or Type 2 diabetes will be randomized into either routine care with glycemic targets as currently recommended by ADA and AC... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/09/2023
Locations: Los Angeles County + University of Southern California Medical Center (LAC+USC), Los Angeles, California
Conditions: Diabetes Mellitus in Pregnancy, Diabetes, Gestational, Diabetes Mellitus, Type 2
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Aneurysm Genetic Risk in Patients With QIB Changes
NCT05317169
Recruiting
Intracranial aneurysm rupture is a leading cause of hemorrhagic strokes which carry high mortality and disability rates as well as high healthcare costs. Unruptured intracranial aneurysms (UIA) are common in the general population, occurring in 1-2% of individuals. Previous studies have shown that UIA growth and rupture are strongly associated with each other, with growing aneurysms 9-12 times more likely to rupture, and nearly all aneurysms growing prior to rupture. Thanks to advanced medical i... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/04/2023
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Brain Aneurysm
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Study of Dietary Composition in Crohn's Disease
NCT04431700
Recruiting
Patients with inflammatory bowel disease (IBD) often have narrowed microbial diversity and altered composition and function of the gut microbiome. We anticipate the anti-inflammatory diet, when compared with the usual diet, to produce favorable changes in these multi-omics profiles. These findings will provide insight into the interactions between diet and host biology, while providing clues on the mechanisms of diet therapy's effect and CD pathogenesis.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/04/2023
Locations: UCLA Center for Human Nutrition, 1000 Veteran Ave., Los Angeles, California
Conditions: Inflammatory Bowel Diseases, Crohn Disease
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Closed-Loop Deep Brain Stimulation for Major Depression
NCT04004169
Recruiting
Neurons are specialized types of cells that are responsible for carrying out the functions of the brain. Neurons communicate with electrical signals. In diseases such as major depression this electrical communication can go awry. One way to change brain function is using electrical stimulation to help alter the communication between groups of neurons in the brain. The purpose of this study is to test a personalized approach to brain stimulation as an intervention for depression. The study resea... Read More
Gender:
ALL
Ages:
Between 22 years and 70 years
Trial Updated:
04/27/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Major Depressive Disorder
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KRT-232 Versus Best Available Therapy for the Treatment of Subjects With Myelofibrosis Who Are Relapsed or Refractory to JAK Inhibitor Treatment
NCT03662126
Recruiting
This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, for the treatment of patients with myelofibrosis (MF) who no longer benefit from treatment with a JAK inhibitor. Inhibition of MDM2 is a novel mechanism of action in MF. This study will be conducted in 2 phases. Phase 2 will determine the KRT-232 recommended dose and dosing schedule; Phase 3 will test KRT-232 vs Best Available Therapy (BAT). Patients in the Phase 3 part of the study will be randomized 2:1 to receive ei... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/26/2023
Locations: University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Primary Myelofibrosis (PMF), Post-Polycythemia Vera MF (Post-PV-MF), Post-Essential Thrombocythemia MF (Post-ET-MF)
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Benzodiazepine Taper With Telehealth-Delivered Cognitive Behavioral Therapy for Patients Using Prescription Opioids
NCT05845606
Recruiting
The study aims to examine the efficacy of a telehealth-delivered cognitive behavioral therapy (CBT) + benzodiazepine taper (BZ-TP) program in facilitating reductions in benzodiazepine use among patients who are prescribed opioids for pain.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
04/25/2023
Locations: UCLA Health MPTF Toluca Lake Primary Care Clinic, Burbank, California
Conditions: Substance Use Disorders, Anxiety Disorders, Chronic Pain
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Enhance Study: Evaluation of Accuracy and Safety of the Eversense CGM System With Enhanced Features
NCT05131139
Recruiting
A Prospective, Multicenter Evaluation of Accuracy and Safety of the Eversense CGM System with Enhanced Features. The purpose of this clinical investigation is to evaluate the accuracy of the Eversense 524 Continuous Glucose Monitoring System (Eversense 524 CGM System) and ROME CGM System with next generation feature enhancements compared to reference glucose measurements in adults 18 years of age and older with diabetes. The investigation will also evaluate safety of the Eversense 524 CGM System... Read More
Gender:
ALL
Ages:
14 years and above
Trial Updated:
04/24/2023
Locations: AMCR Institute Inc., Escondido, California
Conditions: Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
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Investigating Medication vs. Prostatic Urethral Lift: Assessment and Comparison of Therapies for BPH
NCT04987892
Recruiting
This prospective, multicenter, two-arm, 1:1 randomized controlled trial (RCT) will enroll approximately 250 males at approximately 25 sites located within the United States. All enrolled subjects will be 45 years of age or older diagnosed with symptomatic benign prostatic hyperplasia (BPH). They will be randomized to one of two readily available, marketed BPH therapies; Prostatic Urethral Lift procedure with the UroLift System (PUL Arm) or 0.4mg tamsulosin HCl (MED Arm).
Gender:
MALE
Ages:
45 years and above
Trial Updated:
04/24/2023
Locations: Neotract, Pleasanton, California
Conditions: BPH
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A Clinical Investigation to Follow the Progress of Exuding Chronic Wounds Using Mepilex® Up as the Primary Dressing.
NCT05588583
Recruiting
The goal of this clinical trial is to follow the progress of wounds in those with venous leg ulcers and diabetic foot ulcers while using an absorbent dressing called Mepilex Up. The main objective is to follow the progress of these wounds over time from initial visit to each follow-up visit. Participants will be asked to wear Mepilex Up dressing for up to 6 weeks of treatment or until healed, changed at every one-week interval.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/18/2023
Locations: Center for Clinical Research, Inc., Castro Valley, California
Conditions: Wounds, Wound of Skin, Wound Leg, Wound; Foot, Diabetic Foot Ulcer, Venous Leg Ulcer
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