California is currently home to 5930 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Single Arm sTudy to Evaluate the Effectiveness of EndoAVF in a Pre-dialysis Population (STEP Study)
Recruiting
This is an investigator-initiated post-marketing study that will evaluate use of the WaveLinQ system, a new and novel method of fistula creation using a percutaneous method in patients who require the creation of an arteriovenous fistula (AVF).
Gender:
All
Ages:
18 years and above
Trial Updated:
02/07/2023
Locations: California Institute of Renal Research, Escondido, California
Conditions: CKD Stage 3, CKD Stage 4, CKD Stage 5
Prospective Pilot Feasibility Study Comparing Envarsus Once-a-day to Tacrolimus Twice-a-day Immunosuppressive Regimen on Drug Bioavailability in Hispanic First Time Kidney Transplant Recipients
Recruiting
This investigator-initiated post-marketing study will evaluate the role of Hispanic ethnicity on drug dosing of Envarsus in first-time stable renal transplant recipients. Tacrolimus trough drug levels will be studied as a primary endpoint at 24 hours after drug dosing and at steady state (e.g., trough level at 3 months post conversion) and secondary compliance assessments will be done by pill counts at clinic visits. Secondary outcomes will be the safety of once a day dosing as well as assessmen... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/07/2023
Locations: California Institute of Renal Research, San Diego, California
Conditions: Kidney Transplant; Complications, Kidney Transplant Failure and Rejection
EXCOR Active Driving System for the EXCOR Pediatric VAD IDE Study
Recruiting
The purpose of this study is to evaluate the device performance and monitor the safety and effectiveness of the Berlin Heart EXCOR Active Driving System while being used with the approved EXCOR Pediatric Ventricular Assist Device. EXCOR Active Driving System is intended for use with the approved EXCOR Pediatric VAD. The EXCOR Pediatric VAD is intended to provide mechanical circulatory support as a bridge to cardiac transplantation for pediatric patients. Pediatric candidates with severe isolat... Read More
Gender:
All
Ages:
21 years and below
Trial Updated:
02/06/2023
Locations: Children's Hospital of Los Angeles, Los Angeles, California
Conditions: Heart Failure, Transplant; Failure, Heart, Congenital Heart Disease
Validation of a Salivary miRNA Diagnostic Test for ASD
Recruiting
This study involves sample collection to identify biomarkers relating to Autism Spectrum Disorder(ASD) in the saliva of children who are between the ages of 18 months to 6 years and 11 months. Participants will at each timepoint have a non-invasive saliva swab collected and complete a brief demographic and medical history questionnaire as well. Children in the pediatric/provider setting who will receive a referral for an ASD diagnosis because they were determined to have a suspicion of developin... Read More
Gender:
All
Ages:
Between 18 months and 7 years
Trial Updated:
02/06/2023
Locations: University of California - Irvine, Santa Ana, California
Conditions: Autism Spectrum Disorder, Developmental Delay
Artificial Intelligence Guided Echocardiographic Screening of Rare Diseases (EchoNet-Screening)
Recruiting
Despite rapidly advancing developments in targeted therapeutics and genetic sequencing, persistent limits in the accuracy and throughput of clinical phenotyping has led to a widening gap between the potential and the actual benefits realized by precision medicine. Recent advances in machine learning and image processing techniques have shown that machine learning models can identify features unrecognized by human experts and more precisely/accurately assess common measurements made in clinical... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/06/2023
Locations: Cedars-Sinai Medical Centre (Los Angeles), Los Angeles, California
Conditions: Cardiac Amyloidosis
ZZ06 in Adult Patients With Advanced EGFR Positive Solid Tumor Malignancies
Recruiting
This is a Phase 1, Multicenter, Open-label study to assess the safety, tolerability and preliminary efficacy of ZZ06 in participants with all Adult Patients with Advanced EGFR-positive Solid Tumor Malignancies who are not able to have current standard anti-tumor therapies. The purpose of this study is to determine the maximum tolerated dose (MTD) , to characterise the safety, pharmacokinetics (PK), immunogenicity, pharmacodynamics (PD) and anti-tumor activity of ZZ06 as a single agent in adult p... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/06/2023
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Advanced EGFR Positive Solid Tumor
Study of Infigratinib in Children With Achondroplasia
Recruiting
This is a Phase 2, multicenter, open-label, dose-escalation and dose-expansion study to evaluate the safety, tolerability, and efficacy of infigratinib, a fibroblast growth factor receptor (FGFR) 1-3-selective tyrosine kinase inhibitor, in children 3 to 11 years of age with Achondroplasia (ACH) who previously participated in the PROPEL study (Protocol QBGJ398-001) for at least 6 months. The study includes dose escalation with extended treatment, and dose expansion. The study also includes a PK S... Read More
Gender:
All
Ages:
Between 3 years and 11 years
Trial Updated:
02/06/2023
Locations: UCSF Benioff Children's Hospital, Oakland, California
Conditions: Achondroplasia
Efficacy and Safety of Plecanatide in Children 6 to <18 Years of Age With Irritable Bowel Syndrome With Constipation (IBS-C)
Recruiting
This study of the efficacy and safety of Plecanatide in children 6 to <18 Years of Age with Irritable Bowel Syndrome with Constipation (IBS-C)
Gender:
All
Ages:
Between 6 years and 17 years
Trial Updated:
02/06/2023
Locations: Synergy Research Site, Corona, California
Conditions: Irritable Bowel Syndrome With Constipation
Whole-Heart Myocardial Blood Flow Quantification Using MRI
Recruiting
This study hopes to provide significant technical improvement in a Myocardial Blood Flow (MBF) cardiac magnetic resonance (CMR) quantification technique to address challenges and technical limitations for MBF CMR. By developing and validating novel techniques to improve first-pass perfusion (FPP) cardiac MR, we propose to increase diagnostic accuracy by minimizing false positives and false negatives, allow for better evaluation and accurate quantification of total ischemic burden and reduce imag... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/06/2023
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Coronary Artery Disease, Coronary Microvascular Disease
Genetic, Metabolic, and Growth Factor Repository for Cerebrovascular Disorders
Recruiting
This study encompasses the maintenance and utilization of a repository of samples from patients with cerebrovascular disease and stroke. The types of tissue taken are blood, cerebrospinal fluid (CSF), tissue, and microdialysis samples. Future analysis of these samples can potentially help investigators to better categorize groups of patients, understand the underlying etiology of these pathologies, identify markers that are associated with favorable or poor outcomes, and track changes that occur... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/06/2023
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Cerebrovascular Diseases, Ischemic Stroke, Repository
Pituitary Tumor Surveillance: Pathogenic Correlation
Recruiting
The purpose of this study is to observe predictors of pituitary tumor recurrence and markers of persistent disease activity in patients harboring pituitary mass lesions of all types.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/06/2023
Locations: Cedars-Sinai Medical Center, Pituitary Center, Los Angeles, California
Conditions: Pituitary Tumor
Efficacy of mHealth Applications in Weight Management in a Population Affected by Overweight or Obesity
Recruiting
The purpose of this study is to determine the effectiveness of mobile health applications in improving health outcomes in patients with overweight and obesity. This study will involve a 6-month long commitment where participants will be expected to use an mHealth app daily, weigh themselves and check their fasting blood glucose levels every morning.
Gender:
All
Ages:
Between 18 years and 64 years
Trial Updated:
02/03/2023
Locations: San Diego State University, San Diego, California
Conditions: Overweight and Obesity