California is currently home to 5934 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
NBTXR3 With or Without Cetuximab in LA-HNSCC
Recruiting
This is a global, open-label, randomized, 2-arm, Investigator's choice Phase 3 (Pivotal Stage) study to investigate the efficacy/performance and safety of NBTXR3/RT±cetuximab versus RT±cetuximab in treatment-naïve, platinum-ineligible, elderly participants with LA-HNSCC.
Gender:
All
Ages:
65 years and above
Trial Updated:
12/28/2022
Locations: University of California San Francisco, San Francisco, California
Conditions: Locally Advanced Head and Neck Squamous Cell Carcinoma, Aged
Pilot Study of Mirtazapine for the Dual Tx of Depression and CINV in High-Grade Glioma Pts on TMZ
Recruiting
The purpose of the study is to estimate the ability of mirtazapine to reduce depression, nausea, and vomiting, and maintain weight in depressed glioma patients undergoing Temozolomide (TMZ) therapy. Of equal importance, the investigators will monitor the tolerability of Mirtazapine in these patients over the course of the study.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/26/2022
Locations: UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California
Conditions: Glioma of Brain
Study in Patients Undergoing Debridement, Antibiotics, and Implant Retention (DAIR) for Treatment of a Periprosthetic Joint Infection (PJI) Occurring After Total Knee Arthroplasty (TKA)
Recruiting
The purpose of this study is to learn about the safety and effects of PLG0206 for treating periprosthetic joint infections (PJI) in conjunction with the DAIR (debridement, antibiotics and implant retention) surgical procedure for patients with periprosthetic joint infections (PJI) after total knee arthroplasty (TKA) .
Gender:
All
Ages:
Between 18 years and 79 years
Trial Updated:
12/21/2022
Locations: Stanford Hospital, Palo Alto, California
Conditions: Joint Infection
Mobile Biosensor for Measuring Vital Signs in Healthcare and Home Settings
Recruiting
This study will record vital signs (heart rate and blood oxygen levels) using a new cell phone integrated biosensor and compare it to routine measurements carried out in the clinics and hospital at UCSD. Cell phones will be given to a selected group of subjects for use at home and data collected.
Gender:
All
Ages:
13 years and above
Trial Updated:
12/21/2022
Locations: UCSD AntiViral Research Center, San Diego, California
Conditions: Pulse Oximetry
Near Infrared Spectroscopy (NIRS) for Assessment of Depression
Recruiting
Develop a NIRSIT testing protocol that can be administered in the diagnostic setting and reliably distinguishes the symptoms and severity of depression, with the help of repeated measure (up to five visits per subject) comparison of patients being treated for Major Depressive Disorder with control, non-depressed subjects.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/21/2022
Locations: San Francisco Veterans Affairs Medical Center, San Francisco, California
Conditions: Major Depressive Disorder
FTIH of ECC5004 in Healthy and Diabetic Participants
Recruiting
This is a Phase 1, randomized, double-blind, placebo-controlled, single ascending dose and multiple ascending dose study of ECC5004 in healthy participants and in patients with Type 2 Diabetes Mellitus
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
12/19/2022
Locations: Eccogene Investigational Site, Anaheim, California
Conditions: Type 2 Diabetes Mellitus
Dose Escalation and Dose Expansion Study of CPO-100 in Patients With Advanced Solid Tumors
Recruiting
This is a Phase 1, multicenter, open-label, dose escalation and dose expansion study to evaluate the safety, tolerability, pharmacokinetics, and preliminary evidence of antitumor activity of CPO-100 administered intravenously in cycles of 3 weekly doses with 1 week rest (1 cycle = 4 weeks) in adult patients with advanced solid tumors.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/16/2022
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Solid Tumor
Effects of Brain Beta-Amyloid on Postoperative Cognition
Recruiting
Postoperative cognitive decline (POCD) affects up to 50% of non-cardiac surgical patients greater than or equal to 65 years of age. This study will test the hypothesis that preoperative presence of brain beta-amyloid plaques in non-demented subjects increases postoperative cognitive decline (POCD) in elderly subjects scheduled for hip or knee replacement. The investigators hypothesize that preoperative beta-amyloid plaques will predict postoperative cognitive decline.
Gender:
All
Ages:
65 years and above
Trial Updated:
12/16/2022
Locations: San Francisco VA Medical Center, San Francisco, California
Conditions: Postoperative Cognitive Dysfunction
Understanding Individual Differences in Working Memory Training and Transfer in Older Adults
Recruiting
The present study investigates how individual differences in cognitive processing contribute to the efficacy of working memory training programs in an older adult population. In a randomized crossover design, different types of working memory training interventions will be evaluated within the same participants. Adding game-like elements to working memory training programs can increase motivation and engagement, which can increase learning. However this process, termed gamification, adds sensor... Read More
Gender:
All
Ages:
Between 50 years and 85 years
Trial Updated:
12/15/2022
Locations: University of California, Irvine, Irvine, California
Conditions: Cognitive Change
Efficacy and Safety of Cariprazine in the Treatment of Adolescent Participants (13 to 17 Years of Age) With Schizophrenia
Recruiting
The purpose of this study is to evaluate the efficacy and safety of cariprazine in the treatment of schizophrenia in the adolescent population.
Gender:
All
Ages:
Between 13 years and 17 years
Trial Updated:
12/15/2022
Locations: ProScience Research Group, Culver City, California
Conditions: Schizophrenia
Ceralasertib (AZD6738) Alone and in Combination With Olaparib or Durvalumab in Patients With Solid Tumors
Recruiting
This phase II trial studies how well Ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor AZD6738 works alone or in combination with olaparib or durvalumab in treating participants with renal cell carcinoma (RCC), urothelial carcinoma, all pancreatic cancers, endometrial cancer, and other solid tumors excluding clear cell ovarian cancer that have spread to nearby tissue or lymph nodes or other parts of the body. ATR kinase inhibitor AZD6738 and olaparib or durvalumab may stop the growth... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/14/2022
Locations: University of California, San Francisco, San Francisco, California
Conditions: Clear Cell Renal Cell Carcinoma, Locally Advanced Pancreatic Cancer, Locally Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm, Metastatic Renal Cell Carcinoma, Metastatic Urothelial Carcinoma, Metastatic Pancreatic Cancer, Stage III Pancreatic Cancer, Stage III Renal Cell Cancer, Stage IV Pancreatic Cancer, Stage IV Renal Cell Cancer, Endometrial Cancer, Metastatic Castration-resistant Prostate Cancer
Microbiome, Anxiety and Cognitive Orientation Study
Recruiting
Mounting evidence shows that the gut microbiome plays an important role in communication within the gut-brain axis. However, the relationship between gut microbiota and their influence on anxiety is still not fully understood. Recent studies on mice found a specific microbe-produced molecule, 4-ethylphenyl sulfate (4EPS), can induce anxious behavior. 4EPS is produced by gut microbes in mice and humans. Research suggests higher 4EPS levels may strongly be associated with anxiety levels. However,... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/12/2022
Locations: Endominance Inc., Irvine, California
Conditions: Anxiety, Microbiome, Mood Disorders, Neurodegeneration, Depression