California is currently home to 5930 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study of ZN-c3 in Participants With Solid Tumors
Recruiting
This is a Phase 1 open-label, multicenter study of ZN-c3 monotherapy which consists of Dose Escalation, a Food Effect Cohort, and Dose Expansion.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/30/2023
Locations: Site 0167, Newport Beach, California
Conditions: Solid Tumor
Transcranial Magnetic Stimulation and Tobacco Use Disorder
Recruiting
The purpose of this study is to determine if brain stimulation using repetitive transcranial magnetic stimulation (rTMS) directed at different parts of the brain can decrease feelings of cigarette craving and symptoms of cigarette withdrawal, and also if men and women have different responses to rTMS. Participants will visit the University of California, Los Angeles (UCLA) five times: First, for in-person screening, then for four rTMS sessions, four three different brain regions. Everyone in th... Read More
Gender:
All
Ages:
Between 18 years and 45 years
Trial Updated:
01/27/2023
Locations: Semel Institute of Neuroscience, Los Angeles, California
Conditions: Tobacco Use Disorder
Open Label Study for the Use of Transcranial Ultrasound Treatment of Tremor
Recruiting
The purpose of this Phase I open label study is to evaluate longer term tolerability and potential effectiveness of transcranial ultrasound in people with tremor as a results of Parkinson's Disease or Essential Tremor.
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
01/25/2023
Locations: Neurological Associates of West Los Angeles, Los Angeles, California
Conditions: Tremor, Parkinson Disease, Essential Tremor
The Effects of Specialty Coffee on Cognitive Function in People With Type 2 Diabetes
Recruiting
Coffee has been found to have beneficial effects on cognitive function and blood sugar control. Benefits include reduced risk of cognitive decline and improved performance on cognitive tests, as well as reduced risk of diabetes and improved blood sugar control in people with diabetes, a population that is at a higher risk of cognitive decline. These effects have been observed for both caffeinated and decaffeinated coffee, and have been associated with the polyphenol chlorogenic acid (CGA). This... Read More
Gender:
All
Ages:
Between 55 years and 70 years
Trial Updated:
01/24/2023
Locations: Kaiser Permanente, Berkeley, California
Conditions: Type 2 Diabetes
Outcomes After Weight Loss Surgery in Low-Risk Patients
Recruiting
The purpose of this research is to determine patient-reported outcomes after weight loss surgery, including changes in health, mood, quality of life, health satisfaction, and emotional health, in low-risk patients. Weight loss surgery has been well studied for patients with body mass index (BMI) 35 kg/m^2 or more and those with weight-related medical problems who have a BMI 30 kg/m^2 or more. However, outcomes after weight loss surgery in patients with BMI under 35 kg/m^2 and without co-morbidit... Read More
Gender:
All
Ages:
All
Trial Updated:
01/24/2023
Locations: Dr. Feiz and Associates, Beverly Hills, California
Conditions: Weight Loss, Bariatric Surgery
High Dose Steroid Therapy to Treat Flares in Patients With Inflammatory Bowel Disease (IBD)
Recruiting
This study will examine whether delivery of high dose steroids, directly into the inflamed bowel via its arterial blood supply, will be better for treating uncontrolled flares of inflammatory bowel disease in patients compared to conventional intra-venous or oral administration of this drug. Patients aged 4-25 years of age will be recruited. In this study, we hope to also learn how this directed steroid delivery during an active flare will improve patient symptoms as well as the appearance of i... Read More
Gender:
All
Ages:
Between 4 years and 25 years
Trial Updated:
01/23/2023
Locations: Stanford University, Palo Alto, California
Conditions: Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, Indeterminate Colitis
A Study of Evorpacept (ALX148) in Patients With Advanced HER2+ Gastric Cancer (ASPEN-06)
Recruiting
A Phase 2/3 Study of Evorpacept (ALX148) in Combination With Trastuzumab, Ramucirumab, and Paclitaxel in Patients With Advanced HER2-overexpressing gastric/GEJ adenocarcinoma.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/23/2023
Locations: The Oncology Institute of Hope & Innovation, Anaheim, California
Conditions: Gastric Cancer, Gastroesophageal Junction Adenocarcinoma, Gastric Adenocarcinoma
Efficacy of EsoGuard Assay on Esophageal Surface Cells Collected With EsoCheck vs EGD for the Diagnosis of BE or EAC
Recruiting
The study will assess the performance of the combined system, i.e., the use of the EsoGuard assay (lab developed test) on cells collected using the EsoCheck (501k cleared device) to detect Barrett's Esophagus (BE), with or without dysplasia, and esophageal adenocarcinoma (EAC) as compared to Esophagogastroduodenoscopy (EGD) plus biopsies in both confirmed cases of BE/EAC and in controls (subjects without a prior diagnosis but undergoing screening for BE/EAC)
Gender:
Male
Ages:
50 years and above
Trial Updated:
01/23/2023
Locations: Lucid Investigative Site, Orange, California
Conditions: Barrett Esophagus, Esophageal Adenocarcinoma, Barretts Esophagus With Dysplasia, Barrett's Esophagus Without Dysplasia
Real-World Experience - Barostim™ Advancing the Level of Clinical Evidence (REBALANCE Registry)
Recruiting
The purpose of this registry is to develop valid scientific evidence of the safety and benefit of Barostim Therapy in the commercial setting in patients with heart failure with reduced ejection fraction (HFrEF) that were recently implanted with the Barostim System.
Gender:
All
Ages:
All
Trial Updated:
01/21/2023
Locations: University of Southern California, Los Angeles, California
Conditions: Heart Failure
Atezolizumab for Idiopathic Pulmonary Fibrosis
Recruiting
The purpose of this study is to determine the safety and preliminary efficacy of atezolizumab, an immune checkpoint inhibitor approved for the treatment of various cancers, in patients with idiopathic pulmonary fibrosis (IPF).
Gender:
All
Ages:
Between 50 years and 80 years
Trial Updated:
01/19/2023
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Idiopathic Pulmonary Fibrosis
Buccal Film vs IV Palonosetron for Prevention of CINV in Cancer Patients Receiving MEC
Recruiting
The phase 3 study is to compare the efficacy and safety of palonosetron, a long-acting 5-HT3 receptor antagonist, by buccal film delivery compared to IV injection for the prevention of chemotherapy-induced nausea and vomiting. Subjects receive a single dose of palonosetron prior to moderately emetogenic chemotherapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/19/2023
Locations: Pacific Cancer Medical Center, Anaheim, California
Conditions: Chemotherapy-induced Nausea and Vomiting
G-Tech Feasibility Study for Early Detection of a Post-op Ileus
Recruiting
This feasibility study is for the purpose of determining if the G-Tech Device can differentiate between normal return of GI activity post-operatively and the myoelectric activity in patients who develop a POI.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/18/2023
Locations: El Camino Hospital, Mountain View, California
Conditions: Post-operative Ileus