California is currently home to 5579 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
An Active and Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Ulcerative Colitis
Recruiting
The present study D5272C00001 (Legacy # 3151-201-008) seeks to evaluate the efficacy and safety of brazikumab versus placebo in patients with moderately to severely active UC and will include assessments of clinical responses as demonstrated by improvement of symptoms and of colonic mucosal appearance as observed on endoscopy.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
01/19/2021
Locations: Research Site, Chula Vista, California
Conditions: Ulcerative Colitis
Open-Label Extension Study of BION-1301 in IgA Nephropathy
Recruiting
This is an open-label extension (OLE) study to evaluate the safety, pharmacokinetics (PK), pharmacodynamics (PD), and clinical activity of BION-1301 in adults with IgA nephropathy
Gender:
All
Ages:
18 years and above
Trial Updated:
12/22/2020
Locations: Amicis Research Center, Northridge, California
Conditions: IgA Nephropathy
Clinical Trial Evaluating the Efficacy, Safety, and Tolerability of Cariprazine in a Dose-Reduction Paradigm in the Prevention of Relapse in Patients With Schizophrenia
Recruiting
To evaluate the efficacy and safety of cariprazine at a target dose of 4.5 mg/d compared with placebo in prevention of relapse in patients with schizophrenia To evaluate the efficacy and safety of cariprazine at a target dose of 3.0 mg/d compared with placebo in prevention of relapse in patients with schizophrenia who were initially stabilized on a target dose of 4.5 mg/d
Gender:
All
Ages:
Between 18 years and 64 years
Trial Updated:
08/17/2020
Locations: California Pharmaceutical Research Institute, Inc., Anaheim, California
Conditions: Schizophrenia
Prospective Observational International Registry of Patients With Newly Diagnosed Peripheral T Cell Lymphoma.
Recruiting
This study T-Cell Project 2.0 is based on the former International PTCL study designed by the International T-cell Non-Hodgkin's Lymphoma Study Group (T-Cell Project 1.0: Prospective Collection of Data in Patients With Peripheral T-Cell Lymphoma) as a prospective collection of data to predict the prognosis of patients with the more frequent subtypes of PTCL. It is a prospective, longitudinal, international, observational study of patients with newly diagnosed peripheral T-cell lymphoma aiming to... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/08/2020
Locations: Stanford University, Stanford, California
Conditions: Peripheral T-Cell Lymphoma
Filter Initial & Long Term Evaluation After Placement and Retrieval Registry
Recruiting
A prospective data registry for all patients who undergo IVC (Inferior Vena Cava) filter placement or retrieval at Stanford. Potential enrollees will already be undergoing the procedure. If patients are willing, they will be prospectively enrolled prior to the procedure. As part of the study, chart and clinical data reviews will be used to track patient progress and response to the treatment.
Gender:
ALL
Ages:
All
Trial Updated:
05/09/2020
Locations: Stanford University School of Medicine, Stanford, California
Conditions: Venous Thromboembolism
Epigenetic Regulation of Altered T-cell Immunity in Sarcoidosis
Recruiting
Sarcoidosis is a multi-system granulomatous disorder that is triggered and influenced by gene-environment interactions. Although sarcoidosis predominantly affects the lungs in most cases, the clinical disease course is highly variable and any organ can be affected leading to end organ damage despite currently available therapeutics that unfortunately also have numerous and potentially devastating side effects. The environmental triggers of sarcoidosis are unknown but several occupational, enviro... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
05/04/2020
Locations: University of California, San Francisco (Parnassus), San Francisco, California
Conditions: Sarcoidosis, Sarcoidosis, Pulmonary
Biocellular-Cellular Regenerative Treatment Scaring Alopecia and Alopecia Areata
Recruiting
The primary objective of this study is to evaluate the safety and efficacy of the use of a biocellular mixture of emulsified adipose-derived tissue stromal vascular fraction (AD-tSVF) and high density platelet-rich plasma concentrate (HD- PRP). Additionally, comparison with clinical outcomes of adipose-derived cellular Stromal Vascular Fraction (AD-cSVF) + AD-tSVF + HD PRP; AD-cSVF + emulsified AD-tSVF + HD- PRP; emulsified AD-tSVF + HD PRP + AD-cSVF; AD-cSVF via intravenous infusion in treatmen... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/15/2020
Locations: Kenneth Williams, DO, Irvine, California
Conditions: Alopecia Areata, Scarring Alopecia
Gentamicin for Junctional Epidermolysis Bullosa
Recruiting
Herlitz junctional epidermolysis bullosa (H-JEB), an incurable, fatal, inherited skin disease, is caused by loss-of-function mutations in the LAMA3, LAMB3 or LAMC2 genes, resulting in loss of laminin 332 and poor epidermal-dermal adherence. Eighty percent of H-JEB patients have LAMB3 mutations and about 95% of these are nonsense mutations. The investigators recently demonstrated that gentamicin readily induced nonsense mutation readthrough and produced full-length laminin beta3 in several nonsen... Read More
Gender:
ALL
Ages:
All
Trial Updated:
04/03/2020
Locations: University of Southern California, Los Angeles, California
Conditions: Junctional Epidermolysis Bullosa
Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair
Recruiting
The objective of this trial is to assess the safety and effectiveness of the study device in subjects with degenerative mitral valve disease receiving a mitral valve repair without cardiopulmonary bypass (treatment group) when compared to subjects receiving mitral valve repair using standard surgical techniques with cardiopulmonary bypass (control group).
Gender:
ALL
Ages:
21 years and above
Trial Updated:
12/04/2019
Locations: Sutter Health/Alta Bates Summitt Medical Center, Oakland, California
Conditions: Mitral Valve Insufficiency
Laparotomy Versus Percutaneous Endoscopic Correction of Myelomeningocele
Recruiting
The purpose of this study is to evaluate the feasibility of a fetoscopic surgical technique for antenatal correction of fetal myelomeningocele. Two surgical approaches will be utilized. The percutaneous approach will be offered to participants with a posterior placenta. The laparotomy/uterine exteriorization approach will be offered to participants regardless of placental location.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/11/2019
Locations: University of Southern California / Huntington Memorial Hospital, Los Angeles, California
Conditions: Neural Tube Defects, Spina Bifida, Myelomeningocele, Chiari Malformation
MyHeart Counts Cardiovascular Health Study
Recruiting
The MyHeart Counts Cardiovascular Health Study will utilize mobile health capabilities of smartphones and wearables to assess daily activity measures of the general population and compare these to measures of cardiovascular health risk factors and fitness. How people divide their time among exercise, sedentary behavior, and sleep all affect cardiovascular health, yet to date these have largely gone unmeasured. With the advancement of phone sensors and wearable fitness tracking devices these fact... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/09/2019
Locations: Stanford University, Stanford, California
Conditions: Cardiovascular Health
REtroperitoneal SArcoma Registry: an International Prospective Initiative
Recruiting
Surgery is currently the only potentially curative treatment modality for localized retroperitoneal sarcoma (RPS). Available studies regarding oncologic outcomes are mainly retrospective in nature, and RPS are recognized as a rare disease. Therefore, prospective analysis of high quality data is a top priority. Primary Objectives of this study are: * to prospectively collect standardized clinical data and radiological and pathological material from primary RPS patients treated with surgery at r... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/11/2019
Locations: University of Southern California (USC), Los Angeles, California
Conditions: Retroperitoneal Sarcoma