Texas is currently home to 5037 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Houston, Dallas, San Antonio and Austin. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
YL-13027 in Patients With Advanced Solid Tumors
Recruiting
Part 1 (Phase Ia): This is a dose escalation, 3 + 3 design study, to evaluate the safety and tolerability, and to determine the RP2D of YL-13027 when administered b.i.d. in patients with advanced solid tumors. Up to 4 cohorts of 3-6 patients each will be treated in part 1 of the study. One cycle is 28 days. Part 2: This is a dose expansion phase to further evaluate the safety, tolerability and preliminary anti-tumor activity of YL-13027 at the RP2D.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/16/2022
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Solid Tumor
Neuroimaging Memories of Fear and Safety in the Human Brain
Recruiting
The purpose of this research is to use functional magnetic resonance imaging (fMRI) to investigate how the brain forms associations between neutral and negative stimuli. The ultimate goal is to understand the neural systems involved in regulating negative emotional responses to fearful stimuli.
Gender:
All
Ages:
Between 18 years and 50 years
Trial Updated:
05/16/2022
Locations: The University of Texas at Austin, Austin, Texas
Conditions: Fear Anxiety, PTSD
Cognitive Training for Diabetes Self-Management
Recruiting
The overall objective of this study is to determine the effects of a comprehensive cognitive rehabilitation intervention on biological, cognitive, and diabetes self-management outcomes.
Gender:
All
Ages:
50 years and above
Trial Updated:
05/16/2022
Locations: The University of Texas at Austin, Austin, Texas
Conditions: Diabetes Mellitus, Type 2
Computer Aided Polyp Detection (C3PO) Trial
Recruiting
Computer aided detection (CADe) algorithms have been developed to overcome human errors and assist endoscopists in detecting more polyps during colonoscopy. The aim of this study was to investigate the accuracy of the novel Pentax Discovery CADe system (Discovery-AI) against pre-recorded videos of colon polyps of various size, shape and pathology while using videos of normal colon segments as controls from two different institutes.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/16/2022
Locations: Memorial Hermann Hospital, Houston, Texas
Conditions: Colonic Polyp
CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry
Recruiting
This multinational, investigator-initiated, retrospective study aims to investigate outcomes of patients, who underwent transcatheter mitral valve implantation (TMVI), in comparison to those screened for TMVI but deemed ineligible, who subsequently underwent interventional mitral valve edge-to-edge repair, mitral valve surgery or medical/conservative therapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/16/2022
Locations: Houston Methodist Hospital, Houston, Texas
Conditions: Mitral Regurgitation
Nighttime Agitation and Restless Legs Syndrome in People With Alzheimer's Disease
Recruiting
Nighttime agitation in persons with Alzheimer's disease causes patient suffering, distresses caregivers, and often results in prescriptions for harmful antipsychotics. Effective treatments are lacking because of limited knowledge of the etiology of nighttime agitation. The investigators propose a clinical trial to better elucidate whether a sleep disorder, restless legs syndrome, may be a mechanism for nighttime agitation, and if treatment with gabapentin enacarbil (Horizant®) reduces nighttime... Read More
Gender:
All
Ages:
55 years and above
Trial Updated:
05/16/2022
Locations: The University of Texas at Austin, Austin, Texas
Conditions: Alzheimer Disease
A Prospective Study To Identify Predictive Biological Markers In Blood And Cyst Fluid Aspirates From Patients With Pancreatic Cyst Lesions
Recruiting
The purpose To determine the diagnostic potential of various biological markers in blood and cyst fluid aspirates from patients with Pancreatic Cystic Lesions (PCLs). Research design This is a 10-year prospective cohort and pancreatic cyst fluid repository study enrolling all patients diagnosed with pancreatic cyst and undergoing the cyst aspiration. Procedures to be used Blood Sample Cyst Fluid Sample Data Collection: Medical Record Number Demographics (age, sex, gender, race) Contact infor... Read More
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
05/16/2022
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Pancreatic Cystic Lesions
The TIOB - Collection of Patients' Biospecimens for Analysis of Immunological and Molecular Biomarkers.
Recruiting
The purpose of the Texas Immuno-Oncology Biorepository (TIOB) is to collect and store well-defined and well-annotated serial biospecimens of tissue, blood, urine and stool in a longitudinal manner from cancer patients who are receiving either standard of care surgical interventions and or FDA approved immunotherapeutics across the largest not-for-profit health system in Texas. Comprehensive clinical and radiological data from a diverse population of patients with different racial, social and eth... Read More
Gender:
All
Ages:
All
Trial Updated:
05/11/2022
Locations: Baylor Scott & White Research Institute, Dallas, Texas
Conditions: Cancer
EEG Brain-Machine Interface Control of an Upper-Limb Robotic Exoskeleton for Robot-Assisted Rehabilitation After Stroke
Recruiting
The goal of this study is to develop a clinically feasible, low-cost, nonsurgical neurorobotic system for restoring function to motor-impaired stroke survivors that can be used at the clinic or at home. Moreover, another goal is to understand how physical rehabilitation assisted by robotic device combined with electroencephalograph (EEG) can benefit adults who have had stroke to improve functions of their weaker arm. The proposed smart co-robot training system (NeuroExo) is based on a physical... Read More
Gender:
All
Ages:
Between 20 years and 65 years
Trial Updated:
05/10/2022
Locations: The Institute for Rehabilitation and Research (TIRR) at Memorial Hermann, Houston, Texas
Conditions: Stroke, Hemiparesis
Estetrol for the Treatment of Moderate to Severe Vasomotor Symptoms in Postmenopausal Women (E4Comfort Study I)
Recruiting
This is a two-part study designed to evaluate the effect of Estetrol (E4) 15 or 20 mg, or placebo on the severity and frequency of vasomotor symptoms (VMS) (Efficacy Study Part) and the safety of E4 20 mg (Endometrial and General Safety Study Part)
Gender:
Female
Ages:
Between 40 years and 65 years
Trial Updated:
05/09/2022
Locations: Cedar Health Research, LLC, Dallas, Texas
Conditions: Vasomotor Symptoms, Menopausal Symptoms
Ruxolitinib for Premalignant Breast Disease
Recruiting
This study is evaluating how ruxolitinib affects premalignant breast cells. One half of the study participants will receive ruxolitinib for approximately 15 days, and the other half will receive a placebo (sugar pill) for approximately 15 days. Once study participants have completed their ruxolitinib or placebo, participants will undergo surgery to remove the premalignant breast tissue.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/09/2022
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Ductal Carcinoma In Situ, Atypical Lobular Hyperplasia, Atypical Ductal Hyperplasia, Lobular Carcinoma In Situ
Study of KRT-232 or TL-895 in Janus Associated Kinase Inhibitor Treatment-Naïve Myelofibrosis
Recruiting
This study evaluates either KRT-232 or TL-895 in treatment naïve patients with myelofibrosis (MF) The study will be conducted in 2 stages. Stage 1 will evaluate safety, tolerability, and efficacy of either KRT-232 (Arm 1) or TL-895 (Arm 2) in treatment naïve patients. Stage 2 will expand enrollment in Arm 1 and/or Arm 2 if expansion criteria is met.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/05/2022
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (Post-PV-MF), Post-Essential Thrombocythemia Myelofibrosis (Post-ET-MF)