California is currently home to 5944 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Does Preoperative Pain Medication Management Influence Surgical Outcomes in Spinal Fusion
Recruiting
In light of the current opioid epidemic, there is an urgent need to address chronic opioid use prior to surgery before it is exacerbated by postoperative surgical pain. Our central hypothesis is that patients who taper their opioid use prior to surgery will have reduced postoperative opioid and pain medication usage, less postoperative pain, and improved patient reported outcomes relative to patients that do not taper prior to surgery. Our specific aims include: 1. Determine whether reducing pat... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/10/2022
Locations: Stanford Hospital and Clinics, Redwood City, California
Conditions: Opioid Use, Spine Fusion
Adenoma Detection Rate in Water and Air Colonoscopy Using Computer-aided System
Recruiting
Water exchange (WE) is an effective insertion method to minimize insertion discomfort and maximize ADR. It is characterized by infusing water to guide insertion in an airless lumen with suctioning of infused water during insertion and almost complete removal of the infused water when cecal intubation is achieved. A modified Delphi review reported water exchange showed the highest overall ADR, ADR in screening cases, and in the right side of the colon compared with water immersion and air (or CO2... Read More
Gender:
All
Ages:
Between 50 years and 80 years
Trial Updated:
07/08/2022
Locations: Sepulveda Ambulatory Care Center, Los Angeles, California
Conditions: Colon Adenoma, Colonoscopy
A Phase II Study in Patients With Moderate to Severe ARDS Due to COVID-19
Recruiting
This is a Phase II multi-center, double-blind, placebo-controlled, randomized study in Patients with moderate to severe lung injury due to COVID-19 or other potential viral and bacterial pathogens.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/07/2022
Locations: Providence Medical Foundation, Fullerton, California
Conditions: Covid19
Examination of Immunosuppression Adjustment Impact on Kidney Function in Liver Transplant
Recruiting
This is a study to help understand how well new combinations of immunosuppressive medications (medications that weaken your immune system to prevent your body from rejecting the transplanted liver) work compared to standard immunosuppressive medications after your liver transplant. Also the study will assess how safe the new combination of immunosuppressive medicines are and if there are any changes in how your kidneys work after taking these medicines.
Gender:
All
Ages:
Between 18 years and 78 years
Trial Updated:
07/06/2022
Locations: UCLA Medical Center, Los Angeles, California
Conditions: Asses Immunosuppression Modulation on Renal Recovery Post LT
Ocular Pathogen and Transcriptome Investigation Using Comprehensive Sequencing
Recruiting
This is a multi-center randomized controlled evaluator-masked trial designed to compare metagenomic deep sequencing (MDS) versus standard of care testing for improvement of outcomes for intraocular infections. Patients with presumed intraocular infections who meet the eligibility criteria will be randomized to receive MDS testing results or not to receive MDS testing results. All patients will receive standard-of-care testing to guide management. Enrolled patients will be followed at week 2, wee... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/05/2022
Locations: University of California San Francisco (UCSF), San Francisco, California
Conditions: Uveitis, Infectious Disease
Responsive Neurostimulation for Post-Traumatic Stress Disorder
Recruiting
Post-traumatic stress disorder (PTSD) refractory to treatment is marked by failure of fear extinction and its biological substrate, amygdala reactivity to trauma reminders. Decades of research have clarified the neuronal mechanisms coordinating fear extinction and consolidation. Fear cells and extinction cells in the basolateral amygdala (BLA) alter their firing rate based on the nature of the stimulus and the influence from the medial prefrontal cortex (mPFC) and the ventral hippocampus (vHPC).... Read More
Gender:
Male
Ages:
Between 25 years and 60 years
Trial Updated:
07/05/2022
Locations: VA Greater Los Angeles, Los Angeles, California
Conditions: Post-Traumatic Stress Disorder
Phase 2 Study of Efficacy and Safety of AK120, in Subjects With Moderate-to-Severe Atopic Dermatitis
Recruiting
This is a phase 2, multi-center, randomized, placebo-controlled, double-blind, parallel-group, dose-ranging study, conducted in subjects with moderate-to-severe atopic dermatitis.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/04/2022
Locations: AkesoBio Investigative Site 2010, Canoga Park, California
Conditions: Atopic Dermatitis
A Study to Monitor Ambulatory Blood Pressure Monitoring in Hypogonadal Men Treated With Nasal Testosterone Gel
Recruiting
The purpose of this study is to assess the change in 24-hour ambulatory blood pressure monitoring (ABPM) between baseline (Day 0) and Day 120 following 4 months of testosterone therapy with Natesto.
Gender:
Male
Ages:
Between 18 years and 80 years
Trial Updated:
07/04/2022
Locations: Valley Clinical Trials, Northridge, California
Conditions: Hypogonadism
Artisan Aphakia Lens for the Correction of Aphakia in Children
Recruiting
The purpose of this study is to determine the safety and effectiveness of the Artisan Aphakia Lens in the treatment of aphakia in children.
Gender:
All
Ages:
Between 2 years and 21 years
Trial Updated:
06/24/2022
Locations: The Vision Center, Los Angeles, California
Conditions: Aphakia
Artisan Aphakia Lens for the Correction of Aphakia (Secondary) in Adults
Recruiting
This study will determine the safety and effectiveness of the Artisan Aphakia Lens when used as a secondary implant to correct aphakia in adults.
Gender:
All
Ages:
22 years and above
Trial Updated:
06/24/2022
Locations: Assil Eye Institute, Beverly Hills, California
Conditions: Aphakia
Tabelecleucel for Solid Organ or Allogeneic Hematopoietic Cell Transplant Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease (EBV+ PTLD) After Failure of Rituximab or Rituximab and Chemotherapy
Recruiting
The purpose of this study is to determine the clinical benefit and characterize the safety profile of tabelecleucel for the treatment of Epstein-Barr virus-associated post-transplant lymphoproliferative disease (EBV+ PTLD) in the setting of (1) solid organ transplant (SOT) after failure of rituximab and rituximab plus chemotherapy or (2) allogeneic hematopoietic cell transplant (HCT) after failure of rituximab.
Gender:
All
Ages:
All
Trial Updated:
06/23/2022
Locations: City of Hope (Adults and Pediatrics), Duarte, California
Conditions: Epstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD), Solid Organ Transplant Complications, Lymphoproliferative Disorders, Allogeneic Hematopoietic Cell Transplant, Stem Cell Transplant Complications
Evaluation of the Effectiveness of PermeaDerm® (PD) as Compared to Mepilex Ag®
Recruiting
A total of 68 adult and pediatric patients who suffer from at least one discrete partial thickness thermal burn wound (Grade II) will be recruited. Subjects will be randomized (1:1) to either PermeaDerm® or Mepilex Ag®. Evaluations will occur at 7, 14 and 21 days with long term follow-up at 6 and 12 months.
Gender:
All
Ages:
75 years and below
Trial Updated:
06/21/2022
Locations: University of California, Davis, Sacramento, California
Conditions: Thermal Burn