California is currently home to 5930 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
MultiStem® Administration for Stroke Treatment and Enhanced Recovery Study
Recruiting
A Phase 3 study to examine the safety and effectiveness of the allogeneic, adult stem cell investigational product, MultiStem, in adults who have suffered an acute ischemic stroke in the previous 18-36 hours.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/08/2022
Locations: Athersys Investigational Site 122, Palo Alto, California
Conditions: Ischemic Stroke
Impact of Immunosuppression Adjustment on COVID-19 Vaccination Response in Kidney Transplant Recipients
Recruiting
Immunocompromised individuals, such as solid organ transplant (SOT) recipients are at high risk of COVID-19 associated complications and mortality. Retrospective studies so far have shown that a majority of SOT recipients did not develop appreciable anti-spike antibody response after a first, second, or even third dose of mRNA vaccine. Treatment with antimetabolites was associated with poor vaccine response. The goal of this study is 1) examine whether transient immunosuppression reduction impro... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/07/2022
Locations: University of California, Davis, Sacramento, California
Conditions: COVID-19, Immunosuppression, Vaccine Response Impaired
Innovative Liver Elasticity, Attenuation, and Dispersion Ultrasound Study
Recruiting
The objective of this study is: (1) to investigate the correlation of ultrasound parameters (SW speed, Dispersion slope, Attenuation value, Normalized Local Variance, Liver / Kidney Intensity Ratio) with the pathological parameters (fibrosis, intralobular inflammation, ballooning degeneration and steatosis); (2) to evaluate the diagnostic performance of SW speed for liver fibrosis, Dispersion slope for intralobular inflammation and Attenuation value for steatosis by comparison with the tissue di... Read More
Gender:
All
Ages:
20 years and above
Trial Updated:
02/06/2022
Locations: University of Southern California, Los Angeles, California
Conditions: Nonalcoholic Steatohepatitis, Ultrasound, Elastography
Blood Flow Restriction Exercise in the Treatment of Lateral Epicondylalgia Traditional Treatment
Recruiting
The purpose of this study is to compare the clinical effectiveness and outcomes between current evidence based clinical care and use of personalized blood flow restriction training in the treatment of lateral epicondylalgia ("tennis elbow").
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
02/04/2022
Locations: Navy Medical Readiness & Training Command San Diego, San Diego, California
Conditions: Tennis Elbow, Lateral Epicondylitis
Reduced Oligodendrocyte-specific Cytotoxicity and Ofatumumab Treatment
Recruiting
In this study the investigators wish to test the hypothesis that the repertoire of solutes secreted by leukocytes isolated from patients with relapsing-remitting forms of Multiple Sclerosis (MS) following 6 months of treatment with Ofatumumab (Kesimpta®) will be less toxic to mouse-derived oligodendrocyte lineage cells, grown in a dish, than solutes secreted by the same leukocyte populations prior to treatment with Ofatumumab.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
02/03/2022
Locations: University of Southern California, Los Angeles, California
Conditions: Relapsing Remitting Multiple Sclerosis
Treatment of Radiation and Cisplatin Induced Toxicities With Tempol
Recruiting
A 10 week trial to assess the ability of Tempol to prevent and/or reduce toxicities associated with cisplatin and radiation treatment in head and neck cancer patients. Over the course of the 10 week trial, mucositis, nephrotoxicity, and ototoxicity will be monitored and assessed.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/02/2022
Locations: UCSD, La Jolla, California
Conditions: Mucositis, Nephrotoxicity, Ototoxicity
HIV Prevention Peer Navigation for Justice Involved Women
Recruiting
Women involved in the criminal justice system have complex and highly stigmatized sexual and substance use risk profiles and are particularly vulnerable to, and experience, high rates of HIV. Criminal justice settings represent an important opportunity to address health disparities in HIV by linking women, who experience multiple, intersecting stigmas with innovative biomedical HIV prevention strategies, like pre-exposure prophylaxis (PrEP). The investigators propose to develop and test a peer-l... Read More
Gender:
Female
Ages:
Between 18 years and 49 years
Trial Updated:
02/01/2022
Locations: University of California San Francisco, San Francisco, California
Conditions: HIV Infections, Stigma, Social
Study of TBX-3400 in Subjects With Solid Malignant Tumors Resistant or Refractory to Standard Therapies
Recruiting
This is a study of treatment with TBX-3400 in subjects with solid malignant tumors that are resistant or refractory to standard therapies. The subject's own blood cells are exposed to a protein that has been shown in the laboratory to result in anti-tumor activity. The study hypothesis is that TBX-3400 cells will enhance anti-tumor activity and improve the body's immune response to the tumor.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/01/2022
Locations: The Angeles Clinic and Research Institute, Los Angeles, California
Conditions: Cancer, Tumor, Solid, Refractory Cancer
NA-831, Atazanavir and Dexamethasone Combination Therapy for the Treatment of COVID-19 Infection
Recruiting
This Phase 2/3 trial evaluates four treatment strategies for non-critically ill hospitalized participants (not requiring ICU admission and/or mechanical ventilation) with SARS CoV-2 infection, in which participants will receive NA-831 or Atazanavir with or without Dexamethasone.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
01/31/2022
Locations: Coronavirus Research Institute- Testing Site, Los Angeles, California
Conditions: Coronavirus Infection, Severe Acute Respiratory Infection, Severe Acute Respiratory Syndrome Coronavirus 2
A Tissue Collection Study in Patients Who Respond to Immune Checkpoint Inhibitors to Identify Targets of Tumor-Reactive T Cells.
Recruiting
T Cell Receptor-engineered T-cell therapy (TCR T-cell therapy) offers a potentially transformative approach to treating cancer, but is currently limited by the lack of known targets (Maus and June, 2016; Ping et al., 2018). Arguably the most clinically meaningful way to discover new targets and TCRs for TCR T-cell therapy is to study the tumor-infiltrating lymphocytes of patients that are actively responding to immune checkpoint inhibitor (ICI) therapy. These T cells are clonally expanded as a r... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/27/2022
Locations: USC Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Solid Tumor, Adult
Bone Marrow Aspirate Concentrate (BMAC)Treatment for Knee Osteoarthritis
Recruiting
The purpose of this study is to investigate the safety and effectiveness of bone marrow aspirate concentrate (BMAC) in patients with moderate to severe osteoarthritis of the knee. BMAC provides a rich source of mesenchymal stem cells (MSCs) and is a stem cell-based therapy that has been reported to preserve or improve the structure of joints. The Angel System is the device used in this study to concentrate bone marrow from the patient and is intended to separate a mixture of blood and bone marro... Read More
Gender:
All
Ages:
Between 45 years and 75 years
Trial Updated:
01/24/2022
Locations: University of California San Diego Koman Outpatient Pavilion, La Jolla, California
Conditions: Osteo Arthritis Knee
Treatment of Ocular Demodex Infestation With Topical Ivermectin Cream 1%
Recruiting
Patients with Demodex infestation of the eyelids will have the sleeves from both eyes cleaned off with microblepharoexfoliation. Afterwards, one eye will be randomly selected for treatment with topical ivermectin 1% cream. The treatment will be repeated on that eye 2 weeks later. Afterwards, the patients will present monthly for photographs of the eyelashes. The photographs will be reviewed by an ophthalmologist outside of our institution who will be blind to which eye was treated and independen... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/20/2022
Locations: Helm Vision Group, Santa Clarita, California
Conditions: The Focus of the Study is to Assess the Effectiveness of Topical Ivermectin on Eliminating Eyelash Sleeves