California is currently home to 5958 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Outreach and Choice in Colorectal Cancer Screening
Recruiting
The primary objective of this clinical trial will be to compare overall colorectal cancer (CRC) screening participation between an active choice (fecal immunochemical test [FIT] or colonoscopy) and a sequential choice (FIT offered first, then colonoscoscopy offered in those still unscreened) arm. Secondarily, we will (1) compare the proportions of FIT vs. colonoscopy per arm, (2) compare active choice vs FIT only in the initial 3 months of the study, (3) characterize changes in physician knowled... Read More
Gender:
All
Ages:
Between 45 years and 75 years
Trial Updated:
09/21/2021
Locations: Stanford University Primary Care Clinics, Palo Alto, California
Conditions: Colorectal Cancer Screening
Continuous Monitoring and Control of Hypoglycemia
Recruiting
Evaluate safety of non-adjunctive CGM use in CGM naive participants.
Gender:
All
Ages:
2 years and above
Trial Updated:
09/17/2021
Locations: Scripps Whittier Diabetes Institute, La Jolla, California
Conditions: Diabetes
A Study of MPT-0118 in Subjects With Advanced or Metastatic Refractory Solid Tumors
Recruiting
This is a Phase 1/1b open-label, dose-escalation, and cohort expansion study with BID (tablet) oral dose of MPT-0118 in subjects with advanced or metastatic refractory solid tumors. The study will be conducted in 3 parts: Part A: MPT-0118 dose-escalation Part B: MPT-0118 dose-escalation in combination with pembrolizumab Part C: Cohort expansion of MPT-0118 in combination with pembrolizumab
Gender:
All
Ages:
18 years and above
Trial Updated:
09/15/2021
Locations: St. John's Cancer Center, Santa Monica, California
Conditions: Solid Tumor, Adult, Advanced Solid Tumor, Advanced Cancer, Metastatic Cancer, Refractory Cancer
Investigation of Dysynchrony in Patients With Pulmonary Hypertension
Recruiting
The purpose of the study is to determine whether patients with pulmonary hypertension (PH) have dysynchrony, and if so whether it is electrical or mechanical. Once this has been determined, during a catheterization the investigators will test if pacing the heart improves blood circulation.
Gender:
All
Ages:
5 years and above
Trial Updated:
09/15/2021
Locations: Stanford Hospital, Stanford, California
Conditions: Pulmonary Hypertension
An Adaptive Phase II/III, Two-Part, Double-Blind, Randomized, Placebo-controlled, Dose-Finding, Multi-center Study of the Safety and Efficacy of NaBen®, as an Add-on Therapy With Clozapine, for Residual Symptoms of Refractory Schizophrenia in Adults
Recruiting
This is an adaptive, Phase II/III study in 2 parts (i.e. Part 1 (dose ranging) and Part 2 (Hypothesis testing)). NaBen® is granted Breakthrough Therapy Designation by US FDA as treatment for refractory schizophrenia. Part 1 Objectives: There are two primary objectives for Part 1 of this study: To evaluate, in terms of dose-response, the effectiveness of NaBen® (1000 and 2000 mg/day) compared to Placebo (0 mg/day), when combined with clozapine, in improving the residual symptoms associated with... Read More
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
09/10/2021
Locations: For additional information regarding investigative sites for this trial, contact SyneuRx International Corp., Pasadena, California
Conditions: Refractory Schizophrenia
Study to Evaluate Safety & Efficacy of NaBen® as Add-on Treatment for Schizophrenia in Adults
Recruiting
The proposed Phase IIb/III study is designed to evaluate the safety and efficacy of NaBen® in improving the symptoms of schizophrenia in adults. NaBen® is granted Breakthrough Therapy Designation by US FDA as add-on treatment for schizophrenia. The trial is designed as a multi-center, prospective, randomized, placebo-controlled, in which adult subjects with schizophrenia will be enrolled. The study will include four parts: a 2 week Screening part, a 4 week run-in part, an 8 week double-blind tre... Read More
Gender:
All
Ages:
Between 18 years and 45 years
Trial Updated:
09/10/2021
Locations: For additional information regarding investigative sites for this trial, contact SyneuRx International Corp., Pasadena, California
Conditions: Schizophrenia
Adaptive Phase II Study to Evaluate the Safety & Efficacy of NaBen®
Recruiting
The purpose of this study is to determine if NaBen® is a safe and effective add-on treatment for schizophrenia in adolescents.
Gender:
All
Ages:
Between 12 years and 17 years
Trial Updated:
09/10/2021
Locations: CiTrials, Bellflower, California
Conditions: Schizophrenia
Myeloma-Developing Regimens Using Genomics (MyDRUG)
Recruiting
The MyDRUG study is a type of Precision Medicine trial to treat patients with drugs targeted to affect specific genes that are mutated as part of the disease. Mutations in genes can lead to uncontrolled cell growth and cancer. Patients with a greater than 25% mutation to any of the following genes; CDKN2C, FGFR3, KRAS, NRAS, BRAF V600E, IDH2 or T(11;14) can be enrolled to one of the treatment arms. These arms have treatments specifically directed to the mutated genes. Patients that do not have a... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
09/09/2021
Locations: City of Hope, Duarte, California
Conditions: Relapsed Refractory Multiple Myeloma
Clinical Study Of Affinity Versus SOC In The Management Of VLUs
Recruiting
This prospective, multi-center, randomized, controlled clinical study compares Affinity® plus SOC to SOC alone in subjects with VLUs. Affinity® will be used along with standard of care on venous leg ulcers (VLUs) of greater than 4 weeks which have not adequately responded to conventional ulcer therapy.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
09/07/2021
Locations: ILD Research, Carlsbad, California
Conditions: Venous Leg Ulcer
A Study to Explore the Role of Gut Flora in COVID-19 Infection
Recruiting
This study seeks to determine whether the virus which causes COVID-19, SARS-CoV-2, is shed in the stools of patients who are infected.
Gender:
All
Ages:
18 years and above
Trial Updated:
09/02/2021
Locations: ProgenaBiome, Ventura, California
Conditions: Gut Microbiome, Gastrointestinal Microbiome, COVID, COVID-19, Corona Virus Infection, Coronavirus, Coronaviridae Infections, Coronavirus 19, Coronavirus-19, COVID 19
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease
Recruiting
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
Gender:
All
Ages:
12 years and above
Trial Updated:
09/02/2021
Locations: Sabine Hazan, Ventura, California
Conditions: Gut Microbiome, Gastrointestinal Microbiome
Immunosuppression Management in Renal Transplant Recipients With Transplant Excellence Based on TruGraf Test
Recruiting
This is an investigator-initiated, single-center, prospective, randomized, proof of concept study. In this study patients who are status post kidney transplantation and meet the inclusion and exclusion criteria will undergo immunosuppression reduction and will be followed closely to assess stability of graft function.
Gender:
All
Ages:
18 years and above
Trial Updated:
08/26/2021
Locations: California Pacific Medical Center, San Francisco, California
Conditions: Kidney Transplant Rejection, Immunosuppression