California is currently home to 5930 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
JSP191 Antibody Conditioning Regimen in MDS/AML Subjects Undergoing Allogenic Hematopoietic Stem Cell Transplantation
Recruiting
This is a Phase 1a/b study to evaluate the safety and tolerability of an antibody conditioning regimen known as JSP191, in combination with low dose radiation and fludarabine, in subjects with Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML) undergoing allogenic blood stem cell transplantation.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/08/2021
Locations: City of Hope Comprehensive Cancer Center, Duarte, California
Conditions: MYELODYSPLASTIC SYNDROME; MDS, ACUTE MYELOID LEUKEMIA; AML
Long-Term Follow-up Protocol
Recruiting
The main objective of this prospective, observational, long-term follow-up (LTFU) study is to evaluate the long-term safety profile of the gene therapy products evaluated by Krystal Biotech, Inc. which have a shared backbone of HSV-1, in participants who received at least one dose of investigational product (IP).
Gender:
All
Ages:
6 months and above
Trial Updated:
06/07/2021
Locations: Mission Dermatology Center, Rancho Santa Margarita, California
Conditions: Dystrophic Epidermolysis Bullosa, Recessive Dystrophic Epidermolysis Bullosa, Dominant Dystrophic Epidermolysis Bullosa
An Extension Study to Evaluate the Efficacy and Safety of HORIZANT in Adolescents With Moderate-to-Severe Primary RLS
Recruiting
The objectives of the trial are to evaluate the long-term efficacy and safety of HORIZANT (Gabapentin Enacarbil) 600 mg daily, for the treatment of RLS in adolescents (13 to 17 years of age) diagnosed with moderate-to-severe primary RLS.
Gender:
All
Ages:
Between 13 years and 17 years
Trial Updated:
06/07/2021
Locations: Stanford Sleep Medicine Center, Redwood City, California
Conditions: RLS
Sequential Dose-escalation Study to Assess the Safety, Tolerability and Pharmacokinetics of TB006 in Healthy Subjects
Recruiting
This is a single dose, dose-escalation study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of TB006, a monoclonal antibody that will be studied as a disease modifying treatment for Alzheimer's disease.
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
06/03/2021
Locations: Collaborative Neuroscience Research, LLC (CNS), Long Beach, California
Conditions: Alzheimer Disease
A Multi-center Randomized Control Cross-over Study to Evaluate the Safety and Effectiveness of the Dayspring Active Wearable Compression Device vs. an Advanced Pneumatic Compression Device for Treating Breast Cancer Related Lymphedema
Recruiting
To evaluate the Dayspring Active Wearable Compression Device in contrast to an advanced pneumatic compression device (APCD)
Gender:
All
Ages:
18 years and above
Trial Updated:
05/28/2021
Locations: PT works, Los Altos, California
Conditions: Lymphedema, Lymphedema of Upper Arm, Lymphedema, Breast Cancer
A Non-randomized, Open-Label Study to Evaluate the Safety and Effectiveness of the Dayspring Technology for Patients With Breast Cancer Related Lymphedema (BCRL) After Lymphatic Surgery
Recruiting
To evaluate the Dayspring Active Wearable Compression Technology in enhancing lymph movement and its safety and effectiveness after lymphatic surgery
Gender:
All
Ages:
18 years and above
Trial Updated:
05/18/2021
Locations: Dung Nguyen, MD, PharmD, Palo Alto, California
Conditions: Lymphedema, Lymphedema, Breast Cancer, Lymphedema Arm
Effects on Cellulite Appearance
Recruiting
Evaluate the safety and feasibility effecting the appearance of cellulite on the thigh using CoolSculpting.
Gender:
All
Ages:
Between 22 years and 65 years
Trial Updated:
05/05/2021
Locations: Innovation Research Center, Pleasanton, California
Conditions: Body Fat Disorder
Monitoring Treatment Response With On-board DWI During Neo-adjuvant Chemo-radiation for Rectal Cancer Using Magnetic Resonance-guided-radiotherapy Systems
Recruiting
feasibility of using a diffusion sequence of a MRgRT system as an early marker of treatment response during nRCT of rectal adenocarcinoma.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/05/2021
Locations: University of California Los Angeles (UCLA), Los Angeles, California
Conditions: Rectal Adenocarcinoma
Multidimensional Classification of Mild Traumatic Brain Injury (mTBI)
Recruiting
This study aims to explore possible solutions needed for valid and reliable multidimensional objective assessment tools to use in screening performers for concussions, as well as, for use postinjury assessment and management of the mild traumatic brain injury, regardless of time since injury occurrence. These mobile tools would also enable clinicians to test the effectiveness of the interventions used post-concussion, prior to fully releasing the performer back into full performance/active statu... Read More
Gender:
All
Ages:
Between 18 years and 50 years
Trial Updated:
04/30/2021
Locations: California State University, Los Angeles, Los Angeles, California
Conditions: Mild Traumatic Brain Injury
Botanical Blend on the Gut Microbiome and Gut-Skin-Axis in Small Intestinal Bacterial Overgrowth (SIBO)
Recruiting
The purpose of this study is to assess how an oral botanical blend alters the gut microbiome and the skin biophysical properties in people with SIBO.
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
04/29/2021
Locations: Integrative Skin Science and Research, Sacramento, California
Conditions: Small Intestinal Bacterial Overgrowth (SIBO)
Study Investigating the Efficacy of Crenolanib With Chemotherapy vs Chemotherapy Alone in R/R FLT3 Mutated AML
Recruiting
This is a randomized, multi-center, double-blind, placebo-controlled study designed to evaluate the efficacy of crenolanib administered following salvage chemotherapy, consolidation chemotherapy, post bone marrow transplantation and as maintenance in relapsed/refractory AML subjects with FLT3 activating mutation.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
04/28/2021
Locations: City of Hope National Medical Center, Sacramento, California
Conditions: Relapsed/Refractory Acute Myeloid Leukemia With FLT3 Activating Mutations
Cancer Therapy Effects on the Heart
Recruiting
Anthracycline chemotherapies (e.g. doxorubicin, daunorubicin) are commonly given to treat pediatric cancer, and carry a risk of cardiotoxicity. Over the long term, children who receive these therapies have an increased risk of heart failure and early cardiovascular death. However, current strategies for identifying patients who are at risk prior to the development of significant changes in heart function are limited. This study will focus on imaging markers of cardiac injury and dysfunction with... Read More
Gender:
All
Ages:
Between 13 years and 39 years
Trial Updated:
04/27/2021
Locations: Rady Children's Hospital, San Diego, California
Conditions: Cardiotoxicity, Pediatric Cancer, Heart Failure