California is currently home to 5954 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair
Recruiting
The objective of this trial is to assess the safety and effectiveness of the study device in subjects with degenerative mitral valve disease receiving a mitral valve repair without cardiopulmonary bypass (treatment group) when compared to subjects receiving mitral valve repair using standard surgical techniques with cardiopulmonary bypass (control group).
Gender:
All
Ages:
21 years and above
Trial Updated:
12/04/2019
Locations: Sutter Health/Alta Bates Summitt Medical Center, Oakland, California
Conditions: Mitral Valve Insufficiency
Laparotomy Versus Percutaneous Endoscopic Correction of Myelomeningocele
Recruiting
The purpose of this study is to evaluate the feasibility of a fetoscopic surgical technique for antenatal correction of fetal myelomeningocele. Two surgical approaches will be utilized. The percutaneous approach will be offered to participants with a posterior placenta. The laparotomy/uterine exteriorization approach will be offered to participants regardless of placental location.
Gender:
Female
Ages:
18 years and above
Trial Updated:
11/11/2019
Locations: University of Southern California / Huntington Memorial Hospital, Los Angeles, California
Conditions: Neural Tube Defects, Spina Bifida, Myelomeningocele, Chiari Malformation
MyHeart Counts Cardiovascular Health Study
Recruiting
The MyHeart Counts Cardiovascular Health Study will utilize mobile health capabilities of smartphones and wearables to assess daily activity measures of the general population and compare these to measures of cardiovascular health risk factors and fitness. How people divide their time among exercise, sedentary behavior, and sleep all affect cardiovascular health, yet to date these have largely gone unmeasured. With the advancement of phone sensors and wearable fitness tracking devices these fact... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/09/2019
Locations: Stanford University, Stanford, California
Conditions: Cardiovascular Health
REtroperitoneal SArcoma Registry: an International Prospective Initiative
Recruiting
Surgery is currently the only potentially curative treatment modality for localized retroperitoneal sarcoma (RPS). Available studies regarding oncologic outcomes are mainly retrospective in nature, and RPS are recognized as a rare disease. Therefore, prospective analysis of high quality data is a top priority. Primary Objectives of this study are: to prospectively collect standardized clinical data and radiological and pathological material from primary RPS patients treated with surgery at ref... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/11/2019
Locations: University of Southern California (USC), Los Angeles, California
Conditions: Retroperitoneal Sarcoma
Bicuspid Aortic Valve Stenosis Transcatheter Aortic Valve Replacement Registry
Recruiting
The objective of this study is to evaluate the procedural and clinical outcomes of patients with bicuspid aortic valve stenosis undergoing transcatheter aortic valve replacement.
Gender:
All
Ages:
Between 19 years and 129 years
Trial Updated:
02/07/2019
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Bicuspid Aortic Valve
SOLEMN Study - Synergy Optical Coherence Tomography in Left Main PCI
Recruiting
BACKGROUD: Percutaneous coronary intervention (PCI) is increasingly used to treat unprotected left main coronary artery stenosis. Protected LM PCI is considered standard of care in most centers. OCT allows for precise determination of stent placement, stent expansion and apposition. The pattern of vessel healing can be very precisely studied if immediate post-stent implantation OCT/IVUS data is compared to the 6-month post-PCI interval. While OCT cannot be optimally used for ostial lesion ima... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/14/2019
Locations: VA Long Beach Healthcare, Long Beach, California
Conditions: Percutaneous Coronary Intervention, Optical Coherence Tomography, In-stent Coronary Artery Restenosis
Impact of Unrestrictive Exercise Following Mid-Urethral Sling Surgery
Recruiting
To determine the impact of unrestricted postoperative activity on intermediate- and long-term continence outcomes of mid-urethral sling surgery in women with stress urinary incontinence. To assess the natural return to baseline activity level when patients are unrestricted following mid-urethral sling surgery with or without concomitant anterior or posterior pelvic organ prolapse repair.
Gender:
Female
Ages:
18 years and above
Trial Updated:
07/17/2018
Locations: Cedars-Sinai Medical Center, Beverly Hills, California
Conditions: Stress Urinary Incontinence
The Use of cineMRI to Evaluate Botox in Patients With Medication Refractory Overactive Bladder
Recruiting
With the goal of providing improved treatment to patients with overactive bladder symptoms (OAB), the investigators seek to apply the new technology of time-resolved (cine) MRI combined with urodynamics (UDS) to understand the exact effect of intravesical botulinum toxin on bladder physiology. The investigators will specifically aim to assess the physiological mechanism by which intravesical botulinum alleviates urgency and urge incontinence symptoms in women with OAB refractory to medical thera... Read More
Gender:
Female
Ages:
21 years and above
Trial Updated:
07/17/2018
Locations: Cedars-Sinai Medical Center, Beverly Hills, California
Conditions: Overactive Bladder
Does Bladder Instillation Reduce Time to Discharge After Sling Surgery
Recruiting
The purpose of this randomized control trial study is to determine if intraoperative bladder instillation of fluid decreases the time to discharge after having an outpatient mid-urethral sling procedure, and to measure the cost savings of this decrease in hospital stay. Charges will be broken down between recovery room charges and discharge area, as recovery room charges are significantly higher. The investigators suspect that a shorter time in the recovery room will translate into fewer charges... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
07/17/2018
Locations: Cedars-Sinai Medical Center, Beverly Hills, California
Conditions: Stress Urinary Incontinence
Treating Primary Sclerosing Cholangitis and Biliary Atresia With Vancomycin
Recruiting
The purpose of this study is twofold. First, is to determine whether vancomycin is effective in the early treatment of Biliary Atresia (BA) and Primary Sclerosing Cholangitis (PSC), and if so, by what mechanism. Secondly, to characterize human intestinal microbial communities and their interactions with the host.
Gender:
All
Ages:
Between 2 weeks and 40 years
Trial Updated:
11/10/2016
Locations: Sacramento Pediatric Gastroenterology, Sacramento, California
Conditions: Primary Sclerosing Cholangitis, Biliary Atresia
Neurobiologic, Immunologic, and Rheumatologic Markers in Youth With PANS
Recruiting
This study is an investigation of the neurologic, immunologic, and rheumatologic markers of Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS). PANS is a condition characterized by the abrupt, dramatic onset of obsessive compulsive disorder (OCD) and/or eating restriction accompanied by equally abrupt and severe co-morbid neuropsychiatric symptoms, which include anxiety, emotional lability, depression, irritability, aggression, oppositionality, deterioration in school performance, behavioral... Read More
Gender:
All
Ages:
Between 4 years and 18 years
Trial Updated:
10/05/2016
Locations: Stanford University, Palo Alto, California
Conditions: Pediatric Acute-Onset Neuropsychiatric Syndrome, Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections, PANS, PANDAS
Identification Genetic, Immunologic and Microbial Markers of Hirschsprung Associated Enterocolitis in Children With Hirschsprung Disease
Recruiting
To identify demographic, clinical, genetic, immunologic and/or microbial (i.e., fecal stream characterization) risk factors that influence the likelihood of development of the HAEC phenotype in children who carry the diagnosis of HD. The newly formed HAEC Collaborative Research Group (HCRG) will utilize the 4 participating centers in the current consortia and recruit additional centers to enroll children diagnosed with Hirschsprung disease. 1a: To recruit 200 patients with Hirschsprung disease... Read More
Gender:
All
Ages:
Between 1 day and 17 years
Trial Updated:
08/10/2016
Locations: Cedars-Sinai Medical Center 8723 Alden Drive, Suite 240, Los Angeles, California
Conditions: Hirschsprung Disease, Enterocolitis