Texas is currently home to 4891 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Houston, Dallas, San Antonio and Austin. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study of mRNA-1647 Cytomegalovirus Vaccine in Healthy Participants 9 to 15 Years of Age and Participants 16 to 25 Years of Age
Recruiting
The main purpose of study is to evaluate the safety and immunogenicity of different dose levels of mRNA-1647 versus control in healthy cytomegalovirus (CMV)-seronegative and CMV-seropositive female and male participants 9 to 15 years of age. In addition, mRNA-1647 will be evaluated in female participants 16 to 25 years as a comparator cohort.
Gender:
ALL
Ages:
Between 9 years and 25 years
Trial Updated:
06/27/2025
Locations: Tekton Research - Texas - PPDS, Austin, Texas
Conditions: Cytomegalovirus
A Study to Learn About the Safety, Effects and Pharmacokinetics of Study Medication (PF-07054894) for the Treatment of Ulcerative Colitis
Recruiting
This is a study to learn if the experimental medicine (called PF-07054894) is safe, effective, and how it is processed in adult people with ulcers in the colon.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/27/2025
Locations: Carta - Clinical Associates In Research Therapeutics Of America, San Antonio, Texas
Conditions: Ulcerative Colitis
Mocravimod as Adjunctive and Maintenance Treatment in AML Patients Undergoing Allo-HCT
Recruiting
This is a multi-center, randomized, double-blinded, placebo controlled trial.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/27/2025
Locations: Baylor Charles A. Sammons Cancer Center, Dallas, Texas
Conditions: Adult Acute Myeloid Leukemia
Tractography Guided Subcallosal Cingulate Deep Brain Stimulation for Treatment Resistant Depression
Recruiting
Treatment resistant depression remains a major problem for individuals and society. Surgical procedures may provide relief for some of these patients. The most frequently considered surgical approach is deep brain stimulation (DBS) of a part of the brain called the subcallosal cingulate region. However, the effectiveness and safety is not well established. The investigators will use a novel approach using advanced imaging technique (magnetic resonance tractography) to evaluate the feasibility an... Read More
Gender:
ALL
Ages:
Between 21 years and 70 years
Trial Updated:
06/27/2025
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Treatment Resistant Depression, Undergoing Deep Brain Stimulation (DBS) Surgery
Dapagliflozin Plus Pioglitazone in T1DM
Recruiting
Purpose: To examine the effect of addition of combination therapy with dapagliflozin plus pioglitazone to insulin on glucose control and plasma ketone concentration in patients with type 1 diabetes (T1DM) Research Design: 120 patients with type 1 diabetes who otherwise are healthy constitute the study population. After screening, eligible subjects will start 4 week run in. At week 4, subjects will receive dapagliflozin for 12 weeks. At week 16, subjects will be randomized to receive in a double... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/27/2025
Locations: University Health System Texas Diabetic Institute, San Antonio, Texas
Conditions: Type 1 Diabetes Mellitus
SGLT2i, Pioglitazone, and Ketone Production in T2D
Recruiting
To examine whether the empagliflozin-induced stimulation of EGP, lipolysis, and ketone production in T2D individuals can be blocked by pioglitazone (which has direct hepatic and adipose tissue effects).
Gender:
ALL
Ages:
Between 30 years and 75 years
Trial Updated:
06/26/2025
Locations: Texas Diabetes Institute/UH, San Antonio, Texas
Conditions: Type 2 Diabetes
SGLT2i, Ketoacidosis, Volume Contraction, and Insulinopenia
Recruiting
To examine the 2-HIT hypothesis that the SGLT2i-induced stimulation of EGP, lipolysis, and ketone production requires the combination of volume depletion plus insulinopenia in T2D individuals.
Gender:
ALL
Ages:
Between 30 years and 75 years
Trial Updated:
06/26/2025
Locations: Texas Diabetes Institute/UH, San Antonio, Texas
Conditions: Type 2 Diabetes
SGLT2i, Hepatic Glucose Production, and SNS
Recruiting
In this study, we will test the hypothesis that distinct mechanisms account for the SGLT2i-induced stimulation of ketogenesis and lipolysis versus endogenous (hepatic) glucose production in patients with type 2 diabetes (T2D) and type 1 diabetes (T1D), and that the increases in ketone production and lipolysis can be prevented by concomitant administration of the thiazolidinedione pioglitazone. We will conduct five distinct experiments to test this hypothesis in patients with T2D and T1D. Sub-st... Read More
Gender:
ALL
Ages:
Between 30 years and 75 years
Trial Updated:
06/26/2025
Locations: Texas Diabetes Institute/UH, San Antonio, Texas
Conditions: Type 2 Diabetes
Recovery Through Inspiration, Support, and Empowerment
Recruiting
The goal of this pilot study is to test the effectiveness of a novel intervention for young adults (ages 18-27) with mental health conditions who have been released from an acute care psychiatric facility. The intervention aims to reduce suicidality, depression, anxiety, re-hospitalization, and improve mental health recovery by using outpatient services. The current standard of care (SOC) for these patients at discharge includes a discharge plan with a list of their medications, anticipated out... Read More
Gender:
ALL
Ages:
Between 18 years and 27 years
Trial Updated:
06/26/2025
Locations: The University of Texas Southwestern Medical Center, Dallas, Texas
Conditions: Suicidal Ideation, Suicide Attempt, Anxiety, Depression Disorders
Lymphedema Prevention Through Immediate Lymphatic Reconstruction (LILY) Trial.
Recruiting
To learn if reconstruction of the lymphatic system at the time of axillary lymphadenectomy can reduce the risk of developing lymphedema.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/26/2025
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Lymphedema
HB-adMSCs vs Placebo for the Treatment of Juvenile Idiopathic Arthritis
Recruiting
Methodology: Randomized, double-blind, AB/BA cross-over study with a washout period of 12 weeks. Treatment Duration: 8 weeks per group General Objectives: To assess the efficacy and safety of multiple intravenous infusions of allogeneic HB-adMSCs by improving signs and symptoms of juvenile idiopathic arthritis in this subject population. Number of Subjects: 66 (6 subjects in Cohort 1 and 60 subjects in Cohort 2) Indication: Juvenile Idiopathic Arthritis
Gender:
ALL
Ages:
Between 2 years and 16 years
Trial Updated:
06/26/2025
Locations: Hope Biosciences Research Foundation, Sugar Land, Texas
Conditions: Juvenile Idiopathic Arthritis (JIA)
A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Systemic Lupus Erythematosus
Recruiting
Phase 1b, open-label study of CLN-978 administered subcutaneously in patients with Moderate to Severe Systemic Lupus Erythematosus (SLE).
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/26/2025
Locations: Cullinan Investigative Site, Plano, Texas
Conditions: SLE, SLE (Systemic Lupus)