California is currently home to 5955 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study of Pembrolizumab+ sEphB4 in Metastatic Urothelial Carcinoma
Recruiting
sEphB-HSA may prevent tumor cells from multiplying and blocks several compounds that promote the growth of blood vessels that bring nutrients to the tumor. The purpose of this study is to evaluate the combination of Pembrolizumab + sEphB4-HSA in the population of patients with previously untreated advanced (metastatic or recurrent) urothelial carcinoma who are chemotherapy ineligible or who refuse chemotherapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/11/2022
Locations: Sarcoma Oncology Center, Santa Monica, California
Conditions: Metastatic Urothelial Carcinoma
A Study of sEphB4-HSA in Kaposi Sarcoma
Recruiting
sEphB-HSA may prevent tumor cells from multiplying and blocks several compounds that promote the growth of blood vessels that bring nutrients to the tumor. The purpose of this study is to learn if sEphB4-HSA will decrease the number or size of Kaposi sarcoma lesions in people.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/11/2022
Locations: AIDS Healthcare Foundation, Beverly Hills, California
Conditions: Kaposi Sarcoma
Cyclophosphamide and Dexamethasone for the Treatment of Metastatic Castration Resistant Prostate Cancer
Recruiting
This phase I trial tests the safety and side effects of cyclophosphamide given together with dexamethasone in treating patients with castration resistant prostate cancer that has spread to other places in the body (metastatic). Chemotherapy drugs, such as cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving low doses of cyclophosphamide daily may reduce side effects. Dex... Read More
Gender:
Male
Ages:
18 years and above
Trial Updated:
10/08/2022
Locations: University of California Davis Comprehensive Cancer Center, Sacramento, California
Conditions: Castration-Resistant Prostate Carcinoma, Metastatic Prostate Adenocarcinoma, Stage IVB Prostate Cancer American Joint Committee on Cancer (AJCC) v8
Percutaneous Endoluminal Benign Biliary Laser
Recruiting
This study is being done to evaluate the safety and efficacy of Percutaneous transhepatic cholangioscopic (PTCS) laser incision as an ancillary therapy to traditional approaches such as balloon dilation and large drain placement for Benign Biliary Strictures (BBS). Narrowing or blockage of the bile ducts (biliary stricture) is a difficult to treat medical condition that leads to life-threatening complications. Treatment usually involves multiple procedures or surgeries spanned over months or ye... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/07/2022
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Benign Biliary Strictures With Current or Prior Biliary Obstruction
Pembrolizumab Administered Via the Sofusa® DoseConnect™ in Patients With Relapsed/Refractory Cutaneous T-cell Lymphoma.
Recruiting
In this pilot study, pembrolizumab will be administered via DoseConnect in patient with relapsed or refractory cutaneous T-cell lymphoma to assess through pharmacodynamic assessment in the tumor tissue to assess if lymphatic delivery of pembrolizumab using Sofusa DoseConnect is feasible.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/07/2022
Locations: City of Hope, Duarte, California
Conditions: Mycosis Fungoides
An Intervention to Reduce Risk Factors for Adolescent Pregnancy
Recruiting
Investigators will assess the preliminary effects of Girls Invest, an innovative savings intervention that aims to reduce economic, social, and health behavior risks associated with disproportionately high rates of pregnancy among US Latina adolescents. Girls Invest involves a multidisciplinary conceptual model adapting the most effective prevention strategies from the disciplines of public health and economics. Participants receive a savings account (via our collaborating bank) with $100 deposi... Read More
Gender:
Female
Ages:
Between 15 years and 22 years
Trial Updated:
10/06/2022
Locations: San Diego State University, San Diego, California
Conditions: Behavioral Changes
Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age
Recruiting
This study will establish the relationship between magnitude of opioid exposure and a pupillary measure referred to as PUAL (pupillary unrest in ambient light), in subjects aged 40-60. Previous investigation demonstrated that loss of PUAL was a sensitive, discriminative indicator of opioid toxicity and respiratory depression among subjects aged 20-40 years old. Population data indicate that pupil size and PUAL decline slightly with age. The investigators will explore whether PUAL proves to be a... Read More
Gender:
All
Ages:
Between 40 years and 60 years
Trial Updated:
10/04/2022
Locations: University of California San Francisco, San Francisco, California
Conditions: Opioid Toxicity, Pupillary Miosis, Respiratory Depression
Surveillance AFter Extremity Tumor surgerY
Recruiting
Following treatment for a primary extremity sarcoma, patients remain at risk for the development of local and systemic disease recurrence. Metastasis (distant recurrence) to the lung is the most frequent single location of disease recurrence in sarcoma patients, occurring in almost half of all patients. Therefore, careful post-operative surveillance is an integral element of patient care. However, the detection of metastases does not necessarily affect long-term survival and may negatively impac... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/04/2022
Locations: University of California Davis Medical Center, Sacramento, California
Conditions: Soft Tissue Sarcoma, Lung Metastases
Does the Cap Increase the Finding of Polyps When Water Exchange Colonoscopy is Used
Recruiting
This is a study to compare two different, but normally, used methods of colonoscopy in patients that require a routine or repeat colonoscopy. There will be three arms in this study: WE water control, water plus Cap-1, and water plus Cap-2. The patient will prepare himself/herself for the colonoscopy as per normal instructions and he/she will be given the information for the study at that time so that he/she can make a decision to participate in the study. The control method will use water instea... Read More
Gender:
All
Ages:
Between 50 years and 75 years
Trial Updated:
10/04/2022
Locations: Sacramento VAMC, VA Northern California Healthcare System, Mather, California
Conditions: Colonoscopy, Polyp of Colon
Progressive Myopia Treatment Evaluation for NaturalVue Multifocal Contact Lens Trial
Recruiting
This is a multi-center, randomized, double-masked clinical trial. All study devices are market approved/cleared in the localities where the study is conducted. Subjects will be randomly assigned to wear NaturalVue Sphere single vision contact lenses (SVCL) or NaturalVue Multifocal (NVMF) soft contact lenses for a total of three years.
Gender:
All
Ages:
Between 7 years and 13 years
Trial Updated:
10/03/2022
Locations: Fig Garden Optometry, Fresno, California
Conditions: Myopia
A Clinical Evaluation of the MicroSTent® PeripherAl Vascular SteNt in Subjects With Arterial Disease Below the Knee (STAND)
Recruiting
Randomized multicenter clinical trial consisting of two arms; one arm treated with PTA plus the MicroStent® System and one arm treated with PTA alone. Purpose to evaluate the safety and effectiveness of using the MicroStent® Peripheral Vascular Stent System, hereafter referred to as the MicroStent® System, for the treatment of infrapopliteal lesions in subjects with peripheral arterial disease.
Gender:
All
Ages:
21 years and above
Trial Updated:
10/03/2022
Locations: St. Helena Hospital, Saint Helena, California
Conditions: Peripheral Arterial Disease
Safety and Efficacy Study of BRIMOCHOL™ PF and Carbachol PF in Subjects With Emmetropic Phakic and Pseudophakic Presbyopia
Recruiting
Safety and Efficacy Study of BRIMOCHOL™ PF and Carbachol PF in Subjects With Emmetropic Phakic and Pseudophakic Presbyopia
Gender:
All
Ages:
Between 45 years and 80 years
Trial Updated:
09/30/2022
Locations: Visus Therapeutics Investigative Site, Glendale, California
Conditions: Presbyopia