California is currently home to 5930 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Recording of Intraoperative Spinal Cord Stimulation and Monitoring
Recruiting
Opioid overdose suppresses brainstem respiratory circuits, causes apnea, and may result in death. Epidural electrical stimulation (EES) at the cervical spinal cord facilitated motor activity in rodents and humans, and we hypothesized that EES of the cervical spinal cord could antagonize opioid-induced respiratory depression in humans. In this study, we will stimulate the spinal cord during surgery and assess its effects on respiratory function in human patients.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/28/2022
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Cervical Stenosis, Disk, Herniated, Spondylosis
Multi-Atlas and Whole Body Radiomics Approaches for Image-Guided Treatment of Gynecologic Cancers
Recruiting
To compare acute toxicity and chemotherapy delivery for atlas-based IG-IMRT vs. PET/CT-based IG-IMRT vs. conventional RT, and assess the impact of treatment on changes in hematopoietic compensatory response. To develop and validate machine learning and radiomics techniques for dose accumulation, automated treatment planning, and prediction of treatment response.
Gender:
Female
Ages:
18 years and above
Trial Updated:
04/27/2022
Locations: University of California, San Diego, La Jolla, California
Conditions: Gynecologic Cancer
High Intensity Ultrasound for the Treatment of Upper Inner Arm Skin Laxity
Recruiting
Upper inner arms of enrolled subjects will be randomized to two (2) treatment groups: Sofwave and Ultherapy, with subjects receiving treatment with one device on their right side and the other on their left.
Gender:
All
Ages:
Between 35 years and 70 years
Trial Updated:
04/27/2022
Locations: Cosmetic Laser Dermatology, San Diego, California
Conditions: Skin Laxity
Mesenchymal Stem Cells for the Treatment of Various Chronic and Acute Conditions
Recruiting
This multi-arm, multi-site study investigates the safety, tolerability, and efficacy of stem cell therapy for the treatment of various acute and chronic conditions. Clinically observed initial findings and an extensive body of research indicate regenerative treatments are both safe and effective for the treatment of multiple conditions.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/27/2022
Locations: Southern California Hospital at Culver City / Southern California Hospital at Hollywood / Multiple US-based Sub-Investigator Sites, Culver City, California
Conditions: Autoimmune Diseases, Cardiovascular Disorders, Diabetes Complications, Integumentary Disease, Musculoskeletal Disorders, Neurodegenerative Disorders, Neurologic Disorders, Pulmonary Disorders, Sexual Dysfunction, Urologic Disorders, Viral Illness
Clinical Investigation of K'Watch - Lab & Home Study
Recruiting
This study categorized as a non significant risk trial is a monocentric, prospective, open-label comparative, paired-design trial aims to evaluate the performance and the tolerance of K'Watch CGM system in comparison with conventional reference (YSI system, BGM system and CGM systems ) . This trial will be conducted on patients with Type 1 and 2 of diabetes for 8 days.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
04/25/2022
Locations: AMCR Institute, San Diego, California
Conditions: Diabetes
Evaluation of Novel Cardio-Pulmonary Physiological Monitor, the VQm PHM™, for Acute Care Medicine
Recruiting
This is a prospective, observational study to assess agreement of pulmonary health parameters measured by a new non-invasive physiologic monitor, the VQm pulmonary health monitor (PHM)™ with clinical gold standards.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
04/25/2022
Locations: UC Davis Medical Center, Sacramento, California
Conditions: Elective Procedures Requiring Mechanical Ventilation
Appraising the Embolization of Aneurysms Using Balt Optima™ Coil System (APPLY Study)
Recruiting
In recent years, many developments have been made to the tools and techniques used to treat IAs via endovascular intervention. Specifically, to the detachable coils themselves. In March 2018, the US Food and Drug administration granted Balt USA 510(k) clearance for the Optima Coil System™. Earlier this year, the list of devices included within the system has expanded to include OptiMAX Complex Super Soft and Complex Soft coils. It consists of coils that come in Standard, Soft and Super Soft prof... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/25/2022
Locations: Vascular Neurology of Southern California, Thousand Oaks, California
Conditions: Aneurysm, Intracranial Aneurysm, Ruptured Aneurysm, Subarachnoid Hemorrhage, Aneurysmal, Cerebral Aneurysm Unruptured
Trial of Pirfenidone to Prevent Progression in Chronic Kidney Disease
Recruiting
Kidney disease is a global health problem, affecting more than 10% of the world's population and more than half of adults over 70 years of age in the United States. Persons with kidney disease are at higher risk for cardiovascular disease, heart failure, physical function decline, and mortality. Kidney scarring is a dominant factor in the development of kidney disease. Our group has evaluated several tests to determine the severity of scarring without requiring kidney biopsies, using MRI imaging... Read More
Gender:
All
Ages:
21 years and above
Trial Updated:
04/25/2022
Locations: VA San Diego Healthcare System, San Diego, California
Conditions: Chronic Kidney Disease
Point-of-care Lung Ultrasound (POCUS)-Integrated Study of Admitted Patients With COVID-19
Recruiting
This study seeks to define the ultrasound profile of patients with COVID-19, and document the progression of these ultrasound findings to develop prognostication and clinical decision instruments that can help guide management of patient with COVID-19. Primary aims include the development of ARDS, refractory hypoxemia, acute cardiac injury, pulmonary embolism, pneumothorax or death. Secondary aims include potential change in CT and plain film utilization given the use of POCUS, as well as emerge... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/22/2022
Locations: UCLA-Ronald Reagan, Los Angeles, California
Conditions: Lung Injury, ARDS, Acute Cardiac Event, Covid19, Ultrasound, Hypoxemia, Acute Respiratory Distress Syndrome
Lemborexant Shift Work Treatment Study
Recruiting
Insomnia and daytime sleepiness are common complaints among night shift workers, but effective sleep treatments in shift workers are lacking. The aim of this Phase IV double-blind, placebo-controlled, randomized study is to test whether a dual orexin antagonist, Lemborexant (5mg or 10mg), which would be expected to block the clock-driven orexin-mediated wakefulness during the day, will increase daytime sleep time in shift workers who complain of difficulty sleeping during the daytime compared to... Read More
Gender:
All
Ages:
Between 20 years and 60 years
Trial Updated:
04/19/2022
Locations: University of California, San Francisco, San Francisco, California
Conditions: Shift-Work Related Sleep Disturbance
PRP as Adjuvant Treatment to CTR for Severe CTS Tunnel Syndrome
Recruiting
This study assesses the potential benefit of adjuvant platelet-rich plasma (PRP) with carpal tunnel release (CTR) for patients with severe carpal tunnel syndrome (CTS). CTR is a rather common procedure performed and seems to be quite effective for those with moderate CTS, but a number of patients with severe CTS do not have quite the same response post-CTR. The investigators will recruit patients who fall into the severe CTS category and compare CTR with and without adjuvant PRP to see if PRP ca... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/18/2022
Locations: Stanford University, Redwood City, California
Conditions: Carpal Tunnel Syndrome, PRP
Clinical and Genetic Analysis of ROP
Recruiting
Retinopathy of Prematurity (ROP) is a vascular disease affecting the retinas (back of the eye) of low birth weight infants. Although it can be treated effectively if diagnosed early, it continues to be a leading cause of childhood blindness in the United States and throughout the world. The investigators feel that this study will result in specific knowledge discovery about ROP, as well as general knowledge about how image-based data and genetic data can be combined to better understand clinical... Read More
Gender:
All
Ages:
1 year and below
Trial Updated:
04/18/2022
Locations: Stanford University, Palo Alto, California
Conditions: Retinopathy of Prematurity