California is currently home to 5930 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
SMILE (Small Incision Lenticule Extraction) in the DoD (Department of Defense)
Recruiting
The Use of the VisuMaxTM Femtosecond Laser Small-Incision Lenticule Extraction (SMILE) Procedure for the Correction of Myopia with or without Astigmatism study is a prospective, non-randomized, multicenter clinical study that will be conducted by the Navy Refractive Surgery Center, Naval Medical Center San Diego, CA in collaboration with the U.S. Air Force 59th Medical Wing, Wilford Hall Eye Center, TX, and the U.S. Army Warfighter Refractive Eye Surgery Program and Research Center, Fort Belvoir... Read More
Gender:
All
Ages:
22 years and above
Trial Updated:
04/14/2022
Locations: Navy Warfighter Refractive Surgery Center, San Diego, California
Conditions: Myopia, Astigmatism
TruGraf and TRAC In Pediatrics Study
Recruiting
This is a pilot 3 center prospective study of pediatric renal kidney recipients undergoing protocol biopsies examining the performance of the TruGraf gene expression test in children and adolescents.
Gender:
All
Ages:
Between 1 year and 18 years
Trial Updated:
04/12/2022
Locations: UCLA Mattel Children's Hospital, Los Angeles, California
Conditions: Kidney Transplant Rejection
A Study of RX108 in Patients With Locally Advanced or Metastatic Solid Tumors
Recruiting
RX108 is a novel, potent, small-molecule inhibitor of Na+/K+-ATPase. The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK) and efficacy of RX108 in patients with locally advanced or metastatic solid tumors.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/12/2022
Locations: Cedars-Sinai, Los Angeles, California
Conditions: Locally Advanced Solid Tumors, Metastatic Solid Tumors
Adipose-Derived Biocellular Regenerative Therapy for Osteoarthritis
Recruiting
Use of Biocellular and cellular approaches to treatment of Osteoarthritis (OA), musculoskeletal aging processes, pain, and degenerative changes are to be studied with minimally invasive protocols, and non-pharmaceutical means to relieve OA and its associated issues. Traditional surgical interventions have not yielded convincing long-term outcomes, including total joint replacement surgeries and medical management of the supportive structures. This study is to use a person's own stem/stromal Cel... Read More
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
04/07/2022
Locations: Hemwall Center for Orthopedic Regenerative Medicine, Valencia, California
Conditions: Osteoarthritis, Osteo Arthritis Knee, Osteo Arthritis Shoulders, Osteoarthritis of Multiple Joints, Osteoarthritis, Hip, Osteoarthritis - Ankle/Foot
Dynamic Vision Testing and Concussion Management Dream Team 65
Recruiting
The purpose of this study is to determine the value of including dynamic vision testing into California State University, Northridge (CSUN) Athletics' established concussion protocol. The study's hypotheses are 1) dynamic vision testing will reveal vision impairments right after a person sustains a concussion, 2) these impairments may still be present upon clearance to return to play.
Gender:
All
Ages:
All
Trial Updated:
04/06/2022
Locations: California State University, Jacranda Hall 1578, 1576, 1574, Northridge, California
Conditions: Head Injury, Sport Injury, Concussion, Brain
Amyloid Prediction in Early Stage Alzheimer's Disease Through Speech Phenotyping - PAST Extension
Recruiting
The primary objective of the study is to evaluate whether a set of algorithms analysing acoustic and linguistic patterns of speech can detect amyloid-specific cognitive impairment in early stage Alzheimer's disease, based on archival spoken or written language samples, as measured by the area under the curve (AUC) of the receiver operating characteristic curve of the binary classifier distinguishing between amyloid positive and amyloid negative arms. Secondary objectives include (1) evaluating h... Read More
Gender:
All
Ages:
Between 50 years and 85 years
Trial Updated:
04/06/2022
Locations: Syrentis Clinical Research, Santa Ana, California
Conditions: Alzheimer Disease, Alzheimer's Disease (Incl Subtypes), Preclinical Alzheimer's Disease, Prodromal Alzheimer's Disease, Mild Cognitive Impairment, Normal Cognition
Introducing Palliative Care (PC) Within the Treatment of End Stage Liver Disease (ESLD)
Recruiting
This is a comparative effectiveness study of two pragmatic models aiming to introduce palliative care for end stage liver disease patients. The 2 comparators are: Model 1: Consultative Palliative Care (i.e. direct access to Palliative Care provider), Model 2: Trained Hepatologist- led PC intervention (i.e. a hepatologist will receive formal training to deliver Palliative Care services) Primary Outcome: The change in quality of life from baseline to 3 months post enrollment as assessed by FACT-... Read More
Gender:
All
Ages:
Between 18 years and 120 years
Trial Updated:
04/05/2022
Locations: UCSF Fresno, Fresno, California
Conditions: End Stage Liver Disease
Descartes-08 Consolidation Treatment in Patients With High-Risk Multiple Myeloma Who Have Residual Disease After Induction Therapy
Recruiting
To assess Minimal Residual Disease (MRD)-negative Complete Response (sCR) rate after consolidation treatment with Descartes-08 in patients with high-risk myeloma who have residual disease following induction therapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/04/2022
Locations: University of California Irvine, Orange, California
Conditions: Myeloma Multiple
UCLA Breast Cancer Survivor Health Promotion Research Study
Recruiting
Pilot randomized controlled parallel group behavior change comparative effectiveness trial involves 30 breast cancer survivors interested in losing excess body fat. Both interventions include dietary + exercise prescriptions that hold promise for reducing the survivors' risk of cancer recurrence. Both interventions are consistent with the Dietary Guidelines for Americans but the Diabetes Prevention Program (DPP)-based approach focuses on weight loss through calorie restriction and increased phys... Read More
Gender:
Female
Ages:
Between 50 years and 75 years
Trial Updated:
04/01/2022
Locations: UCLA Center for Cancer Prevention & Control Research, Los Angeles, California
Conditions: Breast Cancer
MeSenteric SpAring Versus High Ligation Ileocolic Resection for the Prevention of REcurrent Crohn's DiseaSe (SPARES)
Recruiting
Study description - Patients will be randomized according to post-operative recurrence risk to either a high ligation of ileocolic artery or mesenteric sparing ileocolic resection for terminal ileal Crohn's disease. The primary endpoint 6-month endoscopic recurrence. Endpoints - Primary endpoint; 6 months Secondary endpoints at 1 and 5 years post ileocecal resection Study population - Adult Crohn's disease patients with medically refractory terminal ileal Crohn's disease undergoing a primary i... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
04/01/2022
Locations: Cedars-Sinai Hospital System, Los Angeles, California
Conditions: Crohn Disease
A Proprioceptive Training Program Using an Uneven Terrain Treadmill for Patients With Ankle Instability
Recruiting
The ROCKY REHAB trial will provide a pragmatic approach to evaluate if incorporating a rocky, uneven terrain treadmill into the proprioceptive rehabilitation received during physical therapy can improve outcomes and reduce reinjury rates in patients with ankle instability.
Gender:
All
Ages:
Between 18 years and 49 years
Trial Updated:
03/30/2022
Locations: Naval Hospital Camp Pendelton, Oceanside, California
Conditions: Instability; Ankle (Ligaments) (Old Injury), Sprain of Ankle
Digitally-Captured Step Counts for Evaluating Performance Status in Advanced Cancer Patients
Recruiting
The purpose of this study is to examine the relationships between objectively measured physical activity and provider-assessed and patient-reported functional outcomes in patients with advanced cancer. Findings from this study will help us better understand how change in daily physical activity, as measured using the wearable activity monitor, is related to change in a patient's functional status and clinical condition.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/30/2022
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Cancer, Cancer, Metastatic, Neoplasms