California is currently home to 5803 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Prospective Observational International Registry of Patients With Newly Diagnosed Peripheral T Cell Lymphoma.
Recruiting
This study T-Cell Project 2.0 is based on the former International PTCL study designed by the International T-cell Non-Hodgkin's Lymphoma Study Group (T-Cell Project 1.0: Prospective Collection of Data in Patients With Peripheral T-Cell Lymphoma) as a prospective collection of data to predict the prognosis of patients with the more frequent subtypes of PTCL. It is a prospective, longitudinal, international, observational study of patients with newly diagnosed peripheral T-cell lymphoma aiming to... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/08/2020
Locations: Stanford University, Stanford, California
Conditions: Peripheral T-Cell Lymphoma
Study of Crenolanib vs Midostaurin Following Induction Chemotherapy and Consolidation Therapy in Newly Diagnosed FLT3 Mutated AML
Recruiting
A phase III randomized multi-center study designed to compare the efficacy of crenolanib with that of midostaurin when administered following induction chemotherapy, consolidation chemotherapy and bone marrow transplantation in newly diagnosed AML subjects with FLT3 mutation. About 510 subjects will be randomized in a 1:1 ratio to receive either crenolanib in addition to standard first line treatment of AML (chemotherapy and if eligible, transplantation) (arm A) or midostaurin and standard treat... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
05/21/2020
Locations: City of Hope National Medical Center, Duarte, California
Conditions: Newly Diagnosed FLT3 Mutated AML
Filter Initial & Long Term Evaluation After Placement and Retrieval Registry
Recruiting
A prospective data registry for all patients who undergo IVC (Inferior Vena Cava) filter placement or retrieval at Stanford. Potential enrollees will already be undergoing the procedure. If patients are willing, they will be prospectively enrolled prior to the procedure. As part of the study, chart and clinical data reviews will be used to track patient progress and response to the treatment.
Gender:
All
Ages:
All
Trial Updated:
05/09/2020
Locations: Stanford University School of Medicine, Stanford, California
Conditions: Venous Thromboembolism
Epigenetic Regulation of Altered T-cell Immunity in Sarcoidosis
Recruiting
Sarcoidosis is a multi-system granulomatous disorder that is triggered and influenced by gene-environment interactions. Although sarcoidosis predominantly affects the lungs in most cases, the clinical disease course is highly variable and any organ can be affected leading to end organ damage despite currently available therapeutics that unfortunately also have numerous and potentially devastating side effects. The environmental triggers of sarcoidosis are unknown but several occupational, enviro... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
05/04/2020
Locations: University of California, San Francisco (Parnassus), San Francisco, California
Conditions: Sarcoidosis, Sarcoidosis, Pulmonary
Biocellular-Cellular Regenerative Treatment Scaring Alopecia and Alopecia Areata
Recruiting
The primary objective of this study is to evaluate the safety and efficacy of the use of a biocellular mixture of emulsified adipose-derived tissue stromal vascular fraction (AD-tSVF) and high density platelet-rich plasma concentrate (HD- PRP). Additionally, comparison with clinical outcomes of adipose-derived cellular Stromal Vascular Fraction (AD-cSVF) + AD-tSVF + HD PRP; AD-cSVF + emulsified AD-tSVF + HD- PRP; emulsified AD-tSVF + HD PRP + AD-cSVF; AD-cSVF via intravenous infusion in treatmen... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
04/15/2020
Locations: Kenneth Williams, DO, Irvine, California
Conditions: Alopecia Areata, Scarring Alopecia
Gentamicin for Junctional Epidermolysis Bullosa
Recruiting
Herlitz junctional epidermolysis bullosa (H-JEB), an incurable, fatal, inherited skin disease, is caused by loss-of-function mutations in the LAMA3, LAMB3 or LAMC2 genes, resulting in loss of laminin 332 and poor epidermal-dermal adherence. Eighty percent of H-JEB patients have LAMB3 mutations and about 95% of these are nonsense mutations. The investigators recently demonstrated that gentamicin readily induced nonsense mutation readthrough and produced full-length laminin beta3 in several nonsen... Read More
Gender:
All
Ages:
All
Trial Updated:
04/03/2020
Locations: University of Southern California, Los Angeles, California
Conditions: Junctional Epidermolysis Bullosa
Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair
Recruiting
The objective of this trial is to assess the safety and effectiveness of the study device in subjects with degenerative mitral valve disease receiving a mitral valve repair without cardiopulmonary bypass (treatment group) when compared to subjects receiving mitral valve repair using standard surgical techniques with cardiopulmonary bypass (control group).
Gender:
All
Ages:
21 years and above
Trial Updated:
12/04/2019
Locations: Sutter Health/Alta Bates Summitt Medical Center, Oakland, California
Conditions: Mitral Valve Insufficiency
Laparotomy Versus Percutaneous Endoscopic Correction of Myelomeningocele
Recruiting
The purpose of this study is to evaluate the feasibility of a fetoscopic surgical technique for antenatal correction of fetal myelomeningocele. Two surgical approaches will be utilized. The percutaneous approach will be offered to participants with a posterior placenta. The laparotomy/uterine exteriorization approach will be offered to participants regardless of placental location.
Gender:
Female
Ages:
18 years and above
Trial Updated:
11/11/2019
Locations: University of Southern California / Huntington Memorial Hospital, Los Angeles, California
Conditions: Neural Tube Defects, Spina Bifida, Myelomeningocele, Chiari Malformation
MyHeart Counts Cardiovascular Health Study
Recruiting
The MyHeart Counts Cardiovascular Health Study will utilize mobile health capabilities of smartphones and wearables to assess daily activity measures of the general population and compare these to measures of cardiovascular health risk factors and fitness. How people divide their time among exercise, sedentary behavior, and sleep all affect cardiovascular health, yet to date these have largely gone unmeasured. With the advancement of phone sensors and wearable fitness tracking devices these fact... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/09/2019
Locations: Stanford University, Stanford, California
Conditions: Cardiovascular Health
REtroperitoneal SArcoma Registry: an International Prospective Initiative
Recruiting
Surgery is currently the only potentially curative treatment modality for localized retroperitoneal sarcoma (RPS). Available studies regarding oncologic outcomes are mainly retrospective in nature, and RPS are recognized as a rare disease. Therefore, prospective analysis of high quality data is a top priority. Primary Objectives of this study are: to prospectively collect standardized clinical data and radiological and pathological material from primary RPS patients treated with surgery at ref... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/11/2019
Locations: University of Southern California (USC), Los Angeles, California
Conditions: Retroperitoneal Sarcoma
Bicuspid Aortic Valve Stenosis Transcatheter Aortic Valve Replacement Registry
Recruiting
The objective of this study is to evaluate the procedural and clinical outcomes of patients with bicuspid aortic valve stenosis undergoing transcatheter aortic valve replacement.
Gender:
All
Ages:
Between 19 years and 129 years
Trial Updated:
02/07/2019
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Bicuspid Aortic Valve
Impact of Unrestrictive Exercise Following Mid-Urethral Sling Surgery
Recruiting
To determine the impact of unrestricted postoperative activity on intermediate- and long-term continence outcomes of mid-urethral sling surgery in women with stress urinary incontinence. To assess the natural return to baseline activity level when patients are unrestricted following mid-urethral sling surgery with or without concomitant anterior or posterior pelvic organ prolapse repair.
Gender:
Female
Ages:
18 years and above
Trial Updated:
07/17/2018
Locations: Cedars-Sinai Medical Center, Beverly Hills, California
Conditions: Stress Urinary Incontinence