California is currently home to 5930 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study to Evaluate Effects of INL1 in Patients With Heart Failure and Reduced Ejection Fraction
Recruiting
This is a multicenter, randomized, double-blind, placebo-controlled, dose-response trial in patients with chronic stable Heart Failure (HF) and reduced Left Ventricular Ejection Fraction (LVEF) to evaluate the efficacy and safety of three INL1 doses compared with placebo. Patients will be treated for approximately 12 weeks with one of three INL1 doses: 50 mg, 150 mg, 300 mg, or, placebo capsules, taken twice daily (BID).
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
03/28/2022
Locations: UCLA School of Medicine, Torrance, California
Conditions: Heart Failure, Reduced Ejection Fraction
Bright Light as a Countermeasure for Circadian Desynchrony
Recruiting
Light is the primary means by which the internal circadian clock remains aligned ("entrained") with the external world. Misalignment of this internal clock can occur during situations such as shift work and jet travel across multiple time zones (jet lag). The purpose of this study is to examine how sequences of brief flashes of light can affect entrainment of the clock.
Gender:
All
Ages:
Between 18 years and 35 years
Trial Updated:
03/28/2022
Locations: VA Palo Alto Health Care System, Palo Alto, California
Conditions: Healthy
NA-AION Risk Factors: New Perspectives
Recruiting
The purpose of the study is to use new diagnostic methods (OCT and OCT-A) to shed light on risk factors for the development of NA-AION. The risk factors we are focusing on are comorbidities along with anatomical and vascular characteristics of the optic nerve.
Gender:
All
Ages:
11 years and above
Trial Updated:
03/22/2022
Locations: Stanford Medicine, Palo Alto, California
Conditions: Non-arteritic Ischemic Optic Neuropathy, Optic Disk Drusen
Study of Safety and Efficacy of ANG-3070 in Chronic Kidney Disease
Recruiting
The major objective is to demonstrate the safety and efficacy of ANG-3070 in patients with primary glomerular disease and persistent proteinuria.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/22/2022
Locations: Amicis Reserach Center, Northridge, California
Conditions: Glomerular Disease, Proteinuria
Capsule Endoscopy for Severe Hematochezia
Recruiting
Patients with severe hematochezia (bright red blood per rectum) may have a bleeding source proximal to the colon. Visualization of the entire gastrointestinal tract using a second-generation colon capsule endoscopy system could improve diagnostic yields and form the basis for a new approach to early diagnosis that could change guidelines and practice management in these patients. The hypothesis of this study is that urgent colon capsule endoscopy will have higher rates of lesion localization and... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/21/2022
Locations: VA Greater Los Angeles Healthcare System, Los Angeles, California
Conditions: Hematochezia
Standard Endoscopic Hemostasis Versus OVESCO Severe Non-variceal UGI Hemorrhage
Recruiting
The primary specific aim is to perform a randomized controlled trial (RCT) to compare 30 day rebleed rates and other clinical outcomes of patients with severe, non-variceal upper GI hemorrhage (NVUGIH) - ulcers and Dieulafoy's lesions who are randomized as initial treatment with the new large over-the-scope-clip device for endoscopic hemostasis versus standard endoscopic hemostasis.
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
03/21/2022
Locations: VA Greater Los Angeles Healthcare System, Los Angeles, California
Conditions: Upper Gastrointestinal Hemorrhage
A Clinical Trial of Intravenous Lidocaine After Spinal Surgery to Prevent Delirium and Reduce Pain
Recruiting
Postoperative delirium is one of the most frequent adverse events following elective non-cardiac surgery and is associated with cognitive impairment at discharge, as well as in-hospital and long-term mortality, however, despite being a well-recognized problem there is a dearth of effective interventions for prevention and management. A modifiable risk factor associated with postoperative delirium is poor postoperative pain control, and by improving the pain regimen the investigators may be able... Read More
Gender:
All
Ages:
60 years and above
Trial Updated:
03/17/2022
Locations: University of California, San Francisco, San Francisco, California
Conditions: Postoperative Delirium, Postoperative Pain, Spinal Fusion
Comparison of microMend® Devices to Sutures in Closing Lacerations in Children
Recruiting
This study will gather information on the use of microMend® to repair lacerations in children and compare the efficacy of microMend® to sutures for laceration repair. microMend® has previously been shown to be less painful and easier to use than sutures, which are the current standard of care for primary wound closures. Results of this research will inform how the treatment of laceration repairs in the pediatric patient population.
Gender:
All
Ages:
Between 7 years and 17 years
Trial Updated:
03/11/2022
Locations: CHOC Children's, Orange, California
Conditions: Laceration, Skin Wound, Wound Heal
mHealth Systems Navigation- Breaking Systems Barriers for Trans Women Living With HIV
Recruiting
The proposed study will test a mHealth peer navigation intervention for trans women living with HIV in a trans public health clinics to increase initiation and engagement in mental health and substance use services. The peer will navigate and provide support in-person and via mobile phone with HIPAA-compliant text messaging. Ecological momentary assessments will be conducted to enhance self-monitoring of mental health stress and coping-related substance use.
Gender:
Female
Ages:
18 years and above
Trial Updated:
03/09/2022
Locations: San Francisco Department of Public Health, San Francisco, California
Conditions: Mental Health Issue, Substance Use
Utility of Pupillary Metrics in Diagnosis and Management of Concussion in Children
Recruiting
The purpose of this study is to gather information and compare the potential use of pupillometry to identify concussions and post concussive syndrome with standard age appropriate assessments. The study will compare concussed pediatric patients 5-17 years of age recruited from the emergency department within 72 hours following injury with age and gender matched non-concussed pediatric patients recruited from primary care clinics. Assessment of both concussed and non-concussed subjects will take... Read More
Gender:
All
Ages:
Between 5 years and 17 years
Trial Updated:
03/09/2022
Locations: CHOC Children's, Orange, California
Conditions: Brain Concussion, Reflex, Pupillary, Post-Concussion Syndrome, Brain Injuries, Traumatic
Non Exudative AMD Imaged With SS-OCT- Extension
Recruiting
The investigators wish to better understand the role of the choriocapillaris (CC) in the formation and progression of non-exudative in age related macular degeneration (armd) by imaging the retinal pigment epithelium (rpe) and the choroidal microvasculature and by studying their inter-dependence to determine if the loss of the CC could prove useful as an anatomic clinical trial endpoint in future drug trials.
Gender:
All
Ages:
All
Trial Updated:
03/08/2022
Locations: University of California Los Angeles Doheny Eye Institute, Los Angeles, California
Conditions: Dry Macular Degeneration
Prospective Global Registry for the Study of Chronic Total Occlusion Intervention
Recruiting
Percutaneous coronary intervention (PCI) of chronic total occlusions (CTOs) is increasingly being performed in patients with advanced coronary artery disease, but there is limited information on the techniques utilized and the procedural outcomes. The goal of this multicenter, investigator initiated registry is to collect information on treatment strategies and outcomes of consecutive patients undergoing CTO PCI among various participating centers. The information collected will be used to deter... Read More
Gender:
All
Ages:
All
Trial Updated:
03/08/2022
Locations: San Diego VAMC and University of California, San Diego, California
Conditions: Coronary Artery Disease