California is currently home to 5966 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Prospective Global Registry for the Study of Chronic Total Occlusion Intervention
Recruiting
Percutaneous coronary intervention (PCI) of chronic total occlusions (CTOs) is increasingly being performed in patients with advanced coronary artery disease, but there is limited information on the techniques utilized and the procedural outcomes. The goal of this multicenter, investigator initiated registry is to collect information on treatment strategies and outcomes of consecutive patients undergoing CTO PCI among various participating centers. The information collected will be used to deter... Read More
Gender:
All
Ages:
All
Trial Updated:
03/08/2022
Locations: San Diego VAMC and University of California, San Diego, California
Conditions: Coronary Artery Disease
Clinical Outcomes of the Endoscopic Resection of Premalignant and Malignant Gastrointestinal Lesions
Recruiting
To evaluate clinical outcome for patients receiving treatment of suspected premalignant and malignant gastrointestinal lesions at Interventional Endoscopy Services. The primary outcome is curative endoscopic resection. Secondary outcomes include resection technique utilized, rates of en bloc resection and adverse event rates, including infection, bleeding, perforation and death, and one-year survival rates.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/08/2022
Locations: Interventional Endoscopy Services, San Francisco, California
Conditions: Gastrointestinal Neoplasms, Benign Neoplasm of Intestinal Tract
Calibration of MR and PET-MR Imaging Protocols at RIC
Recruiting
This is a protocol to facilitate on-site calibration of the technical aspects of the Siemens Biograph mMR (molecular MR) Positron Emission Tomography-Magnetic Resonance (PET-MR) scanner and the 3T Siemens Vida MR scanner at the Cedars-Sinai Medical Center (CSMC) Biomedical Imaging Research Institute (BIRI) Research Imaging Core after scanner installation. The mMR is a FDA-approved standard clinical device (non-experimental) and will be used in accordance with clearance and approval from the FDA.... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/07/2022
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Cancer, Coronary Artery Disease
AV-101 Alone and in Combination With Probenecid in Healthy Subjects
Recruiting
This is an open-label, two period, fixed-sequence, drug-drug interaction study to compare the PK and PD of orally administered AV-101 alone and in combination with probenecid in healthy subjects. In Treatment Period 1, subjects will receive AV-101 following an overnight fast of at least 8 hours. In Treatment Period 2, subjects will fast overnight for at least 8 hours, and then receive AV-101 2 hours after receiving 1,000 mg probenecid. Each Treatment Period will be separated by a washout period.... Read More
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
03/03/2022
Locations: Parexel Early Phase Clinical Unit, Glendale, California
Conditions: Drug Drug Interaction
Validation of Ejection Fraction and Cardiac Output Using Biostrap Wristband
Recruiting
In this study, the investigators will compare the accuracy of the Biostrap wristband, a wearable device with a clinical-grade Photoplethysmography (PPG) sensor, to measure ejection fraction and cardiac output in patients undergoing a cardiac ultrasound and pulmonary arterial catheterization, respectively.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/03/2022
Locations: Ronald Reagan UCLA Medical Center, Los Angeles, California
Conditions: Heart Failure
Steroid vs. Anti-vascular Endothelial Growth Factor for Diabetic Macular Edema Prior to Phacoemulsification
Recruiting
The primary objective of this study is to compare the efficacy of antecedent intravitreal anti-vascular endothelial growth factor therapy vs. Ozurdex in reducing post-cataract surgery related macular edema in patients with pre-existing diabetic macular edema.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/01/2022
Locations: Bay Area Retina Associates, Walnut Creek, California
Conditions: Diabetic Macular Edema, Cataract
NOVOCART®3D for Treatment of Articular Cartilage of the Knee
Recruiting
This study is to compare NOVOCART 3D relative to Microfracture for the treatment of knee cartilage defects. Efficacy will be evaluated by both pain and function. Safety will also be evaluated.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
03/01/2022
Locations: Core Orthopedic, Encinitas, California
Conditions: Articular Cartilage of the Femoral Condyle Between 2-6cm2
Almond Supplementation on Mild to Moderate Acne
Recruiting
This study will assess the effect of almond supplementation on acne and on gut health.
Gender:
All
Ages:
Between 15 years and 45 years
Trial Updated:
02/25/2022
Locations: Integrative Skin Science and Research, Sacramento, California
Conditions: Acne Vulgaris
External Pharyngeal Exerciser for Dysphagia
Recruiting
Pharyngeal muscle weakness and dysphagia is common in individuals post-stroke or with Parkinson's disease and in individuals with head/neck cancer who have undergone surgery and/or radiation therapy. Therapeutic options for these patients are limited. This pilot study is intended to assess the feasibility, safety, and efficacy of the External Pharyngeal Exerciser (EPE) on patients with pharyngeal dysphagia receiving swallow therapy. Feasibility will be assessed by patient acceptance and practice... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/23/2022
Locations: Anisa Shaker, Los Angeles, California
Conditions: Pharyngeal Dysphagia, Dysphagia, Oral Pharyngeal Dysphagia
Intra-arterial Gemcitabine vs. IV Gemcitabine and Nab-Paclitaxel Following Radiotherapy for LAPC
Recruiting
The study is a multi-center, un-blinded, randomized control study of subjects with locally advanced pancreatic adenocarcinoma which is unresectable.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/23/2022
Locations: VA Loma Linda Healthcare System, Loma Linda, California
Conditions: Locally Advanced Pancreatic Cancer
Evaluation of Intravenous Dalbavancin for Peritonitis
Recruiting
This study evaluates the use of Dalbavancin 1500 mg IV x 1 dose for treating patients with gram positive peritonitis in patients requiring peritoneal dialysis.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/22/2022
Locations: University of Colorado Hospital, Aurora, California
Conditions: Peritonitis, Peritonitis Bacterial
Performance of the Dexcom Continuous Glucose Monitoring (CGM) System in Pregnant Women With Diabetes Mellitus
Recruiting
Performance of the Dexcom Continuous Glucose Monitoring (CGM) System in Pregnant Women With Diabetes Mellitus
Gender:
Female
Ages:
18 years and above
Trial Updated:
02/17/2022
Locations: Sansum Diabetes Research Institute, Santa Barbara, California
Conditions: Diabetes Mellitus