California is currently home to 5930 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Qualification for Cone-Optogenetics
Recruiting
This study aims to prepare for the first-in-human clinical trial of cone optogenetics vision restoration. As a first step, this worldwide multicenter ocular imaging study (EyeConic Study) is performed to identify eligible patients.
Gender:
All
Ages:
All
Trial Updated:
01/19/2022
Locations: University of California San Francisco, Department of Ophthalmology, San Francisco, California
Conditions: Retinal Dystrophies
Study of Acalabrutinib (ACP-196) in Combination With Venetoclax (ABT-199), With and Without Obinutuzumab (GA101) Versus Chemoimmunotherapy for Previously Untreated CLL
Recruiting
The purpose of this study is to evaluate the efficacy and safety of acalabrutinib in combination with venetoclax and acalabrutinib in combination with venetoclax with and without obinutuzumab compared to chemoimmunotherapy in subjects with previously untreated CLL.
Gender:
All
Ages:
Between 18 years and 130 years
Trial Updated:
01/14/2022
Locations: Research Site, Fountain Valley, California
Conditions: Chronic Lymphocytic Leukemia
Advancing Dignity, Health, and Optimism in Connection With Long Acting Injectables
Recruiting
ADHOC-LA is an observational study of people living with HIV who either are taking, or have taken, a long-acting injectable therapy to manage their HIV. Data from this study will be used to research the ways in which HIV impacts the lives of these patients.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/13/2022
Locations: Mazonson & Santas Inc, Menlo Park, California
Conditions: HIV
The EMPOWER Study: Endometriosis Diagnosis Using microRNA
Recruiting
Endometriosis is a complex, heterogeneous disease that may present inconsistently across women. Using disease-specific biomarkers and advanced biostatistics, DotLab is developing a biomarker test to confirm the presence of endometriosis.This is a multi-center, prospective, observational, minimal risk study in women undergoing laparoscopy, laparotomy or other pelvic surgical procedure for endometriosis, infertility or another benign gynecological indication. Participants will undergo 2 study visi... Read More
Gender:
Female
Ages:
Between 18 years and 49 years
Trial Updated:
01/11/2022
Locations: Stanford University Hospital, Palo Alto, California
Conditions: Endometriosis
CGX1321 in Subjects With Advanced Solid Tumors and CGX1321 With Pembrolizumab or Encorafenib + Cetuximab in Subjects With Advanced GI Tumors (Keynote 596)
Recruiting
This is a multicenter, open-label study conducted in two phases: Phase 1 consisting of a CGX1321 Single Agent Dose Escalation Phase in solid tumors, CGX1321 Single Agent Dose Expansion Phase in GI tumors and Roll-over Cohort of CGX1321 and pembrolizumab in subjects who have progressed on single agent CGX1321 and Phase 1b consisting of CGX1321 in combination with pembrolizumab in colorectal tumors and CGX1321 in combination with encorafenib + cetuximab in BRAFV600E mutated colorectal tumors. Both... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/11/2022
Locations: Memorial Care, Long Beach, California
Conditions: Solid Tumors, GI Cancer
A Phase 3, Multi-Center Study Evaluating PL9643 in Patients With Dry Eye
Recruiting
This is a multi-center, double-masked, randomized, vehicle-controlled study testing PL9643, an opthalmic solution to determine if safe and efficacious for dry eye patients. After a 2-week run-in period, patients will be randomized equally to the PL9643 opthalmic solution or vehicle opthalmic solution administered bilaterally three times a day for 12 weeks. A Data Monitoring Committee will be engaged to review interim data.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/08/2022
Locations: Palatin Clinical Site #9, Newport Beach, California
Conditions: Dry Eye, Dry Eye Syndromes
Transcatheter Aortic Valve Replacement (TAVR) Double Balloon Valvuloplasty
Recruiting
In this study, the investigators evaluate whether routine double inflation of the valve could have a lasting impact. The investigators hypothesize that a routine second reinflation of the balloon, or "double tap", will improve flow across the valve when compared to a single inflation. The investigators hypothesize that "double tap" (1) will decrease mean gradient between first and second inflation during the procedure, (2) will decrease mean gradient on immediate post procedure and 30 day postpr... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/28/2021
Locations: Community Memorial Hospital, Ventura, California
Conditions: Aortic Valve Stenosis
POC Study to Evaluate the Performance of the AcuVid COVID-19 Rapid Antigen Saliva Test
Recruiting
The AcuVid COVID-19 Rapid Antigen Saliva Test is a lateral flow immunoassay to detect SARS-CoV-2 nucleocapsid antigens in human saliva specimens from individuals suspected of COVID-19 by their healthcare provider within the first seven days of symptom onset, or from individuals without symptoms or other epidemiological reasons to suspect. The AcuVid COVID-19 Rapid Antigen Saliva Test performance will be compared to a high sensitivity FDA EUA approved RT-PCR COVID-19 test. Nasopharyngeal (for RT... Read More
Gender:
All
Ages:
12 years and above
Trial Updated:
12/21/2021
Locations: Covid Clinic Inc., Modesto, California
Conditions: COVID-19
Effect of Prehabilitation on Surgical Outcomes of Abdominally-based Plastic Surgery Procedures
Recruiting
The purpose of this study is to determine whether a program to optimize patient physical fitness and nutrition ("prehabilitation") prior to and after plastic surgery involving the abdomen improves surgical outcomes. The investigators hope to determine how a multimodal peri-operative prehabilitation program can be most effective in engaging and motivating patients to physically and mentally get ready for an abdominally-based plastic surgery operation. The overall goal is to determine if this prog... Read More
Gender:
All
Ages:
19 years and above
Trial Updated:
12/14/2021
Locations: Stanford Cancer Center South Bay, San Jose, California
Conditions: Ventral Hernia, Panniculus, Abdominoplasty, Flap Reconstruction
Trigger Point Injections Versus Lidocaine Patch for Myofascial Pain in the Emergency Department
Recruiting
The aim of this trial is to investigate the efficacy of trigger point injections with 1% lidocaine in reducing myofascial back and neck pain in the Emergency Department compared to lidocaine patches 5%.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/08/2021
Locations: Emergency Room at UCI Medical Center, Orange, California
Conditions: Myofascial Trigger Point Pain, Myofacial Pain
Single-Blind Study of STAT-205 in Mild COVID-19
Recruiting
This is a randomized, single blind, study. Males and females meeting inclusion criteria who have symptoms of mild COVID-19 and in whom a positive PCR result for SARS-CoV-2 is obtained may be enrolled to the study treatment within 72 hours of the positive PCR result. Eligible patients are those considered to be at high risk for COVID-19 disease progression. This includes patients ≥ 65 years of age or with any one or more of certain medical conditions including: cancer, COPD, cardiovascular diseas... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/07/2021
Locations: Loma Linda University, Loma Linda, California
Conditions: COVID-19
COVID-19 Administration of Single-Dose Subcutaneous Anti- Spike(s) SARS-CoV-2 Monoclonal Antibodies Casirivimab and Imdevimab in High-Risk Pediatric Participants Under 12 Years of Age
Recruiting
The primary objective of the study is to characterize the concentrations of casirivimab+imdevimab in serum over time after a single subcutaneous (SC) administration The secondary objectives of the study are: To assess the safety and tolerability of SC or single administration of casirivimab+imdevimab To assess the occurrence of grade ≥3 injection site reactions and grade ≥3 hypersensitivity reactions, in participants treated with SC doses of casirivimab+imdevimab To assess the immunogenicity o... Read More
Gender:
All
Ages:
12 years and below
Trial Updated:
12/06/2021
Locations: Advanced Research Center, Inc, Anaheim, California
Conditions: COVID-19