California is currently home to 5930 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study to Assess Switching to B/F/TAF in Treatment Experienced People With HIV Who Are at Least 65 Years of Age
Recruiting
To assess patient reported treatment satisfaction and medication tolerability in virologically suppressed HIV-1 infected adults who are at least 65 years of age who switch to a bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) fixed-dose combination regimen.
Gender:
All
Ages:
65 years and above
Trial Updated:
12/06/2021
Locations: DAP Health, Palm Springs, California
Conditions: HIV-1-infection
A Retrospective Study to Examine the Effect of CMF Stimulation on Primary ACDF Patients
Recruiting
A retrospective parallel group comparison study to support expansion of the indication of the company's FDA approved Spinalogic™ device to include the cervical spine. The SpinalogicTM device was initially approved by FDA as an adjunct to one- or two-level lumbar fusion (P910066/S011). It is a non-invasive bone growth stimulator (BGS) that generates a combined magnetic field (CMF) that has been proven to accelerate bone healing and fusion in the lumbar spine.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
12/06/2021
Locations: SIOSD, San Diego, California
Conditions: Degeneration of Cervical Intervertebral Disc
Prediction of Outcomes After Surgery for Unruptured Intracranial Aneurysms
Recruiting
Accurate preoperative identification of patients at high risk for adverse outcomes would be clinically advantageous, as it would allow enhanced resource preparation, better surgical decision-making, enhanced patient education and informed consent, and potentially even modification of certain modifiable risk factors. The aim of the Prediction of adverse events after microsurgery for intracranial unruptured aneurysms (PRAEMIUM) study is therefore to develop and externally validate a clinically app... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/05/2021
Locations: UCLA, Los Angeles, California
Conditions: Aneurysm, Brain
Osteopathic Manipulative Treatment for Recurrent Mastitis
Recruiting
This study will investigate whether Osteopathic Manipulative Treatment (OMT) is effective in treating recurrent mastitis without the use of antibiotics and if it helps in preventing future recurrence of mastitis in individuals who have had multiple occurrences of mastitis.
Gender:
Female
Ages:
Between 18 years and 50 years
Trial Updated:
11/12/2021
Locations: Western University of Health Sciences, Pomona, California
Conditions: Mastitis
A Phase 1/2, Study of YL-15293 in Subjects With Advanced Solid Tumors With a KRAS G12C Mutation
Recruiting
This is a Phase 1/2, open-label, multicenter study designed to evaluate the maximum tolerated, safety, tolerability and PK of oral YY-15293 in patients with advanced solid tumors with a KRAS G12C mutation, to confirm the recommended phase 2 dose of YY-15293, and to obtain preliminary efficacy information in patients with advanced non-small cell lung cancer (NSCLC) with a KRAS G12C mutation.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/11/2021
Locations: Innovative Clinical Research Institute, Whittier, California
Conditions: Advanced Solid Tumor
Sample Collection Study for the CellMax Life Circulating Tumor Cell and Circulating Tumor DNA Platforms for the Early Detection of Colorectal Cancer and Adenomas
Recruiting
The purpose of this study is to collect clinical specimens from subjects with a diagnosis of colorectal cancer/advanced adenoma or undergoing a screening colonoscopy and meeting study eligibility criteria.
Gender:
All
Ages:
Between 45 years and 80 years
Trial Updated:
11/09/2021
Locations: CellMax Site O, Chula Vista, California
Conditions: Colorectal Cancer Screening
Repetitive Transcranial Magnetic Stimulation in Women With Overactive Bladder With Urgency Incontinence
Recruiting
Overactive bladder (OAB) affects an estimated 16-30% of women in the US and urgency urinary incontinence (UUI) affects 7-11% of women with OAB. It is known that repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA) can modulate the pelvic floor muscle activity with potential benefits for various urologic conditions. The goal of this study is to assess feasibility of rTMS as a treatment option for OAB with UUI by determining which rTMS frequency is most effec... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
11/09/2021
Locations: University of Southern California, Los Angeles, California
Conditions: Overactive Bladder, Urge Incontinence
Longitudinal Performance of Epi proColon
Recruiting
This study will evaluate longitudinal performance of Epi proColon with respect to test positivity, longitudinal adherence to Epi proColon screening, adherence to follow-up colonoscopy and diagnostic yield, as well as assay failure rates.
Gender:
All
Ages:
Between 50 years and 74 years
Trial Updated:
10/29/2021
Locations: Veterans Affairs San Diego Healthcare System, San Diego, California
Conditions: Colorectal Cancer, Colorectal Neoplasms
Improvement in the Appearance of Periorbital Wrinkles
Recruiting
The primary objective of this study is to evaluate the efficacy of DefenAge 8-in-1 BioSerum supplemented with the enhanced concentration of defensins (enhanced 8-in-1 BioSerum) in the improvement of periorbital wrinkles.
Gender:
All
Ages:
31 years and above
Trial Updated:
10/26/2021
Locations: West Dermatology Research Center/Cosmetic Laser Dermatology, San Diego, California
Conditions: Periorbital Wrinkles
Duration of Botox Using OLD Versus COLD for Treatment of Glabellar Lines
Recruiting
This is a blinded, randomized study in the US to compare the duration response of two different concentrations of BOTOX in healthy female subjects with moderate to severe dynamic glabellar lines on maximum frown.
Gender:
Female
Ages:
18 years and above
Trial Updated:
10/20/2021
Locations: Clinical Testing of Beverly Hills, Encino, California
Conditions: Glabellar Frown Lines
A Study of Hydroxychloroquine, Vitamin C, Vitamin D, and Zinc for the Prevention of COVID-19 Infection
Recruiting
This is a Phase II interventional study testing whether treatment with hydroxychloroquine, Vitamin C, Vitamin D, and Zinc can prevent symptoms of COVID-19
Gender:
All
Ages:
18 years and above
Trial Updated:
10/19/2021
Locations: ProgenaBiome, Ventura, California
Conditions: COVID-19, Coronavirus Infection, Sars-CoV2, Corona Virus Infection, COVID, Coronavirus, Coronavirus-19, Coronavirus 19
Sample Collection Study to Assess Prevalence of Gene Mutations: Establishing Population Norms
Recruiting
This is a multi-center, sample collection study to quantitatively assess the presence of gene mutations in subject's skin collected non-invasively. Subjects who consult with a dermatologist or other clinicians will be approached for participation in the study. Once IRB approved informed consent is obtain, subject demographic information, history of sun exposure and samples will be collected.
Gender:
All
Ages:
21 years and above
Trial Updated:
10/14/2021
Locations: West Dermatology, San Diego, California
Conditions: Photoaging