California is currently home to 5954 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
PyL in Patients With High Risk and Biochemically Recurrent Prostate Cancer
Recruiting
The standard of care imaging of prostate cancer metastases recommended by the National Comprehensive Cancer Network (NCCN), CT of the chest/abdomen/pelvis and bone scan, may be suboptimal. PyL is a novel PET tracer designed to detect prostate specific membrane antigen (PSMA) expressed on prostate cancer cells. PyL PET/CT may provide improved evaluation of clinically significant metastases in patients with prostate cancer.
Gender:
Male
Ages:
18 years and above
Trial Updated:
07/26/2021
Locations: Hoag Memorial Hospital Presbyterian, Irvine, California
Conditions: Prostate Cancer
Safety, Tolerability, PK, and Analgesic Effect of INL-001 in Children Following Open Inguinal Hernia Repair
Recruiting
A multicenter, single-dose study in children 12 to <17 years of age, 6 to <12 years of age, and 2 to <6 years of age who are scheduled for elective open inguinal hernia repair. Enrollment in this study will start with the oldest age group (12 to <17 years) and will continue in a stepwise fashion until appropriate doses are established for all 3 pediatric age groups (12 to <17 years, 6 to <12 years, 2 to <6 years).
Gender:
All
Ages:
Between 2 years and 16 years
Trial Updated:
07/23/2021
Locations: Alliance Research Centers, Laguna Hills, California
Conditions: Inguinal Hernia, Postoperative Pain
Prospective US Radiofrequency SUI Trial
Recruiting
PURSUIT: Prospective US Radiofrequency SUI Trial (VI-17-06) is a prospective, randomized, sham controlled, double blind study in premenopausal women with stress urinary incontinence. The study will be conducted in 390 subjects, randomized 2:1 with active or sham treatment. Study duration is 12 months post treatment. The primary objective is to evaluate the efficacy of the Viveve treatment, SUI protocol, in improving mild to moderate stress urinary incontinence (SUI), assessed using the 1-hour Pa... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
07/19/2021
Locations: Long Beach Clinical Trials Services, Inc., Long Beach, California
Conditions: Urinary Incontinence, Stress
Sleep and Emotional Reactivity in Alcohol Use Disorder
Recruiting
Alcohol use disorder (AUD) is a multifaceted, chronic relapsing disorder suffered by millions of men and women in the United States. AUD is associated with disrupted sleep continuity and architecture, which impact health-related quality of life, and contribute to relapse. However, many alcohol-sleep interactions and their underlying mechanisms remain unclear, especially those involving AUD and chronic sleep problems. Rapid eye movement (REM) sleep is altered long into abstinence, with excess dur... Read More
Gender:
All
Ages:
Between 25 years and 65 years
Trial Updated:
07/16/2021
Locations: SRI International, Menlo Park, California
Conditions: Alcohol Use Disorder (AUD)
Injectable DMAU for Male Contraception in Healthy Male Volunteers (CCN015)
Recruiting
This is a Phase I multicenter, double-blind, single dose, dose-ranging study, in healthy men to evaluate the safety and tolerability, pharmacokinetics and pharmacodynamics of Dimethandrolone Undecanoate (DMAU) administered as an intramuscular or subcutaneous injection.
Gender:
Male
Ages:
Between 18 years and 50 years
Trial Updated:
07/07/2021
Locations: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California
Conditions: Healthy Men, Male Contraception
Acupuncture for the Treatment of Medication-Dependent Hypotension in Heart Failure
Recruiting
Acupuncture is believed to increase blood pressure in people who struggle with low blood pressure. This is a common problem facing people with heart failure, and sometimes these people need to take medications to artificially increase their blood pressure. This study is designed to determine if using acupuncture in people with heart failure can improve their blood pressure enough to not require medications to artificially increase blood pressure.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/02/2021
Locations: Scripps La Jolla Medical Center, La Jolla, California
Conditions: Congestive Heart Failure, Hypotension
Multi-Center Study to Evaluate the Efficacy and Safety of Sildenafil Cream (3.6%) in Premenopausal Patients With Female Sexual Arousal Disorder
Recruiting
This study is looking to minimize side effects, while maintaining and potentially improving the therapeutic benefit to patients suffering from Female Sexual Arousal Disorder by providing a topical preparation of Sildenafil locally to the vulvar-vaginal tissue.
Gender:
Female
Ages:
21 years and above
Trial Updated:
06/24/2021
Locations: Collaborative Neuroscience Network, Garden Grove, California
Conditions: Female Sexual Arousal Disorder
OneinSeven Gestational Diabetes Genetic and Socioeconomic Risk Study
Recruiting
The objective of the Gestational Diabetes Genetic Socioeconomic Risk Study is to generate genome wide association study data (GWAS) to calculate polygenic risk scores (PRS) for the development of gestational diabetes in pregnant women. Oshun Medical's GWAS study will be conducted by collecting DNA samples alongside medical and socioeconomic data and applying data science methodology to generate a polygenic risk score algorithm for gestational diabetes. Our hypothesis is that key genetic variants... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
06/24/2021
Locations: Illumina Accelerator, Foster City, California
Conditions: Gestational Diabetes, Pregnancy Complications, Pregnancy Related, Genetic Predisposition, Risk Reduction
Pilot Study of Liposomal Bupivacaine Redosing in Patients Undergoing Major Gynecologic Procedures
Recruiting
The purpose of this research study is to find out which type of transversus abdomens plane (TAP) and block (bupivacaine, liposomal bupivacaine or liposomal bupivacaine with re-dosing at 48-60 hours) improves your pain control and lowers your risk of post-operative common side effects of surgery and narcotic pain medications.
Gender:
Female
Ages:
18 years and above
Trial Updated:
06/15/2021
Locations: University of California, Irvine, Orange, California
Conditions: Ovarian Cancer, Fibroids, Uterine Cancer
JSP191 Antibody Conditioning Regimen in MDS/AML Subjects Undergoing Allogenic Hematopoietic Stem Cell Transplantation
Recruiting
This is a Phase 1a/b study to evaluate the safety and tolerability of an antibody conditioning regimen known as JSP191, in combination with low dose radiation and fludarabine, in subjects with Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML) undergoing allogenic blood stem cell transplantation.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/08/2021
Locations: City of Hope Comprehensive Cancer Center, Duarte, California
Conditions: MYELODYSPLASTIC SYNDROME; MDS, ACUTE MYELOID LEUKEMIA; AML
Long-Term Follow-up Protocol
Recruiting
The main objective of this prospective, observational, long-term follow-up (LTFU) study is to evaluate the long-term safety profile of the gene therapy products evaluated by Krystal Biotech, Inc. which have a shared backbone of HSV-1, in participants who received at least one dose of investigational product (IP).
Gender:
All
Ages:
6 months and above
Trial Updated:
06/07/2021
Locations: Mission Dermatology Center, Rancho Santa Margarita, California
Conditions: Dystrophic Epidermolysis Bullosa, Recessive Dystrophic Epidermolysis Bullosa, Dominant Dystrophic Epidermolysis Bullosa
An Extension Study to Evaluate the Efficacy and Safety of HORIZANT in Adolescents With Moderate-to-Severe Primary RLS
Recruiting
The objectives of the trial are to evaluate the long-term efficacy and safety of HORIZANT (Gabapentin Enacarbil) 600 mg daily, for the treatment of RLS in adolescents (13 to 17 years of age) diagnosed with moderate-to-severe primary RLS.
Gender:
All
Ages:
Between 13 years and 17 years
Trial Updated:
06/07/2021
Locations: Stanford Sleep Medicine Center, Redwood City, California
Conditions: RLS