Texas is currently home to 4891 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Houston, Dallas, San Antonio and Austin. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Neurophysiologic Biomarkers in Rett Syndrome
Recruiting
The goal of this observational study is to identify candidate biomarkers in individuals with Rett Syndrome (RTT). The main questions it aims to answer are: * Do these biomarkers change during clinical changes in individuals with RTT? * Are biomarkers stable over time in clinically stable individuals? * Do these biomarkers correlate with severity of RTT? Participants will be asked to undergo an electroencephalogram (EEG) with measurements of Evoked Potentials (EP) to measure electrical activity... Read More
Gender:
FEMALE
Ages:
Between 1 year and 18 years
Trial Updated:
11/08/2024
Locations: Texas Children's Hospital, Houston, Texas
Conditions: Rett Syndrome, RTT, Rett Syndrome, Atypical
First-Time-in-Human Study of GSK4381562 in Participants With Advanced Solid Tumors
Recruiting
This is a first time in-human (FTIH) study designed to investigate the safety, tolerability, pharmacokinetics (PK), and immunogenicity of GSK4381562 in participants with select loco-regionally recurrent solid tumors or metastatic solid tumors where curative or standard treatment options have been exhausted.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/08/2024
Locations: GSK Investigational Site, Dallas, Texas
Conditions: Neoplasms
Clinical and Basic Investigations Into Congenital Disorders of Glycosylation
Recruiting
The purpose of this research is to study the natural history of congenital disorders of glycosylation and its causes and treatments.
Gender:
ALL
Ages:
All
Trial Updated:
11/07/2024
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Congenital Disorders of Glycosylation
Gene Signatures to Guide HR+MBC Therapy in a Diverse Cohort
Recruiting
This is an open-label, multicenter, two-arm Phase II clinical trial that will evaluate the impact of 2nd line chemotherapy (i.e. capecitabine) on survival in patients with non-Luminal A hormone receptor-positive (HR+) metastatic breast cancer (MBC)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/06/2024
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Invasive Mammary Carcinoma, Metastatic Breast Cancer
FID-007 and Cetuximab in Treating Patients With Advanced Head and Neck Squamous Cell Carcinoma
Recruiting
The goal of this FID-007 Clinical Trial is to compare the efficacy of different dosing regimens of FID-007 in combination with Cetuximab in patients with recurrent or metastatic Head and Neck Squamous Cell Carcinoma (HNSCC). The main questions it aims to answer are: to evaluate the efficacy, and to characterize the safety and tolerability. Eligible participants will be enrolled and randomized to 1 of 2 arms of FID-007 with fixed-dose Cetuximab in each 28-day cycle.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/05/2024
Locations: Texas Oncology - Baylor Charles A. Sammons Cancer Center, Dallas, Texas
Conditions: Head and Neck Squamous Cell Carcinoma
EGCG for Hepatocellular Carcinoma Chemoprevention
Recruiting
This phase II trial tests epigallocatechin gallate (EGCG) for its efficacy and safety in preventing development of hepatocellular carcinoma (HCC) in patients with liver cirrhosis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/05/2024
Locations: UT Southwestern, Dallas, Texas
Conditions: Cirrhosis, Liver
Evaluation of Oral Potentially Malignant Disorders (OPMDs) with STRATICYTE™
Recruiting
The purpose of this study is to validate the ability of the STRATICYTE™ predictive model to predict the transformation of oral potentially malignant disorders (OPMDs) to oral squamous cell carcinoma (OSCC) in a retrospective cohort of patients who received biopsies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/05/2024
Locations: MD Anderson Cancer Cetner, Houston, Texas
Conditions: Mouth Diseases
Prevention of Age-associated Cardiac and Vascular Dysfunction Using Avmacol ES
Recruiting
Our local IRB approved clinical studies seeking proof of principle for the hypothesis that SFN can be safely administered to humans at doses sufficient to protect age-associated cardiac dysfunctions. Beneficial effects of SFN-therapy will be assessed by Pre- and post-intervention echocardiography, and exercise endurance at 0 and 24 weeks. Peripheral blood cells from treated and control subjects will be compared for mitochondrial respiratory function, oxidative damage, pro-inflammatory cytokines,... Read More
Gender:
ALL
Ages:
Between 60 years and 80 years
Trial Updated:
11/05/2024
Locations: Texas Tech University Health Sciences Center (TTUHSC), Lubbock, Texas
Conditions: Diastolic Dysfunction, Systolic Dysfunction, Diastolic Heart Failure
Patient Specific Talus Spacer Post Approval Study
Recruiting
Humanitarian Device Exemption Approved Patient Specific Talus Spacer Post Approval Study.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
11/05/2024
Locations: UT Physicians Orthopedics - Pearland, Pearland, Texas
Conditions: Avascular Necrosis of the Talus
Customized TULSA-PRO Ablation Registry
Recruiting
This patient registry will capture data from patients who have been or who are undergoing the transurethral ultrasound ablation (TULSA) procedure as part of their routine clinical care. The registry will shed light on real-world outcomes of safety and efficacy of the procedure and understand how a patient's quality of life is affected throughout their follow-up and lifetime.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
11/05/2024
Locations: University of Texas Southwestern Medical Center, Dallas, Texas
Conditions: Prostate Cancer, Prostate Adenocarcinoma, Benign Prostatic Hyperplasia
Prospective Data Bank Creation to Study Vaginal Conditions
Recruiting
The purpose of this study is to identify and elucidate the pattern and perhaps role of atypical proteins, cytokines and vaginal microbial flora in the pathogenic mechanisms involved in the development of vulvodynia, recurrent fungal and bacterial vaginosis and preterm labor.
Gender:
FEMALE
Ages:
Between 21 years and 75 years
Trial Updated:
11/05/2024
Locations: TTUHSC Permian Basin, Midland, Texas
Conditions: Vulvodynia, Mycoses, Bacterial Vaginosis, Preterm Labor
Safety, Tolerability, and Pharmacokinetics of DCR-PDL1 in Adults With Solid Tumors
Recruiting
The study will evaluate the safety, tolerability, and pharmacokinetics of intravenous DCR-PDL1 in adults with solid tumors. Participants will be enrolled in one of 4 ascending-dose cohorts. Each treatment cycle will consist of multiple intravenous (IV) doses. Dose escalation decisions will be based on data collected during the dose-limiting toxicity (DLT) period.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/04/2024
Locations: Next Oncology, San Antonio, Texas
Conditions: Solid Tumors, Adult