Texas is currently home to 4888 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Houston, Dallas, San Antonio and Austin. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Evaluating the Effect of Itraconazole on Pathologic Complete Response Rates in Esophageal Cancer
Recruiting
Esophageal cancer, which has a low 5-year overall survival rate for all stages (\<20%) , is increasing in incidence. Previous studies have shown that the Hedgehog (Hh) and AKT signaling pathways are activated in a significant proportion of esophageal cancers. Itraconazole, a widely used anti-fungal medication, has been shown to inhibit various pathways involved in esophageal cancer tumorigenesis including Hh and AKT. In this phase II clinical trial, the investigators aim to evaluate the effect o... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/02/2021
Locations: Dallas VA Medical Center, Dallas, Texas
Conditions: Esophagus Adenocarcinoma, Esophagus Squamous Cell Carcinoma, Gastroesophageal Junction Adenocarcinoma
iGlucose® Remote Patient Monitoring Device as an Adjunct to Routine Glucose Meter Devices for Glycemic Management and Control in Gestational Diabetes
Recruiting
The purpose of this study is to investigate whether automation of glucose monitoring data to facilitate the total number of recommended and completed SMBG checks improve clinical outcomes for women living with gestational and type 2 diabetes during pregnancy? This is a RCT
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
09/01/2021
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Gestational Diabetes, Type2 Diabetes, Pregnancy in Diabetic
Breast Mesh Used in Two-staged Breast Reconstruction
Recruiting
This is the first prospective randomized and controlled study on the efficacy and safety of TiLOOP® Bra mesh in patients with expander-implant breast reconstruction. The investigators hypothesize that incoporating TiLOOP Bra mesh with tissue expanders will reduce the rates of capsular contraction, improve the efficiency of expansion and provide better aesthetic result.
Gender:
FEMALE
Ages:
Between 18 years and 70 years
Trial Updated:
07/19/2021
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Breast Cancer, Radiation, Breast Reconstruction, Synthetic Mesh
Sternal Block With Liposomal Bupivacaine vs. Saline Prior to Incision in Cardiac Surgery
Recruiting
The purpose of this study is to find out what effects (good and bad) that the study medicine called "liposomal bupivacaine" has on subjects that are undergoing a sternotomy. Liposomal bupivacaine solution, is a drug that the doctor will inject before they make the cut through patient's breastbone (sternotomy). Normally pain medicine like this is given right before the surgeon closes up the patient's breastbone, at the end of the surgery. For this study, they want to see if giving the medicine be... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/08/2021
Locations: Baylor Scott & White Heart Hospital - Plano, Plano, Texas
Conditions: Cardiovascular Surgery, Pain, Postoperative, Block
Registry and Biorepository for IBD in Central Texas
Recruiting
This is a prospective, non-interventional registry and biorepository for patients with IBD. Longitudinal follow-up data is collected from both patients and their treating gastroenterologist during routine clinical encounters. The biorepository will consist of prospective collection of blood samples, tissue samples, and fecal samples for research purposes, while the participants are undergoing a clinically-indicated procedure (i.e. venipuncture for routine tests, IV catheter placement, and/or end... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
05/13/2021
Locations: Dell Medical School, UT Austin, Austin, Texas
Conditions: Crohn Disease, Ulcerative Colitis, Inflammatory Bowel Diseases
Designing a Predictive Tool to Identify Whether a Cancer Patient Has Bacteremia Due to Ceftriaxone-Resistant Escherichia Coli
Recruiting
This study aims to develop a tool to predict whether a cancer patient has bacteria in the blood (bacteremia) due to ceftriaxone-resistant Escherichia (E.) coli. This study may help researchers identify risk factors for ceftriaxone-resistant E. coli bacteremia in cancer patients and improve antibiotic treatment in these patients.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/28/2021
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Escherichia Coli Infection, Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies, the PROCEED Study
Recruiting
This study gathers information on patients at different stages of chronic pancreatitis to better understand the natural course and risk factors associated with pancreatitis. Chronic pancreatitis is a disease that occurs when the pancreas is inflamed (swollen and irritated) all of the time. It is important for doctors to diagnose chronic pancreatitis in the beginning stages of the disease. Over time, as chronic pancreatitis gets worse, the pancreas may stop working correctly. Since treatment opti... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
04/22/2021
Locations: Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
Conditions: Acute Pancreatitis, Chronic Pancreatitis
To Assess the Safety, Tolerability and Efficacy of Itacitinib Immediate Release Tablets in Participants With Primary or Secondary Myelofibrosis Who Have Received Prior Ruxolitinib and/or Fedratinib Monotherapy. (LIMBER-213)
Recruiting
This is a 2-part study. In Part 1, participants will be dosed at 2 different dose levels in order to select the RP2D for Part 2 of the study.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/27/2021
Locations: Renovatio Clinical Consultants Llc, Spring, Texas
Conditions: Myelofibrosis, Polycythemia Vera, Thrombocythemia
ABX196 in Combination With Nivolumab in Patients With Hepatocellular Carcinoma
Recruiting
Open-label, uncontrolled, phase 1-2 study to evaluate the safety, tolerability, pharmacodynamic effects, and preliminary efficacy of ABX196 administered in combination with nivolumab in patients with hepatocellular carcinoma
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/25/2021
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Carcinoma, Hepatocellular
To Evaluate the Efficacy and Safety of Parsaclisib and Ruxolitinib in Participants With Myelofibrosis (LIMBER-313)
Recruiting
The purpose of the study is to compare the efficacy of parsaclisib when combined with ruxolitinb versus placebo combined with ruxolitinib in participants with myelofibrosis.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/24/2021
Locations: Renovatio Clinical, Houston, Texas
Conditions: Myelofibrosis, Primary Myelofibrosis, Post Essential Thrombocythemia Myelofibrosis, Post Polycythemia Vera Myelofibrosis
Safety and Efficacy of Endoscopic Assisted Push Gastrostomy Using Gastrostomy Technique
Recruiting
Most pediatric gastroenterologists use an endoscopic pull technique to place gastrostomy tubes. We assessed an endoscopic gastropexy technique for gastrostomy tube placement that allows immediate placement of a low profile gastrostomy tube or gastro-jejunostomy tube. The procedure involves endoscopy with the placement of three T-fasteners that are placed through the skin into the stomach, placating and securing the stomach to the abdominal wall. This attachment process promotes formation of a st... Read More
Gender:
ALL
Ages:
17 years and below
Trial Updated:
01/26/2021
Locations: The Children's Hospital of San Antonio, San Antonio, Texas
Conditions: Gastrostomy, Gastrostomy Complications, Gastrostomy Tube Site Complication, Pain, Postoperative
An Active and Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Ulcerative Colitis
Recruiting
The present study D5272C00001 (Legacy # 3151-201-008) seeks to evaluate the efficacy and safety of brazikumab versus placebo in patients with moderately to severely active UC and will include assessments of clinical responses as demonstrated by improvement of symptoms and of colonic mucosal appearance as observed on endoscopy.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
01/19/2021
Locations: Research Site, Amarillo, Texas
Conditions: Ulcerative Colitis