Texas Clinical Trials

A listing of Texas clinical trials actively recruiting patient volunteers.

With over 100,000 clinical trials happening every year in United States, there are always many clinical trials going on in every state, including Texas. Hospitals, universities, pharmaceutical companies, and research organizations conduct clinical trials, and while some of them require a stay at the facilities, others just require daily or weekly visits from the volunteers.

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4911 trials found

A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Adult and Adolescent Participants With Atypical Hemolytic Uremic Syndrome (aHUS)

NCT04861259

This study aims to evaluate the efficacy and safety of crovalimab in adult and adolescent participants with aHUS.

Conditions: Atypical Hemolytic Uremic Syndrome

Endocrine, Metabolic and Microbiome Influence on the Post COVID-19 Syndrome

NCT04860869

The aim of this study is characterize the endocrine, metabolic and microbiomes of patients with post-COVID syndrome.

Conditions: Covid19

Trilaciclib, a CDK 4/6 Inhibitor, in Patients Receiving Docetaxel for Metastatic Non-Small Cell Lung Cancer (NSCLC) (PRESERVE 4)

NCT04863248

This is a randomized, double-blind, placebo-controlled, global, multicenter, Phase 2 trial evaluating the effect of trilaciclib on overall survival when administered prior to docetaxel in patients with mNSCLC treated in the 2nd or 3rd line setting.

Conditions: Metastatic Non-Small Cell Lung Cancer, NSCLC, Lung Cancer

Effects of Breathing Patterns on Post-prandial Vascular Function

NCT04864184

The purpose of this study is investigate the effects of two different breathing styles on postprandial vascular function and oxidative stress markers. Participants will complete 2 breathing conditions in random order.

Conditions: Healthy
Phase: Not Applicable

NBTXR3, Radiation Therapy, and Pembrolizumab for the Treatment of Recurrent or Metastatic Head and Neck Squamous Cell Cancer

NCT04862455

This phase II trial investigates the effect of NBTXR3, radiation therapy, and pembrolizumab in treating patients with head and neck squamous cancer that has come back (recurrent) or has spread to other places in the body (metastatic). NBTXR3 may help make tumor cells more sensitive to the radiation therapy. Radiation therapy, such as stereotactic body radiation therapy, uses special equipment to position a patient and deliver radiation to tumors with high precision. This method may kill tumor ce ...

Conditions: Metastatic Head and Neck Squamous Cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma

Clinical Comparison of Two Daily Disposable Contact Lenses

NCT04865354

The purpose of this study is to compare the clinical performance of PRECISION1™ contact lenses to Clariti® 1 day contact lenses.

Conditions: Refractive Errors
Phase: Not Applicable

A Study of ERAS-007 in Patients With Advanced or Metastatic Solid Tumors

NCT04866134

To evaluate the safety and tolerability of ERAS-007 monotherapy administered once weekly (QW) and twice daily-once weekly (BID-QW). To determine the Maximum Tolerated Dose (MTD) and/or Recommended Dose (RD) of ERAS-007 monotherapy administered BID-QW. To characterize the pharmacokinetic (PK) profile of ERAS-007 monotherapy. To determine the optimal dose and schedule of ERAS-007 monotherapy. To evaluate antitumor activity of ERAS-007 in various solid tumors.

Conditions: Advanced or Metastatic Solid Tumors
Phase: Phase 1/2

A Phase I, Single Center, Open-label Clinical Pharmacology Study to Evaluate the Effect of Tipifarnib on Cardiac Safety in Subjects With Advanced Solid Malignancies

NCT04865159

A Phase I, single center, open-label clinical pharmacology study designed to evaluate the effect of tipifarnib on cardiac repolarization (corrected QT interval [QTc] duration) following a single dose of 900 mg and after repeated twice daily administration of 600 mg in subjects with advanced solid malignancies. Subjects will receive a 900 mg single dose at cycle 1 day 1 follow by 600 mg twice a day orally with a meal (Days 2-7 and 15-21) in 28-day cycles. Beginning on Day 2 of Cycle 1, subjects w ...

Conditions: Advanced Solid Tumor

Intraoperative Laser Speckle Contrast Imaging of Cerebral Blood Flow

NCT04865718

The purpose of this research study is to evaluate the ability of laser speckle contrast imaging to visualize blood flow in real time during neurosurgery. Real-time blood flow visualization during surgery could help neurosurgeons better understand the consequences of vascular occlusion events during surgery, recognize potential adverse complications, and thus prompt timely intervention to reduce the risk of stroke. The current standard for visualizing cerebral blood flow during surgery is indocya ...

Conditions: Aneurysm, Brain, Arteriovenous Malformation of Brain, Neurovascular Disorder

A Research Study to Find Out How Semaglutide Works in the Kidneys Compared to Placebo, in People With Type 2 Diabetes and Chronic Kidney Disease (the REMODEL Trial)

NCT04865770

We are doing this study to learn more about how semaglutide may help fight chronic kidney disease in people with type 2 diabetes. We are doing this by looking into how semaglutide works in the kidneys. Participants will either get semaglutide or placebo (a 'dummy' medicine) - which treatment participants get is decided by chance. Semaglutide is a medicine doctors can prescribe in some countries for the treatment of type 2 diabetes. Participants will get the study medicine in a pen. Participan ...

Conditions: Diabetes Mellitus, Type 2, Chronic Kidney Disease

Cardiovascular and Renal Treatment in Heart Failure Patients With Hyperkalaemia or at High Risk of Hyperkalaemia

NCT04864795

The CARE-HK in HF is a registry study based on the hypothesis that adherence to guidelines is associated with improved real-world outcomes for heart failure (HF) patients. For the purpose of this study, adherence to guidelines is defined as 1) adherence to potassium (sK+) monitoring recommendations, and 2) adherence to renin-angiotensin-aldosterone system inhibitor (RAASi) treatment recommendations, according to the most current local guidelines at the time of assessment. The study aims to eval ...

Conditions: Heart Failure, Hyperkalemia

Designing a Predictive Tool to Identify Whether a Cancer Patient Has Bacteremia Due to Ceftriaxone-Resistant Escherichia Coli

NCT04866186

This study aims to develop a tool to predict whether a cancer patient has bacteria in the blood (bacteremia) due to ceftriaxone-resistant Escherichia (E.) coli. This study may help researchers identify risk factors for ceftriaxone-resistant E. coli bacteremia in cancer patients and improve antibiotic treatment in these patients.

Conditions: Escherichia Coli Infection, Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm

A clinical trial is conducted when a researcher finds a potential new drug, medical device, surgical procedure or intervention that has the potential of improving the lives of many but still needs to be tested to see if it is effective and safe for humans. In the state of Texas, there are a number of paid clinical trials for willing participants.

Clinical trials can last for many years because the medication or the intervention needs to be tested on many participants to ensure its safety and effectiveness. Many hospitals such as the Houston Methodist Hospital in Houston, Texas conduct clinical trials especially to find new treatments for diseases such as cancer, heart disease, and hormonal conditions. Hospitals tend to recruit participants by informing patients of the research study inviting them to participate.

On the other hand, pharmaceutical companies that develop new medications or medical devices sometimes need to hire companies to conduct all the different stages of clinical trials for them. These companies are called contract research organizations or CROs.

CROs provide management and support for institutions that need to conduct clinical trials but don't have the expertise or infrastructure to do so. CROs are responsible for recruiting the participants for the study, monitoring the trials, and ensuring that all parts of the study are being conducted according to protocol.

In Texas, there are several CROs that actively recruit volunteers year-round to participate in clinical trials. Some of the major CROs in Texas include: Covance, PPD, and Clinical Trials of Texas.

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