There are currently 133 active clinical trials seeking participants for Pain research studies. The states with the highest number of trials for Autism participants are California, Ohio, Florida and Illinois.
Opioid-Sparing and Pain-Reducing Properties of Syntocinon: A Dose-Effect Determination
NCT04218409
Recruiting
Some research suggests that administration of oxytocin with oxycodone may reduce its abuse liability and improve its ability to reduce pain. In a 6-session laboratory study, the investigators will be evaluating the effects of oxycodone and oxytocin (combined and separately, across sessions) on experimentally-induced pain, subjective effects, decision-making, and activation of different neural substrates.
Gender:
All
Ages:
Between 21 years and 45 years
Trial Updated:
12/07/2023
Locations: University of Florida, Gainesville, Florida
Conditions: Pain
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Mechanisms of Cannabidiol in Persons With MS: the Role of Sleep and Pain Phenotype
NCT05269628
Recruiting
The purpose of this research study is to compare the effects of cannabidiol (CBD), tetrahydrocannabinol (THC), or both, on sleep and pain in persons with multiple sclerosis (MS). Little is known about how CBD and/or THC may help sleep, reduce pain, or perhaps even treat pain through better sleep.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
12/07/2023
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Multiple Sclerosis, Sleep, Pain
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A Study to Evaluate Efficacy and Safety of GSK3858279 in Diabetic Peripheral Neuropathic Pain
NCT05838755
Recruiting
This is a multicenter randomized, double-blind, placebo-controlled phase 2 study to evaluate efficacy, safety, tolerability, pharmacokinetics, and target engagement of GSK3858279 in adult participants with chronic Diabetic Peripheral Neuropathic Pain (DPNP). The primary objective of the study is to assess the efficacy of GSK3858279 in participants with DPNP who have been unable to sufficiently manage their pain.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
12/05/2023
Locations: GSK Investigational Site, Anniston, Alabama +82 locations
Conditions: Pain
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Reliability of Pupil Response to Acute Pain
NCT02628314
Recruiting
The purpose of this research study is to test whether researchers can reliably measure the response pupils have when an acute painful stimulus is experienced. Changes in the size of the pupil of the eye can be an indicator of brain activity in a region of the brain that is important for feeling pain.
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
12/01/2023
Locations: Wake Forest Baptist Medical Center, Winston-Salem, North Carolina
Conditions: Pain, Osteoarthritis
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Discovery and Analytical Validation of Inflammatory Bio-signatures of the Human Pain Experience
NCT05074485
Recruiting
The first objective of the study is to evaluate whether a novel bio-signature (derived from a wide range of pro- and anti-nociceptive IL-1 family cytokine activity) will predict pain experienced and also release of underlying endogenous opioid neurotransmitters during an experimental nociceptive pain challenge, which will be performed while simultaneously quantifying mu-opioid receptor activity in the brain via [11C]-carfentanil PET neuroimaging in healthy subjects. Another objective is to evalu... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
12/01/2023
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Pain
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The Potential of Oxytocin to Reduce Opioid Abuse Liability and Pain Among Older Adults
NCT05761860
Recruiting
Some research suggests that administration of oxytocin with oxycodone may reduce its abuse liability and improve its ability to reduce pain. In a 6-session laboratory study, we will be evaluating the effects of oxycodone and oxytocin (combined and separately, across sessions) on experimentally-induced pain, subjective effects, and decision-making.
Gender:
All
Ages:
Between 45 years and 85 years
Trial Updated:
11/29/2023
Locations: University of Florida, Gainesville, Florida
Conditions: Pain
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Post-Op Pain Control for Prophylactic Intramedullary Nailing.
NCT03823534
Recruiting
Nationally, the opioid crisis has become a major epidemic with increasing mortality rates each year. Orthopedic surgeons routinely prescribe narcotics instead of NSAIDs for post-op pain control because of risk of delayed healing and nonunion due to NSAID use. Orthopedic oncology, however, has a unique subset of patients that undergo prophylactic placement of intramedullary femoral nails. Because no fracture is present, these patients do not rely on inflammatory healing factors, allowing for post... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/29/2023
Locations: Saint Louis University, Saint Louis, Missouri
Conditions: Bone Metastases, Lymphoma, Multiple Myeloma, Opioid Use, Pain
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Analgesic and Subjective Effects of Terpenes
NCT04451863
Recruiting
The purpose of this research is to assess the analgesic and subjective effects of terpenes administered alone and in combination of THC.
Gender:
All
Ages:
Between 21 years and 55 years
Trial Updated:
11/29/2023
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Pain, Abuse, Drug
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A Pilot Study Assessing the Effectiveness of Use of Guided Imagery for Treatment of Pain and Symptom Management in Women With Post-mastectomy Pain Syndrome
NCT05408741
Recruiting
To learn if using guided imagery and deep breathing techniques can help with pain management in patients who have post-mastectomy pain syndrome.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/28/2023
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Pain Syndrome, Pain, Symptom Management
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Virtual Reality (VR) for Prone Pain Procedures
NCT05615675
Recruiting
The purpose of this study is to evaluate the effectiveness of virtual reality (VR) distraction in patients undergoing interventional pain procedures in the prone position. VR has been shown to improve patient experience during interventional pain procedures, however, many of these procedures are done in the prone position making VR a challenge. This study will evaluate the effect of a VR headset and support in patients undergoing prone interventional pain procedures compared to control.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/27/2023
Locations: UC Davis Interventional Pain Clinic, Sacramento, California
Conditions: Virtual Reality, Anxiety, Pain
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Regional Blocks for Lateral Condyle Fractures
NCT03796572
Recruiting
The purpose of this study is to investigate the post-operative pain control in pediatric patients with closed lateral condyle fractures who undergo open reduction and percutaneous pinning. Patients will be randomized into one of two groups. Group 1 will receive an infraclavicular nerve block to the affected extremity by a fellowship trained pediatric anesthesiologist prior to surgery. Group 2 will undergo the Orthopaedic Institute of Children's (OIC) standard preoperative protocol. Post-operativ... Read More
Gender:
All
Ages:
Between 4 years and 12 years
Trial Updated:
11/22/2023
Locations: Orthopaedic Institute for Children, Los Angeles, California
Conditions: Fractures, Closed, Humeral Fractures, Pain
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Virtual Reality at End-of-life
NCT06149429
Recruiting
The purpose of this research is to determine the effect that repeated, personalized virtual reality experiences have on symptom severity, comparing self-reported symptom severity both pre and post each session, and overtime across sessions. We will also determine if this intervention results in a high rating of presence in VR, and if presence is related to the magnitude of the change in symptoms.
Gender:
All
Ages:
All
Trial Updated:
11/20/2023
Locations: Hospice and Palliative Care Buffalo, Cheektowaga, New York
Conditions: End of Life, Pain, Nausea, Fatigue, Well-Being, Psychological, Depression, Dyspnea, Appetite Loss, Anxiety
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