There are currently 127 active clinical trials seeking participants for Pain research studies. The states with the highest number of trials for Pain participants are California, Ohio, Florida and Illinois.
Chronic Pain in Rheumatoid Arthritis
NCT05038553
Recruiting
The objective is to identify modifiable clinical factors and neurobiological pathways that lead to the development of chronic pain in patients with early rheumatoid arthritis. Participants will undergo quantitative sensory testing, a type of testing that involves assessing response to well-defined, quantifiable painful stimuli, at 0, 3, and 12 months. A subset of participants will also undergo magnetic resonance imaging at 0 and 12 months to assess neuroimaging markers that have previously been... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/24/2025
Locations: University of Colorado, Denver, Colorado +4 locations
Conditions: Arthritis, Rheumatoid, Pain
Register for Updates
Clinical and Scientific Assessment of Pain and Painful Disorders
NCT02707029
Recruiting
Background: Researchers want to better understand pain by studying people with and without different kinds of pain. To do this, researchers will expose people to pleasant and unpleasant sensations. They will ask them questions about their pain. Researchers also want to see if these people are eligible for other research studies at the National Center for Complementary and Integrative Health. Objectives: To study the experience of pain. Also to find people eligible to join other NIH studies.... Read More
Gender:
ALL
Ages:
Between 12 years and 120 years
Trial Updated:
04/23/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Normal Physiology, Pain
Register for Updates
Does Psychoeducation Improve the Pain Relief Derived From a Brief Intervention
NCT06952049
Recruiting
This project is a single-site, five-arm, randomized controlled trial investigating whether providing patients in an orthopedic clinic waiting room psychoeducation about mindfulness impacts the degree of pain relief they experience during a mindfulness-based intervention.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: Tallahassee Orthopedic Clinic (TOC), Tallahassee, Florida
Conditions: Pain, Acute Pain
Register for Updates
Neuropathic Pain and Operant Conditioning of Cutaneous Reflexes After SCI
NCT05492188
Recruiting
The purpose of the second part of the study is to examine the effect of reflex training in the leg to decrease neuropathic pain. For this, the researchers are recruiting 15 individuals with neuropathic pain due to spinal cord injury to participate in the reflex training procedure. The study involves approximately 50 visits with a total study duration of about 6.5 months (3 months for baseline and training phases followed by 1 month and 3 month follow-up visits).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/21/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Spinal Cord Injuries, Neuropathic Pain, Neurological Injury, Pain
Register for Updates
The Potential of Oxytocin to Reduce Opioid Abuse Liability and Pain Among Older Adults
NCT05761860
Recruiting
Some research suggests that administration of oxytocin with oxycodone may reduce its abuse liability and improve its ability to reduce pain. In a 6-session laboratory study, we will be evaluating the effects of oxycodone and oxytocin (combined and separately, across sessions) on experimentally-induced pain, subjective effects, and decision-making.
Gender:
ALL
Ages:
Between 45 years and 85 years
Trial Updated:
04/21/2025
Locations: University of Florida, Gainesville, Florida
Conditions: Pain
Register for Updates
A Study to Evaluate How the Body Processes 14C-VX-993 After a Single Oral Dose
NCT06886269
Recruiting
The purpose of the study is to evaluate the routes and rate of elimination and recovery of total radioactivity (TRA) and characterize the Pharmacokinetic (PK) of VX-993 after a single oral dose of 14C-VX-993
Gender:
MALE
Ages:
Between 18 years and 55 years
Trial Updated:
04/15/2025
Locations: Celerion - Lincoln, Lincoln, Nebraska
Conditions: Pain
Register for Updates
The Impact of Gender Affirming Hormone Therapy on Pain In Gender Minority Adults
NCT06939257
Recruiting
TRANSPIRE is an observational study of \~200 individuals who (1) will be initiating gender-affirming hormone therapy (GHT) or (2) are gender minority individuals who do not use GHT. The primary outcome will be to identify how the presence of chronic pain changes overtime with GHT through the use of surveys, quantitative sensory testing (QST), brain MRIs, and qualitative interviews. Following recruitment and consent, participants will complete baseline survey measures and will repeat those measu... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
04/14/2025
Locations: The University of Kansas Medical Center, Kansas City, Kansas
Conditions: Pain, Gender Minority Individuals
Register for Updates
Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean Delivery
NCT06767566
Recruiting
The purpose of this study is to identify pharmacokinetics of postpartum ketamine infusion. This study will assess ketamine kinetics and metabolism in this setting. Ketamine is expected to exert different kinetics during the physiologic state of post-pregnancy. The goal in conducting this study is to better understand the pharmacokinetics and pharmacodynamics of postpartum ketamine infusion. A secondary goal is to compare these kinetics to reproductive age matched controls and to assess sex diffe... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: Magee Womens Hospital of UPMC, Pittsburgh, Pennsylvania +1 locations
Conditions: Pain, Postpartum Depression
Register for Updates
The Effect of Electroacupuncture on Nerve Pain Caused by Chemotherapy (Chemotherapy-Induced Peripheral Neuropathy)
NCT04917796
Recruiting
This study is a randomized controlled trial of electroacupuncture (referred to as EA) versus sham acupuncture (referred to as EA) as effective treatments for Chemotherapy-Induced Peripheral Neuropathy/CIPN pain in cancer survivors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts +5 locations
Conditions: Chemotherapy-induced Peripheral Neuropathy, Nerve Pain, Neuropathy, Neuropathy, Painful, Pain, CIPN - Chemotherapy-Induced Peripheral Neuropathy
Register for Updates
Scrambler Therapy With Duloxetine-based Usual Care vs Duloxetine-based Usual Care for Chemotherapy Induced Peripheral Neuropathy
NCT06914557
Recruiting
The Investigators hypothesize that Scrambler therapy with duloxetine compared to duloxetine-based usual care will result in greater improvement in CIPN as measured by the BPI-Short Form. In addition, the Investigators will further assess pain using the EORTC CIPN-20 and determine whether Scrambler therapy will result in improved levels of function as measured with the PDQ, and decreased need for opioid medications. Our primary objective Investigate whether Scrambler therapy with duloxetine is s... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: Fox Chase Cancer Center, Philadelphia, Pennsylvania
Conditions: CIPN - Chemotherapy-Induced Peripheral Neuropathy, Pain
Register for Updates
Pain Alleviation With Testosterone in Opioid-Induced Hypogonadism
NCT04798469
Recruiting
The aim of this trial is to evaluate whether testosterone replacement results in greater improvement in pain perception, pain tolerance, sexual function, fatigue, and quality of life when compared with placebo in men with chronic spinal pain treated with opioids who have opioid-induced hypogonadism (low testosterone).
Gender:
MALE
Ages:
18 years and above
Trial Updated:
03/30/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Opioid Use, Pain, Hypogonadism, Male
Register for Updates
Oklahoma Study of Native American Pain Risk III: Stress and Resilience
NCT05723081
Recruiting
The goal of this observational study is to learn about the relationship between environmental structural racism and discrimination and chronic pain risk in Native American adults. The main questions it aims to answer are: 1. How does environmental structural racism and discrimination affect chronic pain-promoting mechanisms in Native Americans? 2. What psychosocial factors buffer the negative effects of environmental structural racism and discrimination on chronic pain-promoting mechanisms?
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: University of Oklahoma - Schusterman Center, Tulsa, Oklahoma
Conditions: Discrimination, Racial, Stress Physiology, Pain
Register for Updates