There are currently 135 active clinical trials seeking participants for Pain research studies. The states with the highest number of trials for Pain participants are California, Ohio, Florida and Illinois.
Opioid-Sparing and Pain-Reducing Properties of Syntocinon: A Dose-Effect Determination
NCT04218409
Recruiting
Some research suggests that administration of oxytocin with oxycodone may reduce its abuse liability and improve its ability to reduce pain. In a 6-session laboratory study, the investigators will be evaluating the effects of oxycodone and oxytocin (combined and separately, across sessions) on experimentally-induced pain, subjective effects, decision-making, and activation of different neural substrates.
Gender:
ALL
Ages:
Between 21 years and 45 years
Trial Updated:
12/09/2024
Locations: University of Florida, Gainesville, Florida
Conditions: Pain
Register for Updates
Low-Dose Ketamine Infusion During Burn Wound Care
NCT06506565
Recruiting
The current standard of care (SOC) (i.e. fentanyl and midazolam) offers limited efficacy for preventing or relieving pain. Ketamine infusions may provide the benefits of analgesia, minimize adverse events, and reduce opioid use. The purpose of this study is to determine if adding a low dose ketamine infusion during wound care will safely provide pain relief for patients with burn injury.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/09/2024
Locations: Regional One Health, Memphis, Tennessee
Conditions: Burn, Pain, Dissociation, Opioid
Register for Updates
Low-dose Buccal Buprenorphine: Relative Abuse Potential and Analgesia
NCT05988710
Recruiting
The goal of this study is to compare the abuse potential of low-dose equianalgesic buccal buprenorphine to a commonly used full mu opioid receptor (MOR) agonist in a highly controlled experimental setting. This is a translational study in which healthy participants are phenotyped for psychosocial and Opioid-Use-Disorder-risk-related metrics. In a within-subjects crossover design, 60 participants will receive a standard postoperative oral oxycodone dose (10 mg), placebo, and 3 different doses of... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/06/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Analgesia, Abuse Opioids, Pain
Register for Updates
The Effect of Yoga on Nerve Pain Caused by Chemotherapy (Chemotherapy-Induced Peripheral Neuropathy)
NCT05121558
Recruiting
The purpose of this study is to test whether yoga can reduce nerve pain caused by cancer treatment (chemotherapy-induced peripheral neuropathy, or CIPN). Participants will take one of three approaches: * Yoga classes * Educational sessions on the causes and impacts of CIPN, how yoga may help with CIPN, and how different therapies may help with CIPN * Usual care with standard-of-care medications for CIPN The researchers will compare how these different approaches affect participants' balance, t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/06/2024
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts +7 locations
Conditions: Chemotherapy-Induced Peripheral Neuropathy, Nerve Pain, Neuropathy, Neuropathy, Painful, Pain, CIPN - Chemotherapy-Induced Peripheral Neuropathy, Chronic Pain
Register for Updates
Passive VS Active VR on HPT Using the Thermal Sensory Analyzer With a Peltier-Based Contact Thermode
NCT05836649
Recruiting
This is a prospective, crossover study of healthy participants evaluating the impact of passive vs. active virtual reality (VR) games on heat pain threshold (HPT).
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
12/05/2024
Locations: Lucile Parkard Children's Hospital, Stanford, California
Conditions: Pain, Anxiety
Register for Updates
Cannabis for Palliative Care in Cancer
NCT06266611
Recruiting
Many cancer patients suffer from pain, sleep, and mood problems and are using cannabis to relieve these symptoms. Cannabis may provide such relief but may also produce negative side effects including cognitive impairment, an especially problematic issue for cancer patients, indicating more research on cannabis use in the cancer context is required. In this endeavor, the present study seeks to compare the use of hemp-derived CBD (Cannabidiol) with and without THC (Delta-9-tetrahydrocannabinol) ve... Read More
Gender:
ALL
Ages:
25 years and above
Trial Updated:
12/03/2024
Locations: Anschutz Health Sciences Building, Aurora, Colorado
Conditions: Sleep, Anxiety, Depression, Pain
Register for Updates
Psychophysical Studies of Cancer Therapy Pain
NCT00515060
Recruiting
The Aim of this Study is to examine the feasibility of using quantitative sensory testing procedures, widely applied to the experimental study of sensory processing in humans both with and without various pain syndromes, to now characterize the psychophysical properties of neuropathic pain that has developed as a consequence of cancer therapy. Skin punch biopsies will be performed in patients with chemotherapy-induced pain to determine whether the impairment of nerve function is due to actual re... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: University of Texas MD Anderson Cancer Center, Houston, Texas
Conditions: Advanced Cancer, Pain
Register for Updates
A Combination Mindfulness and Music Intervention for Acute Pain
NCT06718218
Recruiting
This project is a single-site, four-arm, randomized controlled trial evaluating a combination mindfulness + music intervention on acute pain among patients in an orthopedic clinic waiting room. Participants will be randomized to one of four conditions: 1) a 5-minute mindfulness recording, 2) a 5-minute mindfulness recording with an accompanying sustained tone at 65.41 Hertz, 3) a 5-minute mindfulness recording with an accompanying binaural beat set at 65.41 Hertz in the left ear and 69.41 Hertz... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/02/2024
Locations: Tallahassee Orthopedic Clinic (TOC), Tallahassee, Florida
Conditions: Pain, Acute Pain
Register for Updates
Impact of Art Therapy on Self-Reported Pain and Anxiety Scores of Patients Waiting to Be Seen in the Emergency Department
NCT05540106
Recruiting
The objective of this research is to assess the effects of engaging in coloring activities on patients' self-reported pain and anxiety scores while they wait to be seen by a physician in an emergency department (ED). The current literature on patient visits in the ED highlights the significance of anxiety, stress, and frustration in patient experiences, especially when accounting for long wait times before the physician-patient encounter. The study will address this common problem by looking at... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/26/2024
Locations: Stony Brook University Hospital, Stony Brook, New York
Conditions: Anxiety, Pain
Register for Updates
Using a Patient Navigator to Address the Social Drivers of Health in the Management of Pain
NCT06665906
Recruiting
The purpose of this study is to see if patients with chronic pain can improve how they manage their pain and daily function by working with a care manager and by learning pain coping skills from an online teaching tool.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/22/2024
Locations: Atrium Health Wake Forest Baptist, Winston-Salem, North Carolina
Conditions: Pain
Register for Updates
Diagnostic and Prognostic Biomarkers for High-impact Chronic Pain: Development and Validation
NCT04994249
Recruiting
To identify diagnostic and prognostic biomarker signatures of recovery versus having persisting high-impact chronic pain and functional disability in adults with Chronic Musculoskeletal Pain.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/20/2024
Locations: Stanford University, Palo Alto, California
Conditions: Chronic Musculoskeletal Pain, Pain, Pain, Chronic, Joint Pain
Register for Updates
Sevoflurane's Effect on Neurocognition Study
NCT06044740
Recruiting
The purpose of this study is to determine the effects of acute pain on long-term memory and conditioned physiologic responses in the presence and absence of low dose sevoflurane. Functional magnetic resonance imaging will be used to identify the neural correlates of these phenomena. The study will occur over 2 visits and involves no long-term follow up.
Gender:
ALL
Ages:
Between 18 years and 59 years
Trial Updated:
11/19/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Anesthesia, Pain, Amnesia
Register for Updates