There are currently 135 active clinical trials seeking participants for Pain research studies. The states with the highest number of trials for Pain participants are California, Ohio, Florida and Illinois.
Discovery and Analytical Validation of Inflammatory Bio-signatures of the Human Pain Experience
NCT05074485
Recruiting
The first objective of the study is to evaluate whether a novel bio-signature (derived from a wide range of pro- and anti-nociceptive IL-1 family cytokine activity) will predict pain experienced and also release of underlying endogenous opioid neurotransmitters during an experimental nociceptive pain challenge, which will be performed while simultaneously quantifying mu-opioid receptor activity in the brain via [11C]-carfentanil PET neuroimaging in healthy subjects. Another objective is to evalu... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
12/01/2023
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Pain
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VR to Reduce Pain/Anxiety During Painful Procedures
NCT04268901
Recruiting
This study aims to test the effectiveness of virtual reality (VR) as a non-pharmaceutical intervention to reduce pain and anxiety in children undergoing painful procedures in Phlebotomy, Radiology, Infusion, Orthopedics, Gastroenterology, and Immunology, amongst others, at CHLA, as measured by self- and proxy-report. Examples of the painful procedures include IV sticks, cast removals, allergy testing, and anorectal manometries.
Gender:
All
Ages:
Between 7 years and 21 years
Trial Updated:
10/25/2023
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Phlebotomy, Orthopedics, Radiology, Pain, Anxiety, Virtual Reality, Allergy, Gastroenterology
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Vibratory Anesthesia in Trigger Finger Injections
NCT05405452
Recruiting
This study aims to compare the effectiveness of the use of no topical anesthesia, topical coolant, and the use of vibration in the reduction of pain during trigger finger injections. This will be done by randomizing patients who are diagnosed with trigger finger, warrant and choose to continue with a steroid injection into each of the respective anesthetic (or lack thereof) methods described. After conducting this and gathering data on the subjects pain felt, we will compare the analgesia from e... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/14/2023
Locations: Banner UMC North Hills Clinic, Tucson, Arizona +1 locations
Conditions: Trigger Finger, Pain, Anesthesia, Local
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Defense and Veterans Center for Integrative Pain Management (DVCIPM) Pain Registry Biobank
NCT04004286
Recruiting
This Pain Registry Biobank is a prospective cohort design study whereby data (PASTOR survey, blood and saliva specimens, clinical data) is collected from participants in a longitudinal fashion with continual enrollment.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
08/10/2023
Locations: Naval Medical Center San Diego, San Diego, California +1 locations
Conditions: Pain
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A Study to Assess the Safety of MEB-1170 in Healthy Subjects
NCT05748119
Recruiting
Primary Objective: To determine the safety and tolerability of single and multiple ascending oral doses of MEB-1170 in healthy subjects. Secondary Objectives: To determine the single and multiple oral dose pharmacokinetic profiles of MEB-1170 and the primary metabolite, M373, in healthy subjects. To determine the effect of food on the pharmacokinetic (PK) profile of a single oral dose of MEB-1170 in healthy subjects. To assess the pharmacodynamic (PD) response following single and multiple ora... Read More
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
02/17/2023
Locations: Labcorp Clinical Research Unit, Inc, Daytona Beach, Florida
Conditions: Pain
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A Phase 1, Randomized, Placebo-Controlled Safety and Tolerability Study Of Intravenous SBS-1000 in Healthy Adults
NCT05721287
Recruiting
This study will be a single-center, double-blind, randomized placebo-controlled, adaptive, single ascending dose study.
Gender:
All
Ages:
Between 18 years and 59 years
Trial Updated:
01/31/2023
Locations: Altasciences Clinical Kansas, Overland Park, Kansas
Conditions: Pain, Acute Pain
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AIMS Medical Outcomes Study
NCT04512755
Recruiting
This epidemiologic research is being conducted as an observational prospective case series outcomes study of the use of advanced integrative specialty medical care and its effect on adult and pediatric patients with chronic or serious illnesses or mental health disorders.
Gender:
All
Ages:
All
Trial Updated:
01/30/2023
Locations: AIMS Institute, Seattle, Washington
Conditions: Mental Health Issue, PTSD, Pain, Chronic Pain, Chronic Disease
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Pregabalin vs. Gabapentin on Reducing Opioid Usage
NCT04705480
Recruiting
This is a single-center, randomized, open-label, Phase 4 clinical trial investigating the efficacy of multiple-dose administrations of Pregabalin or Gabapentin in combination with traditional opioid pain medications to decrease the amount of opioid pain medication usage in single-system orthopedic trauma patients.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/11/2023
Locations: Charleston Area Medical Center"s Level 1 Trauma Center, Charleston, West Virginia
Conditions: Analgesics, Gabapentin, Injuries, Narcotics, Pain, Trauma
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STIMFIX Trail Lead Anchor System for Dorsal Column Stimulator Trail Leads (SECURE Study)
NCT05651646
Recruiting
This project will investigate the efficacy of a Stimfix Trail lead anchor system (StimfixTM) in patients undergoing dorsal column stimulator trial. In dorsal column stimulator trails, two leads are placed in the epidural space and various frequencies, pulse widths, and amplitudes are run to reduce pain perception. This therapy has been in use for the last 70 years and today there are about 100,000 implants done annually for various pain indications. The process of obtaining the therapy requires... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/07/2022
Locations: Lake side spine & pain, Lake Havasu City, Arizona +2 locations
Conditions: Pain
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Enhancing Analgesia in Chronic Pain Through Exercise
NCT04862871
Recruiting
Background: Current pain management strategies for pediatric patients are not integrating the analgesic potential of movement-based therapies. To date, experiencing a painful stimulus has been known to disrupt motor activity in an attempt to minimize injury. However, physical activity, even when it increases ongoing pain initially, has been shown to significantly reduce pain symptoms eventually through neuromodulation. In both acute and chronic pain cohorts, exercise protocols and neuromodulatio... Read More
Gender:
All
Ages:
Between 10 years and 24 years
Trial Updated:
05/06/2022
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Pain, Chronic Widespread Pain, Fibromyalgia
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Improving Pain Management and Decreasing LOS After Total Hip Arthroplasty (THA) and Total Knee Arthroplasty (TKA)
NCT05307341
Recruiting
This two arm, patient blinded, randomized, post market clinical trial in a single orthopedic hospital will determine whether there is improved pain management and decreased length of stay when comparing standard of care pain management with and without sufentanil.
Gender:
All
Ages:
Between 50 years and 80 years
Trial Updated:
03/29/2022
Locations: The CORE Institute Specialty Hospital, Phoenix, Arizona
Conditions: Pain
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Impact of Complimentary and Alternative Practices on Patient Wellbeing During Rehabilitation
NCT05082246
Recruiting
The study's objective is to assess whether CAM methods are feasible and beneficial in the WSRH setting; to assess stress (using the Perceived Stress Scale-14 and using BioSquares™), anxiety (using the Generalized Anxiety Disorder-7 scale), depression (using the Patient Health Questionnaire-9 scale), pain (using the Wong-Baker FACES scale), and vital signs using a multidisciplinary complementary approach with Heartfulness Meditation, Conscious Breathing, and Emotional Freedom Technique - the CAM... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/05/2021
Locations: Wellspan Surgery and Rehabilitation Hospital, York, Pennsylvania
Conditions: Anxiety, Depression, Stress, Pain, Heart Rate, Blood Pressure
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