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Pain Clinical Trials
A listing of 128 Pain clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
1 - 12 of 128
There are currently 128 active clinical trials seeking participants for Pain research studies. The states with the highest number of trials for Pain participants are California, Ohio, Florida and Illinois.
Featured Trial
Paid Clinical Studies Nationwide
Recruiting
Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.
Featured Trial
Chronic Cough Study
Recruiting
Are you tired of living with chronic cough? The ASPIRE Study is now looking to enroll people from all backgrounds to help research potential new treatment options for chronic cough. You are under no obligation to take part and health insurance is not required. Find out more today! We’d love to hear from you.
Conditions:
Chronic Cough
Refractory or Unexplained Chronic Cough
Cough
Asthma
Allergic Asthma
Featured Trial
Type 2 Diabetes Clinical Trial
Recruiting
Can changing your breakfast improve your type 2 diabetes? If you have an HbA1C of 7.0% or higher, you are invited to participate in an online study at the University of Michigan.
Conditions:
Type 2 Diabetes
Diabetes Mellitus Type 2 in Obese
Diabetes Type Two
Type 2 Diabetes Mellitus
Diabete Type 2
Featured Trial
Crohn's Disease Clinical Study
Recruiting
Help us study a potential new way to treat Crohn's disease. We are seeking adults living with Crohn's disease to join our latest clinical trial to help us learn more. Eligible participants will receive study-related treatment, assessments, and care at no cost. You will also receive reimbursement for travel while participating. Health insurance is not required to take part.
Conditions:
Crohn's Disease
Crohn Disease
Crohns Disease
Crohn's Disease (CD)
Crohn Colitis
Pain After Buffered Vs Non Buffered Articaine
Recruiting
Pain after buffered versus non buffered articaine.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
07/31/2024
Locations: Clevland Dental Institute, Cleveland, Ohio
Conditions: Pain
Postoperative Pain After Activation of Irrigant
Recruiting
The purpose of this research is to analyze the levels of pain after cleaning and shaping in individuals who are receiving root canal therapy using the IVAC irrigation approach, and those who are treated with ultrasonic irrigation techniques, negative pressure irrigation technique and traditional irrigation techniques.
PICOTS Question:
Does the new Dent's iVac irrigation protocol has an effect on reduction of postoperative pain
By enlisting at least 84 suitable individuals who are undergoing t... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
07/26/2024
Locations: Cleveland Dental Institute, Cleveland, Ohio
Conditions: Pain
Pain Perception Measurement by EEG and NRS
Recruiting
Observational study at CDI Cleveland Dental Institute. Investigators will assess the pain perception in one group of patients using two non-invasive methods. First, a numerical rate scale (NRS) and second, a brain wave EEG.
Gender:
ALL
Ages:
Between 20 years and 60 years
Trial Updated:
07/19/2024
Locations: Cleveland Dental Institute, Cleveland, Ohio
Conditions: Pain, Electroencephalography, Toothache
Testosterone Replacement to Alleviate Pain in Postmenopausal Women (TRAPP Trial)
Recruiting
The aim of this trial is to evaluate whether testosterone replacement results in greater improvement in pain perception, pain tolerance, sexual function, physical function and quality of life when compared with placebo in women with chronic back pain treated with opioids who have low testosterone.
Gender:
FEMALE
Ages:
60 years and above
Trial Updated:
05/06/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Sociocultural & Biobehavioral Influences on Pain Expression and Assessment
Recruiting
Objective
The current proposal investigates behavioral, psychophysiological, and social processes that may help explain biases and disparate outcomes in pain. Health disparities, or health outcomes that adversely affect disadvantaged populations, are pervasive and apparent in many diseases and symptoms, including pain. Pain is the number one reason individuals seek medical treatment. Health disparities in pain encompass both differences in pain experience and treatment for pain. For instance, r... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
05/02/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Normal Physiology, Healthy Volunteers, Pain
Pain With Dementia
Recruiting
The purpose of the study is to develop a caregiver-assisted pain coping skills training program for older adults who have pain and mild to moderate dementia and are living at home with a family caregiver. The investigators are planning to recruit 30 patient-caregiver dyads (60 individuals).
Gender:
ALL
Ages:
50 years and above
Trial Updated:
04/30/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Pain, Dementia, Mild, Dementia, Moderate
Age-dependent Effects of Smoked and Oral Delta-9-THC
Recruiting
This study will assess the age-dependent effects of smoked and oral THC on abuse liability, intoxication, analgesia and impairment as a function of age.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/28/2025
Locations: UCLA Center for Cannabis and Cannabinoids, Los Angeles, California
Conditions: Pain, Abuse, Drug, Intoxication; Cannabinoids
Chronic Pain in Rheumatoid Arthritis
Recruiting
The objective is to identify modifiable clinical factors and neurobiological pathways that lead to the development of chronic pain in patients with early rheumatoid arthritis. Participants will undergo quantitative sensory testing, a type of testing that involves assessing response to well-defined, quantifiable painful stimuli, at 0, 3, and 12 months. A subset of participants will also undergo magnetic resonance imaging at 0 and 12 months to assess neuroimaging markers that have previously been... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/24/2025
Locations: University of Colorado, Denver, Colorado +4 locations
Conditions: Arthritis, Rheumatoid, Pain
Clinical and Scientific Assessment of Pain and Painful Disorders
Recruiting
Background:
Researchers want to better understand pain by studying people with and without different kinds of pain. To do this, researchers will expose people to pleasant and unpleasant sensations. They will ask them questions about their pain. Researchers also want to see if these people are eligible for other research studies at the National Center for Complementary and Integrative Health.
Objectives:
To study the experience of pain. Also to find people eligible to join other NIH studies.... Read More
Gender:
ALL
Ages:
Between 12 years and 120 years
Trial Updated:
04/23/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Normal Physiology, Pain
Does Psychoeducation Improve the Pain Relief Derived From a Brief Intervention
Recruiting
This project is a single-site, five-arm, randomized controlled trial investigating whether providing patients in an orthopedic clinic waiting room psychoeducation about mindfulness impacts the degree of pain relief they experience during a mindfulness-based intervention.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: Tallahassee Orthopedic Clinic (TOC), Tallahassee, Florida
Conditions: Pain, Acute Pain
Neuropathic Pain and Operant Conditioning of Cutaneous Reflexes After SCI
Recruiting
The purpose of the second part of the study is to examine the effect of reflex training in the leg to decrease neuropathic pain. For this, the researchers are recruiting 15 individuals with neuropathic pain due to spinal cord injury to participate in the reflex training procedure. The study involves approximately 50 visits with a total study duration of about 6.5 months (3 months for baseline and training phases followed by 1 month and 3 month follow-up visits).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/21/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Spinal Cord Injuries, Neuropathic Pain, Neurological Injury, Pain
The Potential of Oxytocin to Reduce Opioid Abuse Liability and Pain Among Older Adults
Recruiting
Some research suggests that administration of oxytocin with oxycodone may reduce its abuse liability and improve its ability to reduce pain. In a 6-session laboratory study, we will be evaluating the effects of oxycodone and oxytocin (combined and separately, across sessions) on experimentally-induced pain, subjective effects, and decision-making.
Gender:
ALL
Ages:
Between 45 years and 85 years
Trial Updated:
04/21/2025
Locations: University of Florida, Gainesville, Florida
Conditions: Pain
1 - 12 of 128