There are currently 133 active clinical trials seeking participants for Pain research studies. The states with the highest number of trials for Autism participants are California, Ohio, Florida and Illinois.
PENG vs. FIC Block for Hip Fracture ED Patients
NCT05102760
Recruiting
Ultrasound-guided nerve blocks are an important tool for treating pain due to orthopedic injury in the ED. They provide long lasting, opioid-sparing pain relief that is generally safe and well-tolerated by patients1. Elderly patients with hip fractures commonly present to the ED, and their injury can be painful. Commonly used opioid pain regimens can have deleterious side effects, especially in elderly patients, like somnolence, delirium, hypotension and respiratory depression. The fascia iliac... Read More
Gender:
All
Ages:
Between 18 years and 110 years
Trial Updated:
07/02/2023
Locations: Maimonides Medical Center, Brooklyn, New York
Conditions: Pain, Hip Fracture
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A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD
NCT05081596
Recruiting
The purpose of the study is to examine the effect of Problem Adaptation Therapy for Pain (PATH-Pain) on cognitive functioning, depression and pain-related disability in 100 older adults with cognitive impairment, chronic pain, and depression. The study will test if PATH-Pain has better cognitive, affective, and functional outcomes than Attention Control Usual Care.
Gender:
All
Ages:
60 years and above
Trial Updated:
06/28/2023
Locations: Weill Cornell Medicine, White Plains, New York
Conditions: Depression, Pain, Cognitive Impairment
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Pain Sensitivity During Puberty
NCT05145595
Recruiting
Aim 1- To examine the differences in pain sensitivity between adolescents at early vs. mid pubertal status Aim 2- To determine the relationships between sex hormone levels and pain sensitivity Exploratory Aim 1- To determine the effect of pubertal maturation on pain sensitivity Exploratory Aim 2- To identify parameters related to who will develop chronic pain during puberty Hypothesis 1- Adolescents in early pubertal status will have higher pain ratings and lower pain modulation capabilities co... Read More
Gender:
All
Ages:
Between 9 years and 16 years
Trial Updated:
06/09/2023
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Pain
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Pervasive Sensing and AI in Intelligent ICU
NCT05127265
Recruiting
Important information related to the visual assessment of patients, such as facial expressions, head and extremity movements, posture, and mobility are captured sporadically by overburdened nurses, or are not captured at all. Consequently, these important visual cues, although associated with critical indices such as physical functioning, pain, delirious state, and impending clinical deterioration, often cannot be incorporated into clinical status. The overall objectives of this project are to s... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/04/2023
Locations: University of Florida Health Shands Hospital, Gainesville, Florida
Conditions: Critical Illness, Pain, Delirium, Confusion
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Effects of Dronabinol in Opioid Maintained Patients
NCT04025359
Recruiting
Twenty male and female (ages 18-70) participants with OUD currently receiving methadone or buprenorphine will be enrolled. Prior to their daily methadone or buprenorphine dose and thus at trough plasma levels of opioid, participants will receive dronabinol (2.5 mg, 5mg) or placebo. Subsequently, all participants will undergo laboratory testing of opioid-related outcomes. Pain sensitivity will be measured using a technique called the (QST) quantitative sensory testing, which involves the administ... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
05/25/2023
Locations: VA Healthcare System, West Haven, Connecticut
Conditions: Pain
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Enhancing Exercise and Psychotherapy to Treat Pain and Addiction in Adults With an Opioid Use Disorder (EXPO; R33 Phase)
NCT05688410
Recruiting
This work will involve conducting a randomized trial that will evaluate preliminary efficacy of "assisted" rate cycling, voluntary rate cycling and psychotherapy for pain individually and in combination as adjunctive treatments on cravings (primary outcome) in adults with an opioid use disorder. The investigators will also evaluate the effects of "assisted" rate cycling, voluntary rate cycling and I-STOP on secondary outcomes including depression, anxiety and sleep.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
05/11/2023
Locations: University of Colorado at Denver, Denver, Colorado +1 locations
Conditions: Opioid Use Disorder, Pain
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Neural Mechanisms of Immersive Virtual Reality in Chronic Pain
NCT04851301
Recruiting
This project examines, in chronic pain, the mechanisms of immersive virtual reality compared to the mechanisms of placebo hypoalgesia. The potential of developing new non-pharmacological premises for low-risk interventions for pain management is high.
Gender:
All
Ages:
Between 18 years and 88 years
Trial Updated:
05/09/2023
Locations: Luana Colloca, Baltimore, Maryland
Conditions: Pain, Virtual Reality, Placebo, Temporomandibular Disorder
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Prospective Randomized Trial of CPAP for SDB in Patients Who Use Opioids
NCT04928157
Recruiting
Patients with chronic pain who use opioids appear to be at increased risk for breathing issues during sleep, termed sleep disordered breathing (SDB). Treatment of SDB often consists of use of a device during sleep that provides continuous positive airway pressure (CPAP) via a mask interface. The goal of this study is to determine whether patients with chronic pain who use opioids and have SDB might benefit from the use of CPAP in terms of sleep quality, pain, quality of life, and other measures.... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/05/2023
Locations: University of California San Diego, San Diego, California
Conditions: Sleep Disorder; Breathing-Related, Pain, Sleep Apnea, Obstructive Sleep Apnea, Sleep, Sleep Disorder, Chronic Pain, Opioid Use
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Diagnostic and Prognostic Biomarkers for High-impact Chronic Pain: Development and Validation
NCT04994249
Recruiting
To identify diagnostic and prognostic biomarker signatures of recovery versus having persisting high-impact chronic pain and functional disability in adults with Chronic Musculoskeletal Pain.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
04/10/2023
Locations: Stanford University, Palo Alto, California
Conditions: Chronic Musculoskeletal Pain, Pain, Pain, Chronic, Joint Pain
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AnalgeSiC and appEtite-stimulating Effects of caNnabigerol and THC (ASCENT)
NCT04859296
Recruiting
This study will assess the analgesic, appetite-stimulating, and subjective effects of cannabigerol (CBG) alone and in combination with THC.
Gender:
All
Ages:
Between 21 years and 55 years
Trial Updated:
03/13/2023
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Pain, Appetite Loss, Abuse, Drug
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A Study to Assess the Safety of MEB-1170 in Healthy Subjects
NCT05748119
Recruiting
Primary Objective: To determine the safety and tolerability of single and multiple ascending oral doses of MEB-1170 in healthy subjects. Secondary Objectives: To determine the single and multiple oral dose pharmacokinetic profiles of MEB-1170 and the primary metabolite, M373, in healthy subjects. To determine the effect of food on the pharmacokinetic (PK) profile of a single oral dose of MEB-1170 in healthy subjects. To assess the pharmacodynamic (PD) response following single and multiple ora... Read More
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
02/17/2023
Locations: Labcorp Clinical Research Unit, Inc, Daytona Beach, Florida
Conditions: Pain
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Sciatic Block in Contralateral Limb Phantom and Residual Limb Pain
NCT05046639
Recruiting
Participants with chronic, refractory phantom limb pain (PLP) or residual limb pain (RLP) for more than 6 months will be enrolled in this clinical trial. Aim: Define the attributable pain relief and functional improvement in participants with PLP/RLP after contralateral limb sciatic nerve block. Also, contribute to the basic science understanding of the crossed-withdraw reflex by demonstrating a known animal model phenomenon in human participants. Hypothesis: Contralateral limb sciatic nerve ane... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/01/2023
Locations: Northwestern Memorial Hospital, Chicago, Illinois
Conditions: Pain, Amputation
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