Texas is currently home to 4891 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Houston, Dallas, San Antonio and Austin. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
NAFLD Clinical Care Pathway
Recruiting
Non-alcoholic fatty liver disease (NAFLD) is a new condition that has become the most common chronic liver disease in the world and a main cause of liver cirrhosis, liver failure and liver cancer. Obesity and diabetes, conditions that are very common among Veterans are the main risk factors for NAFLD. Therefore, the burden of NAFLD and its complications among Veterans is substantial. However, most VA patients with NAFLD are undiagnosed and untreated, and their care is not consistent with practic... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/31/2024
Locations: Michael E. DeBakey VA Medical Center, Houston, TX, Houston, Texas
Conditions: NAFLD, MASLD
A Study on TLC590 for Managing Postsurgical Pain
Recruiting
This Phase 2 open-label trial investigates the pharmacokinetics (PK), pharmacodynamics, and safety profile of TLC590 across various surgical procedures. Researchers aim to determine the maximum tolerated dose (MTD) of TLC590 via Safety Monitoring Committee (SMC). The study evaluates TLC590 in bunionectomy, laparoscopy-assisted open ventral hernia repair, breast augmentation, abdominoplasty, and total knee arthroplasty models. Additionally, it determines the relative bioavailability of TLC590 to... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
10/31/2024
Locations: First Surgical Hospital, Bellaire, Texas
Conditions: Postsurgical Pain Management
Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction
Recruiting
The purpose of this study is to determine if intraosseous (IO) morphine decreases pain and post-operative opioid use in patients undergoing anterior cruciate ligament (ACL) reconstruction.
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
10/30/2024
Locations: Houston Methodist Research Institute, Houston, Texas
Conditions: Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
THRIVE Well Cancer FDTN/Exercise_Creatine Supplementation
Recruiting
The study's purpose is to evaluate whether creatine supplementation can help breast cancer survivors respond quicker to exercise by improving strength, endurance, and body composition. We are seeking to compare information collected from healthy woman of the same age who have never had breast cancer to those participants who have had breast cancer and undergone chemotherapy treatment.
Gender:
FEMALE
Ages:
Between 18 years and 75 years
Trial Updated:
10/30/2024
Locations: The University of Texas Medical Branch, Galveston, Galveston, Texas
Conditions: Breast Cancer, Breast Cancer Female, Muscle Weakness
Safety and Efficacy of ALLO-316 in Subjects With Advanced or Metastatic Clear Cell Renal Cell Carcinoma
Recruiting
This is a Phase 1 dose escalation study following a 3+3 study design. The purpose of the TRAVERSE study is to assess the safety, efficacy, and cell kinetics of ALLO-316 in adults with advanced or metastatic clear cell renal cell carcinoma after a lymphodepletion regimen comprising fludarabine, cyclophosphamide, and ALLO-647 to define a Phase 2 dose.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
10/30/2024
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Advanced/Metastatic Clear Cell Renal Cell Carcinoma
LINX Reflux Management System or Fundoplication Clinical Study in Patients With Hiatal Hernia >3 cm
Recruiting
The cohort registry is both retrospective and prospective, multicenter surveillance of subjects who underwent a prior hiatal hernia repair and Magnetic Sphincter Augmentation or fundoplication construction more than 2 years prior to initial study visit.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
10/30/2024
Locations: University of Texas, Austin, Texas
Conditions: Hiatal Hernia Large, Gastro Esophageal Reflux, Hiatal Hernia, Hiatal Hernia, Paraesophageal, Reflux, Gastroesophageal, Reflux Acid
Evaluate the Safety and Clinical Activity of HH2853
Recruiting
This is an open-label, multicenter, first-in-human phase I/II study which is composed of 3 parts: phase I dose escalation, phase I dose extension and phase II. HH2853 will be administered orally on a continuous BID schedule on a continuous 28-day treatment cycle.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/30/2024
Locations: NEXT Oncology, San Antonio, Texas
Conditions: Advanced Solid Tumor, FL Lymphoma, Epithelioid Sarcoma, Peripheral T Cell Lymphoma
Study of Individuals Affected With Hypoplasminogenemia
Recruiting
This is an Investigator initiated retrospective and prospective single cohort study. The study will utilize an international registry and develop a specimen biobank to provide an improved understanding of the natural history of hyposplasminogenemia, to elucidate the heterogeneity of phenotypic expression, identify markers to predict disease course, and inform improved therapeutic modalities
Gender:
ALL
Ages:
All
Trial Updated:
10/30/2024
Locations: Cook Children's Medical Center, Fort Worth, Texas
Conditions: Plasminogen Deficiency
[18F]PT2385 PET/CT in Patients with Renal Cell Carcinoma
Recruiting
This is an exploratory study to assess \[18F\]PT2385 Positron Emission Tomography/Computed Tomography (PET/CT) in patients with renal cell carcinoma (RCC). This is an open-label, nontherapeutic trial. The main objective is to correlate hypoxia-inducible factor-2alpha (HIF2α) levels as determined by an investigational \[18F\]PT2385 PET/CT scan with the levels on subsequently obtained tissue by HIF2α immunohistochemistry (IHC). There will be three cohorts. The first pre-surgical cohort will have \... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/29/2024
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Renal Cell Carcinoma, Clear Cell Renal Cell Carcinoma
Precision Medicine in Action: Phase II Trial of Response Adaptive Ablative Pre-operative SPBI (RAPS) and Non-operative Sentinel Lymph Node Biopsy in Patients With Early-stage ER+ Breast Cancer: RAPS Trial
Recruiting
1. Efficacy of PULSAR preoperative radiation 2. Evaluate potential of microbubble CEUS as an alternative to operative SLNBx 3. Evaluate potential of OA to evaluate treatment response of pre-operative radiation on the tumor
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
10/28/2024
Locations: UT Southwestern Medical Center-Dallas, Dallas, Texas
Conditions: Breast Cancer
Comparing Antipsychotic Medications in LBD Over Time
Recruiting
The primary objective of this study is to determine whether treatment with pimavanserin or quetiapine is associated with a greater improvement in psychosis when used in a routine clinical setting to treat hallucinations and/or delusions due to Parkinson's disease (PD) or dementia with Lewy bodies (DLB) - collectively referred to as Lewy body disease (LBD).
Gender:
ALL
Ages:
All
Trial Updated:
10/28/2024
Locations: University Health System, San Antonio, Texas
Conditions: Parkinson's Disease Psychosis, Dementia With Lewy Bodies
Veri-T: A Trial of Verdiperstat in Patients With svPPA Due to TDP-43 Pathology
Recruiting
The purpose of the study is to test the safety and tolerability of twice daily Verdiperstat in patients with semantic variant primary progressive aphasia (svPPA) due to frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP). Three-fourths of the participants will receive Verdiperstat and one-fourth will receive Placebo during the 24-week treatment duration.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
10/28/2024
Locations: Houston Methodist Hospital - Nantz National Alzheimer Center, Houston, Texas
Conditions: Semantic Dementia