Texas Clinical Trials

A listing of Texas clinical trials actively recruiting patient volunteers.

With over 100,000 clinical trials happening every year in United States, there are always many clinical trials going on in every state, including Texas. Hospitals, universities, pharmaceutical companies, and research organizations conduct clinical trials, and while some of them require a stay at the facilities, others just require daily or weekly visits from the volunteers.

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5213 trials found

A Study to Confirm the Efficacy and Safety of K-161 Ophthalmic Solution for Treatment of Moderate to Severe Dry Eye Disease

NCT05403827

The purpose of this study is to assess the efficacy and safety of K-161 ophthalmic solution for the treatment of moderate to severe dry eye disease.

Conditions: Dry Eye Disease

To Evaluate the Pharmacokinetics (PK) and Safety of Tavapadon in Participants With Mild and Moderate Hepatic Impairment Compared to Participants With Normal Hepatic Function

NCT05404529

The primary purpose of the study is to assess the effect of hepatic impairment on the PK of tavapadon following administration of a single oral dose in participants with mild and moderate hepatic impairment relative to age, body weight, and sex-matched participants with normal hepatic function.

Conditions: Hepatic Impairment

Prospective Data Registry and Quality of Life Assessment of Patients Undergoing Radiotherapy With the RefleXion Medical Radiotherapy System

NCT05406167

The purpose of this prospective cohort study is to assess clinical and quality of life measures as well as to define the severity of adverse effects for the use of the RefleXion system to deliver intensity-modulated radiotherapy (IMRT), stereotactic body radiotherapy (SBRT), in standard of care (SOC) use in the treatment of local,loco-regionally advanced, and oligometastatic malignancies. In addition, patient costs and charges will be analyzed to quantify the health economic impact of this modal ...

Conditions: Cancer, Cancer Central Nervous System, Cancer Thoracic, Cancer, Gastrointestinal, Cancer Gynecologic, Cancer, Genito-Urinary, Cancers Lymphatic, Cancer Head and Neck

Treating Civilian Traumatic Brain Injury With High Definition Transcranial Direct Current Stimulation (ciTBI-HDtDCS)

NCT05408975

The purpose of the study is to test whether low level electric stimulation, called transcranial Direct Current Stimulation (tDCS), on the part of the brain (i.e., pre-supplementary motor area) thought to aid in memory will improve verbal retrieval in civilian (non-military, non-veteran) participants with histories of traumatic brain injuries. The primary outcome measures are neuropsychological assessments of verbal retrieval, and the secondary measures are neuropsychological assessments of other ...

Conditions: Traumatic Brain Injury, Word Finding Difficulty, Acquired Brain Injury, Cognitive Change
Phase: Phase 1/2

Therapeutic Plantar Electrical Stimulation Intervention During Hemodialysis to Improve Balance and Mobility

NCT05407207

A high prevalence of diabetes has been reported in Qatar with nearly 23% population suffering from the pandemic, thereby increasing the associated healthcare cost. Low compliance with exercise and physical activity in patients with diabetes increases foot risk complications, deteriorates health, and further increases economic costs. This is particularly true among patients with diabetes who are undergoing hemodialysis (HD) process. Exercise interventions have been shown to improve mobility and b ...

Conditions: Diabetes Mellitus, Hemodialysis Complication, Cardiovascular Complication, Quality of Life
Phase: Not Applicable

Rollover Extension Clinical Trial To Evaluate The Long-Term Safety And Efficacy Of US-APR2020 In Subjects With CKD IV Completing The US-APR2020-01 Study

NCT05407389

This is an Open-Label Rollover Extension Clinical Trial to Evaluate the Long-Term Safety and Efficacy of US-APR2020 in Subjects With CKD IV Who Completed the US-APR2020-01 Study

Conditions: Chronic Kidney Disease stage4
Phase: Phase 2/3

A Study Evaluating the Safety and Efficacy of Hormone Replacement Therapy With ST-1891 Compared to Levothyroxine in Patients With Primary Hypothyroidism

NCT05412979

ST-1891-201 is a multicenter, randomized, double-blind, crossover, Phase 2 study evaluating the safety and efficacy of hormone replacement therapy with ST-1891 compared to levothyroxine in patients with primary hypothyroidism.

Conditions: Hypothyroidism

Platelet Function in Patients With Ischemic Stroke Treated With Anti-thrombotic or Thrombolytic

NCT05415150

Acute stroke afflicts nearly 700,000 patients in the US and is the number 3 cause of death. Only 2-9% of this large number is treated with t-PA if they arrive within 4.5 hours. An equally small percentage of patients with large vessel occlusion undergo thrombectomy. The thrombectomy patients may or may not receive t-PA. Some of these patients rarely receive intravenous GPIIB/IIIa inhibitors. Many lines of evidence suggest that GP IIb/IIIa inhibitors, a class of FDA approved potent platelet inhi ...

Conditions: Acute Ischemic Stroke
Phase: Phase 1/2

A Randomized, Placebo-Controlled, Double-Blind Study to Assess Safety and Efficacy of PCN-101 in TRD

NCT05414422

This is a double-blind, randomized, placebo-controlled, multicenter study comprised of 3 phases:screening (up to 2 weeks [Day -15 to Day -2]), In-Clinic Treatment (Day -1 to Day 2; including double-blind treatment [Day 1]), and post-treatment follow-up (7 and 14 days after infusion on Days 8 and 15, respectively). A total of 93 adult subjects with TRD will be randomly allocated in equal cohorts of 31 subjects/arm to the 3 arms of the study in a blinded manner.

Conditions: Treatment Resistant Depression

Proof-of-concept Trial of Apraglutide in GVHD

NCT05415410

The aim of this trial is to assess safety and efficacy of apraglutide in subjects with steroid refractory gastrointestinal acute graft versus host disease (aGVHD).

Conditions: GVHD

Safety and Effects of a Single Intravitreal Injection of vMCO-010 Optogenetic Therapy in Subjects With Stargardt Disease

NCT05417126

The purpose of the study is to evaluate the safety and effects of a single intravitreal injection of virally-carried Multi-Characteristic Opsin (vMCO-010) in Subjects with Stargardt Disease

Conditions: Stargardt Disease

Validation of a Salivary miRNA Diagnostic Test for ASD

NCT05418023

This study involves sample collection to identify biomarkers relating to Autism Spectrum Disorder(ASD) in the saliva of children who are between the ages of 18 months to 6 years and 11 months. Participants will at each timepoint have a non-invasive saliva swab collected and complete a brief demographic and medical history questionnaire as well. Children in the pediatric/provider setting who will receive a referral for an ASD diagnosis because they were determined to have a suspicion of developin ...

Conditions: Autism Spectrum Disorder, Developmental Delay

A clinical trial is conducted when a researcher finds a potential new drug, medical device, surgical procedure or intervention that has the potential of improving the lives of many but still needs to be tested to see if it is effective and safe for humans. In the state of Texas, there are a number of paid clinical trials for willing participants.

Clinical trials can last for many years because the medication or the intervention needs to be tested on many participants to ensure its safety and effectiveness. Many hospitals such as the Houston Methodist Hospital in Houston, Texas conduct clinical trials especially to find new treatments for diseases such as cancer, heart disease, and hormonal conditions. Hospitals tend to recruit participants by informing patients of the research study inviting them to participate.

On the other hand, pharmaceutical companies that develop new medications or medical devices sometimes need to hire companies to conduct all the different stages of clinical trials for them. These companies are called contract research organizations or CROs.

CROs provide management and support for institutions that need to conduct clinical trials but don't have the expertise or infrastructure to do so. CROs are responsible for recruiting the participants for the study, monitoring the trials, and ensuring that all parts of the study are being conducted according to protocol.

In Texas, there are several CROs that actively recruit volunteers year-round to participate in clinical trials. Some of the major CROs in Texas include: Covance, PPD, and Clinical Trials of Texas.

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