There are currently 132 active clinical trials seeking participants for Pain research studies. The states with the highest number of trials for Pain participants are California, Ohio, Florida and Illinois.
VR to Reduce Pain/Anxiety During Painful Procedures
NCT04268901
Recruiting
This study aims to test the effectiveness of virtual reality (VR) as a non-pharmaceutical intervention to reduce pain and anxiety in children undergoing painful procedures in Phlebotomy, Radiology, Infusion, Orthopedics, Gastroenterology, and Immunology, amongst others, at CHLA, as measured by self- and proxy-report. Examples of the painful procedures include IV sticks, cast removals, allergy testing, and anorectal manometries.
Gender:
All
Ages:
Between 7 years and 21 years
Trial Updated:
10/25/2023
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Phlebotomy, Orthopedics, Radiology, Pain, Anxiety, Virtual Reality, Allergy, Gastroenterology
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A Dose-Finding Study to Evaluate the Efficacy and Safety of GSK3858279 in Adults With Knee Osteoarthritis Pain
NCT05838742
Recruiting
This is dose-finding study of GSK3858279 in participants with moderate to severe knee osteoarthritis (OA) pain. The purpose of this study is to investigate and provide the data necessary to select the optimal effective and safe dose(s) of GSK3858279.
Gender:
All
Ages:
Between 40 years and 80 years
Trial Updated:
10/11/2023
Locations: GSK Investigational Site, Cerritos, California +98 locations
Conditions: Pain
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Implementation and Effectiveness of Mindfulness Oriented Recovery Enhancement as an Adjunct to Methadone Treatment
NCT06032559
Recruiting
This hybrid implementation-effectiveness trial will evaluate Mindfulness-Oriented Recovery Enhancement (MORE) for patients with opioid use disorder receiving methadone treatment (MT). The investigators will also assess barriers and facilitators to integrating MORE into methadone treatment, and evaluate the impact of a sustainable train-the-trainer model on provider burden, intervention fidelity, intervention engagement, and outcomes. Participants will be assigned to a higher intensity MORE imple... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/07/2023
Locations: Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey +1 locations
Conditions: Opioid Use, Pain
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Intravenous Gammaglobulin for Sickle Cell Pain Crises
NCT01757418
Recruiting
The purpose of this study is to determine whether intravenous immune globulin is safe and effective in the acute treatment of pain crises in sickle cell disease. Funding Source: Food and Drug Administration (FDA), Office of Orphan Products Development (OOPD)
Gender:
All
Ages:
Between 12 years and 65 years
Trial Updated:
09/29/2023
Locations: Montefiore Medical Center, Bronx, New York
Conditions: Sickle Cell Disease, Pain
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Virtual Reality for Pain Management in Burn Patients
NCT04685486
Recruiting
This study is a randomized proof-of-concept study to assess the efficacy of Virtual Reality (VR) vs standard of care in 50 adult patients in the New York Presbyterian Burn Unit. The participants who are randomized to receive the virtual reality intervention will also receive opioids, which is the standard of care and is known to be effective. Participants will be randomly assigned to two groups. The first group will receive VR during their painful procedure (e.g., wound dressing changes, physica... Read More
Gender:
All
Ages:
8 years and above
Trial Updated:
09/25/2023
Locations: Weill Cornell Medicine, New York, New York
Conditions: Pain
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Baclofen as a Perioperative Analgesic Adjuvant
NCT03720717
Recruiting
The purpose of this study is to determine whether a single, oral dose of baclofen alters postoperative opioid requirements.
Gender:
All
Ages:
19 years and above
Trial Updated:
09/23/2023
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Pain
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Nebulized Sub-dissociative Dose Ketamine at Three Different Dosing Regimens for Treating Acute Pain in the Pediatric ED
NCT03950817
Recruiting
In the situation when intravenous access is not readily available or unobtainable, sub-dissociative dose ketamine can be administered via intranasal route (IN). The data supporting intranasal route in pediatric patients is somewhat conflicting with regards to the optimum intranasal dose (range 0.75-1 mg/kg) and frequencies of administration. Hence, another non-invasive route such as nebulization via Breath-Actuated Nebulizer which allows a controlled patient-initiated delivery of analgesics in t... Read More
Gender:
All
Ages:
Between 7 years and 17 years
Trial Updated:
09/19/2023
Locations: Maimonides Medical Center, Brooklyn, New York
Conditions: Pain
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Impact of Art Therapy on Self-Reported Pain and Anxiety Scores of Patients Waiting to Be Seen in the Emergency Department
NCT05540106
Recruiting
The objective of this research is to assess the effects of engaging in coloring activities on patients' self-reported pain and anxiety scores while they wait to be seen by a physician in an emergency department (ED). The current literature on patient visits in the ED highlights the significance of anxiety, stress, and frustration in patient experiences, especially when accounting for long wait times before the physician-patient encounter. The study will address this common problem by looking at... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
09/13/2023
Locations: Stony Brook University Hospital, Stony Brook, New York
Conditions: Anxiety, Pain
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Neural Correlates of Hypoalgesia Driven by Observation
NCT03897998
Recruiting
Placebo effects held an ambivalent place in health care for at least two centuries. On the one hand, placebos are traditionally used as controls in clinical trials to correct for biases and the placebo response is viewed as an effect to be factored out in order to isolate and accurately measure the effects of the treatment. On the other hand, there is scientific evidence that placebo effects represent fascinating psychoneurobiological events involving the contribution of distinct central nervous... Read More
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
09/11/2023
Locations: University of Maryland, Baltimore, Maryland
Conditions: Pain, Virtual Reality, Placebo
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Study of Low-intensity Focused Ultrasound Effects on Heat Evoked fMRI Signals
NCT05303415
Recruiting
Study aims to examine the effects of noninvasive brain stimulation on brain signals. This insight may have potential clinical implications for addiction, pain, and mental health populations. Participants will receive MRI and CT imaging. Participants receive low-intensity focused ultrasound (LIFU) to temporarily change brain activity. Participants then receive fMRI scans to measure changes in both resting and heat evoked brain signaling using a quantitative sensory testing device. Heart rate, blo... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
08/29/2023
Locations: Fralin Biomedical Research Institute, Roanoke, Virginia
Conditions: Pain
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Brief Cognitive Behavioral Therapy for Chronic Pain to Improve Functioning Among Veterans
NCT04724694
Recruiting
Chronic pain is very common among primary care Veterans and can seriously impact overall patient functioning and well-being. Currently, behavioral treatments for pain management are not often provided in primary care because they are designed to be delivered in specialty care settings, such as chronic pain clinics. To address this gap in care, the proposed study will test if Brief Cognitive Behavioral Therapy for Chronic Pain (Brief CBT-CP) is an effective treatment. Therefore, the first objecti... Read More
Gender:
All
Ages:
Between 18 years and 79 years
Trial Updated:
08/23/2023
Locations: VA Western New York Healthcare System, Buffalo, NY, Buffalo, New York
Conditions: Musculoskeletal Pain, Pain
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Dilution of Verapamil During Intraarterial Administration
NCT05625503
Recruiting
This study will be a randomized, single-blind, prospective trial designed to evaluate the efficacy and safety of intra-arterial (IA) Verapamil diluted with normal saline compared to undiluted IA Nicardipine during transradial access (TRA) for percutaneous coronary angiography. Patients who are 18 years or older and undergoing non-emergent percutaneous coronary angiography via TRA will be included. Patients who are non-English speaking, pregnant, or intubated will be excluded. Patients will be ra... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/21/2023
Locations: University of Illinois Hospital, Chicago, Illinois
Conditions: Vasospasm;Peripheral, Burning, Pain
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