There are currently 122 active clinical trials seeking participants for Pain research studies. The states with the highest number of trials for Pain participants are California, Ohio, Florida and Illinois.
PAINED: Project Addressing INequities in the Emergency Department
NCT05488080
Recruiting
Racial and ethnic inequities in health care quality have been described across a broad range of clinical settings, patient populations, and outcomes. Our overarching goal is to eradicate health care inequities through evidence-based interventions. The objectives of this proposal are to develop and test the impact of two interventions on overcoming clinician implicit bias and mitigating inequities in the management of pain among children seeking care in the emergency department for the treatment... Read More
Gender:
ALL
Ages:
0 years and above
Trial Updated:
07/14/2025
Locations: Children's National Hospital, Washington, District of Columbia
Conditions: Pain, Appendicitis, Bias, Racial, Fractures, Bone
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High Potency Cannabis: Acute and Protracted Effects
NCT06859723
Recruiting
The purpose of this research is to assess the effects of smoked cananbis when cannabis is smoked during periods of cannabis use as usual and after a brief period of abstinence.
Gender:
ALL
Ages:
Between 21 years and 55 years
Trial Updated:
07/14/2025
Locations: UCLA Center for Cannabis and Cannabinoids, Los Angeles, California
Conditions: Abuse Cannabis, Pain, Pharmacokinetics
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Augmented Reality For MRI-Guided Interventions
NCT06224933
Recruiting
The purpose of this study is to determine feasibility and safety of using an augmented reality system in patients undergoing MRI-Guided needle procedures.
Gender:
ALL
Ages:
Between 3 years and 21 years
Trial Updated:
07/09/2025
Locations: Children's National Hospital, Washington, District of Columbia
Conditions: Infections, Pain, Diagnosis
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ESPBs vs TAPs for Satisfactory Analgesia Following DIEP Surgery
NCT06091241
Recruiting
Breast cancer is the second most common cancer diagnosed in American women . For patients who have undergone surgical mastectomy, autologous breast reconstruction is an alternative option to breast implants. Deep Inferior Epigastric Perforator (DIEP) flaps are the gold standard for autologous breast reconstruction . Effective pain control following surgery is imperative and ultrasound-guided bilateral transversus abdominis plane blocks (TAPs) with the infiltration of local anesthetics, such a bu... Read More
Gender:
FEMALE
Ages:
Between 18 years and 70 years
Trial Updated:
07/07/2025
Locations: University of Kansas Medical Center, Kansas City, Kansas
Conditions: Pain
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Transcutaneous Electrical Nerve Stimulation (TENS) for Intrauterine Device (IUD) Insertion Pain
NCT07044622
Recruiting
This study is a double-blind, randomized, placebo-controlled trial to evaluate the use of high frequency TENS for pain control during IUD insertion. Transcutaneous electrical nerve stimulation (TENS) is a relatively low-cost, low-risk, non-pharmacologic intervention for pain management. Previous studies have found that TENS reduces pain associated with other outpatient gynecological procedures. Participants will be randomized in a 1:1 ratio to either active treatment or placebo (placebo TENS) an... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/03/2025
Locations: Center for Women's Health and Midwifery, New Haven, Connecticut +1 locations
Conditions: Pain
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Effect of Magnesium on Neuromonitoring
NCT06975072
Recruiting
Intraoperative neurophysiologic monitoring (IONM) is commonly used during complex spinal surgery to monitor the integrity of neural structures and improve the perioperative safety profile. Transcranial Motor Evoked Potentials (TcMEPs) monitor the integrity of the motor pathways and are one of the most commonly used monitoring modalities in spinal surgery. Because inhaled anesthetics can negatively affect the ability to monitor TcMEPs, anesthesiologists commonly use a combination of propofol and... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: University of California San Francisco Hospital, San Francisco, California
Conditions: Spine, Pain, Spine Surgery, Spine Surgery With Neuromonitoring, Spine Surgery With Motor Evoked Potential Monitoring, Spine Fusion
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Measuring Analgesic Interventions
NCT03794362
Recruiting
It is generally recognized that pain assessment and management especially in newborns, children and other nonverbal populations is an unmet need. According to the American Medical Association, "the pediatric population is at risk of inadequate pain management, with age-related factors affecting pain management in children. Children are often given minimal or no analgesia for procedures that would routinely be treated aggressively in adults. Although much is now known about pain management in chi... Read More
Gender:
ALL
Ages:
Between 7 years and 21 years
Trial Updated:
07/02/2025
Locations: Children's National Health System, Washington, District of Columbia
Conditions: Pain
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Neural Correlates of Hypoalgesia Driven by Observation
NCT03897998
Recruiting
Placebo effects held an ambivalent place in health care for at least two centuries. On the one hand, placebos are traditionally used as controls in clinical trials to correct for biases and the placebo response is viewed as an effect to be factored out in order to isolate and accurately measure the effects of the treatment. On the other hand, there is scientific evidence that placebo effects represent fascinating psychoneurobiological events involving the contribution of distinct central nervous... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
06/24/2025
Locations: University of Maryland, Baltimore, Maryland
Conditions: Pain, Virtual Reality, Placebo
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Neural Mechanisms of Immersive Virtual Reality in Chronic Pain
NCT04851301
Recruiting
This project examines, in chronic pain, the mechanisms of immersive virtual reality compared to the mechanisms of placebo hypoalgesia. The potential of developing new non-pharmacological premises for low-risk interventions for pain management is high.
Gender:
ALL
Ages:
Between 18 years and 88 years
Trial Updated:
06/24/2025
Locations: Luana Colloca, Baltimore, Maryland
Conditions: Pain, Virtual Reality, Placebo, Temporomandibular Disorder
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Neural Mechanisms of Immersive Virtual Reality in Chronic Pain (VR TMD EEG)
NCT06214923
Recruiting
This project examines, in chronic pain, the mechanisms of immersive virtual reality compared to the mechanisms of placebo hypoalgesia. The potential of developing new non-pharmacological premises for low-risk interventions for pain management is high.
Gender:
ALL
Ages:
Between 18 years and 88 years
Trial Updated:
06/24/2025
Locations: Luana Colloca, Baltimore, Maryland +1 locations
Conditions: Pain, Virtual Reality, Placebo, Temporomandibular Disorder
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Patient Controlled Administration of Liquid Acetaminophen
NCT06498713
Recruiting
This is a proof of concept pilot study investigating the feasibility and acceptability of patient controlled oral medication administration, using the commonly used and low risk medication in the hospital, oral acetaminophen.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/18/2025
Locations: Yale New Haven Hospital at St. Raphael's Campus, New Haven, Connecticut
Conditions: Pain, Pain, Postoperative
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Pain Alleviation With Testosterone in Opioid-Induced Hypogonadism
NCT04798469
Recruiting
The aim of this trial is to evaluate whether testosterone replacement results in greater improvement in pain perception, pain tolerance, sexual function, fatigue, and quality of life when compared with placebo in men with chronic spinal pain treated with opioids who have opioid-induced hypogonadism (low testosterone).
Gender:
MALE
Ages:
18 years and above
Trial Updated:
06/17/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Opioid Use, Pain, Hypogonadism, Male
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